WO2002083039A1 - Variable surface area stent - Google Patents
Variable surface area stent Download PDFInfo
- Publication number
- WO2002083039A1 WO2002083039A1 PCT/US2002/011581 US0211581W WO02083039A1 WO 2002083039 A1 WO2002083039 A1 WO 2002083039A1 US 0211581 W US0211581 W US 0211581W WO 02083039 A1 WO02083039 A1 WO 02083039A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stent
- therapeutic agent
- surface area
- variable
- vessel
- Prior art date
Links
- 239000003814 drug Substances 0.000 claims abstract description 82
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 67
- 238000007373 indentation Methods 0.000 claims abstract description 20
- 238000009826 distribution Methods 0.000 claims abstract description 19
- 230000003247 decreasing effect Effects 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 37
- 238000012384 transportation and delivery Methods 0.000 claims description 34
- 230000005855 radiation Effects 0.000 claims description 25
- 230000002285 radioactive effect Effects 0.000 claims description 22
- 229940079593 drug Drugs 0.000 claims description 15
- 238000011282 treatment Methods 0.000 claims description 11
- 230000001681 protective effect Effects 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 7
- 238000005119 centrifugation Methods 0.000 claims description 6
- 238000005530 etching Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 4
- 230000000975 bioactive effect Effects 0.000 claims description 4
- 238000003618 dip coating Methods 0.000 claims description 4
- 230000004888 barrier function Effects 0.000 claims description 3
- 238000000151 deposition Methods 0.000 claims description 3
- 230000008021 deposition Effects 0.000 claims description 3
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 claims description 2
- 229910052786 argon Inorganic materials 0.000 claims description 2
- 239000004715 ethylene vinyl alcohol Substances 0.000 claims description 2
- RZXDTJIXPSCHCI-UHFFFAOYSA-N hexa-1,5-diene-2,5-diol Chemical group OC(=C)CCC(O)=C RZXDTJIXPSCHCI-UHFFFAOYSA-N 0.000 claims description 2
- 238000007735 ion beam assisted deposition Methods 0.000 claims description 2
- 238000001459 lithography Methods 0.000 claims description 2
- 238000006116 polymerization reaction Methods 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 238000005520 cutting process Methods 0.000 claims 4
- 238000001020 plasma etching Methods 0.000 claims 2
- 238000003486 chemical etching Methods 0.000 claims 1
- 238000001312 dry etching Methods 0.000 claims 1
- 238000010329 laser etching Methods 0.000 claims 1
- 239000004576 sand Substances 0.000 claims 1
- 239000011800 void material Substances 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 description 14
- 208000031481 Pathologic Constriction Diseases 0.000 description 8
- 208000037804 stenosis Diseases 0.000 description 8
- 230000036262 stenosis Effects 0.000 description 8
- 150000002500 ions Chemical class 0.000 description 7
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- 230000002792 vascular Effects 0.000 description 6
- 210000004725 window cell Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 238000002399 angioplasty Methods 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 230000002966 stenotic effect Effects 0.000 description 4
- 208000012868 Overgrowth Diseases 0.000 description 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 238000005468 ion implantation Methods 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
- 206010057362 Underdose Diseases 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229940113088 dimethylacetamide Drugs 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 238000007788 roughening Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- -1 Phosphorous (P ) Chemical class 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- 208000024248 Vascular System injury Diseases 0.000 description 1
- 208000012339 Vascular injury Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000007887 coronary angioplasty Methods 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000003698 laser cutting Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 238000012978 minimally invasive surgical procedure Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 229910052702 rhenium Inorganic materials 0.000 description 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 238000005488 sandblasting Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0095—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof radioactive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0025—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in roughness
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
Definitions
- the present invention relates to intravascular implants.
- the present invention relates to stent devices to deliver therapeutic agents such as radioisotopes or drugs.
- PTCA percutaneous transluminal coronary angioplasty
- a PTCA procedure involves the insertion of an angioplasty balloon at the distal end of a catheter to the site of a stenotic lesion. Prior to treatment, the stenotic lesion is bulky and at least partially blocking the coronary artery at issue. Once advanced, the balloon is inflated compressing the stenosis and widening the lumen in order to allow an efScient flow of blood through the lumen.
- a stent may be implanted into the vessel at the site of the former stenosis with a stent delivery catheter.
- a stent is a tubular structure which is delivered to the site of the former stenosis or lesion and compressed against vessel walls thereat, again with a balloon.
- the structure of the stent promotes maintenance of an open vessel lumen.
- the stent can be implanted in conjunction with the angioplasty.
- radiotherapy and drug delivery treatments have been developed and applied to the site of the former stenosis following angioplasty. Generally such treatments can aid in the healing process and significantly reduce the risk of restenosis and other similar problems.
- stent implantation may be combined with drug delivery or radiotherapy.
- a stent may be drug loaded or radioactive.
- a stent with a therapeutic agent may be delivered to the physician about the stent delivery catheter (and with a removable shield if the stent is radioactive).
- the level of uniformity in the delivery of a therapeutic agent to the injured area is dependent upon the particular stent configuration.
- the radioactive stent may have hot spots and cold spots of uneven levels of radioactivity. This is because the stent is made up of struts having radioactivity and window cells having no physical structure or radioactivity (or drug in the case of a drug delivery stent). Therefore, therapeutic agent throughout a particular stent configuration is dependent upon the strut and window cell distribution throughout that stent. Therefore, therapeutic variability results.
- a radioactive stent if about 20 Grays (Gy) of radiation, as measured from 1 mm of tissue depth, are to be delivered to a vessel portion to be treated, a wide range of radiation delivery will actually occur. That is, due to the radioactive stent configuration, a non-uniform delivery, ranging from about 5 Gy to about 25 Gy is more likely delivered to the vessel portion to be treated. Due to limitations of the prior art a range of at least about 20 Gy will be delivered by a radioactive stent throughout the vessel portion to be treated in the given example. As a result, certain portions of the vessel will receive significantly more or significantly less radiation than intended. Such a variability in delivery could lead to underdose failing to reduce the risk of restenosis in certain portions of the vessel, or overdose potentially causing further vascular injury to other portions of the vessel. This variability results regardless of the therapeutic agent to be delivered.
- Edge restenosis is prone to occur near stent ends.
- Edge restenosis involves the formation of vascular overgrowths in vascular areas immediately adjacent radioactive stent ends, generally v ithin about 2 mm of each radioactive stent end. Edge restenosis is a result of delivery of a sub-threshold level of radiation to the vascular areas immediately adjacent the radioactive stent ends. These vascular areas are near or. within the site of the former stenosis. They include vasculature likely to be diseased, or subjected to a recent trauma such as angioplasty.
- a sub-threshold radiation delivery is likely to occur near the radioactive stent ends.
- the level of therapeutic uniformity or focus any particular stent has been able to deliver has been dependent upon that stent' s configuration with respect to strut and window cell distribution.
- a stent structure i.e. strut layout
- strut layout which physically promotes maintenance of an open vessel lumen may be of a particular configuration which is not necessarily best suited for a more uniform delivery of a therapeutic agent.
- this stent configuration may fail to avoid an unintended "candy wrapper" effect in which portions of the vessel adjacent the stent become narrowed.
- An embodiment of the present invention provides a stent having a variable stent surface area per unit length.
- the variable stent surface area is used to accommodate a therapeutic agent.
- Another embodiment of the present invention provides for a stent having an end and a variable stent surface area per unit length to accommodate a therapeutic agent. A decreased level of therapeutic agent in provided at the end.
- An embodiment of the present invention provides for a stent having an end and a variable stent surface area per unit length to accommodate a therapeutic agent. An increased level of therapeutic agent in provided at the end.
- a method of vessel treatment utilizing a stent with a variable stent surface area is provided.
- a therapeutic agent is disposed on the stent surface area to provide a patterned distribution of the therapeutic agent.
- a method of stent manufacture is provided where indentations are cut into a surface of a stent.
- a therapeutic agent is disposed on the surface of the stent.
- a method of stent manufacture is provided where struts of the stent are cut of increased thickness to provide a variable stent surface area. Therapeutic agent is disposed on the variable stent surface area.
- Fig. 1 is a side view of an embodiment of a stent of the present invention.
- FIG. 2 is a pictorial view of an embodiment of a stent of the present invention implanted within a vessel of a patient.
- FIG. 3 is an enlarged view of an embodiment of a strut of the stent of Fig.2.
- Fig. 4 is an enlarged view of an embodiment of a strut of the stent of Fig. 2.
- Fig. 5 is a cross sectional view of an embodiment of a strut taken along the line 5-5 of Fig. 4.
- Fig. 6 is a chart depicting an embodiment of a dose delivery profile of the present invention.
- Fig. 7 is a representation of an embodiment of a source profile of the invention.
- Fig. 8 is a chart depicting an embodiment of a dose delivery profile of the present invention.
- Fig. 9 is a representation of an embodiment of a source profile of the invention.
- a stent 100 of the present invention is shown.
- the stent 100 is formed of struts 180, which provide physical structure, and open spaces, referred to as window cells 190.
- the struts 180 are formed from stainless steel or other materials which are generally biocompatible.
- the struts 180 shown have a cylindrical shape longitudinally. However, in alternate embodiments non-cylindrical strut 180 shapes are used. As discussed further herein the struts 180 provide a variable surface area to the stent 100.
- a stent 200 ofthe present invention is shown within a vessel 2 near the site of a former stenosis 3 to maintain the patency of the vessel lumen 7.
- the stent 200 of Fig. 2 is equipped with struts 280 which have variability in surface area, in terms of a change in surface area per unit length, as described further below.
- strut types 220, 230 of Fig. 2 are shown enlarged.
- the radius (r) (or ⁇ ⁇ and r ) and a given length (1) are shown (see also Fig. 5 showing a radius (r 2 ) of a cross-section of a strut).
- the strut surface area ( ⁇ ) includes a loading surface 340.
- the loading surface 340 portion of the surface area ( ⁇ ) is that portion of the surface area ( ⁇ ), generally facing outward (i.e. toward vessel 2 as shown in Fig. 1), that accommodates therapeutic agent.
- strut surface area ( ⁇ ) varies throughout a given length (1), as it does in the embodiment shown, then the dose amount for a given length (1) (i.e. the dose concentration ( ⁇ )) will vary throughout that same length (1).
- ⁇ 27irlh r , it can be seen that if the variables r or h r of the equation fluctuate in value, for the same given length (1), as is the case in the shown embodiment, then so too will the surface area ( ⁇ ) of the strut type 220, 230 within the given length (1).
