WO2002058672A3 - Microparticles of biodegradable polymer encapsulating a biologically active substance - Google Patents

Microparticles of biodegradable polymer encapsulating a biologically active substance Download PDF

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Publication number
WO2002058672A3
WO2002058672A3 PCT/CH2002/000048 CH0200048W WO02058672A3 WO 2002058672 A3 WO2002058672 A3 WO 2002058672A3 CH 0200048 W CH0200048 W CH 0200048W WO 02058672 A3 WO02058672 A3 WO 02058672A3
Authority
WO
WIPO (PCT)
Prior art keywords
microparticles
active substance
biologically active
biodegradable polymer
polymer encapsulating
Prior art date
Application number
PCT/CH2002/000048
Other languages
French (fr)
Other versions
WO2002058672A2 (en
Inventor
Evelyne Vuaridel
Piero Orsolini
Original Assignee
Debio Rech Pharma Sa
Evelyne Vuaridel
Piero Orsolini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CH2001/000064 external-priority patent/WO2002058671A1/en
Application filed by Debio Rech Pharma Sa, Evelyne Vuaridel, Piero Orsolini filed Critical Debio Rech Pharma Sa
Priority to EP02715353A priority Critical patent/EP1353648A2/en
Priority to JP2002559006A priority patent/JP2004517146A/en
Priority to CA002435415A priority patent/CA2435415A1/en
Priority to US10/250,857 priority patent/US20040052855A1/en
Publication of WO2002058672A2 publication Critical patent/WO2002058672A2/en
Publication of WO2002058672A3 publication Critical patent/WO2002058672A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

The present invention relates to novel microparticles of biodegradable polymer encapsulating a water-soluble or water-insoluble biologically active substance, a method for preparing same and a burst free sustained release pharmaceutical formulation comprising those microparticles.
PCT/CH2002/000048 2001-01-26 2002-01-28 Microparticles of biodegradable polymer encapsulating a biologically active substance WO2002058672A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02715353A EP1353648A2 (en) 2001-01-26 2002-01-28 Microparticles of biodegradable polymer encapsulating a biologically active substance
JP2002559006A JP2004517146A (en) 2001-01-26 2002-01-28 Bioactive substance encapsulated biodegradable polymer microparticles and sustained-release pharmaceutical formulation containing the microparticles
CA002435415A CA2435415A1 (en) 2001-01-26 2002-01-28 Microparticles of biodegradable polymer encapsulating a biologically active substance
US10/250,857 US20040052855A1 (en) 2001-01-26 2002-01-28 Microparticles of biodegradable polymer encapsulating a biologically active substance and sustained release pharmaceutical formulations containing same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/CH2001/000064 WO2002058671A1 (en) 2001-01-26 2001-01-26 Burst free pharmaceutical microparticules
CHPCT/CH01/00064 2001-01-26
IB0101370 2001-07-31
IBPCT/IB01/01370 2001-07-31

Publications (2)

Publication Number Publication Date
WO2002058672A2 WO2002058672A2 (en) 2002-08-01
WO2002058672A3 true WO2002058672A3 (en) 2002-12-19

Family

ID=25705676

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH2002/000048 WO2002058672A2 (en) 2001-01-26 2002-01-28 Microparticles of biodegradable polymer encapsulating a biologically active substance

Country Status (2)

Country Link
CA (1) CA2435415A1 (en)
WO (1) WO2002058672A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
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US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US8378105B2 (en) 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US8592450B2 (en) 2005-05-17 2013-11-26 Sarcode Bioscience Inc. Compositions and methods for treatment of eye disorders
US9085553B2 (en) 2012-07-25 2015-07-21 SARcode Bioscience, Inc. LFA-1 inhibitor and methods of preparation and polymorph thereof

