WO2002043574A2 - System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations - Google Patents
System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations Download PDFInfo
- Publication number
- WO2002043574A2 WO2002043574A2 PCT/US2001/045023 US0145023W WO0243574A2 WO 2002043574 A2 WO2002043574 A2 WO 2002043574A2 US 0145023 W US0145023 W US 0145023W WO 0243574 A2 WO0243574 A2 WO 0243574A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sperm cells
- chromosome bearing
- hoechst
- stain
- concentration
- Prior art date
Links
- 238000000034 method Methods 0.000 claims abstract description 89
- 210000001766 X chromosome Anatomy 0.000 claims abstract description 70
- 210000002593 Y chromosome Anatomy 0.000 claims abstract description 60
- 238000000926 separation method Methods 0.000 claims abstract description 19
- 210000004027 cell Anatomy 0.000 claims description 212
- 241000124008 Mammalia Species 0.000 claims description 110
- 238000010186 staining Methods 0.000 claims description 59
- PRDFBSVERLRRMY-UHFFFAOYSA-N 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole Chemical compound C1=CC(OCC)=CC=C1C1=NC2=CC=C(C=3NC4=CC(=CC=C4N=3)N3CCN(C)CC3)C=C2N1 PRDFBSVERLRRMY-UHFFFAOYSA-N 0.000 claims description 57
- 210000000582 semen Anatomy 0.000 claims description 54
- 230000009027 insemination Effects 0.000 claims description 34
- 210000000349 chromosome Anatomy 0.000 claims description 28
- 241000282817 Bovidae Species 0.000 claims description 21
- 210000000287 oocyte Anatomy 0.000 claims description 16
- 241000894007 species Species 0.000 claims description 16
- 239000012530 fluid Substances 0.000 claims description 14
- 210000001161 mammalian embryo Anatomy 0.000 claims description 11
- 241000282898 Sus scrofa Species 0.000 claims description 8
- 241000282412 Homo Species 0.000 claims description 7
- 241000288906 Primates Species 0.000 claims description 7
- 241001125840 Coryphaenidae Species 0.000 claims description 6
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 230000012173 estrus Effects 0.000 claims description 2
- 238000010257 thawing Methods 0.000 claims 9
- 230000008014 freezing Effects 0.000 claims 7
- 238000007710 freezing Methods 0.000 claims 7
- 235000013601 eggs Nutrition 0.000 claims 3
- 230000000624 ovulatory effect Effects 0.000 claims 2
- 206010042573 Superovulation Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 2
- 238000004806 packaging method and process Methods 0.000 abstract 1
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 23
- 238000000338 in vitro Methods 0.000 description 15
- 230000004720 fertilization Effects 0.000 description 14
- 238000003776 cleavage reaction Methods 0.000 description 11
- 230000007017 scission Effects 0.000 description 11
- 238000005516 engineering process Methods 0.000 description 10
- 230000005284 excitation Effects 0.000 description 9
- 241000283690 Bos taurus Species 0.000 description 8
- 230000009471 action Effects 0.000 description 6
- 244000309464 bull Species 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 241000283153 Cetacea Species 0.000 description 5
- 230000013020 embryo development Effects 0.000 description 5
- 238000000684 flow cytometry Methods 0.000 description 5
- 238000002955 isolation Methods 0.000 description 5
- 241000283073 Equus caballus Species 0.000 description 4
- 238000012864 cross contamination Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 210000002459 blastocyst Anatomy 0.000 description 3
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000004940 nucleus Anatomy 0.000 description 3
- 230000016087 ovulation Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000035899 viability Effects 0.000 description 3
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- 241000282575 Gorilla Species 0.000 description 2
- 241000282579 Pan Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 230000003001 depressive effect Effects 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 1
- -1 Hoechst 33342 Chemical compound 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 1
- 125000002015 acyclic group Chemical group 0.000 description 1
- 238000003975 animal breeding Methods 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 230000008217 follicular development Effects 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000008010 sperm capacitation Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0604—Whole embryos; Culture medium therefor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
- A01N1/0273—Transport containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU3768902A AU3768902A (en) | 2000-11-29 | 2001-11-29 | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
CA2468772A CA2468772C (en) | 2000-11-29 | 2001-11-29 | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
AU2002237689A AU2002237689B2 (en) | 2000-11-29 | 2001-11-29 | System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations |
BRPI0115791-4A BRPI0115791B1 (en) | 2000-11-29 | 2001-11-29 | system for in vitro fertilization with separate spermatozoa in populations with x chromosome and y chromosome |
US10/433,183 US7713687B2 (en) | 2000-11-29 | 2001-11-29 | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
US11/536,576 US7771921B2 (en) | 2000-11-29 | 2006-09-28 | Separation systems of frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations |
AU2008200810A AU2008200810B2 (en) | 2000-11-29 | 2008-02-21 | System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations |
US12/853,196 US8652769B2 (en) | 2000-11-29 | 2010-08-09 | Methods for separating frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations |
