WO2002074042A3 - Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative - Google Patents
Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative Download PDFInfo
- Publication number
- WO2002074042A3 WO2002074042A3 PCT/EP2002/002977 EP0202977W WO02074042A3 WO 2002074042 A3 WO2002074042 A3 WO 2002074042A3 EP 0202977 W EP0202977 W EP 0202977W WO 02074042 A3 WO02074042 A3 WO 02074042A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- epothilone
- combinations
- antidiarrheal agent
- derivative
- antidiarrheal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60229922T DE60229922D1 (en) | 2001-03-19 | 2002-03-18 | COMBINATIONS, AN ANTI-DIARRHOIC AND EPOTHILONE OR AN EPOTHILON DERIVATIVE CONTAINING |
EP02719992A EP1372650B1 (en) | 2001-03-19 | 2002-03-18 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative |
JP2002572770A JP2004519493A (en) | 2001-03-19 | 2002-03-18 | Antidiarrheal agent and combination containing epothilone or epothilone derivative |
SK1170-2003A SK287334B6 (en) | 2001-03-19 | 2002-03-18 | Combination of an antidiarrheal agent and an epothilone or an epothilone derivative, pharmaceutical composition and commercial package comprising it, and use thereof |
AU2002251067A AU2002251067B2 (en) | 2001-03-19 | 2002-03-18 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative |
IL15733302A IL157333A0 (en) | 2001-03-19 | 2002-03-18 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative |
SI200230793T SI1372650T1 (en) | 2001-03-19 | 2002-03-18 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative |
KR1020037012154A KR100863089B1 (en) | 2001-03-19 | 2002-03-18 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative |
CA2440111A CA2440111C (en) | 2001-03-19 | 2002-03-18 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative |
HU0303621A HUP0303621A3 (en) | 2001-03-19 | 2002-03-18 | Pharmaceutical compositions containing combinations comprising an antidiarrheal agent and epothilone or an epothilone |
BR0208142-3A BR0208142A (en) | 2001-03-19 | 2002-03-18 | Combinations comprising an antidiarrheal agent and epothilone or epothilone derivative |
US10/471,904 US7030147B2 (en) | 2001-03-19 | 2002-03-18 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative |
DK02719992T DK1372650T3 (en) | 2001-03-19 | 2002-03-18 | Combinations containing an antidiarrheal agent and an epothilone or epothilone derivative |
MXPA03008462A MXPA03008462A (en) | 2001-03-19 | 2002-03-18 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative. |
PL363427A PL206847B1 (en) | 2001-03-19 | 2002-03-18 | Combination comprising an anti-diarrheal agent and an epothilone derivative and the use of this combination and commercial kit |
ZA2003/06318A ZA200306318B (en) | 2001-03-19 | 2003-08-14 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative |
NO20034094A NO333106B1 (en) | 2001-03-19 | 2003-09-15 | Compositions comprising an anti-diarrheal agent and an epothilone or epothilone derivative, and use thereof |
HK04104401.1A HK1061516A1 (en) | 2001-03-19 | 2004-06-16 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27715301P | 2001-03-19 | 2001-03-19 | |
US60/277,153 | 2001-03-19 | ||
US27720701P | 2001-03-20 | 2001-03-20 | |
US60/277,207 | 2001-03-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002074042A2 WO2002074042A2 (en) | 2002-09-26 |
WO2002074042A3 true WO2002074042A3 (en) | 2003-02-27 |
Family
ID=26958333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/002977 WO2002074042A2 (en) | 2001-03-19 | 2002-03-18 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative |
Country Status (27)
Country | Link |
---|---|
US (1) | US7030147B2 (en) |
EP (1) | EP1372650B1 (en) |
JP (2) | JP2004519493A (en) |
KR (1) | KR100863089B1 (en) |
