WO2002053025A2 - Sensor for transcutaneous measurement of vascular access blood flow - Google Patents
Sensor for transcutaneous measurement of vascular access blood flow Download PDFInfo
- Publication number
- WO2002053025A2 WO2002053025A2 PCT/US2001/048562 US0148562W WO02053025A2 WO 2002053025 A2 WO2002053025 A2 WO 2002053025A2 US 0148562 W US0148562 W US 0148562W WO 02053025 A2 WO02053025 A2 WO 02053025A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sensor
- access
- emitter
- detector
- inboard
- Prior art date
Links
- 230000002792 vascular Effects 0.000 title claims abstract description 46
- 230000017531 blood circulation Effects 0.000 title claims abstract description 23
- 238000005259 measurement Methods 0.000 title claims description 27
- 230000003287 optical effect Effects 0.000 claims abstract description 22
- 238000005534 hematocrit Methods 0.000 claims description 64
- 239000000758 substrate Substances 0.000 claims description 36
- 210000003462 vein Anatomy 0.000 claims description 13
- 239000003973 paint Substances 0.000 claims description 8
- 239000011241 protective layer Substances 0.000 claims description 7
- 238000012544 monitoring process Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims 2
- 238000001631 haemodialysis Methods 0.000 abstract description 19
- 230000000322 hemodialysis Effects 0.000 abstract description 19
- 210000001519 tissue Anatomy 0.000 description 49
- 238000011144 upstream manufacturing Methods 0.000 description 38
- 239000008280 blood Substances 0.000 description 34
- 210000004369 blood Anatomy 0.000 description 34
- 238000000502 dialysis Methods 0.000 description 29
- 238000000034 method Methods 0.000 description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 22
- 239000010410 layer Substances 0.000 description 22
- 230000035515 penetration Effects 0.000 description 20
- 239000011780 sodium chloride Substances 0.000 description 19
- 210000003491 skin Anatomy 0.000 description 17
- 238000002347 injection Methods 0.000 description 16
- 239000007924 injection Substances 0.000 description 16
- 238000010790 dilution Methods 0.000 description 11
- 239000012895 dilution Substances 0.000 description 11
- 238000013459 approach Methods 0.000 description 8
- 230000008569 process Effects 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 125000006850 spacer group Chemical group 0.000 description 5
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 239000012790 adhesive layer Substances 0.000 description 4
- 235000013405 beer Nutrition 0.000 description 4
- 238000003113 dilution method Methods 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000012935 Averaging Methods 0.000 description 3
- 206010016717 Fistula Diseases 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003890 fistula Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000000108 ultra-filtration Methods 0.000 description 3
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000002612 cardiopulmonary effect Effects 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 229920002799 BoPET Polymers 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000005041 Mylar™ Substances 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- -1 bone Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000036564 melanin content Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000008320 venous blood flow Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring haematocrit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14557—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted to extracorporeal circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6825—Hand
- A61B5/6826—Finger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6838—Clamps or clips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6843—Monitoring or controlling sensor contact pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
- A61M1/361—Physical characteristics of the blood, e.g. haematocrit, urea before treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