- the roughness factor (h r ) is 1.0, having no effect on the surface area ( ⁇ ) of the smooth surface strut.
- the surface area ( ⁇ ) will correspondingly increase as shown in the present embodiment. Therefore, the dose concentration ( ⁇ ) of therapeutic agent dehverable to the vessel 2 is increased in corresponding portions of the strut 280 where (h r ) is greater than 1.0.
- an embodiment of a roughened strut 220 is provided of a given length (1).
- the roughness factor (h r ) changes as indicated by the change in roughness over that same length (1). That is, increased roughness, as indicated by the granular appearing texture of the loading surface 340, is provided near first portion 360.
- the value ofthe roughness factor (h r ) decreases and approaches a value of 1.0 near second portion 300 as shown by the smoother appearance of the loading surface 340 near second portion 300. Therefore, a roughened strut 220, as in the
- ⁇ dose concentration throughout that same length (1).
- ⁇ dose concentration throughout that same length (1).
- the stent 200 is dry etched by sand blasting or plasma etched with argon in order to increase roughness.
- Another embodiment focuses the increased roughness factor (h r ) at particular struts 280 by a lithography technique of coating the stent 200 with a protective polymer such as ethylene vinyl alcohol.
- the stent 200 is then selectively treated with a solvent, such as dimethyl sulfoxide (DMSO), dimethyl formamide (DMF), or dimethyl acetamide (DMAc), in strut 280 areas to remove portions of the protective polymer.
- a solvent such as dimethyl sulfoxide (DMSO), dimethyl formamide (DMF), or dimethyl acetamide (DMAc)
- a stent end 250 is dipped into the solvent to remove protective polymer from portions of the struts 280 nearer the stent end 250.
- these portions ofthe stent 200 are susceptible to increased roughening following application of an etching process to an exterior ofthe stent.
- an increased roughness factor (h r ) is present at the stent end 250.
- increasing roughness interior ofthe stent 1 is avoided in order to promote a flow of blood through the stent.
- the roughened strut 220 embodiment shown is viewed in light of its positioning in the stent 200. It can be seen that the roughened strut 220 is found near stent end 250.
- the roughened strut 220 includes a loading surface 340 which has been roughened as discussed above. The degree of roughening increases moving toward the first portion 360 (nearer the stent end 250) of the roughened strut 220. Alternatively, the loading surface 340 becomes smoother moving toward a second portion 300 (nearer the stent body 251). That is, in view ofthe stent 200 as a whole, additional surface area ( ⁇ ), and thus, increased radioactivity upon activation, is found near the stent end 250 due to the roughened strut 220 patterning provided.
- struts 280 are. formed as increased thickness struts 230.
- an embodiment of an increased thickness strut 230 is provided of a given length (1).
- an increased thickness strut 230 provides an increased thickness strut 230
- the increased thickness strut 230 is shown near opposite stent end 260 of Fig. 1.
- increased surface area ( ⁇ ) and thus, increased radioactivity upon activation is provided near opposite stent end 260.
- the stent 200 is laser cut from, for example, a stainless steel tube.
- the laser cutting process is run according to an automated process to form a particular stent configuration.
- the automated process is programmed to cut a strut 280 of increasing radius (r), for example, near opposite stent end 260. In this manner, an increased thickness strut 230 is provided.
- Figs. 4 and 5 a cross section taken from the line 5-5 of Fig. 4 is shown as Fig. 5.
- the increased thickness strut 230 of Fig. 4 includes increased size indentations 435.
- the increased size indentations 435 have been cut into the loading surface 340 with a laser during manufacture to provide additional loading surface 340 at the interior of the increased size indentations 435 by providing additional interior surface with the increased size indentations 435.
- Each indentation may increase surface area by about threefold per unit area. Where the depth L is increased, surface area provided by the indentation is increased.
- Increased size indentations may have a depth L of about one half of the increased thickness strut 230 at the location of the indentation.
- Increased size indentations 435 have a depth L beyond about 60-80 microns, and are provided as thickness increases (as shown toward the opposite strut end 400 of Fig. 4).
- the increased size indentations 435 provide a volume as well as increased surface area ( ⁇ ).
- the indentations 435 are of a truncated cone shape. However, in other embodiments, other shapes are used. For example, in one embodiment of the invention, the indentations 435 are of a dimpled shape
- the surface area ( ⁇ ) discussed in relation to the above embodiments is increased by the use of particular increased size indentations 435, an increased thickness strut 230, and a roughened strut 220.
- all of these features, alone and in any combination, are used in other embodiments to increase surface area ( ⁇ ) in particular stent 200 portions and provide particularly configured and focused loading surfaces 340 for accommodating therapeutic agents. Once a particular stent 200 configuration of increased surface area (7) is chosen and provided, it is activated with therapeutic agent, accommodated at the loading surface 340.
- plasma ion implantation ofthe isotopes into the loading surface 340 is used for activation.
- Embodiments of the invention employ Plasma and Ion Beam Assisted Deposition for loading.
- Plasma ion implantation results in radioactive ions being implanted below the loading surface 340 ofthe stent 200.
- a radioactive layer is formed which is shielded from a biological environment when the stent 200 is later inserted into a patient.
- Plasma ion implantation involves loading the stent 200 into an isolation chamber where a plasma of radioactive ions is generated.
- the plasma is provided by providing a liquid or gas which includes a stable precursor to the ion type to be used.
- Radio Frequency (RF) or microwave power are coupled to the isolation chamber to transform the mixture into a plasma state within the chamber.
- Negative voltage energy pulses are then applied to the treatment stent 1 to cause implantation of ions below the loading surface 40.
- ions such as Phosphorous (P ), Rhenium (Re 188 ), Yttrium (Y 90 ), Palladium (Pd 103 ), Iodine (I 125 ), and Ruthenium (Ru 106 ) are loaded above and below the loading surface 340 in this manner.
- the therapeutic agent to be provided includes bioactive drugs
- alternate methods of loading onto the loading surface 340 are used.
- a dip coating, spray, or centrifugation process is used.
- the dip coating process involves submerging the stent 200 in a solvent having an anti-coagulant or other drug solution. Heparin or heparin coating substances such as Duraflo®, available from Baxter International, Inc., are used as part ofthe drug solution.
- the stent 200 is then placed into a centrifugation chamber and spun to direct the first solution to particular portions ofthe stent 200.
- the stent 200 is then dried and submerged in a second drug solution. This second drug solution also contains radioactive ions as additional therapeutic agent.
- drug solution is deposited therein as a result of such methods of loading described above.
- methods of loading are repeated to add bioactive elutable drugs or even a separate anti-coagulant barrier to encase drug solution on the loading surface 340.
- the barrier is added by dipping, centrifugation and plasma deposition as indicated, or alternately by spraying or plasma polymerization.
- increased surface area is provided in areas of the stent 200 known to deliver an under-dose of therapeutic agent.
- less surface area is present in areas known to deliver an overdose of therapeutic agent. These surface area configurations are used to help avoid irregularities or significant variation in delivery of therapeutic agent.
- increased surface area struts 280 are developed to focus an increased amount of therapeutic agent near stent ends 250, 260.
- This embodiment helps avoid delivery of sub-threshold levels of radiation to portions of a vessel immediately adjacent stent ends 250, 260 (i.e. to avoid delivery of between about 2 and about 10 Grays, as measured at 1mm of tissue depth to the vessel 2 in this area).
- another similar embodiment helps provide other therapeutic agents to help combat edge restenosis in this manner.
- variability in surface area can be used to minimize delivery of a radioactive therapeutic agent near stent ends 250, 260 in order to avoid sub-threshold radiation delivery and edge restenosis.
- Figs. 6-9 show the results of making use of particular variable surface area stent embodiments having unique focuses of therapeutic agent distribution. The results are shown with respect to dose delivery and source profiles.
- Fig. 6 depicts a chart indicating the distribution of therapeutic agent, in the form of radioisotopes, with respect to dose delivery for an embodiment of the invention.
- the x-axis labeled 'Nessel Length
- the y-axis labeled “Dose Delivery (Gy)”
- Fig. 7 represents a source profile of a stent 700 according to the therapeutic distribution indicated in the embodiment of Fig. 6.
- the profile includes an extension of radioactivity 730 significantly beyond stent ends 750, 760 (ie. hot ends) to help avoid edge restenosis.
- a uniform field of radioactivity 755 throughout the stent body 751 is provided.
- an increased amount of therapeutic agent is provided near stent ends 750, 760 due to the increased loading surface provided thereat. Therefore, where the therapeutic agent is radiation, as with the embodiments of Figs. 6 and 7, delivery of a sub-threshold level of radiation is avoided at vessel portions immediately adjacent the stent 700 (i.e. within about 2mm ofthe stent longitudinally).
- the stent 700 is configured with increased loading surface directed toward portions of the stent 700 previously responsible for a more uneven distribution of therapeutic agent.
- a more uniform field of radioactivity 755 provides a more consistent delivery of therapeutic agent (i.e. radiation) throughout the stent body 751 ofthe stent 700.
- a prior art distribution of radiation 51 is un-even. That is, the uniform surface area of a prior art stent may deliver a highly variable dose within a stent length 601.
- the variable dose can include a maximum dose 91 that is 20 Gy greater than a n ⁇ nimum dose 92 while delivering only an average dose of 20 Gy (with all measurements taken at 1 mm of tissue depth).
- a more level delivery of radioactivity 650 is provided in embodiments ofthe invention.
- Embodiments ofthe invention can also include peak deliveries of radioactivity 630 to ensure avoidance of sub-threshold delivery 21 in vessel areas of concern, within about 2mm of the stent longitudinally.
- a decreased amount of radioactivity i.e. an early termination of radioactivity 930
- a decreased loading surface provided at the stent ends 950, 960 as compared to the remainder of the stent 900.
- Delivery of a sub-threshold level of radiation is nevertheless minimized or avoided at portions of a vessel immediately adjacent the stent 900 (i.e. within about 2mm of the stent ends 950, 960). That is, any radiation delivered here is below a sub-threshold level to help avoid edge restenosis.
- the stent 900 represented by Fig. 9 has been configured to have increased surface area directed toward portions of a stent 900 that would otherwise be responsible for an uneven distribution of therapeutic agent.
- a more uniform field of radioactivity 955 provides a more consistent delivery of therapeutic agent (i.e. radiation) throughout a stent body of the stent 900 as seen above the x-axis throughout stent length 860.
