WO2002080764A9 - Non-invasive determination of blood components - Google Patents
Non-invasive determination of blood componentsInfo
- Publication number
- WO2002080764A9 WO2002080764A9 PCT/US2002/010804 US0210804W WO02080764A9 WO 2002080764 A9 WO2002080764 A9 WO 2002080764A9 US 0210804 W US0210804 W US 0210804W WO 02080764 A9 WO02080764 A9 WO 02080764A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- color
- image
- substance
- values
- subject
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/1032—Determining colour for diagnostic purposes
- A61B5/1034—Determining colour for diagnostic purposes by means of colour cards
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/443—Evaluating skin constituents, e.g. elastin, melanin, water
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
- A61B2560/0228—Operational features of calibration, e.g. protocols for calibrating sensors using calibration standards
- A61B2560/0233—Optical standards
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
Definitions
- the invention relates to determining hemoglobin concentrations and more particularly
- hemoglobin (Hb) concentrations is often useful in diagnosis and treatment
- Hb concentrations are useful in diagnosing whether a person is a person.
- the invention provides a method of estimating an amount of a
- the image being a digital image of pixels of at least one color
- Implementations of the invention may include one or more of the following features.
- obtaining the second value comprises obtaining a
- Implementations of the invention may also include one or more of the following
- first portion is a biologically perfused surface of the subject.
- a biologically perfused surface of the subject for example, a biologically
- perfused surface or tissue is one which contains blood vessels.
- the tissue or surface is one which contains blood vessels.
- the tissue or surface is one which contains blood vessels.
- vascularized e.g., the conjunctiva of the eye or soft tissues such as a mucous
- Implementations of the invention may also include one or more of the following
- the calculating are performed in real time. The obtaining a first value, the obtaining a second
- the method further includes displaying the estimated amount.
- the invention provides a method of determining factors
- the method includes capturing an image including at least a
- the image comprises a plurality of colors for each pixel, wherein the establishing
- the calculating uses averages of the component
- separator module configured to decompose a digital color image of a perfused surface of a
- FIG. 3 is a simplified diagram of an image, taken using the camera shown in FIG. 1,
- FIG. 4 is a block flow diagram of a process of estimating hemoglobin concentration.
- FIG. 5 is a block flow diagram of a process of determining weighting constants for estimating hemoglobin concentration.
- bodily fluids such as blood for diagnostic purposes.
- the methods are useful to determine whether bodily fluids such as blood for diagnostic purposes.
- the methods are useful to determine whether bodily fluids such as blood for diagnostic purposes.
- pathological condition such as anemia, dyshemoglobinemia, methemoglobinemia,
- a user digitally photographs a patient and a gray
- the digitally-captured image is processed based on known relationships of images and the gray reference with known hemoglobin concentrations
- concentration figure is produced. This figure can be used to diagnose hemoglobin-related
- hemoglobin levels outside a normal range 14-18 g/dL for human male subjects; 12-
- a system 10 includes a subject 12, a gray-reference card 14, a
- the subject is a person whose hemoglobin concentration is
- the gray-reference card 14 is a known shade of gray, here an 18%
- photographic standard gray card i.e., the card is 18% of the way from pure white to pure
- the card 14 is disposed adjacent an area 20 of the subject 12 to be imaged.
- the subject 12 Preferably,
- the area 20 is a biologically perfused surface that's color is influenced by the subject's blood.
- the area 20 can be, e.g., the subject's conjunctiva, a mucous membrane, nail bed,
- the camera 16 can resolve the level of red, green, and blue values for each pixel.
- the camera 16 can resolve the level of red, green, and blue values for each pixel.
- the camera 16 is configured with computer-
- camera 16 includes a display screen for displaying estimated hemoglobin concentrations in
- Each of the modules 22, 24, 26 includes
- the imaging module 21 includes both hardware and software. The imaging module 21 is configured to cause the camera 16 to take
- the outlining module can be any module that can be used to determine the area 20 of the subject 12, and the card 14. As shown in FIG. 3, the outlining module can be used to determine the area 20 of the subject 12, and the card 14. As shown in FIG. 3, the outlining module can be used to determine the area 20 of the subject 12, and the card 14. As shown in FIG. 3, the outlining module can be used to determine the area 20 of the subject 12, and the card 14. As shown in FIG. 3, the outlining module can be
- the subject 12 that has been exposed by turning down the lower eyelid of the subject 12.