AU2011201281A AU2011201281B2 (en) | 2000-11-29 | 2011-03-22 | System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25378500P | 2000-11-29 | 2000-11-29 | |
US25378700P | 2000-11-29 | 2000-11-29 | |
US60/253,785 | 2000-11-29 | ||
US60/253,787 | 2000-11-29 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10433183 A-371-Of-International | 2001-11-29 | ||
US11/536,576 Continuation US7771921B2 (en) | 2000-11-29 | 2006-09-28 | Separation systems of frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations |
Publications (4)
Publication Number | Publication Date |
---|---|
WO2002043574A2 true WO2002043574A2 (en) | 2002-06-06 |
WO2002043574A3 WO2002043574A3 (en) | 2002-08-29 |
WO2002043574A8 WO2002043574A8 (en) | 2003-11-20 |
WO2002043574A9 WO2002043574A9 (en) | 2003-12-18 |
Family
ID=26943568
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/045237 WO2002043486A1 (en) | 2000-11-29 | 2001-11-29 | System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations |
PCT/US2001/045023 WO2002043574A2 (en) | 2000-11-29 | 2001-11-29 | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/045237 WO2002043486A1 (en) | 2000-11-29 | 2001-11-29 | System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations |
Country Status (7)
Country | Link |
---|---|
US (4) | US7094527B2 (en) |
AR (2) | AR036870A1 (en) |
AU (5) | AU2002220018A1 (en) |
BR (2) | BRPI0115791B1 (en) |
CA (3) | CA2822983C (en) |
UY (1) | UY27051A1 (en) |
WO (2) | WO2002043486A1 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004012837A2 (en) | 2002-08-01 | 2004-02-12 | Xy, Inc. | Low pressure sperm cell separation system |
US7335507B2 (en) | 2003-03-28 | 2008-02-26 | Monsanto Technology Llc | Process for the staining of sperm |
US7723116B2 (en) | 2003-05-15 | 2010-05-25 | Xy, Inc. | Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm |
EP2194379A1 (en) | 2003-03-28 | 2010-06-09 | Inguran, LLC | Apparatus and methods for providing sex-sorted animal sperm |
US7772005B1 (en) | 1998-07-30 | 2010-08-10 | Xy, Llc | Method of establishing an equine artificial insemination sample |
US7838210B2 (en) | 2004-03-29 | 2010-11-23 | Inguran, LLC. | Sperm suspensions for sorting into X or Y chromosome-bearing enriched populations |
US7855078B2 (en) | 2002-08-15 | 2010-12-21 | Xy, Llc | High resolution flow cytometer |
US7998700B2 (en) | 2004-03-29 | 2011-08-16 | Inguran, Llc | Use of a composition which regulates oxidation/reduction reactions intracellularly and/or extracellulary in a staining or sorting process |
US8486618B2 (en) | 2002-08-01 | 2013-07-16 | Xy, Llc | Heterogeneous inseminate system |
US8553226B2 (en) | 1997-01-31 | 2013-10-08 | Xy, Llc | Optical apparatus |
US9879221B2 (en) | 2000-11-29 | 2018-01-30 | Xy, Llc | Method of in-vitro fertilization with spermatozoa separated into X-chromosome and Y-chromosome bearing populations |
US10208345B2 (en) | 2000-05-09 | 2019-02-19 | Xy, Llc | Method for producing high purity X-chromosome bearing and Y-chromosome bearing populations of spermatozoa |
US11230695B2 (en) | 2002-09-13 | 2022-01-25 | Xy, Llc | Sperm cell processing and preservation systems |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
US7208265B1 (en) * | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
CA2529724A1 (en) * | 2002-06-17 | 2003-12-24 | Kobenhavns Amts Sygehus, Herlev | In vitro fertilisation |
MX2007000888A (en) | 2004-07-22 | 2007-04-02 | Monsanto Technology Llc | Process for enriching a population of sperm cells. |
GB0707776D0 (en) * | 2007-04-23 | 2007-05-30 | Robio Systems Ltd | A Container for culturing and/or transporting embryos or oocytes. an insert for the container and a method of transporting same |
CL2008002118A1 (en) * | 2007-07-19 | 2008-12-19 | Xy Llc | Method for the production of an equine embryo of selected sex by intracytoplasmic sperm injection using equine sperm selected by sex. |
AU2008338530A1 (en) | 2007-12-14 | 2009-06-25 | Minitube Of America, Inc. | Gender-specific separation of sperm cells and embryos |
FR2925917B1 (en) * | 2007-12-27 | 2010-03-19 | Agronomique Inst Nat Rech | METHOD FOR PRESERVING SPERM AND ITS APPLICATIONS |
US8512224B2 (en) * | 2009-01-24 | 2013-08-20 | Xy, Llc | Method of producing an inseminate |
US8251887B2 (en) * | 2009-01-24 | 2012-08-28 | Xihe Li | Reproductive technology of low dose semen production and in vitro/in vitro fertilization in domestic animals |
US9781919B2 (en) | 2011-06-01 | 2017-10-10 | Inguran, Llc | Compositions and methods for improving the quality of processed sperm |
US9347038B2 (en) | 2011-06-01 | 2016-05-24 | Inguran, Llc | Compositions and methods for processing sperm |
US9888990B2 (en) | 2012-06-06 | 2018-02-13 | Inguran, Llc | Methods for use of sex sorted semen to improve genetic management in swine |
US9433195B2 (en) | 2012-06-06 | 2016-09-06 | Inguran, Llc | Methods for increasing genetic progress in a line or breed of swine using sex-selected sperm cells |
CN102726367A (en) * | 2012-06-12 | 2012-10-17 | 宁波市畜牧工程技术研究服务中心 | Low-temperature protective agent of boar semen |
CN102726371A (en) * | 2012-07-11 | 2012-10-17 | 于文龙 | Long-acting boar semen diluting powder and preparation method thereof |
IN2014MU00233A (en) * | 2014-01-22 | 2015-09-11 | Shivani Scient Ind Private Ltd | |
CN107535482A (en) * | 2017-10-11 | 2018-01-05 | 山东大学齐鲁医院 | A kind of bulk Vitrification of Ovarian Tissue carrier and its application |
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US6149867A (en) * | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
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