- a prior art distribution of radiation 51 is uneven and a sub-threshold level of radiation 21 is delivered by a prior art stent to vessel areas within 2mm ofthe stent.
- a more level delivery of radioactivity 850 is provided in embodiments of the invention.
- Embodiments of the invention can also include tapered deliveries of radioactivity 830 to ensure avoidance of sub-threshold delivery 21 in vessel areas of concern.
- Embodiments of the invention described above include a therapeutic stent which is able to provide an overall pattern of therapeutic agent, where the pattern is not determined solely by strut and window cell distribution throughout the stent.
- Embodiments of the invention also include patterns of therapeutic agent which help avoid edge restenosis while also helping to avoid delivery of a non-uniform level of therapeutic agent throughout the portion of a vessel to be treated. While such exemplary embodiments have been shown and described in the form of particular stents having variable surface area, many changes, modifications, and substitutions may be made without departing from the spirit and scope of this invention.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/834,012 | 2001-04-12 | ||
US09/834,012 US6764505B1 (en) | 2001-04-12 | 2001-04-12 | Variable surface area stent |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002083039A1 true WO2002083039A1 (en) | 2002-10-24 |
Family
ID=25265875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/011581 WO2002083039A1 (en) | 2001-04-12 | 2002-04-12 | Variable surface area stent |
Country Status (2)
Country | Link |
---|---|
US (3) | US6764505B1 (en) |
WO (1) | WO2002083039A1 (en) |
Cited By (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002093988A1 (en) | 2001-05-11 | 2002-11-21 | Epion Corporation | Method and system for improving the effectiveness of medical devices by adhering drugs to the surface thereof |
EP1402849A1 (en) * | 2002-09-20 | 2004-03-31 | Abbott Laboratories Vascular Enterprises Limited | Stent with rough surface and its manufacturing method |
EP1416885A2 (en) * | 2001-07-26 | 2004-05-12 | Avantec Vascular Corporation | Methods and devices for delivery of therapeutic capable agents with variable release profile |
EP1547530A1 (en) * | 2003-12-17 | 2005-06-29 | Cordis Neurovascular, Inc. | Activatable bioactive vascular occlusive device and method of use |
WO2007103667A2 (en) * | 2006-03-06 | 2007-09-13 | Boston Scientific Limited | Medical device delivery systems |
WO2008106311A1 (en) * | 2007-02-27 | 2008-09-04 | Medtronic Vascular Inc. | Ion beam etching a surface of an implantable medical device |
WO2008097511A3 (en) * | 2007-02-07 | 2009-06-04 | Cook Inc | Medical device coatings for releasing a therapeutic agent at multiple rates |
US7666223B2 (en) * | 2002-11-12 | 2010-02-23 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
US7981150B2 (en) | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
US8067054B2 (en) | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
US8066763B2 (en) | 1998-04-11 | 2011-11-29 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
WO2012036930A3 (en) * | 2010-09-17 | 2012-05-10 | Medtronic Vascular Inc. | Apparatus and methods for loading a drug eluting medical device |
US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8221822B2 (en) | 2007-07-31 | 2012-07-17 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
US8353949B2 (en) | 2006-09-14 | 2013-01-15 | Boston Scientific Scimed, Inc. | Medical devices with drug-eluting coating |
US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
US8574615B2 (en) | 2006-03-24 | 2013-11-05 | Boston Scientific Scimed, Inc. | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
US8771343B2 (en) | 2006-06-29 | 2014-07-08 | Boston Scientific Scimed, Inc. | Medical devices with selective titanium oxide coatings |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
US8900292B2 (en) | 2007-08-03 | 2014-12-02 | Boston Scientific Scimed, Inc. | Coating for medical device having increased surface area |
US8920491B2 (en) | 2008-04-22 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
US8932346B2 (en) | 2008-04-24 | 2015-01-13 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
US9005696B2 (en) | 2008-08-07 | 2015-04-14 | Exogenesis Corporation | Medical device for bone implant and method for producing such a device |
US9284409B2 (en) | 2007-07-19 | 2016-03-15 | Boston Scientific Scimed, Inc. | Endoprosthesis having a non-fouling surface |
Families Citing this family (251)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1289815B1 (en) * | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | ANGIOPLASTIC STENT AND RELATED PRODUCTION PROCESS |
US10028851B2 (en) | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
US6240616B1 (en) | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US8172897B2 (en) | 1997-04-15 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Polymer and metal composite implantable medical devices |
US20030040790A1 (en) | 1998-04-15 | 2003-02-27 | Furst Joseph G. | Stent coating |
US20020099438A1 (en) * | 1998-04-15 | 2002-07-25 | Furst Joseph G. | Irradiated stent coating |
US8070796B2 (en) | 1998-07-27 | 2011-12-06 | Icon Interventional Systems, Inc. | Thrombosis inhibiting graft |
US7967855B2 (en) | 1998-07-27 | 2011-06-28 | Icon Interventional Systems, Inc. | Coated medical device |
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US7807211B2 (en) | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
US6953560B1 (en) | 2000-09-28 | 2005-10-11 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
US7807210B1 (en) | 2000-10-31 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Hemocompatible polymers on hydrophobic porous polymers |
US6780424B2 (en) * | 2001-03-30 | 2004-08-24 | Charles David Claude | Controlled morphologies in polymer drug for release of drugs from polymer films |
US6764505B1 (en) | 2001-04-12 | 2004-07-20 | Advanced Cardiovascular Systems, Inc. | Variable surface area stent |
US7666462B2 (en) * | 2001-05-11 | 2010-02-23 | Exogenesis Corporation | Method of controlling a drug release rate |
US7923055B2 (en) * | 2001-05-11 | 2011-04-12 | Exogenesis Corporation | Method of manufacturing a drug delivery system |
US8889169B2 (en) * | 2001-05-11 | 2014-11-18 | Exogenesis Corporation | Drug delivery system and method of manufacturing thereof |
US7862495B2 (en) * | 2001-05-31 | 2011-01-04 | Advanced Cardiovascular Systems, Inc. | Radiation or drug delivery source with activity gradient to minimize edge effects |
AU2002345328A1 (en) | 2001-06-27 | 2003-03-03 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
US6695920B1 (en) | 2001-06-27 | 2004-02-24 | Advanced Cardiovascular Systems, Inc. | Mandrel for supporting a stent and a method of using the mandrel to coat a stent |
US8741378B1 (en) | 2001-06-27 | 2014-06-03 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device |
US6656216B1 (en) | 2001-06-29 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Composite stent with regioselective material |
US7682669B1 (en) | 2001-07-30 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device |
US8303651B1 (en) | 2001-09-07 | 2012-11-06 | Advanced Cardiovascular Systems, Inc. | Polymeric coating for reducing the rate of release of a therapeutic substance from a stent |
US7285304B1 (en) | 2003-06-25 | 2007-10-23 | Advanced Cardiovascular Systems, Inc. | Fluid treatment of a polymeric coating on an implantable medical device |
US7989018B2 (en) | 2001-09-17 | 2011-08-02 | Advanced Cardiovascular Systems, Inc. | Fluid treatment of a polymeric coating on an implantable medical device |
US6863683B2 (en) | 2001-09-19 | 2005-03-08 | Abbott Laboratoris Vascular Entities Limited | Cold-molding process for loading a stent onto a stent delivery system |
CA2462509A1 (en) | 2001-10-04 | 2003-04-10 | Neovasc Medical Ltd. | Flow reducing implant |
US7291165B2 (en) * | 2002-01-31 | 2007-11-06 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US7445629B2 (en) * | 2002-01-31 | 2008-11-04 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US7326245B2 (en) * | 2002-01-31 | 2008-02-05 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US7794743B2 (en) | 2002-06-21 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of making the same |
US7033602B1 (en) | 2002-06-21 | 2006-04-25 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of coating implantable medical devices |
US8506617B1 (en) | 2002-06-21 | 2013-08-13 | Advanced Cardiovascular Systems, Inc. | Micronized peptide coated stent |
US7056523B1 (en) | 2002-06-21 | 2006-06-06 | Advanced Cardiovascular Systems, Inc. | Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine |
US7217426B1 (en) | 2002-06-21 | 2007-05-15 | Advanced Cardiovascular Systems, Inc. | Coatings containing polycationic peptides for cardiovascular therapy |
EP1521603B1 (en) * | 2002-07-12 | 2011-01-19 | Cook Incorporated | Coated medical device |
US8016881B2 (en) | 2002-07-31 | 2011-09-13 | Icon Interventional Systems, Inc. | Sutures and surgical staples for anastamoses, wound closures, and surgical closures |
US20040093056A1 (en) | 2002-10-26 | 2004-05-13 | Johnson Lianw M. | Medical appliance delivery apparatus and method of use |
US7875068B2 (en) | 2002-11-05 | 2011-01-25 | Merit Medical Systems, Inc. | Removable biliary stent |
US7637942B2 (en) | 2002-11-05 | 2009-12-29 | Merit Medical Systems, Inc. | Coated stent with geometry determinated functionality and method of making the same |
US7959671B2 (en) | 2002-11-05 | 2011-06-14 | Merit Medical Systems, Inc. | Differential covering and coating methods |
US7758880B2 (en) | 2002-12-11 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Biocompatible polyacrylate compositions for medical applications |
