WO2002068406A3 - Substituted amine derivatives and their use for the treatment of angiogenesis - Google Patents

Substituted amine derivatives and their use for the treatment of angiogenesis Download PDF

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Publication number
WO2002068406A3
WO2002068406A3 PCT/US2002/003064 US0203064W WO02068406A3 WO 2002068406 A3 WO2002068406 A3 WO 2002068406A3 US 0203064 W US0203064 W US 0203064W WO 02068406 A3 WO02068406 A3 WO 02068406A3
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WO
WIPO (PCT)
Prior art keywords
treatment
angiogenesis
diseases
substituted amine
amine derivatives
Prior art date
Application number
PCT/US2002/003064
Other languages
French (fr)
Other versions
WO2002068406A2 (en
Inventor
Guoqing Chen
Jeffrey Adams
Jean Bemis
Michael Croghan
Lucian Dipietro
Celia Dominguez
Daniel Elbaum
Julie Germain
Qi Huang
Joseph L Kim
Xiaohu Ouyang
Vinod F Patel
Leon M Smith
Andrew Tasker
Ning Xi
Shimin Xu
Chester Chenguang Yuan
Tae-Seong Kim
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP02723086A priority Critical patent/EP1467721A2/en
Application filed by Amgen Inc filed Critical Amgen Inc
Priority to IL15673702A priority patent/IL156737A0/en
Priority to AU2002253890A priority patent/AU2002253890B2/en
Priority to KR10-2003-7009276A priority patent/KR20030078068A/en
Priority to SK874-2003A priority patent/SK8742003A3/en
Priority to CA2434178A priority patent/CA2434178C/en
Priority to HU0302719A priority patent/HUP0302719A3/en
Priority to EEP200300325A priority patent/EE200300325A/en
Priority to JP2002567920A priority patent/JP4338974B2/en
Priority to MXPA03006260A priority patent/MXPA03006260A/en
Publication of WO2002068406A2 publication Critical patent/WO2002068406A2/en
Publication of WO2002068406A3 publication Critical patent/WO2002068406A3/en
Priority to BG108013A priority patent/BG108013A/en

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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

Selected amines of formula (I) are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
PCT/US2002/003064 2001-01-12 2002-01-11 Substituted amine derivatives and their use for the treatment of angiogenesis WO2002068406A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA2434178A CA2434178C (en) 2001-01-12 2002-01-11 Substituted amine derivatives and methods of use
IL15673702A IL156737A0 (en) 2001-01-12 2002-01-11 Substituted amine derivatives and methods of use
AU2002253890A AU2002253890B2 (en) 2001-01-12 2002-01-11 Substituted Amine Derivatives and Methods of Use
KR10-2003-7009276A KR20030078068A (en) 2001-01-12 2002-01-11 Substituted Amine Derivatives and Methods of Use
SK874-2003A SK8742003A3 (en) 2001-01-12 2002-01-11 Substituted amine derivatives and their use for treatment of angiogenesis
EP02723086A EP1467721A2 (en) 2001-01-12 2002-01-11 Substituted amine derivatives and their use for the treatment of angiogenesis
HU0302719A HUP0302719A3 (en) 2001-01-12 2002-01-11 Substituted amine derivatives and their use for the treatment of angiogenesis
MXPA03006260A MXPA03006260A (en) 2001-01-12 2002-01-11 Substituted amine derivatives and methods of use.
JP2002567920A JP4338974B2 (en) 2001-01-12 2002-01-11 Substituted amine derivatives and their use to treat angiogenesis
EEP200300325A EE200300325A (en) 2001-01-12 2002-01-11 Substituted amine derivatives and methods for their use
BG108013A BG108013A (en) 2001-01-12 2003-07-21 Substituted amine derivatives and methods for use thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US26188201P 2001-01-12 2001-01-12
US60/261,882 2001-01-12
US32380801P 2001-09-19 2001-09-19
US60/323,808 2001-09-19
US10/046,622 2002-01-10
US10/046,622 US7105682B2 (en) 2001-01-12 2002-01-10 Substituted amine derivatives and methods of use

Publications (2)

Publication Number Publication Date
WO2002068406A2 WO2002068406A2 (en) 2002-09-06
WO2002068406A3 true WO2002068406A3 (en) 2003-04-24

Family

ID=27366941

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Application Number Title Priority Date Filing Date
PCT/US2002/003064 WO2002068406A2 (en) 2001-01-12 2002-01-11 Substituted amine derivatives and their use for the treatment of angiogenesis

Country Status (16)

Country Link
US (2) US7105682B2 (en)
EP (1) EP1467721A2 (en)
JP (1) JP4338974B2 (en)
KR (1) KR20030078068A (en)
CN (1) CN1538836A (en)
AU (1) AU2002253890B2 (en)
BG (1) BG108013A (en)
CA (1) CA2434178C (en)
CZ (1) CZ20031883A3 (en)
EE (1) EE200300325A (en)
HU (1) HUP0302719A3 (en)
IL (1) IL156737A0 (en)
MX (1) MXPA03006260A (en)
PL (1) PL366834A1 (en)
SK (1) SK8742003A3 (en)
WO (1) WO2002068406A2 (en)

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