CN (1) | CN100540001C (en) |
AT (1) | ATE414514T1 (en) |
AU (1) | AU2002251067B2 (en) |
BR (1) | BR0208142A (en) |
CA (1) | CA2440111C (en) |
CY (1) | CY1108845T1 (en) |
CZ (1) | CZ302848B6 (en) |
DE (1) | DE60229922D1 (en) |
DK (1) | DK1372650T3 (en) |
ES (1) | ES2318001T3 (en) |
HK (1) | HK1061516A1 (en) |
HU (1) | HUP0303621A3 (en) |
IL (1) | IL157333A0 (en) |
MX (1) | MXPA03008462A (en) |
NO (1) | NO333106B1 (en) |
NZ (1) | NZ541703A (en) |
PT (1) | PT1372650E (en) |
RU (1) | RU2330661C2 (en) |
SI (1) | SI1372650T1 (en) |
SK (1) | SK287334B6 (en) |
TW (1) | TWI331525B (en) |
WO (1) | WO2002074042A2 (en) |
ZA (1) | ZA200306318B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE41990E1 (en) | 1996-12-03 | 2010-12-07 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
US7018981B2 (en) * | 2000-08-24 | 2006-03-28 | Chugai Seiyaku Kabushiki Kaisha | Cyclic motilin receptor antagonists |
EP1383490B1 (en) | 2001-03-14 | 2012-04-25 | Bristol-Myers Squibb Company | Combination of an epothilone analog and chemotherapeutic agents for the treatment of proliferative diseases |
US6727261B2 (en) | 2001-12-27 | 2004-04-27 | Hoffman-La Roche Inc. | Pyrido[2,1-A]Isoquinoline derivatives |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
DE60330407D1 (en) | 2002-08-23 | 2010-01-14 | Sloan Kettering Inst Cancer | Synthesis of epothilones, intermediates thereof, analogs and their use |
WO2004087053A2 (en) * | 2003-03-25 | 2004-10-14 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
EP1506967B1 (en) * | 2003-08-13 | 2007-11-21 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
JP2007505121A (en) * | 2003-09-08 | 2007-03-08 | 武田薬品工業株式会社 | Dipeptidyl peptidase inhibitor |
EP1697342A2 (en) * | 2003-09-08 | 2006-09-06 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2005095381A1 (en) | 2004-03-15 | 2005-10-13 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
RU2253440C1 (en) * | 2004-03-31 | 2005-06-10 | Открытое Акционерное Общество "Фаберлик" | Preparation for removing disorders of neurogenic and endocrine regulation in the system of capillary circulation |
EP1753730A1 (en) * | 2004-06-04 | 2007-02-21 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
EP2805953B1 (en) | 2004-12-21 | 2016-03-09 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EP2634252B1 (en) | 2005-02-11 | 2018-12-19 | University of Southern California | Method of expressing proteins with disulfide bridges |
EP1942898B2 (en) * | 2005-09-14 | 2014-05-14 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
MY159522A (en) * | 2005-09-14 | 2017-01-13 | Takeda Pharmaceuticals Co | Administration of dipeptidyl peptidase inhibitors |
TW200745080A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor |
EP1924567B1 (en) | 2005-09-16 | 2012-08-22 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
TW200745079A (en) * | 2005-09-16 | 2007-12-16 | Takeda Pharmaceuticals Co | Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US8008256B2 (en) * | 2006-05-01 | 2011-08-30 | University Of Southern California | Combination therapy for treatment of cancer |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
BRPI0820338A2 (en) * | 2007-11-09 | 2017-05-02 | Novartis Ag | corticosteroids to treat epothilone-induced or epothilone-derived diarrhea |
US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
EP2571525A4 (en) | 2010-05-18 | 2016-04-27 | Cerulean Pharma Inc | Compositions and methods for treatment of autoimmune and other diseases |
KR101478925B1 (en) * | 2013-12-31 | 2015-01-08 | 아주대학교산학협력단 | Pharmaceutical composition for treating or preventing cancer disease comprising proteasome inhibitor and loperamide |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001092255A2 (en) * | 2000-05-26 | 2001-12-06 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
