WO2002043600A1 - Vascular snare and method of forming the same - Google Patents
Vascular snare and method of forming the same Download PDFInfo
- Publication number
- WO2002043600A1 WO2002043600A1 PCT/US2001/044225 US0144225W WO0243600A1 WO 2002043600 A1 WO2002043600 A1 WO 2002043600A1 US 0144225 W US0144225 W US 0144225W WO 0243600 A1 WO0243600 A1 WO 0243600A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- loops
- intravascular
- loop
- snare
- intravascular snare
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 10
- 230000002792 vascular Effects 0.000 title description 5
- 239000000463 material Substances 0.000 claims abstract description 31
- 229910000734 martensite Inorganic materials 0.000 claims description 27
- 239000012781 shape memory material Substances 0.000 claims description 9
- 229910000510 noble metal Inorganic materials 0.000 claims description 7
- 229910045601 alloy Inorganic materials 0.000 description 12
- 239000000956 alloy Substances 0.000 description 12
- 229910001000 nickel titanium Inorganic materials 0.000 description 9
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 9
- 239000002131 composite material Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 229910001566 austenite Inorganic materials 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 210000005166 vasculature Anatomy 0.000 description 3
- -1 MP35N Inorganic materials 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 241000722921 Tulipa gesneriana Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical compound [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 description 2
- 238000004513 sizing Methods 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 229910001040 Beta-titanium Inorganic materials 0.000 description 1
- 229920004934 Dacron® Polymers 0.000 description 1
- 229920000271 Kevlar® Polymers 0.000 description 1
- 229910000990 Ni alloy Inorganic materials 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005489 elastic deformation Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000004761 kevlar Substances 0.000 description 1
- 210000000244 kidney pelvis Anatomy 0.000 description 1
- 238000001755 magnetron sputter deposition Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
- A61B2017/2215—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having an open distal end
Definitions
- the device In the thermally triggered devices, the device is cooled below a temperature transformation level to a martensitic state and thereby softened for loading into a catheter in a relatively compressed and elongated state. To regain the memorized shape in an austenitic state, the device is warmed to a selected temperature transformation level, such as human body temperature.
- a selected temperature transformation level such as human body temperature.
- the two interchangeable shapes are possible because of the two distinct microcrystalline structures that are interchangeable with a small variation in temperature.
- the temperature at which the device assumes its first configuration may be varied within wide limits by changing the composition of the alloy. Thus, for human use, the alloy may be focused on a transition temperature range close to 98.6°F.
- intra vascular medical devices such as stents and filters which expand and are held in position by engagement with the inner wall of a vessel
- intra vascular snares to retrieve these foreign bodies from the peripheral vessels of the cardiovascular system.
- Single loop snares such as those shown by U.S. Patent Nos. 3,828,790 to Curtiss et al. and 5,171,233 to Amplatz et al. are commonly used snares.
- the Amplatz snare consists of a super-elastic nitinol cable with a single-formed loop. Because of the snare's super elastic construction, the loop can be introduced through small lumen catheters without risk of deformation.
- the loop is formed at approximately 90° to the cable, and this allows for the user to advance the loop over a foreign body and ensnare it by closing the loop with a small catheter.
- the foreign body is removed from the vasculature by withdrawing the device into a guiding catheter or vascular sheath.
- this snare is a significant improvement over earlier forward facing stainless steel snares that are easily deformed and difficult to advance over foreign bodies, the Amplatz snare is geometrically sensitive and requires appropriate sizing to the vasculature in order to allow for successful ensnarement.
- the single loop design has poor cross sectional vessel coverage and thereby requires skilled manipulation to capture the desired object.
- multi loop snares such as those shown by U.S. Patent Nos. 5,098,440 to Hillstead and 6,099,534 to Bates have been developed. These snares include loops which are joined only at their proximal ends to a shaft, and otherwise are not joined at any point between the shaft and the distal ends of the loops. This provides the advantage over single loop snares of enhanced cross sectional vessel coverage, and the free distal ends of the loops can be brought together to engage multiple surfaces of an intravascular medical device to be removed.
- the problem with multiloop snares having loops attached at only the proximal ends is that the relative geometry of the free loops is difficult to maintain. The relative position of the loops can change, both within a catheter or delivery tube and within a vessel, and the loops can actually become displaced or entangled during delivery.