US7776926B1 (en) | 2002-12-11 | 2010-08-17 | Advanced Cardiovascular Systems, Inc. | Biocompatible coating for implantable medical devices |
US7074276B1 (en) | 2002-12-12 | 2006-07-11 | Advanced Cardiovascular Systems, Inc. | Clamp mandrel fixture and a method of using the same to minimize coating defects |
US8435550B2 (en) | 2002-12-16 | 2013-05-07 | Abbot Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
US7758881B2 (en) | 2004-06-30 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
US20060002968A1 (en) | 2004-06-30 | 2006-01-05 | Gordon Stewart | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders |
US20070239251A1 (en) * | 2002-12-31 | 2007-10-11 | Abbott Cardiovascular Systems Inc. | Flexible stent |
US20090093875A1 (en) * | 2007-05-01 | 2009-04-09 | Abbott Laboratories | Drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations |
US7637934B2 (en) | 2003-03-31 | 2009-12-29 | Merit Medical Systems, Inc. | Medical appliance optical delivery and deployment apparatus and method |
US7604660B2 (en) | 2003-05-01 | 2009-10-20 | Merit Medical Systems, Inc. | Bifurcated medical appliance delivery apparatus and method |
US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
US7785512B1 (en) | 2003-07-31 | 2010-08-31 | Advanced Cardiovascular Systems, Inc. | Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices |
US7198675B2 (en) | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
US9114198B2 (en) | 2003-11-19 | 2015-08-25 | Advanced Cardiovascular Systems, Inc. | Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same |
IL158960A0 (en) | 2003-11-19 | 2004-05-12 | Neovasc Medical Ltd | Vascular implant |
US8192752B2 (en) | 2003-11-21 | 2012-06-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same |
US7435788B2 (en) | 2003-12-19 | 2008-10-14 | Advanced Cardiovascular Systems, Inc. | Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents |
US8137397B2 (en) * | 2004-02-26 | 2012-03-20 | Boston Scientific Scimed, Inc. | Medical devices |
JP2007535342A (en) | 2004-03-11 | 2007-12-06 | パーキュテイニアス カルディオバスキュラー ソリューションズ ピー・ティー・ワイ リミテッド | Percutaneous prosthetic heart valve |
US8685431B2 (en) | 2004-03-16 | 2014-04-01 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same |
US8778014B1 (en) | 2004-03-31 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Coatings for preventing balloon damage to polymer coated stents |
US7820732B2 (en) | 2004-04-30 | 2010-10-26 | Advanced Cardiovascular Systems, Inc. | Methods for modulating thermal and mechanical properties of coatings on implantable devices |
US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
US9561309B2 (en) | 2004-05-27 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Antifouling heparin coatings |
US20050271700A1 (en) * | 2004-06-03 | 2005-12-08 | Desnoyer Jessica R | Poly(ester amide) coating composition for implantable devices |
US7563780B1 (en) | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
US8568469B1 (en) | 2004-06-28 | 2013-10-29 | Advanced Cardiovascular Systems, Inc. | Stent locking element and a method of securing a stent on a delivery system |
US20050287184A1 (en) | 2004-06-29 | 2005-12-29 | Hossainy Syed F A | Drug-delivery stent formulations for restenosis and vulnerable plaque |
US8241554B1 (en) | 2004-06-29 | 2012-08-14 | Advanced Cardiovascular Systems, Inc. | Method of forming a stent pattern on a tube |
US7971333B2 (en) | 2006-05-30 | 2011-07-05 | Advanced Cardiovascular Systems, Inc. | Manufacturing process for polymetric stents |
US8747878B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device by controlling crystalline structure |
US8778256B1 (en) | 2004-09-30 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Deformation of a polymer tube in the fabrication of a medical article |
US8747879B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device to reduce chance of late inflammatory response |
US7731890B2 (en) | 2006-06-15 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Methods of fabricating stents with enhanced fracture toughness |
US7494665B1 (en) | 2004-07-30 | 2009-02-24 | Advanced Cardiovascular Systems, Inc. | Polymers containing siloxane monomers |
US8357391B2 (en) | 2004-07-30 | 2013-01-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages |
US9283099B2 (en) | 2004-08-25 | 2016-03-15 | Advanced Cardiovascular Systems, Inc. | Stent-catheter assembly with a releasable connection for stent retention |
US7648727B2 (en) | 2004-08-26 | 2010-01-19 | Advanced Cardiovascular Systems, Inc. | Methods for manufacturing a coated stent-balloon assembly |
US7244443B2 (en) | 2004-08-31 | 2007-07-17 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrophilic monomers |
US7229471B2 (en) | 2004-09-10 | 2007-06-12 | Advanced Cardiovascular Systems, Inc. | Compositions containing fast-leaching plasticizers for improved performance of medical devices |
US8110211B2 (en) | 2004-09-22 | 2012-02-07 | Advanced Cardiovascular Systems, Inc. | Medicated coatings for implantable medical devices including polyacrylates |
US7887579B2 (en) | 2004-09-29 | 2011-02-15 | Merit Medical Systems, Inc. | Active stent |
US7875233B2 (en) | 2004-09-30 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Method of fabricating a biaxially oriented implantable medical device |
US8173062B1 (en) | 2004-09-30 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Controlled deformation of a polymer tube in fabricating a medical article |
US8043553B1 (en) | 2004-09-30 | 2011-10-25 | Advanced Cardiovascular Systems, Inc. | Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article |
US7344560B2 (en) | 2004-10-08 | 2008-03-18 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
US8603634B2 (en) | 2004-10-27 | 2013-12-10 | Abbott Cardiovascular Systems Inc. | End-capped poly(ester amide) copolymers |
US7390497B2 (en) | 2004-10-29 | 2008-06-24 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide) filler blends for modulation of coating properties |
US8609123B2 (en) | 2004-11-29 | 2013-12-17 | Advanced Cardiovascular Systems, Inc. | Derivatized poly(ester amide) as a biobeneficial coating |
US7892592B1 (en) | 2004-11-30 | 2011-02-22 | Advanced Cardiovascular Systems, Inc. | Coating abluminal surfaces of stents and other implantable medical devices |
US7632307B2 (en) * | 2004-12-16 | 2009-12-15 | Advanced Cardiovascular Systems, Inc. | Abluminal, multilayer coating constructs for drug-delivery stents |
US7604818B2 (en) | 2004-12-22 | 2009-10-20 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrocarbon monomers |
US7419504B2 (en) | 2004-12-27 | 2008-09-02 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide) block copolymers |
US8007775B2 (en) | 2004-12-30 | 2011-08-30 | Advanced Cardiovascular Systems, Inc. | Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same |
US8057543B2 (en) * | 2005-01-28 | 2011-11-15 | Greatbatch Ltd. | Stent coating for eluting medication |
US9107899B2 (en) | 2005-03-03 | 2015-08-18 | Icon Medical Corporation | Metal alloys for medical devices |
US7540995B2 (en) * | 2005-03-03 | 2009-06-02 | Icon Medical Corp. | Process for forming an improved metal alloy stent |
WO2006110197A2 (en) | 2005-03-03 | 2006-10-19 | Icon Medical Corp. | Polymer biodegradable medical device |
US20060200048A1 (en) * | 2005-03-03 | 2006-09-07 | Icon Medical Corp. | Removable sheath for device protection |
US7452502B2 (en) * | 2005-03-03 | 2008-11-18 | Icon Medical Corp. | Metal alloy for a stent |
AU2006221046B2 (en) * | 2005-03-03 | 2012-02-02 | Icon Medical Corp. | Improved metal alloys for medical device |
US7381048B2 (en) | 2005-04-12 | 2008-06-03 | Advanced Cardiovascular Systems, Inc. | Stents with profiles for gripping a balloon catheter and molds for fabricating stents |
US7795467B1 (en) | 2005-04-26 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial polyurethanes for use in medical devices |
US8778375B2 (en) | 2005-04-29 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Amorphous poly(D,L-lactide) coating |
US7731654B2 (en) | 2005-05-13 | 2010-06-08 | Merit Medical Systems, Inc. | Delivery device with viewing window and associated method |
US7622070B2 (en) * | 2005-06-20 | 2009-11-24 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing an implantable polymeric medical device |
US7823533B2 (en) | 2005-06-30 | 2010-11-02 | Advanced Cardiovascular Systems, Inc. | Stent fixture and method for reducing coating defects |
US8021676B2 (en) | 2005-07-08 | 2011-09-20 | Advanced Cardiovascular Systems, Inc. | Functionalized chemically inert polymers for coatings |
US7785647B2 (en) | 2005-07-25 | 2010-08-31 | Advanced Cardiovascular Systems, Inc. | Methods of providing antioxidants to a drug containing product |
US7735449B1 (en) | 2005-07-28 | 2010-06-15 | Advanced Cardiovascular Systems, Inc. | Stent fixture having rounded support structures and method for use thereof |
US7658880B2 (en) | 2005-07-29 | 2010-02-09 | Advanced Cardiovascular Systems, Inc. | Polymeric stent polishing method and apparatus |
US9248034B2 (en) | 2005-08-23 | 2016-02-02 | Advanced Cardiovascular Systems, Inc. | Controlled disintegrating implantable medical devices |
AU2006315812B2 (en) | 2005-11-10 | 2013-03-28 | Cardiaq Valve Technologies, Inc. | Balloon-expandable, self-expanding, vascular prosthesis connecting stent |
US20070112421A1 (en) * | 2005-11-14 | 2007-05-17 | O'brien Barry | Medical device with a grooved surface |
US7976891B1 (en) | 2005-12-16 | 2011-07-12 | Advanced Cardiovascular Systems, Inc. | Abluminal stent coating apparatus and method of using focused acoustic energy |
US7867547B2 (en) | 2005-12-19 | 2011-01-11 | Advanced Cardiovascular Systems, Inc. | Selectively coating luminal surfaces of stents |
US20070156230A1 (en) | 2006-01-04 | 2007-07-05 | Dugan Stephen R | Stents with radiopaque markers |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US7951185B1 (en) | 2006-01-06 | 2011-05-31 | Advanced Cardiovascular Systems, Inc. | Delivery of a stent at an elevated temperature |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
