WO2002074942B1 - Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics - Google Patents
Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimicsInfo
- Publication number
- WO2002074942B1 WO2002074942B1 PCT/CA2002/000229 CA0200229W WO02074942B1 WO 2002074942 B1 WO2002074942 B1 WO 2002074942B1 CA 0200229 W CA0200229 W CA 0200229W WO 02074942 B1 WO02074942 B1 WO 02074942B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptide
- seq
- isolated
- set forth
- nucleic acid
- Prior art date
Links
- 108700023372 Glycosyltransferases Proteins 0.000 title abstract 6
- 102000045442 glycosyltransferase activity proteins Human genes 0.000 title abstract 6
- 108700014210 glycosyltransferase activity proteins Proteins 0.000 title abstract 6
- 241000589876 Campylobacter Species 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 150000002270 gangliosides Chemical class 0.000 title 2
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 22
- 108010066816 Polypeptide N-acetylgalactosaminyltransferase Proteins 0.000 claims abstract 18
- 102000039446 nucleic acids Human genes 0.000 claims abstract 15
- 108020004707 nucleic acids Proteins 0.000 claims abstract 15
- 102000003838 Sialyltransferases Human genes 0.000 claims abstract 11
- 108090000141 Sialyltransferases Proteins 0.000 claims abstract 11
- 230000000694 effects Effects 0.000 claims abstract 5
- 102100021700 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Human genes 0.000 claims abstract 4
- 101000896564 Homo sapiens Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Proteins 0.000 claims abstract 4
- 229920001184 polypeptide Polymers 0.000 claims 39
- 102000004196 processed proteins & peptides Human genes 0.000 claims 39
- 108090000765 processed proteins & peptides Proteins 0.000 claims 39
- 108091033319 polynucleotide Proteins 0.000 claims 21
- 102000040430 polynucleotide Human genes 0.000 claims 21
- 239000002157 polynucleotide Substances 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 102000004357 Transferases Human genes 0.000 claims 4
- 108090000992 Transferases Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- -1 wherein the β-l Proteins 0.000 claims 4
- 241000589875 Campylobacter jejuni Species 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 230000001588 bifunctional effect Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
Abstract
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02703414A EP1385941A2 (en) | 2001-03-21 | 2002-02-22 | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
MXPA03008565A MXPA03008565A (en) | 2001-03-21 | 2002-02-22 | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics. |
AU2002237122A AU2002237122B2 (en) | 2001-03-21 | 2002-02-22 | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
JP2002574334A JP4431312B2 (en) | 2001-03-21 | 2002-02-22 | Campylobacter glycosyltransferase for the biosynthesis of gangliosides and ganglioside mimetics |
CA2441570A CA2441570C (en) | 2001-03-21 | 2002-02-22 | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/816,028 US6699705B2 (en) | 1999-02-01 | 2001-03-21 | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
US09/816,028 | 2001-03-21 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002074942A2 WO2002074942A2 (en) | 2002-09-26 |
WO2002074942A3 WO2002074942A3 (en) | 2003-03-13 |
WO2002074942B1 true WO2002074942B1 (en) | 2003-07-03 |
Family
ID=25219498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2002/000229 WO2002074942A2 (en) | 2001-03-21 | 2002-02-22 | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
Country Status (7)
Country | Link |
---|---|
US (22) | US6699705B2 (en) |
EP (2) | EP1914302B1 (en) |
JP (2) | JP4431312B2 (en) |
AU (1) | AU2002237122B2 (en) |
CA (1) | CA2441570C (en) |
MX (1) | MXPA03008565A (en) |
WO (1) | WO2002074942A2 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6689604B1 (en) * | 1998-03-20 | 2004-02-10 | National Research Council Of Canada | Lipopolysaccharide α-2,3 sialyltransferase of Campylobacter jejuni and its uses |
US7696168B2 (en) * | 2000-04-21 | 2010-04-13 | Tufts Medical Center, Inc. | G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same |
AU2004236174B2 (en) | 2001-10-10 | 2011-06-02 | Novo Nordisk A/S | Glycopegylation methods and proteins/peptides produced by the methods |
WO2004055491A2 (en) * | 2002-05-20 | 2004-07-01 | Massachusetts Institute Of Technology | Novel method for sequence determination using nmr |
ES2391525T3 (en) * | 2002-08-01 | 2012-11-27 | National Research Council Of Canada | Campylobacter glycans and glycopeptides |
WO2004071177A2 (en) * | 2003-02-11 | 2004-08-26 | Arizona Board Of Regents, Acting For And On Behalf Of, Arizona State University | Sialylation of glycoproteins in plants |
MXPA05009480A (en) | 2003-03-06 | 2006-02-22 | Neose Technologies Inc | Methods and compositions for the enzymatic synthesis of gangliosides. |
US7627651B2 (en) * | 2003-10-27 | 2009-12-01 | American Power Conversion Corporation | System and method for network device communication |
US7287761B2 (en) * | 2004-12-09 | 2007-10-30 | Charles James Montgomery | Method and an assembly for selectively adjusting the height and load capacity of a motorized assembly and a motorized assembly incorporating the method |
US7355376B2 (en) | 2005-03-03 | 2008-04-08 | Cardiac Pacemakers, Inc. | Battery status indicator compensating for battery voltage recovery |
CA2604621C (en) | 2005-04-11 | 2014-01-21 | National Research Council Of Canada | Identification of a beta-1,3-n-acetylgalactosaminyltransferase (cgte) from campylobacter jejuni lio87 |
US7820422B2 (en) * | 2005-06-16 | 2010-10-26 | Centre National De La Recherche Scientifique (Cnrs) | Efficient production of oligosaccharides using metabolically engineered microorganisms |
US8771991B2 (en) | 2005-08-11 | 2014-07-08 | National Research Council Of Canada | SOAT polypeptide reaction mixture |
WO2007087711A1 (en) * | 2006-01-31 | 2007-08-09 | National Research Council Of Canada | Production of polysialic acid containing glyconjugates using a self-priming polysialyltransferase |
ATE542915T1 (en) * | 2006-02-01 | 2012-02-15 | Biogenerix Ag | CST-II MODIFICATIONS FOR INCREASED PROTEIN EXPRESSION |
JP5544164B2 (en) * | 2006-05-02 | 2014-07-09 | ナショナル リサーチ カウンセル オブ カナダ | Α-1,4-galactosyltransferase (CgtD) derived from Campylobacter jejuni |
EP1911850A1 (en) * | 2006-10-09 | 2008-04-16 | Centre National De La Recherche Scientifique (Cnrs) | Method of producing 6-thio-sialylated glycoproteins and glycoconjugates |
US8409583B2 (en) * | 2007-04-20 | 2013-04-02 | National Research Council Of Canada | Engineered versions of CgtB (β-1,3 galactosyltransferase) enzymes, with enhanced enzymatic properties |
US8460909B2 (en) | 2007-06-15 | 2013-06-11 | National Research Council Of Canada | Engineered versions of polysialyltransferases with enhanced enzymatic properties |
WO2009126308A2 (en) * | 2008-04-11 | 2009-10-15 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for vaccine and virus production |
EP2927316B1 (en) * | 2014-03-31 | 2018-11-07 | Jennewein Biotechnologie GmbH | Total fermentation of oligosaccharides |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
KR102371465B1 (en) * | 2019-11-08 | 2022-03-08 | 영남대학교 산학협력단 | Codon-optimized N-acetylgalactosamine transferase and galactose transferase derived from Campylobacter jejuni, and production method of E. coli-based soluble transferase using the same |
DK202270078A1 (en) * | 2022-03-02 | 2023-12-04 | Dsm Ip Assets Bv | New sialyltransferases for in vivo synthesis of lst-a |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56500138A (en) | 1979-03-16 | 1981-02-12 | ||
US4710490A (en) | 1985-10-01 | 1987-12-01 | Angio Medical Corporation | Compositions containing ganglioside molecules with enhanced angiogenic activity |
US5374641A (en) * | 1991-02-25 | 1994-12-20 | Terumo Kabushiki Kaisha | N-(3-pyridylalkyl)sulfonamide compounds which have useful pharmaceutical activity |
FI88654C (en) | 1991-03-15 | 1993-06-10 | Datacity Center Oy | Fluorescenshoejningsmetod |
DE69231127D1 (en) | 1991-03-18 | 2000-07-06 | Scripps Research Inst La Jolla | OLIGOSACCHARIDES AS ENZYME SUBSTRATES AND INHIBITORS: METHODS AND COMPOSITIONS |