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US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
BRPI0409032A (en) 2003-04-10 2006-05-02 Pr Pharmaceuticals method for the production of emulsion-based microparticles
EP1651136B1 (en) 2003-07-15 2017-03-08 Evonik Corporation Method for the preparation of controlled release formulations
AU2004259209A1 (en) * 2003-07-23 2005-02-03 Pr Pharmaceuticals, Inc. Controlled release compositions
PT1682537E (en) 2003-11-05 2012-06-20 Sarcode Bioscience Inc Modulators of cellular adhesion
FR2865938B1 (en) * 2004-02-05 2006-06-02 Sod Conseils Rech Applic SOLID DELAY FORMULATION COMPRISING TRIPTORELINE ACETATE
FR2869801B1 (en) * 2004-05-05 2008-09-12 Ethypharm Sa PROCESS FOR THE PREPARATION OF PROLONGED RELEASE COMPOSITIONS AND USE THEREOF FOR THE TREATMENT OF CHRONIC AFFECTIONS OF THE CENTRAL NERVOUS SYSTEM (CNS)
EP2089000A2 (en) * 2006-10-05 2009-08-19 Panacea Biotec Ltd. Injectable depot composition and its process of preparation
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EA020466B1 (en) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
MX2010004281A (en) 2007-10-19 2010-09-10 Sarcode Corp Compositions and methods for treatment of diabetic retinopathy.
JP2011522828A (en) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX362218B (en) 2011-05-04 2019-01-09 Balance Therapeutics Inc Pentylenetetrazole derivatives.
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
JP2016514670A (en) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase receptor agonists in combination with other drugs
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2926691A1 (en) 2013-10-10 2015-04-16 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions
CN108884130B (en) 2016-01-11 2022-09-13 博士医疗爱尔兰有限公司 Formulations and methods for treating ulcerative colitis
IT202000017191A1 (en) 2020-07-15 2022-01-15 Xbrane Biopharma Ab WATERLESS PROCESS FOR PREPARING A PHARMACEUTICAL COMPOSITION FOR A LONGER AND CONTROLLED RELEASE OF TRIPTORELIN OR A SALT ITS

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0601799A1 (en) * 1992-12-07 1994-06-15 Takeda Chemical Industries, Ltd. Sustained-release preparation
WO2000062761A1 (en) * 1999-04-15 2000-10-26 Debio Recherche Pharmaceutique S.A. Process for microencapsulation of water soluble substances
WO2002028386A1 (en) * 2000-10-03 2002-04-11 Debiopharm S.A. Method for preparing microspheres containing a water-soluble substance
WO2002058671A1 (en) * 2001-01-26 2002-08-01 Debio Recherche Pharmaceutique S.A. Burst free pharmaceutical microparticules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0601799A1 (en) * 1992-12-07 1994-06-15 Takeda Chemical Industries, Ltd. Sustained-release preparation
WO2000062761A1 (en) * 1999-04-15 2000-10-26 Debio Recherche Pharmaceutique S.A. Process for microencapsulation of water soluble substances
WO2002028386A1 (en) * 2000-10-03 2002-04-11 Debiopharm S.A. Method for preparing microspheres containing a water-soluble substance
WO2002058671A1 (en) * 2001-01-26 2002-08-01 Debio Recherche Pharmaceutique S.A. Burst free pharmaceutical microparticules

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BLANCO-PRÍETO M J ET AL: "In vitro and in vivo evaluation of a somatostatin analogue released from PLGA microspheres.", JOURNAL OF CONTROLLED RELEASE: OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY. NETHERLANDS 15 JUN 2000, vol. 67, no. 1, 15 June 2000 (2000-06-15), pages 19 - 28, XP002216451, ISSN: 0168-3659 *
WANG H T ET AL: "INFLUENCE OF FORMULATION METHODS ON THE IN VITRO CONTROLLED RELEASE OF PROTEIN FROM POLY (ESTER) MICROSPHERES", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 17, no. 1, 1 September 1991 (1991-09-01), pages 23 - 31, XP000223264, ISSN: 0168-3659 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592450B2 (en) 2005-05-17 2013-11-26 Sarcode Bioscience Inc. Compositions and methods for treatment of eye disorders
US8758776B2 (en) 2005-05-17 2014-06-24 Sarcode Bioscience Inc. Compositions and methods for treatment
US8771715B2 (en) 2005-05-17 2014-07-08 Sarcode Bioscience Inc. Compositions and methods for treatment
US9045458B2 (en) 2005-05-17 2015-06-02 Sarcode Bioscience Inc. Compositions and methods for treatment
US9045457B2 (en) 2005-05-17 2015-06-02 Sarcode Bioscience Inc. Compositions and methods for treatment
US9051297B2 (en) 2005-05-17 2015-06-09 Sarcode Bioscience Inc. Compositions and methods for treatment
US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US8367701B2 (en) 2008-04-15 2013-02-05 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US8871935B2 (en) 2008-04-15 2014-10-28 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US8378105B2 (en) 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US8927574B2 (en) 2009-10-21 2015-01-06 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US9085553B2 (en) 2012-07-25 2015-07-21 SARcode Bioscience, Inc. LFA-1 inhibitor and methods of preparation and polymorph thereof

Also Published As

Publication number Publication date
WO2002058672A2 (en) 2002-08-01
CA2435415A1 (en) 2002-08-01

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