WO2002057757A3 - System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics - Google Patents

System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics Download PDF

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Publication number
WO2002057757A3
WO2002057757A3 PCT/US2002/003094 US0203094W WO02057757A3 WO 2002057757 A3 WO2002057757 A3 WO 2002057757A3 US 0203094 W US0203094 W US 0203094W WO 02057757 A3 WO02057757 A3 WO 02057757A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
reflectance
fluorescence
light scattering
tissue characteristics
Prior art date
Application number
PCT/US2002/003094
Other languages
French (fr)
Other versions
WO2002057757A2 (en
Inventor
Irene Georgakoudi
Michael S Feld
Qingguo Zhang
Markus G Mueller
Original Assignee
Massachusetts Institue Of Tech
Irene Georgakoudi
Michael S Feld
Qingguo Zhang
Markus G Mueller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institue Of Tech, Irene Georgakoudi, Michael S Feld, Qingguo Zhang, Markus G Mueller filed Critical Massachusetts Institue Of Tech
Priority to CA002431769A priority Critical patent/CA2431769A1/en
Priority to AU2002253891A priority patent/AU2002253891A1/en
Priority to JP2002557989A priority patent/JP2004518124A/en
Priority to EP02723087A priority patent/EP1352231A2/en
Publication of WO2002057757A2 publication Critical patent/WO2002057757A2/en
Publication of WO2002057757A3 publication Critical patent/WO2002057757A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4318—Evaluation of the lower reproductive system
    • A61B5/4331—Evaluation of the lower reproductive system of the cervix
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence

Abstract

The present invention utilizes a plurality of spectroscopic systems and methods to measure characteristics of tissue useful in the diagnosis of disease. In a preferred embodiment, a combination of fluorescence, reflectance and light scattered spectra can be measured and processed to provide biochemical, architectural and morphological state of tissue. The methods and systems can be used particularly in the early detection of carcinoma within tissue in vivo and in vitro.
PCT/US2002/003094 2001-01-19 2002-01-18 System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics WO2002057757A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002431769A CA2431769A1 (en) 2001-01-19 2002-01-18 System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics
AU2002253891A AU2002253891A1 (en) 2001-01-19 2002-01-18 System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics
JP2002557989A JP2004518124A (en) 2001-01-19 2002-01-18 Fluorescence, reflectance and light scattering spectroscopic systems and methods for measuring tissue characteristics
EP02723087A EP1352231A2 (en) 2001-01-19 2002-01-18 System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/766,879 2001-01-19
US09/766,879 US6697652B2 (en) 2001-01-19 2001-01-19 Fluorescence, reflectance and light scattering spectroscopy for measuring tissue

Publications (2)

Publication Number Publication Date
WO2002057757A2 WO2002057757A2 (en) 2002-07-25
WO2002057757A3 true WO2002057757A3 (en) 2003-02-27

Family

ID=25077802

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/003094 WO2002057757A2 (en) 2001-01-19 2002-01-18 System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics

Country Status (6)

Country Link
US (3) US6697652B2 (en)
EP (2) EP1942335A1 (en)
JP (1) JP2004518124A (en)
AU (1) AU2002253891A1 (en)
CA (1) CA2431769A1 (en)
WO (1) WO2002057757A2 (en)

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