US20070196428A1 (en) | 2006-02-17 | 2007-08-23 | Thierry Glauser | Nitric oxide generating medical devices |
US7713637B2 (en) | 2006-03-03 | 2010-05-11 | Advanced Cardiovascular Systems, Inc. | Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer |
US7964210B2 (en) | 2006-03-31 | 2011-06-21 | Abbott Cardiovascular Systems Inc. | Degradable polymeric implantable medical devices with a continuous phase and discrete phase |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
US8304012B2 (en) | 2006-05-04 | 2012-11-06 | Advanced Cardiovascular Systems, Inc. | Method for drying a stent |
US8003156B2 (en) | 2006-05-04 | 2011-08-23 | Advanced Cardiovascular Systems, Inc. | Rotatable support elements for stents |
US7985441B1 (en) | 2006-05-04 | 2011-07-26 | Yiwen Tang | Purification of polymers for coating applications |
US7761968B2 (en) | 2006-05-25 | 2010-07-27 | Advanced Cardiovascular Systems, Inc. | Method of crimping a polymeric stent |
US7775178B2 (en) | 2006-05-26 | 2010-08-17 | Advanced Cardiovascular Systems, Inc. | Stent coating apparatus and method |
US20130325104A1 (en) | 2006-05-26 | 2013-12-05 | Abbott Cardiovascular Systems Inc. | Stents With Radiopaque Markers |
US7951194B2 (en) | 2006-05-26 | 2011-05-31 | Abbott Cardiovascular Sysetms Inc. | Bioabsorbable stent with radiopaque coating |
US7959940B2 (en) | 2006-05-30 | 2011-06-14 | Advanced Cardiovascular Systems, Inc. | Polymer-bioceramic composite implantable medical devices |
US8343530B2 (en) | 2006-05-30 | 2013-01-01 | Abbott Cardiovascular Systems Inc. | Polymer-and polymer blend-bioceramic composite implantable medical devices |
US7842737B2 (en) | 2006-09-29 | 2010-11-30 | Abbott Cardiovascular Systems Inc. | Polymer blend-bioceramic composite implantable medical devices |
US8568764B2 (en) | 2006-05-31 | 2013-10-29 | Advanced Cardiovascular Systems, Inc. | Methods of forming coating layers for medical devices utilizing flash vaporization |
US9561351B2 (en) | 2006-05-31 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Drug delivery spiral coil construct |
US8486135B2 (en) | 2006-06-01 | 2013-07-16 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from branched polymers |
US8034287B2 (en) | 2006-06-01 | 2011-10-11 | Abbott Cardiovascular Systems Inc. | Radiation sterilization of medical devices |
US8703167B2 (en) | 2006-06-05 | 2014-04-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug |
US8778376B2 (en) | 2006-06-09 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating |
US8114150B2 (en) | 2006-06-14 | 2012-02-14 | Advanced Cardiovascular Systems, Inc. | RGD peptide attached to bioabsorbable stents |
US8603530B2 (en) | 2006-06-14 | 2013-12-10 | Abbott Cardiovascular Systems Inc. | Nanoshell therapy |
US8048448B2 (en) | 2006-06-15 | 2011-11-01 | Abbott Cardiovascular Systems Inc. | Nanoshells for drug delivery |
US8535372B1 (en) | 2006-06-16 | 2013-09-17 | Abbott Cardiovascular Systems Inc. | Bioabsorbable stent with prohealing layer |
US8333000B2 (en) | 2006-06-19 | 2012-12-18 | Advanced Cardiovascular Systems, Inc. | Methods for improving stent retention on a balloon catheter |
US8017237B2 (en) | 2006-06-23 | 2011-09-13 | Abbott Cardiovascular Systems, Inc. | Nanoshells on polymers |
US9072820B2 (en) | 2006-06-26 | 2015-07-07 | Advanced Cardiovascular Systems, Inc. | Polymer composite stent with polymer particles |
US8128688B2 (en) | 2006-06-27 | 2012-03-06 | Abbott Cardiovascular Systems Inc. | Carbon coating on an implantable device |
US7794776B1 (en) | 2006-06-29 | 2010-09-14 | Abbott Cardiovascular Systems Inc. | Modification of polymer stents with radiation |
US7740791B2 (en) * | 2006-06-30 | 2010-06-22 | Advanced Cardiovascular Systems, Inc. | Method of fabricating a stent with features by blow molding |
US9028859B2 (en) | 2006-07-07 | 2015-05-12 | Advanced Cardiovascular Systems, Inc. | Phase-separated block copolymer coatings for implantable medical devices |
US7823263B2 (en) | 2006-07-11 | 2010-11-02 | Abbott Cardiovascular Systems Inc. | Method of removing stent islands from a stent |
US7998404B2 (en) | 2006-07-13 | 2011-08-16 | Advanced Cardiovascular Systems, Inc. | Reduced temperature sterilization of stents |
US7757543B2 (en) | 2006-07-13 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Radio frequency identification monitoring of stents |
US7794495B2 (en) | 2006-07-17 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Controlled degradation of stents |
US7886419B2 (en) | 2006-07-18 | 2011-02-15 | Advanced Cardiovascular Systems, Inc. | Stent crimping apparatus and method |
US8016879B2 (en) | 2006-08-01 | 2011-09-13 | Abbott Cardiovascular Systems Inc. | Drug delivery after biodegradation of the stent scaffolding |
EP2054537A2 (en) | 2006-08-02 | 2009-05-06 | Boston Scientific Scimed, Inc. | Endoprosthesis with three-dimensional disintegration control |
US8703169B1 (en) | 2006-08-15 | 2014-04-22 | Abbott Cardiovascular Systems Inc. | Implantable device having a coating comprising carrageenan and a biostable polymer |
US9173733B1 (en) | 2006-08-21 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Tracheobronchial implantable medical device and methods of use |
US7923022B2 (en) | 2006-09-13 | 2011-04-12 | Advanced Cardiovascular Systems, Inc. | Degradable polymeric implantable medical devices with continuous phase and discrete phase |
JP2010503494A (en) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | Biodegradable endoprosthesis and method for producing the same |
WO2008034031A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprostheses and methods of making the same |
CA2663220A1 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices and methods of making the same |
WO2008034048A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprosthesis with biostable inorganic layers |
EP2068962B1 (en) | 2006-09-18 | 2013-01-30 | Boston Scientific Limited | Endoprostheses |
CA2663573C (en) * | 2006-09-21 | 2015-04-07 | Cleveny Technologies | A specially configured and surface modified medical device with certain design features that utilize the intrinsic properties of tungsten, zirconium, tantalum and/or niobium |
US7780798B2 (en) | 2006-10-13 | 2010-08-24 | Boston Scientific Scimed, Inc. | Medical devices including hardened alloys |
CN101663054B (en) * | 2006-10-20 | 2013-08-07 | 生物传感器国际集团有限公司 | Drug-delivery endovascular stent and method of use |
US8067055B2 (en) * | 2006-10-20 | 2011-11-29 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method of use |
US8099849B2 (en) | 2006-12-13 | 2012-01-24 | Abbott Cardiovascular Systems Inc. | Optimizing fracture toughness of polymeric stent |
US8597673B2 (en) | 2006-12-13 | 2013-12-03 | Advanced Cardiovascular Systems, Inc. | Coating of fast absorption or dissolution |
ES2506144T3 (en) | 2006-12-28 | 2014-10-13 | Boston Scientific Limited | Bioerodible endoprosthesis and their manufacturing procedure |
US8070797B2 (en) | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
US8646444B2 (en) * | 2007-03-27 | 2014-02-11 | Electrolux Home Products, Inc. | Glide rack |
US8262723B2 (en) | 2007-04-09 | 2012-09-11 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from polymer blends with star-block copolymers |
US8147769B1 (en) | 2007-05-16 | 2012-04-03 | Abbott Cardiovascular Systems Inc. | Stent and delivery system with reduced chemical degradation |
US8211162B2 (en) | 2007-05-25 | 2012-07-03 | Boston Scientific Scimed, Inc. | Connector node for durable stent |
US9056155B1 (en) | 2007-05-29 | 2015-06-16 | Abbott Cardiovascular Systems Inc. | Coatings having an elastic primer layer |
US7829008B2 (en) | 2007-05-30 | 2010-11-09 | Abbott Cardiovascular Systems Inc. | Fabricating a stent from a blow molded tube |
US7959857B2 (en) | 2007-06-01 | 2011-06-14 | Abbott Cardiovascular Systems Inc. | Radiation sterilization of medical devices |
US8202528B2 (en) | 2007-06-05 | 2012-06-19 | Abbott Cardiovascular Systems Inc. | Implantable medical devices with elastomeric block copolymer coatings |
US8293260B2 (en) | 2007-06-05 | 2012-10-23 | Abbott Cardiovascular Systems Inc. | Elastomeric copolymer coatings containing poly (tetramethyl carbonate) for implantable medical devices |
US8425591B1 (en) | 2007-06-11 | 2013-04-23 | Abbott Cardiovascular Systems Inc. | Methods of forming polymer-bioceramic composite medical devices with bioceramic particles |
US8048441B2 (en) | 2007-06-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Nanobead releasing medical devices |
US8109904B1 (en) | 2007-06-25 | 2012-02-07 | Abbott Cardiovascular Systems Inc. | Drug delivery medical devices |
US7901452B2 (en) | 2007-06-27 | 2011-03-08 | Abbott Cardiovascular Systems Inc. | Method to fabricate a stent having selected morphology to reduce restenosis |
US7955381B1 (en) | 2007-06-29 | 2011-06-07 | Advanced Cardiovascular Systems, Inc. | Polymer-bioceramic composite implantable medical device with different types of bioceramic particles |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US20090076591A1 (en) * | 2007-09-19 | 2009-03-19 | Boston Scientific Scimed, Inc. | Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface |
US7833266B2 (en) * | 2007-11-28 | 2010-11-16 | Boston Scientific Scimed, Inc. | Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment |
EP2247269B1 (en) * | 2008-01-24 | 2011-08-24 | Boston Scientific Scimed, Inc. | Stent for delivering a therapeutic agent from a side surface of a stent strut |
US20090198321A1 (en) * | 2008-02-01 | 2009-08-06 | Boston Scientific Scimed, Inc. | Drug-Coated Medical Devices for Differential Drug Release |
AU2009260694B2 (en) * | 2008-03-27 | 2014-09-04 | Boston Scientific Scimed, Inc. | Ureteral stents for release of urologically beneficial agents |
WO2009126550A2 (en) | 2008-04-08 | 2009-10-15 | Med Institute, Inc. | Surface structure of a component of a medical device and a method of forming the surface structure |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
WO2009155328A2 (en) | 2008-06-18 | 2009-12-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
WO2010011515A2 (en) * | 2008-07-23 | 2010-01-28 | Boston Scientific Scimed, Inc. | Medical devices having inorganic barrier coatings |
US7951193B2 (en) | 2008-07-23 | 2011-05-31 | Boston Scientific Scimed, Inc. | Drug-eluting stent |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
JP2011530347A (en) * | 2008-08-07 | 2011-12-22 | エクソジェネシス コーポレーション | Drug delivery system and method of manufacturing the drug delivery system |
CA2749026C (en) | 2008-09-29 | 2018-01-09 | Impala, Inc. | Heart valve |
EP2845569A1 (en) | 2008-10-01 | 2015-03-11 | Cardiaq Valve Technologies, Inc. | Delivery system for vascular implant |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
WO2010101901A2 (en) | 2009-03-02 | 2010-09-10 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
WO2010121076A2 (en) | 2009-04-15 | 2010-10-21 | Cardiaq Valve Technologies, Inc. | Vascular implant and delivery system |
US9730790B2 (en) | 2009-09-29 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Replacement valve and method |
EP2338534A2 (en) * | 2009-12-21 | 2011-06-29 | Biotronik VI Patent AG | Medical implant, coating method and implantation method |
US8568471B2 (en) | 2010-01-30 | 2013-10-29 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds |
US8808353B2 (en) | 2010-01-30 | 2014-08-19 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds having a low crossing profile |
US8398916B2 (en) * | 2010-03-04 | 2013-03-19 | Icon Medical Corp. | Method for forming a tubular medical device |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
US8685433B2 (en) | 2010-03-31 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Absorbable coating for implantable device |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
JP5902165B2 (en) * | 2010-08-02 | 2016-04-13 | コーディス・コーポレイションCordis Corporation | Flexible spiral stent with different spiral regions |
US8333801B2 (en) * | 2010-09-17 | 2012-12-18 | Medtronic Vascular, Inc. | Method of Forming a Drug-Eluting Medical Device |
EP2618784B1 (en) | 2010-09-23 | 2016-05-25 | Edwards Lifesciences CardiAQ LLC | Replacement heart valves and delivery devices |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
KR101310865B1 (en) * | 2011-05-11 | 2013-09-25 | 한국과학기술연구원 | Method of fabrication for nano particle complex catalyst by plasma ion implantation and Device for the method |
US8726483B2 (en) | 2011-07-29 | 2014-05-20 | Abbott Cardiovascular Systems Inc. | Methods for uniform crimping and deployment of a polymer scaffold |
EP2744460A4 (en) * | 2011-10-21 | 2015-03-11 | Abbott Cardiovascular Systems | Surface modification of medical devices to enhance endothelial adhesion and coverage |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US10639179B2 (en) | 2012-11-21 | 2020-05-05 | Ram Medical Innovations, Llc | System for the intravascular placement of a medical device |
US10583002B2 (en) | 2013-03-11 | 2020-03-10 | Neovasc Tiara Inc. | Prosthetic valve with anti-pivoting mechanism |
US20140277397A1 (en) | 2013-03-12 | 2014-09-18 | DePuy Synthes Products, LLC | Variable porosity intravascular implant and manufacturing method |
US9730791B2 (en) | 2013-03-14 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery |
US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
NZ619034A (en) | 2013-12-16 | 2015-03-27 | Eddy Current Ltd Partnership | An assembly to control relative speed of movement between parts |
USD755384S1 (en) | 2014-03-05 | 2016-05-03 | Edwards Lifesciences Cardiaq Llc | Stent |
BR112016030273A2 (en) | 2014-06-24 | 2017-08-22 | Icon Medical Corp | MEDICAL DEVICE AND METHOD FOR FORMING SAID DEVICE |
US9999527B2 (en) | 2015-02-11 | 2018-06-19 | Abbott Cardiovascular Systems Inc. | Scaffolds having radiopaque markers |
US9636244B2 (en) | 2015-04-09 | 2017-05-02 | Mubin I. Syed | Apparatus and method for proximal to distal stent deployment |
US9700443B2 (en) | 2015-06-12 | 2017-07-11 | Abbott Cardiovascular Systems Inc. | Methods for attaching a radiopaque marker to a scaffold |
US10779976B2 (en) | 2015-10-30 | 2020-09-22 | Ram Medical Innovations, Llc | Apparatus and method for stabilization of procedural catheter in tortuous vessels |
US10492936B2 (en) | 2015-10-30 | 2019-12-03 | Ram Medical Innovations, Llc | Apparatus and method for improved access of procedural catheter in tortuous vessels |
US11020256B2 (en) | 2015-10-30 | 2021-06-01 | Ram Medical Innovations, Inc. | Bifurcated “Y” anchor support for coronary interventions |
US10327929B2 (en) | 2015-10-30 | 2019-06-25 | Ram Medical Innovations, Llc | Apparatus and method for stabilization of procedural catheter in tortuous vessels |
US11766506B2 (en) | 2016-03-04 | 2023-09-26 | Mirus Llc | Stent device for spinal fusion |
US10173031B2 (en) | 2016-06-20 | 2019-01-08 | Mubin I. Syed | Interchangeable flush/selective catheter |
US10350062B2 (en) | 2016-07-21 | 2019-07-16 | Edwards Lifesciences Corporation | Replacement heart valve prosthesis |
WO2019147846A2 (en) | 2018-01-25 | 2019-08-01 | Edwards Lifesciences Corporation | Delivery system for aided replacement valve recapture and repositioning post- deployment |
US10857014B2 (en) | 2018-02-18 | 2020-12-08 | Ram Medical Innovations, Llc | Modified fixed flat wire bifurcated catheter and its application in lower extremity interventions |
JP7403547B2 (en) | 2019-01-23 | 2023-12-22 | ニオバスク メディカル リミテッド | coated flow modifier |
US11672681B2 (en) | 2019-01-28 | 2023-06-13 | Mubin I. Syed | Variable flow stent |
US20230277723A1 (en) * | 2022-03-03 | 2023-09-07 | Mirus Llc | Medical device that includes a rhenium-chromium alloy |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0701803A1 (en) * | 1994-02-03 | 1996-03-20 | Ao-Forschungsinstitut Davos | Medical device for implantation into living bodies |
EP0850604A2 (en) * | 1996-12-30 | 1998-07-01 | SORIN BIOMEDICA S.p.A. | A stent for angioplasty and associated production process |
US5826586A (en) * | 1995-03-17 | 1998-10-27 | Smith & Nephew, Inc. | Methods for producing medical implants with roughened, particulate-free surfaces |
DE19916086A1 (en) * | 1998-04-11 | 1999-10-14 | Inflow Dynamics Inc | Vascular prosthesis/stent for stenosis reversal |
EP0972498A1 (en) * | 1995-12-05 | 2000-01-19 | Robert E. Fischell | Radioisotope stent with increased radiation field strength at the ends of the stent |
EP1103234A1 (en) * | 1999-11-23 | 2001-05-30 | SORIN BIOMEDICA CARDIO S.p.A. | A device for conveying radioactive agents on angioplasty stents, respective method and kit |
Family Cites Families (196)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR732895A (en) * | 1932-10-18 | 1932-09-25 | Consortium Elektrochem Ind | Articles spun in polyvinyl alcohol |
US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
US5040548A (en) | 1989-06-01 | 1991-08-20 | Yock Paul G | Angioplasty mehtod |
US4800882A (en) | 1987-03-13 | 1989-01-31 | Cook Incorporated | Endovascular stent and delivery system |
US4994560A (en) | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
US4886062A (en) | 1987-10-19 | 1989-12-12 | Medtronic, Inc. | Intravascular radially expandable stent and method of implant |
US4931287A (en) | 1988-06-14 | 1990-06-05 | University Of Utah | Heterogeneous interpenetrating polymer networks for the controlled release of drugs |
DE3821544C2 (en) | 1988-06-25 | 1994-04-28 | H Prof Dr Med Just | Dilatation catheter |
US5328471A (en) | 1990-02-26 | 1994-07-12 | Endoluminal Therapeutics, Inc. | Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens |
US4977901A (en) | 1988-11-23 | 1990-12-18 | Minnesota Mining And Manufacturing Company | Article having non-crosslinked crystallized polymer coatings |
US5087244A (en) | 1989-01-31 | 1992-02-11 | C. R. Bard, Inc. | Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen |
US5100429A (en) | 1989-04-28 | 1992-03-31 | C. R. Bard, Inc. | Endovascular stent and delivery system |
US5258419A (en) | 1989-06-26 | 1993-11-02 | Minnesota Mining And Manufacturing Company | Methods of preparing radiation resistant heat sealable polymer blends |
US5649951A (en) | 1989-07-25 | 1997-07-22 | Smith & Nephew Richards, Inc. | Zirconium oxide and zirconium nitride coated stents |
US5059166A (en) | 1989-12-11 | 1991-10-22 | Medical Innovative Technologies R & D Limited Partnership | Intra-arterial stent with the capability to inhibit intimal hyperplasia |
US5971954A (en) | 1990-01-10 | 1999-10-26 | Rochester Medical Corporation | Method of making catheter |
ATE123658T1 (en) | 1990-06-15 | 1995-06-15 | Cortrak Medical Inc | DEVICE FOR DISPENSING MEDICATIONS. |
US5064435A (en) | 1990-06-28 | 1991-11-12 | Schneider (Usa) Inc. | Self-expanding prosthesis having stable axial length |
US5342283A (en) | 1990-08-13 | 1994-08-30 | Good Roger R | Endocurietherapy |
US5213561A (en) | 1990-09-06 | 1993-05-25 | Weinstein Joseph S | Method and devices for preventing restenosis after angioplasty |
US5344425A (en) | 1990-09-14 | 1994-09-06 | Interface Biomedical Laboratories, Corp. | Intravascular stent and method for conditioning the surfaces thereof |
US5893840A (en) | 1991-01-04 | 1999-04-13 | Medtronic, Inc. | Releasable microcapsules on balloon catheters |
US5302168A (en) | 1991-09-05 | 1994-04-12 | Hess Robert L | Method and apparatus for restenosis treatment |
US5464450A (en) | 1991-10-04 | 1995-11-07 | Scimed Lifesystems Inc. | Biodegradable drug delivery vascular stent |
US5500013A (en) | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
WO1993006792A1 (en) | 1991-10-04 | 1993-04-15 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5366504A (en) | 1992-05-20 | 1994-11-22 | Boston Scientific Corporation | Tubular medical prosthesis |
