WO2002057765A8 - Reference electrode having a microfluidic flowing liquid junction - Google Patents

Reference electrode having a microfluidic flowing liquid junction

Info

Publication number
WO2002057765A8
WO2002057765A8 PCT/US2001/047747 US0147747W WO02057765A8 WO 2002057765 A8 WO2002057765 A8 WO 2002057765A8 US 0147747 W US0147747 W US 0147747W WO 02057765 A8 WO02057765 A8 WO 02057765A8
Authority
WO
WIPO (PCT)
Prior art keywords
nanochannels
array
sample solution
approximately
liquid junction
Prior art date
Application number
PCT/US2001/047747
Other languages
French (fr)
Other versions
WO2002057765A2 (en
WO2002057765A3 (en
Inventor
Scott Broadley
Steven Ragsdale
Herbert Silverman
Original Assignee
Broadley Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Broadley Technologies Corp filed Critical Broadley Technologies Corp
Priority to EP01993242A priority Critical patent/EP1346209A2/en
Priority to JP2002557996A priority patent/JP2004518126A/en
Priority to CA2402527A priority patent/CA2402527C/en
Priority to AU2002245096A priority patent/AU2002245096A1/en
Publication of WO2002057765A2 publication Critical patent/WO2002057765A2/en
Publication of WO2002057765A3 publication Critical patent/WO2002057765A3/en
Publication of WO2002057765A8 publication Critical patent/WO2002057765A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/401—Salt-bridge leaks; Liquid junctions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells

Abstract

A flowing junction reference electrode exhibiting heretofore unattainable potentiometric characteristics is described, comprising a microfluidic liquid junction member that is situated between a reference electrolyte solution and a sample solution. This microfluidic liquid junction member has an array of nanochannels spanning the member and physically connecting the reference electrolyte solution and a sample solution, but while the electrolyte solution flows through the array of nanochannels and into the sample solution at a linear velocity, the sample solution does not substantially enter the array of nanochannels via the mechanisms of diffusion, migration, convection or other known mechanisms. The number of nanochannels in the array is preferably between approximately 100 and approximately 10. Also prefarebly, the nanochannels are substantially straight and are substantially parallel to one another; such an array of nanochannels is herein described as anisotropic. The nanochannels are also preferably coated. The widths of any nanochannels in the array of nanochannels are preferably uniform, in that the width of any nanochannel is substantially equal to the width of any other nanochannels in the array. The nanochannels preferably have widths of greater than approximately 500 nanometers, and most preferably of 70 nanometers. The electrode may be constructed out of any suitable material, and is preferably is constructed of a polymer, most preferably a polymer selected from the group consisting of polycarbonate and polyimide, and may also preferably be constructed of silicon, glass, or ceramic.
PCT/US2001/047747 2000-12-14 2001-12-10 Reference electrode having a microfluidic flowing liquid junction WO2002057765A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01993242A EP1346209A2 (en) 2000-12-14 2001-12-10 Novel reference electrode having a microfluidic flowing liquid junction
JP2002557996A JP2004518126A (en) 2000-12-14 2001-12-10 New reference electrode with microfluidic fluid junction
CA2402527A CA2402527C (en) 2000-12-14 2001-12-10 Novel reference electrode having a microfluidic flowing liquid junction
AU2002245096A AU2002245096A1 (en) 2000-12-14 2001-12-10 Reference electrode having a microfluidic flowing liquid junction

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/738,881 2000-12-14
US09/738,881 US6616821B2 (en) 1999-06-08 2000-12-14 Reference electrode having a microfluidic flowing liquid junction

Publications (3)

Publication Number Publication Date
WO2002057765A2 WO2002057765A2 (en) 2002-07-25
WO2002057765A3 WO2002057765A3 (en) 2002-10-17
WO2002057765A8 true WO2002057765A8 (en) 2004-02-26

Family

ID=24969876

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047747 WO2002057765A2 (en) 2000-12-14 2001-12-10 Reference electrode having a microfluidic flowing liquid junction

