WO2002058758A3 - Antithrombogenic polymer coating - Google Patents

Antithrombogenic polymer coating Download PDF

Info

Publication number
WO2002058758A3
WO2002058758A3 PCT/US2001/044597 US0144597W WO02058758A3 WO 2002058758 A3 WO2002058758 A3 WO 2002058758A3 US 0144597 W US0144597 W US 0144597W WO 02058758 A3 WO02058758 A3 WO 02058758A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
article
polymer
functional group
crosslinking
Prior art date
Application number
PCT/US2001/044597
Other languages
French (fr)
Other versions
WO2002058758A2 (en
Inventor
Zhi Heng Huang
William F Mcdonald
Stacy C Wright
Andrew C Taylor
Original Assignee
Michigan Biotech Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michigan Biotech Inst filed Critical Michigan Biotech Inst
Publication of WO2002058758A2 publication Critical patent/WO2002058758A2/en
Publication of WO2002058758A3 publication Critical patent/WO2002058758A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/02—Polyamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/22—Blood coagulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
    • Y10T428/31562—Next to polyamide [nylon, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31725—Of polyamide

Abstract

An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A)3P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.
PCT/US2001/044597 2000-12-05 2001-11-29 Antithrombogenic polymer coating WO2002058758A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/730,098 2000-12-05
US09/730,098 US6509104B2 (en) 2000-12-05 2000-12-05 Antithrombogenic polymer coating

Publications (2)

Publication Number Publication Date
WO2002058758A2 WO2002058758A2 (en) 2002-08-01
WO2002058758A3 true WO2002058758A3 (en) 2002-10-31

Family

ID=24933892

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044597 WO2002058758A2 (en) 2000-12-05 2001-11-29 Antithrombogenic polymer coating

Country Status (2)

Country Link
US (1) US6509104B2 (en)
WO (1) WO2002058758A2 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050043506A1 (en) * 2000-09-27 2005-02-24 Michigan Biotechnology Institute Polyamide materials based on unsaturated carboxylic acids and amines
US6797743B2 (en) 2000-09-27 2004-09-28 Michigan Biotechnology Institute Antimicrobial polymer
US6630460B2 (en) * 2001-02-09 2003-10-07 Medtronic, Inc. Heparin compositions and methods of making and using the same
US6939554B2 (en) * 2002-02-05 2005-09-06 Michigan Biotechnology Institute Antimicrobial polymer
TW200307734A (en) 2002-03-20 2003-12-16 Michigan Biotech Inst Conductive polymer-based material
US6951902B2 (en) * 2002-08-16 2005-10-04 Michigan Biotechnology Institute Two dimensional polymer that generates nitric oxide
WO2004058324A2 (en) * 2002-12-23 2004-07-15 The Government Of The United State Of America As Represent By The Secretary Of The Department Of Health And Human Services Antithrombotic venous access devices and methods
US8239045B2 (en) * 2003-06-04 2012-08-07 Synecor Llc Device and method for retaining a medical device within a vessel
US7617007B2 (en) * 2003-06-04 2009-11-10 Synecor Llc Method and apparatus for retaining medical implants within body vessels
US7082336B2 (en) * 2003-06-04 2006-07-25 Synecor, Llc Implantable intravascular device for defibrillation and/or pacing
WO2005000398A2 (en) * 2003-06-04 2005-01-06 Synecor Intravascular electrophysiological system and methods
WO2005058415A2 (en) * 2003-12-12 2005-06-30 Synecor, Llc Implantable medical device having pre-implant exoskeleton
WO2005097223A1 (en) * 2004-03-26 2005-10-20 Surmodics, Inc. Composition and method for preparing biocompatible surfaces
CA2559741A1 (en) * 2004-03-26 2005-10-20 Surmodics, Inc. A medical article having a bioactive agent-releasing component with photoreactive groups
MX2008007716A (en) 2005-12-13 2008-09-26 Exthera Ab Method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from blood.
US20070212388A1 (en) * 2006-03-08 2007-09-13 Sahajanand Medical Technologies Pvt. Ltd. Compositions comprising porous articles and uses in implantable medical devices
US8986713B2 (en) * 2006-05-12 2015-03-24 W. L. Gore & Associates, Inc. Medical device capable of being compacted and expanded having anti-thrombin III binding activity
US20080279909A1 (en) * 2006-05-12 2008-11-13 Cleek Robert L Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization
US8021677B2 (en) 2006-05-12 2011-09-20 Gore Enterprise Holdings, Inc. Immobilized biologically active entities having a high degree of biological activity
US9114194B2 (en) * 2006-05-12 2015-08-25 W. L. Gore & Associates, Inc. Immobilized biologically active entities having high biological activity following mechanical manipulation
US9693841B2 (en) 2007-04-02 2017-07-04 Ension, Inc. Surface treated staples, sutures and dental floss and methods of manufacturing the same
US8114465B2 (en) * 2007-04-02 2012-02-14 Ension, Inc. Process for preparing a substrate coated with a biomolecule
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
EP2230244B1 (en) * 2009-03-17 2014-05-07 Ecole Polytechnique DGAR Phosphorus polymers and their uses
CN106178161B (en) 2009-12-01 2020-12-22 艾克塞拉医疗公司 Method for removing cytokines from blood using surface immobilized polysaccharides
GB201004101D0 (en) * 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
BR112013023241B1 (en) 2011-03-11 2019-07-02 W. L. Gore & Associates, Inc. Hyper-branched cationic polymer molecule and device
EP2861273B1 (en) 2012-06-13 2017-08-23 ExThera Medical Corporation Use of heparin and carbohydrates to treat cancer
US20150352265A1 (en) * 2013-01-07 2015-12-10 Narayana GARIMELLA Biocompatible coating composition
EP3013445B1 (en) 2013-06-24 2019-11-06 ExThera Medical Corporation Blood filtration system containing mannose coated substrate
WO2015069942A1 (en) 2013-11-08 2015-05-14 Exthera Medical Corporation Methods for diagnosing infectious diseases using adsorption media
BR112016024569B1 (en) 2014-04-24 2023-01-03 Exthera Medical Corporation EX VIVO METHOD FOR REMOVING BACTERIA FROM A SPECIMEN TAKEN FROM AN INDIVIDUAL WHO IS SUSPECTED TO BE INFECTED WITH THE SAME
EP3197342B1 (en) 2014-09-22 2020-08-05 ExThera Medical Corporation Wearable hemoperfusion device
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
EP3422943A4 (en) 2016-03-02 2019-10-16 ExThera Medical Corporation Method for treating drug intoxication
CN113769176B (en) * 2021-08-26 2022-07-05 海思盖德(苏州)生物医学科技有限公司 Heparin coating drainage tube for reducing intraocular pressure and preparation method thereof
CN114129769B (en) * 2021-09-22 2022-08-05 海思盖德(苏州)生物医学科技有限公司 Artificial aqueous humor micro-drainage tube with drug slow-release function and preparation method thereof
CN114632187B (en) * 2021-11-18 2022-10-04 海思盖德(苏州)生物医学科技有限公司 Heparin coating porous micro-stent for aqueous humor drainage of glaucoma