- Basket type snares having loops connected at both their proximal and distal ends to form an enclosed basket have been developed as shown by U.S. Patent Nos. 5,817,104 to Bilitz et al. and 6,077,274 to Ouchi et al. These basket snares do not have free distal ends which can move along opposed surfaces of an intravascular device, and basket snares are primarily used to remove stones or stone fragments from the gallbladder, bilary tract, renal pelvis and ureter.
- Another object of the present invention is to provide a novel and improved intravascular snare and method of forming the same wherein the snare includes a plurality of loops which are interlaced together between their proximal and distal ends to maintain a predetermined loop geometry while maintaining the distal ends of the loops free.
- a further object of the present invention is to provide a novel and improved intravascular snare and method of forming the same wherein the snare includes a plurality of loops attached at their proximal ends to a central shaft.
- the loops angle outwardly relative to the shaft at approximately a ten to thirty degree angle and spaced from the shaft are angled outwardly at about another ten to thirty degrees to create a greater diameter at the loop distal ends.
- the total angle of each loop to the shaft is preferrably forty degrees or less.
- Yet another object of the present invention is to provide a novel and improved intravascular snare and method of forming the same wherein the snare includes multiple loops of a composite multiple strand material with the strands of each loop being penetrated by an adjacent loop to interlace the loops together.
- a still further object of the present invention is to provide a novel and improved intravascular snare and method of making the same wherein the snare is formed of shape memory material such as nitinol. Martensite is induced in the material, such as by cooling, and in the martensitic state, the material is deformed mechanically to form a new shape by controlled deformation. If cycled elastically, the alloy will remember the new shape rather than the original austenitic shape.
- shape memory material such as nitinol. Martensite is induced in the material, such as by cooling, and in the martensitic state, the material is deformed mechanically to form a new shape by controlled deformation. If cycled elastically, the alloy will remember the new shape rather than the original austenitic shape.
- a snare comprised of a central shaft constructed of super-elastic nitinol with two to eight pre-formed interlaced loops at the distal end of the shaft.
- the loops are formed of equal length and preferably extend at approximately 15° to the central shaft and each loop is also preferably flared outwardly an additional 15° to open the leading edges of the loops to a greater diameter that ultimately increases wire to vessel surface area, contact.
- Individual loops are interlaced together to form a tulip shaped assembly.
- the loops are formed from a composite multiple strand material constructed of nitinol and a noble metal such as gold or platinum iridium. The noble metal provides radiopacity while the nitinol provides shape memory.
- Figure 1 is a plan view of the interlacing of two strands used to form the loops for the intravascular snare of the present invention
- Figure 2 is a plan view of three interlaced strands used for the intravascular snare of the present invention
- Figure 3 is a view in side elevation of the intravascular snare of the present invention.
- Figure 4 is a diagram of the martensitic deformation used to size the intravascular snare of the present invention.
- Figure 5 is a view in end elevation of the expanded intravascular snare of Figure 3.
- Figure 6 is a view in side elevation of a loop for the intravascular snare of Figure 3 covered by a membrane. Description of the Preferred Embodiments
- the loops of the intravascular snare of the present invention are formed from three wires 10, 12, and 14 each of which is formed preferably of a multistrand composite.
- This composite is preferably constructed of nitinol and a noble metal such as gold or platinum iridium, so that the noble metal provides radiopacity while the nitinol provides shape memory.
- the multiple strands forming the wires 10, 12 and 14 can be braided, knitted, woven or wound. Other materials could be used to form the loops such as beta-titanium, MP35N, stainless steel, and possibly fibers such as Dacron (polyester) or Kevlar.
- a fine gauge hypothermic needle 16 is used to penetrate between the strands of the wire 10 so that approximately fifty percent of the strands forming the wire are on each side of the needle. Then the wire 12 is passed through the hypodermic needle and the wire 10 as shown in Figure 1, and the hypodermic needle is withdrawn. This creates an interlaced joinder point 18 between the wires 10 and 12.
- the hypodermic needle is passed through the wire 14 at two spaced locations as shown in Figure 2.
- a first location 20 the wire 10 is passed through the hypodermic needle and the wire 14 to form an interlaced joinder point and at a second location 22, the wire 12 is passed through the hypodermic needle and the wire 14 to form an interlaced joinder point.
- the three wires are interlaced, they form an isosceles triangle 24, the size of which dictates the ultimate diameter of the intravascular snare.