- the estimator module 26 is configured to use ratios of values of the separated colors
- bme s , gme s , and rme s are the means (averages) of the blue, green, and red
- the subject 12 everts the subject's lower eyelid and holds the card 14 adjacent to the subject's
- the user 18 actuates the camera 16 to take the image 38.
- outline module 22 outlines the windows 34, 36 in the region 20 of the subject 12 and within
- a weighting constant is determined for each color (red, green, and blue)
- subjects 12 e.g., derived from phlebotomy and laboratory analysis.
- the provided values are:
- constants are arbitrary, e.g., 1, but may be selected to help reduce the number of iterations
- weighting constants is appropriate (i.e., if the estimated and known
- hemoglobin concentration estimate If any adjustment is made to a weighting constant, then
- the process 60 returns to stage 68 where the hemoglobin concentration for a particular subject
- the weighting constants are stored for future use.
- weighting constants are stored for use in determining estimates of hemoglobin concentrations
- Stage 52 thus provides stage 54 with red, green, and blue weighting constants for use in
- stage 54 estimating hemoglobin concentrations for other subjects 12. Referring also to FIG. 6, stage 54
- Stages may be added, removed, or rearranged.
- stages 60, 62, and 64 shown in FIG. 5 are performed for a non-reference
- the ratios of color values to the gray card 14 determined at stage 80 are
- the concentration estimator is applied to estimate the subject's hemoglobin concentration.
- module 26 uses the ratios provided from the color separation module 24 at stage 80 and the
- the module 26 provides a number indicating the
- hemoglobin concentration upon which a diagnosis of the subject 12 may be based upon which a diagnosis of the subject 12 may be based.
- weighting constants may be updated/refined and
- implementing functions may also be physically located at various positions, including being
- portions of the software described above as being in the camera 16 can be disposed
- One or more of the software modules may be disposed in an
- taken by the camera 16 can be loaded onto a computer that executes the software externally to
- the computer or other external device can display estimated amounts in
- hemoglobin concentrations in units of grams per deciliter (g/dl).
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002442921A CA2442921A1 (en) | 2001-04-05 | 2002-04-05 | Non-invasive determination of blood components |
EP02736548A EP1383422A4 (en) | 2001-04-05 | 2002-04-05 | Non-invasive determination of blood components |
AU2002309545A AU2002309545B2 (en) | 2001-04-05 | 2002-04-05 | Non-invasive determination of blood components |
JP2002578804A JP4467238B2 (en) | 2001-04-05 | 2002-04-05 | Non-invasive measurement method of blood components |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28194101P | 2001-04-05 | 2001-04-05 | |
US60/281,941 | 2001-04-05 | ||
US10/116,258 | 2002-04-04 | ||
US10/116,258 US7711403B2 (en) | 2001-04-05 | 2002-04-04 | Non-invasive determination of blood components |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002080764A1 WO2002080764A1 (en) | 2002-10-17 |
WO2002080764A9 true WO2002080764A9 (en) | 2003-01-03 |
Family
ID=26814050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/010804 WO2002080764A1 (en) | 2001-04-05 | 2002-04-05 | Non-invasive determination of blood components |
Country Status (6)
Country | Link |
---|---|
US (1) | US7711403B2 (en) |
EP (1) | EP1383422A4 (en) |
JP (1) | JP4467238B2 (en) |
AU (1) | AU2002309545B2 (en) |
CA (1) | CA2442921A1 (en) |
WO (1) | WO2002080764A1 (en) |
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-
2002
- 2002-04-04 US US10/116,258 patent/US7711403B2/en active Active
- 2002-04-05 WO PCT/US2002/010804 patent/WO2002080764A1/en active Application Filing
- 2002-04-05 CA CA002442921A patent/CA2442921A1/en not_active Abandoned
- 2002-04-05 EP EP02736548A patent/EP1383422A4/en not_active Withdrawn
- 2002-04-05 AU AU2002309545A patent/AU2002309545B2/en not_active Ceased
- 2002-04-05 JP JP2002578804A patent/JP4467238B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2002309545B2 (en) | 2006-03-16 |
EP1383422A1 (en) | 2004-01-28 |
US20030002722A1 (en) | 2003-01-02 |
US7711403B2 (en) | 2010-05-04 |
CA2442921A1 (en) | 2002-10-17 |
WO2002080764A1 (en) | 2002-10-17 |
JP4467238B2 (en) | 2010-05-26 |
EP1383422A4 (en) | 2006-02-01 |
JP2004535219A (en) | 2004-11-25 |
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