WO2002045691A3 - Laboratory scale milling process - Google Patents

Laboratory scale milling process Download PDF

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Publication number
WO2002045691A3
WO2002045691A3 PCT/US2001/046310 US0146310W WO0245691A3 WO 2002045691 A3 WO2002045691 A3 WO 2002045691A3 US 0146310 W US0146310 W US 0146310W WO 0245691 A3 WO0245691 A3 WO 0245691A3
Authority
WO
WIPO (PCT)
Prior art keywords
suspension
stirring
milling process
laboratory scale
magnetically
Prior art date
Application number
PCT/US2001/046310
Other languages
French (fr)
Other versions
WO2002045691A2 (en
Inventor
Royal J Haskell
Original Assignee
Pharmacia Corp
Royal J Haskell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp, Royal J Haskell filed Critical Pharmacia Corp
Priority to CA002436574A priority Critical patent/CA2436574A1/en
Priority to EP01987269A priority patent/EP1339390A2/en
Priority to JP2002547477A priority patent/JP2004518642A/en
Priority to AU2002239504A priority patent/AU2002239504A1/en
Publication of WO2002045691A2 publication Critical patent/WO2002045691A2/en
Publication of WO2002045691A3 publication Critical patent/WO2002045691A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/005—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls the charge being turned over by magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/16—Mills in which a fixed container houses stirring means tumbling the charge
    • B02C17/163—Stirring means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/18—Details
    • B02C17/20—Disintegrating members
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B5/00—Electrically-operated educational appliances
    • G09B5/08—Electrically-operated educational appliances providing for individual presentation of information to a plurality of student stations
    • G09B5/14—Electrically-operated educational appliances providing for individual presentation of information to a plurality of student stations with provision for individual teacher-student communication
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B9/00—Simulators for teaching or training purposes
    • G09B9/02—Simulators for teaching or training purposes for teaching control of vehicles or other craft
    • G09B9/08—Simulators for teaching or training purposes for teaching control of vehicles or other craft for teaching control of aircraft, e.g. Link trainer

Abstract

There is provided a process fo reducing particle size of a drug, the process comprising: (a) a step of dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension; (b) a step of bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension; (c) a step of magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 νm; and (d) a step of separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring.
PCT/US2001/046310 2000-12-06 2001-12-05 Laboratory scale milling process WO2002045691A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002436574A CA2436574A1 (en) 2000-12-06 2001-12-05 Laboratory scale milling process
EP01987269A EP1339390A2 (en) 2000-12-06 2001-12-05 Laboratory scale milling process
JP2002547477A JP2004518642A (en) 2000-12-06 2001-12-05 Laboratory-scale pulverization process
AU2002239504A AU2002239504A1 (en) 2000-12-06 2001-12-05 Laboratory scale milling process

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25175000P 2000-12-06 2000-12-06
US60/251,750 2000-12-06

Publications (2)

Publication Number Publication Date
WO2002045691A2 WO2002045691A2 (en) 2002-06-13
WO2002045691A3 true WO2002045691A3 (en) 2002-09-06

Family

ID=22953247

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046310 WO2002045691A2 (en) 2000-12-06 2001-12-05 Laboratory scale milling process

Country Status (6)

Country Link
US (2) US6814319B2 (en)
EP (1) EP1339390A2 (en)
JP (1) JP2004518642A (en)
AU (1) AU2002239504A1 (en)
CA (1) CA2436574A1 (en)
WO (1) WO2002045691A2 (en)

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Also Published As

Publication number Publication date
EP1339390A2 (en) 2003-09-03
US20020119200A1 (en) 2002-08-29
US20050023386A1 (en) 2005-02-03
JP2004518642A (en) 2004-06-24
WO2002045691A2 (en) 2002-06-13
CA2436574A1 (en) 2002-06-13
US6814319B2 (en) 2004-11-09
AU2002239504A1 (en) 2002-06-18

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