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005400A1 (en) * 1993-08-19 1995-02-23 Minnesota Mining And Manufacturing Company Heparin functional affinity supports
WO2000017254A1 (en) * 1998-09-24 2000-03-30 Michigan State University PREPARATION OF CROSS-LINKED 2-DIMENSIONAL POLYMERS WITH SIDEDNESS FROM α,β-LACTONES
US6121027A (en) * 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
WO2002038649A2 (en) * 2000-10-27 2002-05-16 Michigan Biotechnology Institute Two dimensional polyamides prepared from unsaturated carboxylic acids and amines

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1083508A (en) 1975-11-13 1980-08-12 Jacques Grange Supports having lateral chains, process for obtaining such supports, process for the fixation of organic compounds comprising a glucidic residue on said supports, products and reactives from said chimical fixation
US4302368A (en) * 1978-04-24 1981-11-24 Becton, Dickinson And Company Nonthrombogenic articles and method of preparation
US4326532A (en) 1980-10-06 1982-04-27 Minnesota Mining And Manufacturing Company Antithrombogenic articles
SE8200751L (en) 1982-02-09 1983-08-10 Olle Larm PROCEDURE FOR COVALENT COUPLING FOR MANUFACTURE OF CONJUGATE AND REQUIRED PRODUCTS
JPS5915401A (en) 1982-07-16 1984-01-26 Seikagaku Kogyo Co Ltd Immobilized physiologically active substance, its production, and carrier used in its production
CH665954A5 (en) * 1985-07-08 1988-06-30 Battelle Memorial Institute SUBSTRATE WITH A SURFACE OF ANTITHROMBOGENIC ACTIVITY.
US4720512A (en) * 1986-03-24 1988-01-19 Becton, Dickinson And Company Polymeric articles having enhanced antithrombogenic activity
US4786556A (en) * 1986-03-24 1988-11-22 Becton, Dickinson And Company Polymeric articles having enhanced antithrombogenic activity
US4874813A (en) 1987-02-09 1989-10-17 Shannessy Daniel J O Proteins bound to a marker or solid phase support matrix using a hydrazone linkage
DE3738721C2 (en) 1987-11-14 1995-10-05 Roehm Gmbh Immobilized antibodies
US4865870A (en) 1988-07-07 1989-09-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic
GB2226032B (en) 1988-12-16 1993-08-18 Urs Heimgartner Detection of glycoproteins
DE3909456A1 (en) 1989-03-22 1990-09-27 Roehm Gmbh IMPROVED METHOD FOR THE PRODUCTION OF IMMOBILIZED ANTIKOERPERS
US6087462A (en) * 1995-06-07 2000-07-11 Biocompatibles Limited Polymeric surface coatings
US6319674B1 (en) * 1999-09-16 2001-11-20 Agilent Technologies, Inc. Methods for attaching substances to surfaces