- the portions of the wires 10, 12, and 14 which form the three sides 26, 28 and 30 of the triangle 24 are then moved outwardly to form the distal closed ends of loops 32, 34 and 36 shown in Figure 3. These distal loop ends, which extend outwardly beyond the joinder points 18, 20 and 22 are also numbered 26, 28 and 30 in Figure 3.
- the snare could be formed from two interconnected wires or from more than three wires.
- the interlaced joinder points will form a square rather than the isosceles-triangle 24; in a five wire snare the joinder points will form a pentagon; in a six wire snare the joinder points will form a hexagon; etc.
- the equal sided geometric interconnection formed by the joinder points dictates the ultimate diameter of the intravascular snare.
- the free ends 38 and 40 of the wire 10, 42 and 44 of the wire 12 and 46 and 48 of the wire 14, which extend outwardly beyond the joinder points 18, 20 and 22, are gathered sequentially to a central point for attachment to a shaft 50.
- the loops 32, 34 and 36 are of equal size, and are interlaced at joinder points 18, 20 and 22 which are spaced inwardly from loop distal ends 26, 28 and 30, leaving the loop distal ends free to close against the sides of an object to be removed from a vessel.
- the snare 52 is positioned on a forming jig to form the geometry of the loops. They extend from the shaft 50 at angles of approximately fifteen degrees, and spaced from the end of the shaft, each loop flares outwardly for approximately another fifteen degrees to open the distal ends of the loops to a greater diameter that ultimately increases wire to vessel surface area contact.
- the loops can be formed to other combined angles which will provide loops which extend up to forty degrees with respect to the shaft 50.
- each loop can be described as a radius and the front view geometry described as a teardrop.
- Individual loops are interlaced together to form a tulip assembly, and the relative position and geometry of the loops is maintained by the joinder points 18, 20, 22. These prevent the loops from becoming displaced or crossed in a catheter or delivery tube. It should be noted that when the loops are interlaced in the manner shown in Figures 1 and 2, the wire side of a loop which passes between the strands of an adjacent loop is adapted for limited longitudinal movement relative to the adjacent loop at the joinder point. This relieves stress on the interconnection at the joinder point as the loops expand and contract.
- the snare 52 is annealed at approximately 500°C for ten minutes.
- the loops can be coated with noble metals by dip casting or ion disposition.
- a preferred method is by an unbalanced magnetron sputtering process providing a well-adhered noble coating on the outside surfaces of the braid. This will prevent coating fracture during loop deformation.
- Radiopacity can also be achieved without a coating process by fabricating one or more strands of the multistrand material forming the loop from a radiopaque material such as a noble metal or from a tubular strand filled with a radiopaque material.
- the wires 10, 12 and 14 may be formed from a single strand of wire filled with a radiopaque material.
- the snare 52 may be formed of nitinol wire or similar thermally responsive shape memory material, and may then be cooled to the martensitic state for insertion into a catheter or delivery tube. When the snare is projected outwardly from the delivery tube within a blood vessel, it can be formed to return to the austenitic state in response to body temperature and expand outwardly into contact with the vessel walls.
- the snare 52 offers significant design advantages over known single loop and multiple loop retrieval systems.
- the snare 52 extends across the entire cross sectional area of a vessel while in contrast, a single loop snare, if oversized or undersized relative to the vessel cross section, leaves large, uncovered voids within the vessel.
- the snare 52 is self sizing to vasculature over a larger range requiring minimal device manipulation in use, and forms to a variety of vessel diameters and geometries. Unlike other single and multiple loop snares, the snare 52 conforms with a consistent geometry to a vessel due to the interlacing of the loops.
- the shape memory of a nitinol medical device can be altered by mechanical deformation in the martensitic state.
- Martensite can be thermally induced in the alloy by cooling, and once martensitic, the alloy is permanently deformed mechanically along line CD in Figure 4.
- line E F G As the alloy is subsequently warmed, it recovers along line E F G to a permanent set that is approximately equal to the permanent deformation of the martensite.
- stress is applied to the alloy, it deforms elastically along line OA, by SIM along line AB, by elastic deformation of the martensite to point C, and then eventually by permanent deformation of the martensite along line CD.
- the alloy As the stress is removed, the alloy partially recovers from D to E (does not recover permanent deformation); then, at a critical stress, the alloy reverts to austenite without requiring a change in temperature. This reversion occurs at constant stress that is lower than that of an elastically deformed alloy (no martensite deformation). Finally, if the stress is removed from the reverted austenite, it recovers elastically along line FG to a permanent set that is approximately equal to the permanent deformation of the martensite.
