WO2002070664A3 - Method for rapid detection and identification of bioagents - Google Patents

Method for rapid detection and identification of bioagents Download PDF

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Publication number
WO2002070664A3
WO2002070664A3 PCT/US2002/006763 US0206763W WO02070664A3 WO 2002070664 A3 WO2002070664 A3 WO 2002070664A3 US 0206763 W US0206763 W US 0206763W WO 02070664 A3 WO02070664 A3 WO 02070664A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioagent
bioagents
identification
base composition
sequence regions
Prior art date
Application number
PCT/US2002/006763
Other languages
French (fr)
Other versions
WO2002070664A2 (en
Inventor
David J Ecker
Richard H Griffey
Rangarajan Sampath
Steven Hofstadler
John Mcneil
Original Assignee
Isis Pharmaceuticals Inc
David J Ecker
Richard H Griffey
Rangarajan Sampath
Steven Hofstadler
John Mcneil
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MX2014010221A priority Critical patent/MX349763B/en
Priority to IL15766102A priority patent/IL157661A0/en
Application filed by Isis Pharmaceuticals Inc, David J Ecker, Richard H Griffey, Rangarajan Sampath, Steven Hofstadler, John Mcneil filed Critical Isis Pharmaceuticals Inc
Priority to AU2002244250A priority patent/AU2002244250B2/en
Priority to CN028091221A priority patent/CN1505685B/en
Priority to JP2002570692A priority patent/JP2005504508A/en
Priority to CA2439655A priority patent/CA2439655C/en
Priority to EP02709785A priority patent/EP1364064B1/en
Priority to NZ527857A priority patent/NZ527857A/en
Priority to MXPA03007927A priority patent/MXPA03007927A/en
Priority to ES02709785T priority patent/ES2394731T3/en
Publication of WO2002070664A2 publication Critical patent/WO2002070664A2/en
Publication of WO2002070664A3 publication Critical patent/WO2002070664A3/en
Priority to IL157661A priority patent/IL157661A/en
Priority to AU2003298030A priority patent/AU2003298030B2/en
Priority to AU2010200893A priority patent/AU2010200893B2/en
Priority to IL238855A priority patent/IL238855A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a 'base composition signature' (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
PCT/US2002/006763 2001-03-02 2002-03-04 Method for rapid detection and identification of bioagents WO2002070664A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
MXPA03007927A MXPA03007927A (en) 2001-03-02 2002-03-04 Method for rapid detection and identification of bioagents.
NZ527857A NZ527857A (en) 2001-03-02 2002-03-04 Identification of an unknown bacterial bioagent comprising an amplification step followed by determining molecular mass of the amplification product
AU2002244250A AU2002244250B2 (en) 2001-03-02 2002-03-04 Method for rapid detection and identification of bioagents
IL15766102A IL157661A0 (en) 2001-03-02 2002-03-04 Method for rapid detection and identification of bioagents
JP2002570692A JP2005504508A (en) 2001-03-02 2002-03-04 Rapid detection and identification of biological materials
CA2439655A CA2439655C (en) 2001-03-02 2002-03-04 Method for rapid detection and identification of bioagents
ES02709785T ES2394731T3 (en) 2001-03-02 2002-03-04 Procedure for rapid detection and identification of bacteria
MX2014010221A MX349763B (en) 2001-03-02 2002-03-04 Method for rapid detection and identification of bioagents.
CN028091221A CN1505685B (en) 2001-03-02 2002-03-04 Methods for rapid detection and identification of bioagents for environmental testing
EP02709785A EP1364064B1 (en) 2001-03-02 2002-03-04 Method for rapid detection and identification of bacteria
IL157661A IL157661A (en) 2001-03-02 2003-08-29 Method for rapid detection and identification of bioagents
AU2003298030A AU2003298030B2 (en) 2001-03-02 2003-12-05 Methods for rapid identification of pathogens in humans and animals
AU2010200893A AU2010200893B2 (en) 2001-03-02 2010-03-10 Methods for rapid identification of pathogens in humans and animals
IL238855A IL238855A0 (en) 2001-03-02 2015-05-17 Method for rapid detection and identification of bioagents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/798,007 2001-03-02
US09/798,007 US20030027135A1 (en) 2001-03-02 2001-03-02 Method for rapid detection and identification of bioagents

Publications (2)

Publication Number Publication Date
WO2002070664A2 WO2002070664A2 (en) 2002-09-12
WO2002070664A3 true WO2002070664A3 (en) 2002-12-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/006763 WO2002070664A2 (en) 2001-03-02 2002-03-04 Method for rapid detection and identification of bioagents

Country Status (13)

Country Link
US (13) US20030027135A1 (en)
EP (4) EP2311992B1 (en)
JP (2) JP2005504508A (en)
CN (2) CN1505685B (en)
AU (2) AU2002244250B2 (en)
CA (2) CA2853831C (en)
ES (3) ES2451003T3 (en)
IL (3) IL157661A0 (en)
MX (2) MXPA03007927A (en)
NZ (1) NZ527857A (en)
RU (1) RU2003129269A (en)
WO (1) WO2002070664A2 (en)
ZA (1) ZA200306810B (en)

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