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005400A1 (en) * 1993-08-19 1995-02-23 Minnesota Mining And Manufacturing Company Heparin functional affinity supports
US6121027A (en) * 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
WO2000017254A1 (en) * 1998-09-24 2000-03-30 Michigan State University PREPARATION OF CROSS-LINKED 2-DIMENSIONAL POLYMERS WITH SIDEDNESS FROM α,β-LACTONES
WO2002038649A2 (en) * 2000-10-27 2002-05-16 Michigan Biotechnology Institute Two dimensional polyamides prepared from unsaturated carboxylic acids and amines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANALYTICAL BIOCHEMISTRY, vol. 260, no. 1, 15 June 1998 (1998-06-15), pages 96 - 102, ISSN: 0003-2697 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 15 June 1998 (1998-06-15), SATOH AYANO ET AL: "Immobilization saccharides and peptides on 96-well microtiter plates coated with methyl vinyl ether-maleic anhydride copolymer.", XP002209719, Database accession no. PREV199800341478 *

Also Published As

Publication number Publication date
WO2002058758A2 (en) 2002-08-01
US20020068183A1 (en) 2002-06-06
US6509104B2 (en) 2003-01-21

Similar Documents

Publication Publication Date Title
WO2002058758A3 (en) Antithrombogenic polymer coating
ATE368070T1 (en) METHOD FOR MODIFYING A POLYMER SUBSTRATE SURFACE AND POLYMERS FORMED THEREFROM
WO1990000343A3 (en) Multifunctional thrombo-resistant coatings and methods of manufacture
ATE399573T1 (en) BIOCOMPATIBLE POLYMER FILM
DE60013323D1 (en) PRODUCTION OF A FUNCTIONAL POLYMER SURFACE
ATE412676T1 (en) INTERPENETRATING POLYMER NETWORKS
ATE401672T1 (en) PREPARATION OF A POLYMERIC DEVICE
TW328549B (en) Improved PVOH-based coating solutions
WO2003077792A3 (en) Low polydispersity poly-hema compositions
DE69916157D1 (en) Local rapamycin delivery stent
EP0359996A3 (en) Synthetic amino acid-and/or peptide-containing graft copolymers
ATE277106T1 (en) THERMOPLASTIC COMPOUND
DE59804617D1 (en) Process for the production of antimicrobial plastics
CA2322815A1 (en) Easily cleanable polymer laminates
WO2002006407A3 (en) Surfaces that resist the adsorption of biological species
DE68912691D1 (en) Process for the preparation of copolymers of diallyldimethylammonium chloride and high molecular weight acrylamide in solvents.
EP0930337A3 (en) Thermoplastic elastomer composition
EP1500685A4 (en) Composition of silicon-containing copolymer, solvent-soluble crosslinked silicon-containing copolymer, and cured articles obtained therefrom
ATE115976T1 (en) PRE-PRIMMED METAL SUBSTRATES FOR MOLDED METAL PROCESSING.
ATE263416T1 (en) CONDUCTIVE POLYMERS FOR COATINGS AND ANTI-ELECTROSTATIC APPLICATIONS
BR0311706A (en) Aqueous coating composition and coated substrates
WO1997049718A3 (en) Conjugates of an oligonucleotide/electronic conductor polymer with a molecule of interest, and their uses
DE68921431T2 (en) Porous surface-hydrated substrates made of polyacrylonitrile, such as pearl derivatives, processes for their preparation and processes for use.
BR8807869A (en) POLYMERIC MATERIAL WITH INTERPENETRATED NETWORKS OF POLYESOLOXANOPOLIARRYLIC, ITS MANUFACTURING PROCESS, AND MOLDED ITEMS OBTAINED
NO961832L (en) Aqueous material containing acetate-functional polymer and multifunctional amine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP