WO2002059112A3 - Pyrazole compounds useful as protein kinase inhibitors - Google Patents

Pyrazole compounds useful as protein kinase inhibitors Download PDF

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Publication number
WO2002059112A3
WO2002059112A3 PCT/US2001/049594 US0149594W WO02059112A3 WO 2002059112 A3 WO2002059112 A3 WO 2002059112A3 US 0149594 W US0149594 W US 0149594W WO 02059112 A3 WO02059112 A3 WO 02059112A3
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WIPO (PCT)
Prior art keywords
protein kinase
kinase inhibitors
pyrazole compounds
compounds useful
ring
Prior art date
Application number
PCT/US2001/049594
Other languages
French (fr)
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WO2002059112A2 (en
Inventor
David Bebbington
Jean-Damien Charrier
Original Assignee
Vertex Pharma
David Bebbington
Jean-Damien Charrier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma, David Bebbington, Jean-Damien Charrier filed Critical Vertex Pharma
Priority to JP2002559414A priority Critical patent/JP2004517927A/en
Priority to EP01994347A priority patent/EP1345929B1/en
Priority to AU2002246754A priority patent/AU2002246754B2/en
Priority to MXPA03005612A priority patent/MXPA03005612A/en
Priority to KR10-2003-7008366A priority patent/KR20030061464A/en
Priority to DE60119777T priority patent/DE60119777T2/en
Priority to CA002432132A priority patent/CA2432132C/en
Priority to NZ526475A priority patent/NZ526475A/en
Publication of WO2002059112A2 publication Critical patent/WO2002059112A2/en
Publication of WO2002059112A3 publication Critical patent/WO2002059112A3/en
Priority to HK04101941A priority patent/HK1062433A1/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

This invention describes novel pyrazole compounds of formula III:wherein Z?1, Z2, and Z3¿ are described in the specification; Q is -S-, -O-, -N (R4) -, or -CH (R6) -; is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl; and R?2 and R2'¿ are as in the specification. The compounds are used as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
PCT/US2001/049594 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors WO2002059112A2 (en)

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AU2002246754A AU2002246754B2 (en) 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors
MXPA03005612A MXPA03005612A (en) 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors.
KR10-2003-7008366A KR20030061464A (en) 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors
DE60119777T DE60119777T2 (en) 2000-12-21 2001-12-20 PYRAZOL COMPOUNDS AS PROTEIN KINASE HEMMER
CA002432132A CA2432132C (en) 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors
NZ526475A NZ526475A (en) 2000-12-21 2001-12-20 Pyrazole compounds useful as protein kinase inhibitors
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