Country Status (6)

Country Link
US (1) US6616821B2 (en)
EP (1) EP1346209A2 (en)
JP (1) JP2004518126A (en)
AU (1) AU2002245096A1 (en)
CA (1) CA2402527C (en)
WO (1) WO2002057765A2 (en)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943026B2 (en) 1999-06-08 2011-05-17 Broadley Technologies Corporation Reference electrode having a flowing liquid junction and filter members
US7344627B2 (en) 1999-06-08 2008-03-18 Broadley-James Corporation Reference electrode having a flowing liquid junction and filter members
US6599409B1 (en) * 1999-06-08 2003-07-29 Broadley Technologies Corporation Reference electrode having a microfluidic flowing liquid junction
EP1389350A1 (en) * 2001-05-24 2004-02-18 University of Saskatchewan Technologies Inc. Nucleic acid circuit elements and methods
US7077939B1 (en) * 2001-06-18 2006-07-18 The Texas A&M University System Method and apparatus for nanoparticle transport and detection
US9678038B2 (en) 2001-07-25 2017-06-13 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
CA2454570C (en) * 2001-07-25 2016-12-20 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US10285694B2 (en) 2001-10-20 2019-05-14 Covidien Lp Surgical stapler with timer and feedback display
US7464847B2 (en) 2005-06-03 2008-12-16 Tyco Healthcare Group Lp Surgical stapler with timer and feedback display
US7767437B2 (en) * 2001-11-02 2010-08-03 Genefluidics, Inc. System for detection of a component in a liquid
US7652574B2 (en) * 2002-04-08 2010-01-26 Sayegh Adel O Article surveillance tag having a vial
EP2484751B1 (en) 2002-04-16 2018-11-28 Princeton University Method of analysing polynucleotides
US20070004047A1 (en) * 2002-04-19 2007-01-04 Lee Jeremy S Methods and apparatus for molecular data storage, retrieval and analysis
US7161356B1 (en) 2002-06-05 2007-01-09 Caliper Life Sciences, Inc. Voltage/current testing equipment for microfluidic devices
AU2003256448A1 (en) * 2002-07-03 2004-01-23 Broadley Technologies Corporation Reference electrode having a microfluidic flowing liquid junction and filter members
EP1548428A1 (en) 2003-12-17 2005-06-29 Hamilton Bonaduz AG Pressurised reference electrode and method for manufacturing it
US7373195B2 (en) * 2004-07-30 2008-05-13 Medtronic, Inc. Ion sensor for long term use in complex medium
US11291443B2 (en) 2005-06-03 2022-04-05 Covidien Lp Surgical stapler with timer and feedback display
CA2609970C (en) 2005-06-03 2014-08-12 Tyco Healthcare Group Lp Battery powered surgical instrument
US8092669B2 (en) * 2005-07-14 2012-01-10 Blincofa Biomedical Technology Corp. System and method of examining trace organic matters in living being's urine
US10060904B1 (en) 2005-10-17 2018-08-28 Stc.Unm Fabrication of enclosed nanochannels using silica nanoparticles
US9156004B2 (en) 2005-10-17 2015-10-13 Stc.Unm Fabrication of enclosed nanochannels using silica nanoparticles
US7825037B2 (en) * 2005-10-17 2010-11-02 Stc.Unm Fabrication of enclosed nanochannels using silica nanoparticles
JP4975828B2 (en) * 2007-01-22 2012-07-11 コミサリア ア レネルジー アトミック エ オ ゼネルジー アルテルナティブ Reference electrode, manufacturing method, and battery including reference electrode
US7431188B1 (en) 2007-03-15 2008-10-07 Tyco Healthcare Group Lp Surgical stapling apparatus with powered articulation
EP2610008A1 (en) * 2007-03-28 2013-07-03 BioNano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
US7950560B2 (en) 2007-04-13 2011-05-31 Tyco Healthcare Group Lp Powered surgical instrument
US8800837B2 (en) 2007-04-13 2014-08-12 Covidien Lp Powered surgical instrument
US11259801B2 (en) 2007-04-13 2022-03-01 Covidien Lp Powered surgical instrument
US20080255413A1 (en) 2007-04-13 2008-10-16 Michael Zemlok Powered surgical instrument