- A61M1/3612—Physical characteristics of the blood, e.g. haematocrit, urea after treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
- A61M1/3656—Monitoring patency or flow at connection sites; Detecting disconnections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3663—Flow rate transducers; Flow integrators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/036—Cuvette constructions transformable, modifiable
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002433278A CA2433278A1 (en) | 2000-12-29 | 2001-12-20 | Sensor for transcutaneous measurement of vascular access blood flow |
EP01996251A EP1345529A2 (en) | 2000-12-29 | 2001-12-20 | Sensor for transcutaneous measurement of vascular access blood flow |
JP2002553980A JP2004523268A (en) | 2000-12-29 | 2001-12-20 | Sensor for percutaneous measurement of vascular access blood flow |
AU2002227400A AU2002227400A1 (en) | 2000-12-29 | 2001-12-20 | Sensor for transcutaneous measurement of vascular access blood flow |
KR10-2003-7008841A KR20030081369A (en) | 2000-12-29 | 2001-12-20 | Sensor for transcutaneous measurement of vascular access blood flow |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/750,076 | 2000-12-29 | ||
US09/750,076 US6725072B2 (en) | 1990-10-06 | 2000-12-29 | Sensor for transcutaneous measurement of vascular access blood flow |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002053025A2 true WO2002053025A2 (en) | 2002-07-11 |
WO2002053025A3 WO2002053025A3 (en) | 2002-11-07 |
Family
ID=25016382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/048562 WO2002053025A2 (en) | 2000-12-29 | 2001-12-20 | Sensor for transcutaneous measurement of vascular access blood flow |
Country Status (7)
Country | Link |
---|---|
US (4) | US6725072B2 (en) |
EP (1) | EP1345529A2 (en) |
JP (1) | JP2004523268A (en) |
KR (1) | KR20030081369A (en) |
AU (1) | AU2002227400A1 (en) |
CA (1) | CA2433278A1 (en) |
WO (1) | WO2002053025A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009042263A1 (en) * | 2007-09-27 | 2009-04-02 | Baxter International Inc. | Access disconnect detection |
WO2011080194A1 (en) * | 2009-12-28 | 2011-07-07 | Gambro Lundia Ab | Device and method for monitoring a fluid flow rate in a cardiovascular system |
EP2565624A1 (en) * | 2011-09-05 | 2013-03-06 | Carl Freudenberg KG | Sensor head for use in transcutaneous organ function measurements |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6725072B2 (en) * | 1990-10-06 | 2004-04-20 | Hema Metrics, Inc. | Sensor for transcutaneous measurement of vascular access blood flow |
SE524166C2 (en) * | 2002-05-17 | 2004-07-06 | Hemapure Ab | Sensor unit and method for detecting a blood related parameter and system comprising such sensor unit |
US20080132797A1 (en) * | 2002-12-10 | 2008-06-05 | Knut Brabrand | Monitoring infusion of a substance |
JP3590047B1 (en) * | 2003-09-24 | 2004-11-17 | 株式会社日立製作所 | Optical measuring device and blood glucose measuring device using the same |
US20060094941A1 (en) * | 2004-10-29 | 2006-05-04 | Ok-Kyung Cho | Optical measurement apparatus and blood sugar level measuring apparatus using the same |
GB0603006D0 (en) * | 2006-02-15 | 2006-03-29 | Dialog Devices Ltd | Assessing blood supply to a peripheral portion of an animal |
RU2309668C1 (en) | 2006-02-20 | 2007-11-10 | Александр Сергеевич Парфенов | Method and device for non-invasive measurement of function of endothelium |
US8652040B2 (en) | 2006-12-19 | 2014-02-18 | Valencell, Inc. | Telemetric apparatus for health and environmental monitoring |
US8157730B2 (en) | 2006-12-19 | 2012-04-17 | Valencell, Inc. | Physiological and environmental monitoring systems and methods |
US8639309B2 (en) | 2007-07-31 | 2014-01-28 | J&M Shuler, Inc. | Method and system for monitoring oxygenation levels of compartments and tissue |
US8100834B2 (en) * | 2007-02-27 | 2012-01-24 | J&M Shuler, Inc. | Method and system for monitoring oxygenation levels of a compartment for detecting conditions of a compartment syndrome |
KR100905571B1 (en) * | 2007-07-19 | 2009-07-02 | 삼성전자주식회사 | Apparatus for measuring living body information |
US8251903B2 (en) | 2007-10-25 | 2012-08-28 | Valencell, Inc. | Noninvasive physiological analysis using excitation-sensor modules and related devices and methods |
WO2009061769A1 (en) * | 2007-11-06 | 2009-05-14 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern Califorina | Measurement of hematocrit and cardiac output from optical transmission and reflection changes |
JP5222706B2 (en) * | 2008-12-04 | 2013-06-26 | 日機装株式会社 | Blood purification apparatus and blood flow calculation method thereof |
US8788002B2 (en) | 2009-02-25 | 2014-07-22 | Valencell, Inc. | Light-guiding devices and monitoring devices incorporating same |
EP3357419A1 (en) | 2009-02-25 | 2018-08-08 | Valencell, Inc. | Light-guiding devices and monitoring devices incorporating same |
US8057400B2 (en) * | 2009-05-12 | 2011-11-15 | Angiologix, Inc. | System and method of measuring changes in arterial volume of a limb segment |
AU2010264669C1 (en) | 2009-06-26 | 2015-04-30 | Gambro Lundia Ab | Devices, a computer program product and a method for data extraction |
US20110060224A1 (en) * | 2009-08-09 | 2011-03-10 | Tz Medical, Inc. | Non-invasive continuous doppler monitoring device for arterial blood flow to distal body parts |
US8239038B2 (en) * | 2010-10-14 | 2012-08-07 | Wolf Ii Erich W | Apparatus and method using near infrared reflectometry to reduce the effect of positional changes during spinal cord stimulation |
US9132273B2 (en) | 2010-10-14 | 2015-09-15 | II Erich W. Wolf | Apparatus and method using near infrared reflectometry to reduce the effect of positional changes during spinal cord stimulation |
US9656097B2 (en) | 2010-10-14 | 2017-05-23 | II Erich W. Wolf | Apparatus and method using near infrared reflectometry to reduce the effect of positional changes during spinal cord stimulation |
US9550063B2 (en) | 2010-10-14 | 2017-01-24 | II Erich W. Wolf | Apparatus and method using near infrared reflectometry to reduce the effect of positional changes during spinal cord stimulation |
US8888701B2 (en) | 2011-01-27 | 2014-11-18 | Valencell, Inc. | Apparatus and methods for monitoring physiological data during environmental interference |
EP2739207B1 (en) | 2011-08-02 | 2017-07-19 | Valencell, Inc. | Systems and methods for variable filter adjustment by heart rate metric feedback |
WO2013109389A1 (en) | 2012-01-16 | 2013-07-25 | Valencell, Inc. | Physiological metric estimation rise and fall limiting |
JP6116017B2 (en) | 2012-01-16 | 2017-04-19 | ヴァレンセル,インコーポレイテッドValencell, Inc. | Reduction of physiological measurement error by inertia rhythm |
US9693697B2 (en) * | 2012-03-29 | 2017-07-04 | Benny Tal | Hand-held device having health monitoring capabilities |
WO2014109982A2 (en) | 2013-01-09 | 2014-07-17 | Valencell Inc. | Cadence detection based on inertial harmonics |
US9788794B2 (en) | 2014-02-28 | 2017-10-17 | Valencell, Inc. | Method and apparatus for generating assessments using physical activity and biometric parameters |
DE102014008446A1 (en) | 2014-06-06 | 2015-12-17 | Fresenius Medical Care Deutschland Gmbh | Device for non-invasive measurement of blood flow |
US10420491B2 (en) * | 2015-05-26 | 2019-09-24 | Lvl Technologies, Inc. | Device and method for generating calibration factors for use in determining biological indicator levels in tissue |
CN107708557A (en) | 2015-06-22 | 2018-02-16 | 费森尤斯医疗控股股份有限公司 | To calculate the percutaneous measurement of the hemoglobin change of the blood volume of the estimation during peritoneal dialysis change |
EP3314253B1 (en) | 2015-06-24 | 2024-03-27 | Fresenius Medical Care Holdings, Inc. | Tunable optical receiver |
EP3111842A1 (en) * | 2015-06-30 | 2017-01-04 | Nokia Technologies Oy | An apparatus comprising a light detector, a light source and optics |
US10610158B2 (en) | 2015-10-23 | 2020-04-07 | Valencell, Inc. | Physiological monitoring devices and methods that identify subject activity type |
US10945618B2 (en) | 2015-10-23 | 2021-03-16 | Valencell, Inc. | Physiological monitoring devices and methods for noise reduction in physiological signals based on subject activity type |
US10966662B2 (en) | 2016-07-08 | 2021-04-06 | Valencell, Inc. | Motion-dependent averaging for physiological metric estimating systems and methods |
KR102437776B1 (en) | 2017-09-26 | 2022-08-26 | 삼성전자주식회사 | Apparatus for estimating biological component and operating method thereof |
CA3106626A1 (en) | 2018-07-16 | 2020-01-23 | Bbi Medical Innovations, Llc | Perfusion and oxygenation measurement |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5520177A (en) * | 1993-03-26 | 1996-05-28 | Nihon Kohden Corporation | Oximeter probe |
EP0928614A1 (en) * | 1998-01-07 | 1999-07-14 | Fresenius Medical Care North America | Method and apparatus for determining hemodialysis parameters |
WO1999039631A1 (en) * | 1998-02-05 | 1999-08-12 | In-Line Diagnostics Corporation | Method and apparatus for non-invasive blood constituent monitoring |
US20010003793A1 (en) * | 1990-10-06 | 2001-06-14 | Steuer Robert R. | Sensor for transcutaneous measurement of vascular access blood flow |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3638640A (en) | 1967-11-01 | 1972-02-01 | Robert F Shaw | Oximeter and method for in vivo determination of oxygen saturation in blood using three or more different wavelengths |
SE361812B (en) | 1972-07-12 | 1973-11-19 | Sie4Ens Elema Ab | |
JPS5725217B2 (en) * | 1974-10-14 | 1982-05-28 | ||
US4014321A (en) | 1974-11-25 | 1977-03-29 | March Wayne F | Non-invasive glucose sensor system |
CA1037285A (en) | 1975-04-30 | 1978-08-29 | Glenfield Warner | Ear oximetry process and apparatus |
JPS5911864B2 (en) | 1975-07-14 | 1984-03-19 | 武田薬品工業株式会社 | Blood leak detection device |
US4081372A (en) | 1975-12-08 | 1978-03-28 | University Of Utah | Leakage indicator for recirculating peritoneal dialysis system |
US4295470A (en) | 1976-10-18 | 1981-10-20 | Oximetrix, Inc. | Optical catheters and method for making same |
US4167331A (en) | 1976-12-20 | 1979-09-11 | Hewlett-Packard Company | Multi-wavelength incremental absorbence oximeter |
US4281645A (en) | 1977-06-28 | 1981-08-04 | Duke University, Inc. | Method and apparatus for monitoring metabolism in body organs |
JPS5524004A (en) | 1978-06-22 | 1980-02-20 | Minolta Camera Kk | Oxymeter |
US4416285A (en) | 1978-11-29 | 1983-11-22 | Oximetrix, Inc. | Improved optical catheter and method for making same |
JPS56104646A (en) | 1980-01-25 | 1981-08-20 | Minolta Camera Kk | Optical analyzer for forming ratio of element contained in organism |
US4715808A (en) * | 1982-03-18 | 1987-12-29 | Heath Rodney T | Thermostatic control system |
DE3382674T2 (en) | 1982-09-02 | 1993-07-08 | Nellcor Inc | OXYGEN MEASURING DEVICE WITH OXYGEN MEASURING PROBE. |
US4770179A (en) | 1982-09-02 | 1988-09-13 | Nellcor Incorporated | Calibrated optical oximeter probe |
US4653498A (en) | 1982-09-13 | 1987-03-31 | Nellcor Incorporated | Pulse oximeter monitor |
US5066589A (en) * | 1984-03-02 | 1991-11-19 | Board Of Regents Of The University Of Okla. | Streptokinase-coding recombinant vectors |
DE3477991D1 (en) | 1984-05-04 | 1989-06-08 | Kurashiki Boseki Kk | Spectrophotometric apparatus for the non-invasive determination of glucose in body tissues |
US4655225A (en) | 1985-04-18 | 1987-04-07 | Kurabo Industries Ltd. | Spectrophotometric method and apparatus for the non-invasive |
US4651741A (en) | 1985-05-30 | 1987-03-24 | Baxter Travenol Laboratories, Inc. | Method and apparatus for determining oxygen saturation in vivo |
US4685464A (en) | 1985-07-05 | 1987-08-11 | Nellcor Incorporated | Durable sensor for detecting optical pulses |
US5059394A (en) | 1986-08-13 | 1991-10-22 | Lifescan, Inc. | Analytical device for the automated determination of analytes in fluids |
US4824242A (en) | 1986-09-26 | 1989-04-25 | Sensormedics Corporation | Non-invasive oximeter and method |
US4714080A (en) | 1986-10-06 | 1987-12-22 | Nippon Colin Co., Ltd. | Method and apparatus for noninvasive monitoring of arterial blood oxygen saturation |