CN1304058C (en) * | 1996-03-12 | 2007-03-14 | Pg-Txl有限公司 | Water soluble paclitaxel prodrugs |
US5969145A (en) * | 1996-08-30 | 1999-10-19 | Novartis Ag | Process for the production of epothilones and intermediate products within the process |
US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
US6103487A (en) * | 1997-08-27 | 2000-08-15 | Merck & Co., Inc. | Method of treating cancer |
US6127390A (en) * | 1997-10-02 | 2000-10-03 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
AR017979A1 (en) * | 1998-02-05 | 2001-10-24 | Novartis Ag | PHARMACEUTICAL FORMULATIONS OF EPOTILONES, METHOD FOR THE PREPARATION AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT |
US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
-
2002
- 2002-03-18 CN CNB028068459A patent/CN100540001C/en not_active Expired - Fee Related
- 2002-03-18 IL IL15733302A patent/IL157333A0/en not_active IP Right Cessation
- 2002-03-18 EP EP02719992A patent/EP1372650B1/en not_active Expired - Lifetime
- 2002-03-18 ES ES02719992T patent/ES2318001T3/en not_active Expired - Lifetime
- 2002-03-18 MX MXPA03008462A patent/MXPA03008462A/en active IP Right Grant
- 2002-03-18 RU RU2003130058/15A patent/RU2330661C2/en not_active IP Right Cessation
- 2002-03-18 BR BR0208142-3A patent/BR0208142A/en not_active Application Discontinuation
- 2002-03-18 NZ NZ541703A patent/NZ541703A/en not_active IP Right Cessation
- 2002-03-18 PT PT02719992T patent/PT1372650E/en unknown
- 2002-03-18 CZ CZ20032529A patent/CZ302848B6/en not_active IP Right Cessation
- 2002-03-18 AT AT02719992T patent/ATE414514T1/en active
- 2002-03-18 JP JP2002572770A patent/JP2004519493A/en not_active Withdrawn
- 2002-03-18 KR KR1020037012154A patent/KR100863089B1/en not_active IP Right Cessation
- 2002-03-18 CA CA2440111A patent/CA2440111C/en not_active Expired - Fee Related
- 2002-03-18 DE DE60229922T patent/DE60229922D1/en not_active Expired - Lifetime
- 2002-03-18 SI SI200230793T patent/SI1372650T1/en unknown
- 2002-03-18 HU HU0303621A patent/HUP0303621A3/en unknown
- 2002-03-18 WO PCT/EP2002/002977 patent/WO2002074042A2/en active IP Right Grant
- 2002-03-18 AU AU2002251067A patent/AU2002251067B2/en not_active Ceased
- 2002-03-18 TW TW091105086A patent/TWI331525B/en not_active IP Right Cessation
- 2002-03-18 DK DK02719992T patent/DK1372650T3/en active
- 2002-03-18 US US10/471,904 patent/US7030147B2/en not_active Expired - Fee Related
- 2002-03-18 SK SK1170-2003A patent/SK287334B6/en not_active IP Right Cessation
-
2003
- 2003-08-14 ZA ZA2003/06318A patent/ZA200306318B/en unknown
- 2003-09-15 NO NO20034094A patent/NO333106B1/en not_active IP Right Cessation
-
2004
- 2004-06-16 HK HK04104401.1A patent/HK1061516A1/en not_active IP Right Cessation
-
2009
- 2009-02-19 CY CY20091100200T patent/CY1108845T1/en unknown
- 2009-08-27 JP JP2009196666A patent/JP2010006830A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001092255A2 (en) * | 2000-05-26 | 2001-12-06 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
Non-Patent Citations (1)
Title |
---|
ALTAHA RAMIN ET AL: "Epothilones: A Novel Class of Non-taxane Microtubule-stabilizing Agents.", CURRENT PHARMACEUTICAL DESIGN. NETHERLANDS 2002, vol. 8, no. 19, 2002, pages 1707 - 1712, XP001119806, ISSN: 1381-6128 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE41990E1 (en) | 1996-12-03 | 2010-12-07 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002074042A3 (en) | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative | |
AU2002338336A1 (en) | Epothilone derivatives and methods for making and using the same | |
HK1061679A1 (en) | Phenylsulfonyl-1,3-dihydro-2h-indole-2-ibe derivatives, their preparation and their therapeutic use. | |