- the material can have one shape remembered in the austenitic phase if elastically cycled and a second shape can be formed by controlled deformation in the martensite phase. Once the new shape is formed, the material will remember the new shape if cycled elastically. Thus a medical device in the martensitic state can be crushed within a delivery device to alter the remembered austenitic shape of the medical device.
- multistrand shape memory wire as our preferred loop material, it could be substituted with tubing with radiopaque fillers, drawn wire, plastics, and other general engineered materials commonly used in the medical device industry. Loops of the snare could be welded, bonded, knotted, and/or crimped together to substitute for strand interlacing. Also, the wires forming the loops can be tapered lengthwise from the shaft 50 to provide a lower profile device and to optimize the radial strength of the snare.
- a thin, flexible membrane or sheet of materials 54 may be attached to points on the distal ends of each of the loops 32, 34 and 36 to stretch across the distal ends of the loops when the loops are in the expanded, open position. This membrane would in turn stretch across a vessel containing the snare 52 to capture clots or foreign objects.
- each of the loops 32, 34 and 36 can be covered, either totally or partially, with a thin, flexible membrane, weave or fabric 56 to assist in capturing clots or tissue.
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002216733A AU2002216733A1 (en) | 2000-11-28 | 2001-11-27 | Vascular snare and method of forming the same |
JP2002545583A JP4457225B2 (en) | 2000-11-28 | 2001-11-27 | Vascular snare and its formation method |
AT01998271T ATE441374T1 (en) | 2000-11-28 | 2001-11-27 | VESSEL LOOP AND METHOD FOR FORMING THE SAME |
EP01998271A EP1337191B1 (en) | 2000-11-28 | 2001-11-27 | Vascular snare and method of forming the same |
CA002429981A CA2429981C (en) | 2000-11-28 | 2001-11-27 | Vascular snare and method of forming the same |
DE60139799T DE60139799D1 (en) | 2000-11-28 | 2001-11-27 | VESSELS AND METHOD FOR THEIR EDUCATION |
DK01998271T DK1337191T3 (en) | 2000-11-28 | 2001-11-27 | Vessel loop and method of forming the same |
HK04101471.2A HK1059554A1 (en) | 2000-11-28 | 2004-02-27 | Vascular snare and method of forming the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/722,826 US6458145B1 (en) | 2000-11-28 | 2000-11-28 | Intra vascular snare and method of forming the same |
US09/722,826 | 2000-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002043600A1 true WO2002043600A1 (en) | 2002-06-06 |
Family
ID=24903550
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/044225 WO2002043600A1 (en) | 2000-11-28 | 2001-11-27 | Vascular snare and method of forming the same |
Country Status (11)
Country | Link |
---|---|
US (1) | US6458145B1 (en) |
EP (1) | EP1337191B1 (en) |
JP (4) | JP4457225B2 (en) |
AT (1) | ATE441374T1 (en) |
AU (1) | AU2002216733A1 (en) |
CA (1) | CA2429981C (en) |
DE (1) | DE60139799D1 (en) |
DK (1) | DK1337191T3 (en) |
ES (1) | ES2331350T3 (en) |
HK (1) | HK1059554A1 (en) |
WO (1) | WO2002043600A1 (en) |
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US8974470B2 (en) | 2011-01-04 | 2015-03-10 | Merit Medical Systems, Inc. | Multiple loop snare |
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US6458145B1 (en) | 2002-10-01 |
JP4457225B2 (en) | 2010-04-28 |
JP2007203081A (en) | 2007-08-16 |
ATE441374T1 (en) | 2009-09-15 |
CA2429981A1 (en) | 2002-06-06 |
AU2002216733A1 (en) | 2002-06-11 |
JP2010172716A (en) | 2010-08-12 |
DE60139799D1 (en) | 2009-10-15 |
EP1337191A4 (en) | 2008-02-13 |
JP5379057B2 (en) | 2013-12-25 |
JP2012176254A (en) | 2012-09-13 |
HK1059554A1 (en) | 2004-07-09 |
JP5622790B2 (en) | 2014-11-12 |
EP1337191A1 (en) | 2003-08-27 |
JP2004520871A (en) | 2004-07-15 |
JP4520473B2 (en) | 2010-08-04 |
DK1337191T3 (en) | 2009-12-21 |
CA2429981C (en) | 2007-08-21 |
EP1337191B1 (en) | 2009-09-02 |
ES2331350T3 (en) | 2009-12-30 |
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