JPS63111837A (en) | 1986-10-29 | 1988-05-17 | 日本光電工業株式会社 | Apparatus for measuring concentration of light absorbing substance in blood |
US5193543A (en) | 1986-12-12 | 1993-03-16 | Critikon, Inc. | Method and apparatus for measuring arterial blood constituents |
US4920972A (en) | 1987-01-27 | 1990-05-01 | Medex, Inc. | Gel-filled blood pressure transducer |
JPS63252239A (en) | 1987-04-09 | 1988-10-19 | Sumitomo Electric Ind Ltd | Reflection type oxymeter |
US4821734A (en) | 1987-04-21 | 1989-04-18 | Nihon Seimitsu Sokki Co., Ltd. | Sphygmomanometer |
DE3726524A1 (en) | 1987-08-10 | 1989-02-23 | Fresenius Ag | HAEMOGLOBIN DETECTOR |
US4805623A (en) | 1987-09-04 | 1989-02-21 | Vander Corporation | Spectrophotometric method for quantitatively determining the concentration of a dilute component in a light- or other radiation-scattering environment |
US4819752A (en) | 1987-10-02 | 1989-04-11 | Datascope Corp. | Blood constituent measuring device and method |
US4825879A (en) | 1987-10-08 | 1989-05-02 | Critkon, Inc. | Pulse oximeter sensor |
US4863265A (en) | 1987-10-16 | 1989-09-05 | Mine Safety Appliances Company | Apparatus and method for measuring blood constituents |
DE3810411A1 (en) | 1988-03-26 | 1989-10-12 | Nicolay Gmbh | DEVICE FOR FIXING A SENSOR, IN PARTICULAR A SENSOR FOR OXIMETRIC MEASUREMENTS |
US4825872A (en) | 1988-08-05 | 1989-05-02 | Critikon, Inc. | Finger sensor for pulse oximetry system |
JPH0257239A (en) | 1988-08-23 | 1990-02-27 | Terumo Corp | Probe for optical sensor |
GB8821944D0 (en) * | 1988-09-19 | 1988-10-19 | Gillette Co | Method & apparatus for forming surface of workpiece |
US5101825A (en) | 1988-10-28 | 1992-04-07 | Blackbox, Inc. | Method for noninvasive intermittent and/or continuous hemoglobin, arterial oxygen content, and hematocrit determination |
CA1331483C (en) * | 1988-11-02 | 1994-08-16 | Britton Chance | User-wearable hemoglobinometer for measuring the metabolic condition of a subject |
JPH06103257B2 (en) | 1988-12-19 | 1994-12-14 | 大塚電子株式会社 | Method and apparatus for measuring absorption coefficient of substance using light scattering |
JPH02164341A (en) | 1988-12-19 | 1990-06-25 | Nippon Koden Corp | Hemoglobin concentration measuring device |
US5111817A (en) | 1988-12-29 | 1992-05-12 | Medical Physics, Inc. | Noninvasive system and method for enhanced arterial oxygen saturation determination and arterial blood pressure monitoring |
DE3900324A1 (en) * | 1989-01-07 | 1990-07-12 | Dorstener Maschf Ag | Method and press for making mould cores from moulding sand for foundry practice |
US5028787A (en) | 1989-01-19 | 1991-07-02 | Futrex, Inc. | Non-invasive measurement of blood glucose |
US5048524A (en) | 1989-03-03 | 1991-09-17 | Camino Laboratories, Inc. | Blood parameter measurement |
DE3909967A1 (en) | 1989-03-25 | 1990-09-27 | Fresenius Ag | HAEMODIALYSIS DEVICE WITH AUTOMATIC ADJUSTMENT OF THE DIALYSIS FLUID FLOW |
US5137023A (en) | 1990-04-19 | 1992-08-11 | Worcester Polytechnic Institute | Method and apparatus for monitoring blood analytes noninvasively by pulsatile photoplethysmography |
US5054487A (en) | 1990-02-02 | 1991-10-08 | Boston Advanced Technologies, Inc. | Laser systems for material analysis based on reflectance ratio detection |
EP0613653B1 (en) * | 1990-02-15 | 1996-11-13 | Hewlett-Packard GmbH | Method for non-invasive measurement of oxygen saturation |
US5386819A (en) * | 1990-03-29 | 1995-02-07 | Olympus Optical Co., Ltd. | Method and apparatus for inhibiting a scattered component in a light having passed through an examined object |
USH1114H (en) * | 1990-04-30 | 1992-12-01 | Medtronic, Inc. | Fiber-optic oxygen saturation/hematocrit sensor |
DE4014591A1 (en) | 1990-05-07 | 1991-11-21 | Berg Extrakorp Syst Medtech | Damper for blood pressure measuring appts. - is integral with valve body in chamber closed by rubber-elastic diaphragm |
US5066859A (en) | 1990-05-18 | 1991-11-19 | Karkar Maurice N | Hematocrit and oxygen saturation blood analyzer |