US7823760B2 (en) 2007-05-01 2010-11-02 Tyco Healthcare Group Lp Powered surgical stapling device platform
US7931660B2 (en) 2007-05-10 2011-04-26 Tyco Healthcare Group Lp Powered tacker instrument
WO2009055295A1 (en) * 2007-10-23 2009-04-30 Hach Company Ionic probe including an extrudable conductive junction material
US7922063B2 (en) 2007-10-31 2011-04-12 Tyco Healthcare Group, Lp Powered surgical instrument
US8172999B2 (en) * 2008-08-14 2012-05-08 Thermo Orion, Inc. Low maintenance reference electrode for electrochemical measurements
US8821514B2 (en) 2009-06-08 2014-09-02 Covidien Lp Powered tack applier
US20110048971A1 (en) * 2009-09-02 2011-03-03 Bower Michael M Robust potentiometric sensor
US8568575B2 (en) * 2009-09-02 2013-10-29 Invensys Systems, Inc. Adjustable, retractable probe insertion assembly
DE102010030874A1 (en) * 2010-07-02 2012-01-05 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Potentiometric probe for measuring a measured quantity of a measuring medium contained in a container
DE102011086591A1 (en) * 2010-12-29 2012-07-19 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Electrochemical half cell, electrochemical sensor and method for measuring at least one property of a measured variable with an electrochemical sensor
EP3088879A1 (en) * 2015-04-30 2016-11-02 Stichting IMEC Nederland A reference electrode with a pore membrane
US11311295B2 (en) 2017-05-15 2022-04-26 Covidien Lp Adaptive powered stapling algorithm with calibration factor
DE102017112225A1 (en) * 2017-06-02 2018-12-06 Endress+Hauser Conducta Gmbh+Co. Kg A method of manufacturing a housing and housing for a reference electrochemical half-cell
US11207066B2 (en) 2017-10-30 2021-12-28 Covidien Lp Apparatus for endoscopic procedures
US10987104B2 (en) 2017-10-30 2021-04-27 Covidien Lp Apparatus for endoscopic procedures
EP3796994A4 (en) * 2018-05-22 2022-03-02 Gate Scientific, Inc. Wirelessly sensing properties of a closed environment and devices thereof
US11497490B2 (en) 2018-07-09 2022-11-15 Covidien Lp Powered surgical devices including predictive motor control
US11197734B2 (en) 2018-10-30 2021-12-14 Covidien Lp Load sensing devices for use in surgical instruments
US10685906B2 (en) * 2018-11-13 2020-06-16 International Business Machines Corporation Electrically conductive deterministic lateral displacement array in a semiconductor device
US11369372B2 (en) 2018-11-28 2022-06-28 Covidien Lp Surgical stapler adapter with flexible cable assembly, flexible fingers, and contact clips
US11202635B2 (en) 2019-02-04 2021-12-21 Covidien Lp Programmable distal tilt position of end effector for powered surgical devices
US11376006B2 (en) 2019-02-06 2022-07-05 Covidien Lp End effector force measurement with digital drive circuit
US11219461B2 (en) 2019-03-08 2022-01-11 Covidien Lp Strain gauge stabilization in a surgical device
US11458244B2 (en) 2020-02-07 2022-10-04 Covidien Lp Irrigating surgical apparatus with positive pressure fluid
US11553913B2 (en) 2020-02-11 2023-01-17 Covidien Lp Electrically-determining tissue cut with surgical stapling apparatus
US11622768B2 (en) 2020-07-13 2023-04-11 Covidien Lp Methods and structure for confirming proper assembly of powered surgical stapling systems
US11744580B2 (en) 2020-11-24 2023-09-05 Covidien Lp Long stapler reloads with continuous cartridge
US11653919B2 (en) 2020-11-24 2023-05-23 Covidien Lp Stapler line reinforcement continuity
US11684362B2 (en) 2021-06-07 2023-06-27 Covidien Lp Handheld electromechanical surgical system
US11771432B2 (en) 2021-06-29 2023-10-03 Covidien Lp Stapling and cutting to default values in the event of strain gauge data integrity loss
US11832823B2 (en) 2022-02-08 2023-12-05 Covidien Lp Determination of anvil release during anastomosis