CA2087132A1 (en) | 1992-01-31 | 1993-08-01 | Michael S. Williams | Stent capable of attachment within a body lumen |
US5599352A (en) | 1992-03-19 | 1997-02-04 | Medtronic, Inc. | Method of making a drug eluting stent |
US5282823A (en) | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
US5571166A (en) | 1992-03-19 | 1996-11-05 | Medtronic, Inc. | Method of making an intraluminal stent |
US5591224A (en) | 1992-03-19 | 1997-01-07 | Medtronic, Inc. | Bioelastomeric stent |
EP0566245B1 (en) | 1992-03-19 | 1999-10-06 | Medtronic, Inc. | Intraluminal stent |
US5342621A (en) | 1992-09-15 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Antithrombogenic surface |
US5344455A (en) | 1992-10-30 | 1994-09-06 | Medtronic, Inc. | Graft polymer articles having bioactive surfaces |
US5278200A (en) | 1992-10-30 | 1994-01-11 | Medtronic, Inc. | Thromboresistant material and articles |
EP0597593A1 (en) | 1992-10-30 | 1994-05-18 | Medtronic, Inc. | Thromboresistant articles |
US5336518A (en) | 1992-12-11 | 1994-08-09 | Cordis Corporation | Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents |
US5350800A (en) | 1993-01-19 | 1994-09-27 | Medtronic, Inc. | Method for improving the biocompatibility of solid surfaces |
US5229172A (en) | 1993-01-19 | 1993-07-20 | Medtronic, Inc. | Modification of polymeric surface by graft polymerization |
US5308641A (en) | 1993-01-19 | 1994-05-03 | Medtronic, Inc. | Biocompatibility of solid surfaces |
US5441515A (en) | 1993-04-23 | 1995-08-15 | Advanced Cardiovascular Systems, Inc. | Ratcheting stent |
US5824048A (en) | 1993-04-26 | 1998-10-20 | Medtronic, Inc. | Method for delivering a therapeutic substance to a body lumen |
US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
IT1276342B1 (en) | 1993-06-04 | 1997-10-30 | Ist Naz Stud Cura Dei Tumori | METAL STENT COVERED WITH BIOCOMPATIBLE POLYMERIC MATERIAL |
US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
EG20321A (en) | 1993-07-21 | 1998-10-31 | Otsuka Pharma Co Ltd | Medical material and process for producing the same |
IL106796A (en) * | 1993-08-25 | 1997-11-20 | Algorithmic Res Ltd | Broadcast encryption |
US5723004A (en) | 1993-10-21 | 1998-03-03 | Corvita Corporation | Expandable supportive endoluminal grafts |
JP2703510B2 (en) | 1993-12-28 | 1998-01-26 | アドヴァンスド カーディオヴァスキュラー システムズ インコーポレーテッド | Expandable stent and method of manufacturing the same |
US5470313A (en) | 1994-02-24 | 1995-11-28 | Cardiovascular Dynamics, Inc. | Variable diameter balloon dilatation catheter |
WO1995024929A2 (en) | 1994-03-15 | 1995-09-21 | Brown University Research Foundation | Polymeric gene delivery system |
CA2188563C (en) | 1994-04-29 | 2005-08-02 | Andrew W. Buirge | Stent with collagen |
US5629077A (en) | 1994-06-27 | 1997-05-13 | Advanced Cardiovascular Systems, Inc. | Biodegradable mesh and film stent |
US5857998A (en) | 1994-06-30 | 1999-01-12 | Boston Scientific Corporation | Stent and therapeutic delivery system |
US5670558A (en) | 1994-07-07 | 1997-09-23 | Terumo Kabushiki Kaisha | Medical instruments that exhibit surface lubricity when wetted |
US5578073A (en) | 1994-09-16 | 1996-11-26 | Ramot Of Tel Aviv University | Thromboresistant surface treatment for biomaterials |
US5649977A (en) | 1994-09-22 | 1997-07-22 | Advanced Cardiovascular Systems, Inc. | Metal reinforced polymer stent |
US5707385A (en) | 1994-11-16 | 1998-01-13 | Advanced Cardiovascular Systems, Inc. | Drug loaded elastic membrane and method for delivery |
US6059752A (en) | 1994-12-09 | 2000-05-09 | Segal; Jerome | Mechanical apparatus and method for dilating and irradiating a site of treatment |
US5637113A (en) | 1994-12-13 | 1997-06-10 | Advanced Cardiovascular Systems, Inc. | Polymer film for wrapping a stent structure |
US5569198A (en) | 1995-01-23 | 1996-10-29 | Cortrak Medical Inc. | Microporous catheter |
US6147168A (en) | 1995-03-06 | 2000-11-14 | Ethicon, Inc. | Copolymers of absorbable polyoxaesters |
US5605696A (en) | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US5730698A (en) | 1995-05-09 | 1998-03-24 | Fischell; Robert E. | Balloon expandable temporary radioisotope stent system |
US5674242A (en) | 1995-06-06 | 1997-10-07 | Quanam Medical Corporation | Endoprosthetic device with therapeutic compound |
US5711812A (en) | 1995-06-06 | 1998-01-27 | Varian Associates, Inc. | Apparatus for obtaining dose uniformity in plasma doping (PLAD) ion implantation processes |
US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
US6010530A (en) | 1995-06-07 | 2000-01-04 | Boston Scientific Technology, Inc. | Self-expanding endoluminal prosthesis |
US5820917A (en) | 1995-06-07 | 1998-10-13 | Medtronic, Inc. | Blood-contacting medical device and method |
AU716005B2 (en) | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
US5693376A (en) | 1995-06-23 | 1997-12-02 | Wisconsin Alumni Research Foundation | Method for plasma source ion implantation and deposition for cylindrical surfaces |
US5667767A (en) | 1995-07-27 | 1997-09-16 | Micro Therapeutics, Inc. | Compositions for use in embolizing blood vessels |
US5722984A (en) | 1996-01-16 | 1998-03-03 | Iso Stent, Inc. | Antithrombogenic radioactive coating for an intravascular stent |
CA2199890C (en) | 1996-03-26 | 2002-02-05 | Leonard Pinchuk | Stents and stent-grafts having enhanced hoop strength and methods of making the same |
US5713949A (en) | 1996-08-06 | 1998-02-03 | Jayaraman; Swaminathan | Microporous covered stents and method of coating |
NZ331269A (en) * | 1996-04-10 | 2000-01-28 | Advanced Cardiovascular System | Expandable stent, its structural strength varying along its length |
US6033719A (en) | 1996-04-25 | 2000-03-07 | Medtronic, Inc. | Method for covalent attachment of biomolecules to surfaces of medical devices |
US5925552A (en) | 1996-04-25 | 1999-07-20 | Medtronic, Inc. | Method for attachment of biomolecules to medical devices surfaces |
US5928916A (en) | 1996-04-25 | 1999-07-27 | Medtronic, Inc. | Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces |
US6783543B2 (en) | 2000-06-05 | 2004-08-31 | Scimed Life Systems, Inc. | Intravascular stent with increasing coating retaining capacity |
US5951881A (en) | 1996-07-22 | 1999-09-14 | President And Fellows Of Harvard College | Fabrication of small-scale cylindrical articles |
US5811151A (en) | 1996-05-31 | 1998-09-22 | Medtronic, Inc. | Method of modifying the surface of a medical device |
US5769884A (en) * | 1996-06-27 | 1998-06-23 | Cordis Corporation | Controlled porosity endovascular implant |
US5871436A (en) | 1996-07-19 | 1999-02-16 | Advanced Cardiovascular Systems, Inc. | Radiation therapy method and device |
US5830178A (en) | 1996-10-11 | 1998-11-03 | Micro Therapeutics, Inc. | Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide |
US6099561A (en) | 1996-10-21 | 2000-08-08 | Inflow Dynamics, Inc. | Vascular and endoluminal stents with improved coatings |
ZA9710342B (en) | 1996-11-25 | 1998-06-10 | Alza Corp | Directional drug delivery stent and method of use. |
US5871437A (en) | 1996-12-10 | 1999-02-16 | Inflow Dynamics, Inc. | Radioactive stent for treating blood vessels to prevent restenosis |
US5980972A (en) | 1996-12-20 | 1999-11-09 | Schneider (Usa) Inc | Method of applying drug-release coatings |
US5858556A (en) | 1997-01-21 | 1999-01-12 | Uti Corporation | Multilayer composite tubular structure and method of making |
US5997517A (en) | 1997-01-27 | 1999-12-07 | Sts Biopolymers, Inc. | Bonding layers for medical device surface coatings |
US5782742A (en) | 1997-01-31 | 1998-07-21 | Cardiovascular Dynamics, Inc. | Radiation delivery balloon |
US6140431A (en) | 1997-02-27 | 2000-10-31 | Rohm And Haas Company | Process for preparing continuously variable-composition copolymers |
US5858990A (en) | 1997-03-04 | 1999-01-12 | St. Elizabeth's Medical Center | Fas ligand compositions for treatment of proliferative disorders |
WO1998043695A1 (en) * | 1997-03-31 | 1998-10-08 | Kabushikikaisha Igaki Iryo Sekkei | Stent for vessels |
US5843172A (en) | 1997-04-15 | 1998-12-01 | Advanced Cardiovascular Systems, Inc. | Porous medicated stent |
US6273913B1 (en) * | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
US6776792B1 (en) * | 1997-04-24 | 2004-08-17 | Advanced Cardiovascular Systems Inc. | Coated endovascular stent |
US5879697A (en) | 1997-04-30 | 1999-03-09 | Schneider Usa Inc | Drug-releasing coatings for medical devices |
US5972029A (en) | 1997-05-13 | 1999-10-26 | Fuisz Technologies Ltd. | Remotely operable stent |
US5902631A (en) | 1997-06-03 | 1999-05-11 | Wang; Lixiao | Lubricity gradient for medical devices |
US6106454A (en) | 1997-06-17 | 2000-08-22 | Medtronic, Inc. | Medical device for delivering localized radiation |
US6110483A (en) | 1997-06-23 | 2000-08-29 | Sts Biopolymers, Inc. | Adherent, flexible hydrogel and medicated coatings |
US5898178A (en) | 1997-07-02 | 1999-04-27 | Implant Sciences Corporation | Ion source for generation of radioactive ion beams |
US5810873A (en) | 1997-07-15 | 1998-09-22 | Advanced Cardiovascular Systems, Inc. | Stent crimping tool and method of use |
US5891507A (en) * | 1997-07-28 | 1999-04-06 | Iowa-India Investments Company Limited | Process for coating a surface of a metallic stent |
US5980928A (en) | 1997-07-29 | 1999-11-09 | Terry; Paul B. | Implant for preventing conjunctivitis in cattle |
US5980564A (en) | 1997-08-01 | 1999-11-09 | Schneider (Usa) Inc. | Bioabsorbable implantable endoprosthesis with reservoir |
US5897911A (en) | 1997-08-11 | 1999-04-27 | Advanced Cardiovascular Systems, Inc. | Polymer-coated stent structure |
US6042606A (en) * | 1997-09-29 | 2000-03-28 | Cook Incorporated | Radially expandable non-axially contracting surgical stent |
US5972027A (en) | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