US5372136A (en) * | 1990-10-06 | 1994-12-13 | Noninvasive Medical Technology Corporation | System and method for noninvasive hematocrit monitoring |
US5351686A (en) | 1990-10-06 | 1994-10-04 | In-Line Diagnostics Corporation | Disposable extracorporeal conduit for blood constituent monitoring |
US5158091A (en) | 1990-11-30 | 1992-10-27 | Ivac Corporation | Tonometry system for determining blood pressure |
JP3143484B2 (en) * | 1991-02-22 | 2001-03-07 | キヤノン株式会社 | Image processing device |
US5218962A (en) * | 1991-04-15 | 1993-06-15 | Nellcor Incorporated | Multiple region pulse oximetry probe and oximeter |
US5246003A (en) | 1991-08-28 | 1993-09-21 | Nellcor Incorporated | Disposable pulse oximeter sensor |
US5371020A (en) | 1991-09-19 | 1994-12-06 | Radiometer A/S | Method of photometric in vitro determination of the content of an analyte in a sample |
US5644240A (en) | 1992-09-30 | 1997-07-01 | Cobe Laboratories, Inc. | Differential conductivity hemodynamic monitor |
IL107396A (en) * | 1992-11-09 | 1997-02-18 | Boehringer Mannheim Gmbh | Method and apparatus for analytical determination of glucose in a biological matrix |
DE4337570A1 (en) * | 1993-11-04 | 1995-05-11 | Boehringer Mannheim Gmbh | Method for the analysis of glucose in a biological matrix |
HRP940025A2 (en) * | 1994-01-14 | 1996-06-30 | Branko Breyer | A blood flow velocity measurement system perpendicular to a single probing beam |
DE4427101A1 (en) * | 1994-07-30 | 1996-02-01 | Boehringer Mannheim Gmbh | Apparatus and method for the optical characterization of the structure and composition of a scattering sample |
US6153109A (en) | 1994-09-16 | 2000-11-28 | Transonic Systmes, Inc. | Method and apparatus to measure blood flow rate in hemodialysis shunts |
US5803909A (en) * | 1994-10-06 | 1998-09-08 | Hitachi, Ltd. | Optical system for measuring metabolism in a body and imaging method |
US5453576A (en) | 1994-10-24 | 1995-09-26 | Transonic Systems Inc. | Cardiovascular measurements by sound velocity dilution |
DE4442260C2 (en) | 1994-11-28 | 2000-06-08 | Mipm Mammendorfer Inst Fuer Ph | Method and arrangement for the non-invasive in vivo determination of oxygen saturation |
US5655225A (en) * | 1995-05-19 | 1997-08-12 | Signwear Inc. | Protective headgear attachment for baseball style caps |
HU216847B (en) | 1995-05-23 | 1999-12-28 | Gyula Domján | Method and arrangement for prompt non-invasive determination of blood parameters |
US5797841A (en) * | 1996-03-05 | 1998-08-25 | Nellcor Puritan Bennett Incorporated | Shunt barrier in pulse oximeter sensor |
US6117099A (en) | 1996-10-23 | 2000-09-12 | In-Line Diagnostics Corporation | System and method for noninvasive hemodynamic measurements in hemodialysis shunts |
AU7934498A (en) * | 1997-06-27 | 1999-01-19 | Toa Medical Electronics Co., Ltd. | Living body inspecting apparatus and noninvasive blood analyzer using the same |
US6041246A (en) | 1997-10-14 | 2000-03-21 | Transonic Systems, Inc. | Single light sensor optical probe for monitoring blood parameters and cardiovascular measurements |
US6189388B1 (en) | 1997-11-12 | 2001-02-20 | Gambro, Inc. | Access flow monitoring using reversal of normal blood flow |
US6167765B1 (en) | 1998-09-25 | 2001-01-02 | The Regents Of The University Of Michigan | System and method for determining the flow rate of blood in a vessel using doppler frequency signals |
US6526300B1 (en) * | 1999-06-18 | 2003-02-25 | Masimo Corporation | Pulse oximeter probe-off detection system |
US6611793B1 (en) * | 1999-09-07 | 2003-08-26 | Scimed Life Systems, Inc. | Systems and methods to identify and disable re-use single use devices based on detecting environmental changes |
US6377829B1 (en) * | 1999-12-09 | 2002-04-23 | Masimo Corporation | Resposable pulse oximetry sensor |
-
2000
- 2000-12-29 US US09/750,076 patent/US6725072B2/en not_active Expired - Fee Related
-
2001
- 2001-12-20 KR KR10-2003-7008841A patent/KR20030081369A/en not_active Application Discontinuation
- 2001-12-20 JP JP2002553980A patent/JP2004523268A/en active Pending