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2595042A (en) * 1950-03-23 1952-04-29 Gulf Research Development Co Nonpolarizing electrode for electric logging of boreholes
NL132114C (en) 1964-12-11
US3607702A (en) * 1968-02-05 1971-09-21 Wolfgand Haller Electrochemical apparatus
US3528904A (en) * 1968-04-12 1970-09-15 Beckman Instruments Inc Range scale circuit including temperature compensation element
US4002547A (en) 1970-08-21 1977-01-11 Beckman Instruments, Inc. Electrochemical reference electrode
US3756936A (en) * 1970-09-28 1973-09-04 Instrumentation Labor Inc Electrochemical electrode structure
US3915829A (en) 1972-10-10 1975-10-28 Instrumentation Labor Inc Electrochemical structure
US3917523A (en) 1973-12-20 1975-11-04 Instrumentation Labor Inc Electrochemical electrode structure
US4012308A (en) 1975-11-07 1977-03-15 Beckman Instruments, Inc. Ion sensitive combination electrode
JPS548489U (en) 1977-06-20 1979-01-20
DE3134275C2 (en) 1980-09-10 1986-11-20 AVL AG, Schaffhausen Capillary body for a capillary reference electrode
US4495052A (en) 1980-12-22 1985-01-22 Corning Glass Works Replaceable junctions for reference electrodes
FR2541462A1 (en) 1983-02-17 1984-08-24 Texaim Miniature electrochemical reference electrode
US4592823A (en) 1985-08-15 1986-06-03 Rohm And Haas Company Flushable reference cell for potentiometric measurements
US4592824A (en) 1985-09-13 1986-06-03 Centre Suisse D'electronique Et De Microtechnique S.A. Miniature liquid junction reference electrode and an integrated solid state electrochemical sensor including the same
US4818366A (en) * 1987-07-30 1989-04-04 The United States Of America As Represented By The United States Department Of Energy Long life reference electrode
GB9118300D0 (en) 1991-08-24 1991-10-09 Kodak Ltd Reference half-cell electrode
US5397452A (en) 1994-05-27 1995-03-14 Hach Company Reference electrode
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
JPH0996622A (en) * 1995-09-29 1997-04-08 Matsushita Electric Ind Co Ltd Gas sensor and its manufacture
JP3851389B2 (en) 1996-09-28 2006-11-29 株式会社堀場製作所 Liquid junction member for comparison electrode and comparison electrode using the same
JP3771707B2 (en) 1998-03-07 2006-04-26 株式会社堀場製作所 Liquid junction member for reference electrode and reference electrode
US6123798A (en) 1998-05-06 2000-09-26 Caliper Technologies Corp. Methods of fabricating polymeric structures incorporating microscale fluidic elements
US6551480B1 (en) 1998-06-04 2003-04-22 Radiometer Medical A/S Reference electrode
US6599409B1 (en) * 1999-06-08 2003-07-29 Broadley Technologies Corporation Reference electrode having a microfluidic flowing liquid junction

Also Published As

Publication number Publication date
WO2002057765A2 (en) 2002-07-25
US6616821B2 (en) 2003-09-09
JP2004518126A (en) 2004-06-17
WO2002057765A3 (en) 2002-10-17
CA2402527A1 (en) 2002-07-25
AU2002245096A1 (en) 2002-07-30
CA2402527C (en) 2017-03-21
US20010045357A1 (en) 2001-11-29
EP1346209A2 (en) 2003-09-24

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