WO2002045571A3 - Fast dissolving tablet - Google Patents

Fast dissolving tablet Download PDF

Info

Publication number
WO2002045571A3
WO2002045571A3 PCT/US2001/046396 US0146396W WO0245571A3 WO 2002045571 A3 WO2002045571 A3 WO 2002045571A3 US 0146396 W US0146396 W US 0146396W WO 0245571 A3 WO0245571 A3 WO 0245571A3
Authority
WO
WIPO (PCT)
Prior art keywords
tablets
mouth
fast dissolving
dissolving tablet
processes
Prior art date
Application number
PCT/US2001/046396
Other languages
French (fr)
Other versions
WO2002045571A2 (en
Inventor
Khawla A Abu-Izza
Vincent H Li
Jee L Look
Graham D Parr
Matthew K Schineller
Original Assignee
Wyeth Corp
Khawla A Abu-Izza
Vincent H Li
Jee L Look
Graham D Parr
Matthew K Schineller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Khawla A Abu-Izza, Vincent H Li, Jee L Look, Graham D Parr, Matthew K Schineller filed Critical Wyeth Corp
Priority to CA2436287A priority Critical patent/CA2436287C/en
Priority to AU3058902A priority patent/AU3058902A/en
Priority to DE60117289T priority patent/DE60117289D1/en
Priority to EP01990823A priority patent/EP1365743B1/en
Priority to MXPA03005098A priority patent/MXPA03005098A/en
Priority to NZ526368A priority patent/NZ526368A/en
Priority to AU2002230589A priority patent/AU2002230589B2/en
Publication of WO2002045571A2 publication Critical patent/WO2002045571A2/en
Publication of WO2002045571A3 publication Critical patent/WO2002045571A3/en
Priority to HK04101984A priority patent/HK1059217A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Abstract

The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouth feel. The tablets of the invention comprise a compound which melts at about 37 °C or lower, have a low hardness, high stability and generally comprise few insoluble disintegrants which may cause a gritty or chalky sensation in the mouth. Convenient and economically feasible processes by which the tablets of the invention may be produced are also provided.
PCT/US2001/046396 2000-12-06 2001-12-04 Fast dissolving tablet WO2002045571A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2436287A CA2436287C (en) 2000-12-06 2001-12-04 Fast dissolving tablet
AU3058902A AU3058902A (en) 2000-12-06 2001-12-04 Fast dissolving tablet
DE60117289T DE60117289D1 (en) 2000-12-06 2001-12-04 QUICK-RELEASE TABLETS
EP01990823A EP1365743B1 (en) 2000-12-06 2001-12-04 Fast dissolving tablets
MXPA03005098A MXPA03005098A (en) 2000-12-06 2001-12-04 Fast dissolving tablet.
NZ526368A NZ526368A (en) 2000-12-06 2001-12-04 Fast dissolving tablet comprising a compound that melts or softens below 37 degrees, a water soluble excipient and an active ingredient, having a hardness of 1kP or lower
AU2002230589A AU2002230589B2 (en) 2000-12-06 2001-12-04 Fast dissolving tablet
HK04101984A HK1059217A1 (en) 2000-12-06 2004-03-17 Fast dissolving tablets

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/731,479 2000-12-06
US09/731,479 US6733781B2 (en) 2000-12-06 2000-12-06 Fast dissolving tablet

Publications (2)

Publication Number Publication Date
WO2002045571A2 WO2002045571A2 (en) 2002-06-13
WO2002045571A3 true WO2002045571A3 (en) 2002-08-29

Family

ID=24939673

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046396 WO2002045571A2 (en) 2000-12-06 2001-12-04 Fast dissolving tablet

Country Status (11)

Country Link
US (1) US6733781B2 (en)
EP (1) EP1365743B1 (en)
AT (1) ATE317689T1 (en)
AU (2) AU2002230589B2 (en)
CA (1) CA2436287C (en)
DE (1) DE60117289D1 (en)
HK (1) HK1059217A1 (en)
MX (1) MXPA03005098A (en)
NZ (1) NZ526368A (en)
WO (1) WO2002045571A2 (en)
ZA (1) ZA200304511B (en)

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US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
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DE10026698A1 (en) * 2000-05-30 2001-12-06 Basf Ag Self-emulsifying active ingredient formulation and use of this formulation
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
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US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US20070243248A1 (en) * 2006-04-14 2007-10-18 Cherukuri S Rao Rapidly disintegrating solid oral dosage form of liquid dispersions
US20070251352A1 (en) 2006-05-01 2007-11-01 Pruitt Judith G Pelletized Feed Material for Biomass Generator
EP2043613A1 (en) * 2006-07-14 2009-04-08 Fmc Corporation Solid form
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Also Published As

Publication number Publication date
ATE317689T1 (en) 2006-03-15
AU3058902A (en) 2002-06-18
CA2436287A1 (en) 2002-06-13
CA2436287C (en) 2010-08-03
NZ526368A (en) 2004-03-26
US6733781B2 (en) 2004-05-11
DE60117289D1 (en) 2006-04-20
EP1365743B1 (en) 2006-02-15
US20020114833A1 (en) 2002-08-22
HK1059217A1 (en) 2004-06-25
MXPA03005098A (en) 2004-02-12
EP1365743A2 (en) 2003-12-03
AU2002230589B2 (en) 2005-11-10
ZA200304511B (en) 2004-03-05
WO2002045571A2 (en) 2002-06-13

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