- 2001-12-20 CA CA002433278A patent/CA2433278A1/en not_active Abandoned
- 2001-12-20 WO PCT/US2001/048562 patent/WO2002053025A2/en not_active Application Discontinuation
- 2001-12-20 AU AU2002227400A patent/AU2002227400A1/en not_active Abandoned
- 2001-12-20 EP EP01996251A patent/EP1345529A2/en not_active Withdrawn
-
2003
- 2003-12-09 US US10/730,102 patent/US6987993B2/en not_active Expired - Fee Related
- 2003-12-09 US US10/730,000 patent/US20040116817A1/en not_active Abandoned
- 2003-12-09 US US10/730,005 patent/US6937882B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010003793A1 (en) * | 1990-10-06 | 2001-06-14 | Steuer Robert R. | Sensor for transcutaneous measurement of vascular access blood flow |
US5520177A (en) * | 1993-03-26 | 1996-05-28 | Nihon Kohden Corporation | Oximeter probe |
EP0928614A1 (en) * | 1998-01-07 | 1999-07-14 | Fresenius Medical Care North America | Method and apparatus for determining hemodialysis parameters |
WO1999039631A1 (en) * | 1998-02-05 | 1999-08-12 | In-Line Diagnostics Corporation | Method and apparatus for non-invasive blood constituent monitoring |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009042263A1 (en) * | 2007-09-27 | 2009-04-02 | Baxter International Inc. | Access disconnect detection |
US9011334B2 (en) | 2007-09-27 | 2015-04-21 | Baxter International Inc. | Access disconnect detection |
WO2011080194A1 (en) * | 2009-12-28 | 2011-07-07 | Gambro Lundia Ab | Device and method for monitoring a fluid flow rate in a cardiovascular system |
EP2565624A1 (en) * | 2011-09-05 | 2013-03-06 | Carl Freudenberg KG | Sensor head for use in transcutaneous organ function measurements |
Also Published As
Publication number | Publication date |
---|---|
US20040116790A1 (en) | 2004-06-17 |
US20010003793A1 (en) | 2001-06-14 |
EP1345529A2 (en) | 2003-09-24 |
KR20030081369A (en) | 2003-10-17 |
US20040122330A1 (en) | 2004-06-24 |
CA2433278A1 (en) | 2002-07-11 |
JP2004523268A (en) | 2004-08-05 |
US6937882B2 (en) | 2005-08-30 |
US6987993B2 (en) | 2006-01-17 |
US6725072B2 (en) | 2004-04-20 |
WO2002053025A3 (en) | 2002-11-07 |
US20040116817A1 (en) | 2004-06-17 |
AU2002227400A1 (en) | 2002-07-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6937882B2 (en) | Sensor for transcutaneous measurement of vascular access blood flow | |
US6804543B2 (en) | Sensor for transcutaneous measurement of vascular access blood flow | |
US6687519B2 (en) | System and method for measuring blood urea nitrogen, blood osmolarity, plasma free hemoglobin and tissue water content | |
US6606509B2 (en) | Method and apparatus for improving the accuracy of noninvasive hematocrit measurements | |
US9194792B2 (en) | Blood chamber for an optical blood monitoring system | |
EP0693900B1 (en) | System and method for noninvasive hematocrit monitoring | |
JP5940099B2 (en) | Shroud-covered sensor clip assembly and blood chamber for optical blood monitoring systems | |
US6746407B2 (en) | Method of measuring transcutaneous access blood flow | |
US8517968B2 (en) | Shrouded sensor clip assembly and blood chamber for an optical blood monitoring system | |
US20130023744A1 (en) | Method for spectrophotometric blood oxygenation monitoring of organs in the body | |
Steuer et al. | Noninvasive transcutaneous determination of access blood flow rate | |
US6339714B1 (en) | Apparatus and method for measuring concentrations of a dye in a living organism | |
JP2003535630A (en) | System and method for measuring serum urea nitrogen, osmolality, plasma free hemoglobin, and tissue water content |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2001996251 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2433278 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002553980 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020037008841 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 2001996251 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1020037008841 Country of ref document: KR |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2001996251 Country of ref document: EP |