AU2001266583A1 (en) | Epothilone derivatives and methods for making and using the same | |
AU2002336273A1 (en) | Heterocyclic compounds and their use as histamine h4 ligands. | |
MY120601A (en) | C-21 modified epothilones | |
AU2003266321A1 (en) | Tetrahydropyrimidine-2-one derivatives and their uses | |
AU2003303388A1 (en) | Triptolide derivatives and their use | |
AU2002228317A1 (en) | Benz-1,3-azole derivatives and their uses as heparanase inhibitors | |
NO20043565L (en) | Heteroberl-substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido [1,2-a] pyrimidin-4-one derivatives. | |
AU2001264043A1 (en) | 4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-(3.2.2)nonane derivatives, preparationand therapeutic use thereof | |
AU2001264042A1 (en) | 1,4-diazabicyclo(3.2.2)nonane-phenylisoxazole derivatives, preparation and therapeutic use thereof | |
AU2002229063A1 (en) | High-energy, high-frequency pulse defibrillator | |
HK1045151A1 (en) | Thiazolidinedione derivative and its use as antidiabetic. | |
AU2003226664A1 (en) | Blue 3h-naphtho-(2,1-b)-pyran derivatives and use thereof | |
AU2002338989A1 (en) | Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine derivatives | |
HK1045304A1 (en) | Thiazolidinedione derivative and its use as antidiabetic. | |
MXPA03006162A (en) | Mikanolide derivatives, their preparation and therapeutic uses. | |
AU2401601A (en) | Check valve, and syringe using the same | |
AU2002953128A0 (en) | Surface treatment for wood and wood products | |
ZA200405173B (en) | 2'-halo-3',5'-dialkoxyphen-1'yl-imino-2-imidazoline derivatives and the use thereof for the treatment of urinary incontinence. | |
AU2002229870A1 (en) | Mikanolide derivatives, their preparation and therapeutic uses | |
AU2002302551A1 (en) | Flavone synthase i enzymes and the use thereof | |
AU2002332244A1 (en) | Demelanizing agents, beautifying agents, demelanizing compositions and beautifying compositions | |
AU2001282268A1 (en) | Phenantridine derivatives and their use as anti-telomerase agent |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LT LU LV MA MD MK MN MX NO NZ OM PH PL PT RO RU SE SG SI SK TJ TM TN TR TT UA US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LT LU LV MA MD MK MN MX NO NZ OM PH PL PT RO RU SE SG SI SK TJ TM TN TR TT UA US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002719992 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1-2003-500852 Country of ref document: PH |
|
WWE | Wipo information: entry into national phase |
Ref document number: 157333 Country of ref document: IL Ref document number: 2002251067 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003/06318 Country of ref document: ZA Ref document number: 200306318 Country of ref document: ZA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002572770 Country of ref document: JP Ref document number: 2440111 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 528083 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10471904 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1465/CHENP/2003 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: PV2003-2529 Country of ref document: CZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 11702003 Country of ref document: SK Ref document number: 1020037012154 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2003/008462 Country of ref document: MX Ref document number: 028068459 Country of ref document: CN |
|
WWP | Wipo information: published in national office |
Ref document number: 2002719992 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: PV2003-2529 Country of ref document: CZ |
|
WWG | Wipo information: grant in national office |
Ref document number: 2002251067 Country of ref document: AU |