US5352670A (en) | 1991-06-10 | 1994-10-04 | Alberta Research Council | Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides |
US5352870A (en) * | 1992-09-29 | 1994-10-04 | Martin Marietta Corporation | Strip heater with predetermined power density |
US5374541A (en) | 1993-05-04 | 1994-12-20 | The Scripps Research Institute | Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides |
JPH09503905A (en) * | 1993-07-15 | 1997-04-22 | ネオゼ ファーマシューティカルス | Method for synthesizing sugar composition |
US5641760A (en) * | 1994-06-17 | 1997-06-24 | Pence, Inc. | Method of treating candida infection |
US5545553A (en) | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
US5728554A (en) | 1995-04-11 | 1998-03-17 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
US5545653A (en) | 1995-06-07 | 1996-08-13 | Eli Lilly And Company | Anti-viral compounds |
US6689604B1 (en) | 1998-03-20 | 2004-02-10 | National Research Council Of Canada | Lipopolysaccharide α-2,3 sialyltransferase of Campylobacter jejuni and its uses |
US6503744B1 (en) | 1999-02-01 | 2003-01-07 | National Research Council Of Canada | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
US6327567B1 (en) | 1999-02-10 | 2001-12-04 | Telefonaktiebolaget L M Ericsson (Publ) | Method and system for providing spatialized audio in conference calls |
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2001
- 2001-03-21 US US09/816,028 patent/US6699705B2/en not_active Expired - Lifetime
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2002
- 2002-02-22 MX MXPA03008565A patent/MXPA03008565A/en not_active Application Discontinuation
- 2002-02-22 EP EP07150045.8A patent/EP1914302B1/en not_active Expired - Lifetime
- 2002-02-22 AU AU2002237122A patent/AU2002237122B2/en not_active Ceased
- 2002-02-22 EP EP02703414A patent/EP1385941A2/en not_active Withdrawn
- 2002-02-22 WO PCT/CA2002/000229 patent/WO2002074942A2/en not_active Application Discontinuation
- 2002-02-22 CA CA2441570A patent/CA2441570C/en not_active Expired - Lifetime
- 2002-02-22 JP JP2002574334A patent/JP4431312B2/en not_active Expired - Fee Related
- 2002-11-21 US US10/303,162 patent/US6723545B2/en not_active Expired - Lifetime
- 2002-11-21 US US10/303,128 patent/US6911337B2/en not_active Expired - Lifetime
- 2002-11-21 US US10/303,161 patent/US7138258B2/en not_active Expired - Lifetime
- 2002-11-21 US US10/303,118 patent/US6905867B2/en not_active Expired - Lifetime
- 2002-11-21 US US10/303,134 patent/US6825019B2/en not_active Expired - Lifetime
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2003
- 2003-12-11 US US10/734,719 patent/US7169914B2/en not_active Expired - Lifetime
- 2003-12-11 US US10/735,419 patent/US7026147B2/en not_active Expired - Lifetime
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2004
- 2004-04-07 US US10/820,536 patent/US7211657B2/en not_active Expired - Lifetime
- 2004-04-08 US US10/821,573 patent/US7192756B2/en not_active Expired - Lifetime
- 2004-04-08 US US10/821,604 patent/US7462474B2/en not_active Expired - Fee Related
- 2004-04-24 US US10/830,825 patent/US7384771B2/en not_active Expired - Lifetime
- 2004-05-12 US US10/845,412 patent/US7166717B2/en not_active Expired - Lifetime
- 2004-05-12 US US10/845,408 patent/US7169593B2/en not_active Expired - Lifetime
- 2004-05-14 US US10/846,219 patent/US7202353B2/en not_active Expired - Lifetime
- 2004-05-17 US US10/847,983 patent/US7208304B2/en not_active Expired - Lifetime
- 2004-05-19 US US10/850,125 patent/US7220848B2/en not_active Expired - Lifetime
- 2004-05-21 US US10/850,807 patent/US7217549B2/en not_active Expired - Lifetime
- 2004-10-08 US US10/961,882 patent/US7078207B2/en not_active Expired - Lifetime
- 2004-10-08 US US10/962,334 patent/US7189836B2/en not_active Expired - Lifetime
- 2004-10-08 US US10/962,235 patent/US7238509B2/en not_active Expired - Lifetime
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2006
- 2006-10-11 US US11/548,514 patent/US7608442B2/en not_active Expired - Fee Related
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2008
- 2008-07-22 JP JP2008189243A patent/JP4460615B2/en not_active Expired - Fee Related
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