US6273850B1 (en) | 1997-10-29 | 2001-08-14 | Medtronic Ave, Inc. | Device for positioning a radiation source at a stenosis treatment site |
US6015541A (en) | 1997-11-03 | 2000-01-18 | Micro Therapeutics, Inc. | Radioactive embolizing compositions |
WO1999024174A1 (en) | 1997-11-10 | 1999-05-20 | Katoot Mohammad W | Method for modifying the surface of an object |
US6149574A (en) | 1997-12-19 | 2000-11-21 | Radiance Medical Systems, Inc. | Dual catheter radiation delivery system |
US6140127A (en) | 1998-02-18 | 2000-10-31 | Cordis Corporation | Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide |
US6488701B1 (en) * | 1998-03-31 | 2002-12-03 | Medtronic Ave, Inc. | Stent-graft assembly with thin-walled graft component and method of manufacture |
US6024918A (en) | 1998-03-13 | 2000-02-15 | Medtronic, Inc. | Method for attachment of biomolecules to surfaces of medical devices |
US7208010B2 (en) | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
US7208011B2 (en) | 2001-08-20 | 2007-04-24 | Conor Medsystems, Inc. | Implantable medical device with drug filled holes |
US6019789A (en) | 1998-04-01 | 2000-02-01 | Quanam Medical Corporation | Expandable unit cell and intraluminal stent |
CA2320259C (en) | 1998-04-27 | 2006-01-24 | Surmodics, Inc. | Bioactive agent release coating |
US6013099A (en) | 1998-04-29 | 2000-01-11 | Medtronic, Inc. | Medical device for delivering a water-insoluble therapeutic salt or substance |
WO1999056663A2 (en) | 1998-05-05 | 1999-11-11 | Scimed Life Systems, Inc. | Stent with smooth ends |
US6296603B1 (en) | 1998-05-26 | 2001-10-02 | Isostent, Inc. | Radioactive intraluminal endovascular prosthesis and method for the treatment of aneurysms |
US6099559A (en) | 1998-05-28 | 2000-08-08 | Medtronic Ave, Inc. | Endoluminal support assembly with capped ends |
US6153252A (en) | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
US6093199A (en) | 1998-08-05 | 2000-07-25 | Endovascular Technologies, Inc. | Intra-luminal device for treatment of body cavities and lumens and method of use |
US6080099A (en) | 1998-08-12 | 2000-06-27 | Syntheon, Llc | Radioactive therapeutic seeds |
US6335029B1 (en) * | 1998-08-28 | 2002-01-01 | Scimed Life Systems, Inc. | Polymeric coatings for controlled delivery of active agents |
US6168619B1 (en) | 1998-10-16 | 2001-01-02 | Quanam Medical Corporation | Intravascular stent having a coaxial polymer member and end sleeves |
US6187024B1 (en) | 1998-11-10 | 2001-02-13 | Target Therapeutics, Inc. | Bioactive coating for vaso-occlusive devices |
US6099455A (en) | 1998-11-25 | 2000-08-08 | Isostent, Inc. | Radioisotope stent with non-radioactive end sections |
DE19913978A1 (en) * | 1999-03-18 | 2000-09-28 | Schering Ag | Asymmetric stent containing irregularly distributed active agents or radioisotopes useful e.g. for treating atherosclerosis and preventing restenosis |
FR2795326B1 (en) | 1999-06-28 | 2001-08-31 | Adir | SOLID THERMOFORMABLE PHARMACEUTICAL COMPOSITION WITH CONTROLLED RELEASE |
US6258121B1 (en) | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
CN1378445B (en) * | 1999-08-06 | 2013-02-06 | 得克萨斯系统大学评议会 | Drug releasing biodegradable fiber implant |
US6287628B1 (en) | 1999-09-03 | 2001-09-11 | Advanced Cardiovascular Systems, Inc. | Porous prosthesis and a method of depositing substances into the pores |
US6379381B1 (en) * | 1999-09-03 | 2002-04-30 | Advanced Cardiovascular Systems, Inc. | Porous prosthesis and a method of depositing substances into the pores |
US6582417B1 (en) | 1999-09-22 | 2003-06-24 | Advanced Cardiovascular Systems, Inc. | Methods and apparatuses for radiation treatment |
US6203551B1 (en) | 1999-10-04 | 2001-03-20 | Advanced Cardiovascular Systems, Inc. | Chamber for applying therapeutic substances to an implant device |
DE19951477A1 (en) | 1999-10-26 | 2001-05-03 | Biotronik Mess & Therapieg | Stent |
US6481262B2 (en) | 1999-12-30 | 2002-11-19 | Advanced Cardiovascular Systems, Inc. | Stent crimping tool |
US6355058B1 (en) * | 1999-12-30 | 2002-03-12 | Advanced Cardiovascular Systems, Inc. | Stent with radiopaque coating consisting of particles in a binder |
EP1132058A1 (en) | 2000-03-06 | 2001-09-12 | Advanced Laser Applications Holding S.A. | Intravascular prothesis |
US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US6510722B1 (en) * | 2000-05-10 | 2003-01-28 | Advanced Cardiovascular Systems, Inc. | Stent crimping tool for producing a grooved crimp |
US6395326B1 (en) * | 2000-05-31 | 2002-05-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for depositing a coating onto a surface of a prosthesis |
WO2002015824A2 (en) | 2000-08-25 | 2002-02-28 | Kensey Nash Corporation | Covered stents, systems for deploying covered stents |
US6254632B1 (en) * | 2000-09-28 | 2001-07-03 | Advanced Cardiovascular Systems, Inc. | Implantable medical device having protruding surface structures for drug delivery and cover attachment |
US6805898B1 (en) * | 2000-09-28 | 2004-10-19 | Advanced Cardiovascular Systems, Inc. | Surface features of an implantable medical device |
US6783793B1 (en) | 2000-10-26 | 2004-08-31 | Advanced Cardiovascular Systems, Inc. | Selective coating of medical devices |
US6558733B1 (en) * | 2000-10-26 | 2003-05-06 | Advanced Cardiovascular Systems, Inc. | Method for etching a micropatterned microdepot prosthesis |
KR20030045847A (en) * | 2000-10-31 | 2003-06-11 | 쿡 인코포레이티드 | Coated implantable medical device |
US6504307B1 (en) | 2000-11-30 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Application of variable bias voltage on a cylindrical grid enclosing a target |
US7077859B2 (en) | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
US20030033007A1 (en) | 2000-12-22 | 2003-02-13 | Avantec Vascular Corporation | Methods and devices for delivery of therapeutic capable agents with variable release profile |
US6524232B1 (en) | 2000-12-22 | 2003-02-25 | Advanced Cardiovascular Systems, Inc. | Method for radioactive stent delivery |
US7083642B2 (en) | 2000-12-22 | 2006-08-01 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
US6663662B2 (en) * | 2000-12-28 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Diffusion barrier layer for implantable devices |
US6764505B1 (en) | 2001-04-12 | 2004-07-20 | Advanced Cardiovascular Systems, Inc. | Variable surface area stent |
US7862495B2 (en) | 2001-05-31 | 2011-01-04 | Advanced Cardiovascular Systems, Inc. | Radiation or drug delivery source with activity gradient to minimize edge effects |
US6656216B1 (en) | 2001-06-29 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Composite stent with regioselective material |
ES2266148T5 (en) * | 2001-07-20 | 2012-11-06 | Sorin Biomedica Cardio S.R.L. | Stent |
US20060224234A1 (en) | 2001-08-29 | 2006-10-05 | Swaminathan Jayaraman | Drug eluting structurally variable stent |
IN2014DN10834A (en) | 2001-09-17 | 2015-09-04 | Psivida Inc | |
DE10150995A1 (en) | 2001-10-08 | 2003-04-10 | Biotronik Mess & Therapieg | Implant e.g. a stent, comprises a decomposable substance which allows contact between the cell proliferation inhibitor and the stent surroundings only after a specified time |
US6939376B2 (en) | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US20030088307A1 (en) | 2001-11-05 | 2003-05-08 | Shulze John E. | Potent coatings for stents |
US20050194348A1 (en) | 2001-12-03 | 2005-09-08 | University Of Southern California | Electrochemical fabrication methods incorporating dielectric materials and/or using dielectric substrates |
US7363494B2 (en) | 2001-12-04 | 2008-04-22 | Rsa Security Inc. | Method and apparatus for performing enhanced time-based authentication |
US6866805B2 (en) | 2001-12-27 | 2005-03-15 | Advanced Cardiovascular Systems, Inc. | Hybrid intravascular stent |
US7445629B2 (en) | 2002-01-31 | 2008-11-04 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US20030153901A1 (en) | 2002-02-08 | 2003-08-14 | Atrium Medical Corporation | Drug delivery panel |
US7101394B2 (en) | 2002-05-02 | 2006-09-05 | Boston Scientific Scimed, Inc. | Energetically-controlled delivery of biologically active material from an implanted medical device |
US7396539B1 (en) | 2002-06-21 | 2008-07-08 | Advanced Cardiovascular Systems, Inc. | Stent coatings with engineered drug release rate |
US20040127976A1 (en) | 2002-09-20 | 2004-07-01 | Conor Medsystems, Inc. | Method and apparatus for loading a beneficial agent into an expandable medical device |
US7135038B1 (en) | 2002-09-30 | 2006-11-14 | Advanced Cardiovascular Systems, Inc. | Drug eluting stent |
US6702850B1 (en) | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
DE60329209D1 (en) | 2002-10-22 | 2009-10-22 | Medtronic Vascular Inc | STENT WITH ECCENTRIC COATING |
US7169178B1 (en) | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
ATE538820T1 (en) | 2003-02-21 | 2012-01-15 | Sorin Biomedica Cardio Srl | METHOD FOR PRODUCING A STENT AND CORRESPONDING STENT |
ATE461681T1 (en) | 2003-04-29 | 2010-04-15 | Gen Hospital Corp | METHODS AND DEVICES FOR SUSTAINED RELEASE OF MULTIPLE DRUGS |
US20050211680A1 (en) | 2003-05-23 | 2005-09-29 | Mingwei Li | Systems and methods for laser texturing of surfaces of a substrate |
US20050228482A1 (en) | 2003-09-26 | 2005-10-13 | William Herzog | Stent covered by a layer having a layer opening |
DE10361940A1 (en) | 2003-12-24 | 2005-07-28 | Restate Patent Ag | Degradation control of biodegradable implants by coating |
US7632307B2 (en) | 2004-12-16 | 2009-12-15 | Advanced Cardiovascular Systems, Inc. | Abluminal, multilayer coating constructs for drug-delivery stents |
US8057543B2 (en) | 2005-01-28 | 2011-11-15 | Greatbatch Ltd. | Stent coating for eluting medication |
US20070173923A1 (en) | 2006-01-20 | 2007-07-26 | Savage Douglas R | Drug reservoir stent |
US8585753B2 (en) | 2006-03-04 | 2013-11-19 | John James Scanlon | Fibrillated biodegradable prosthesis |
EP2073765A2 (en) | 2006-09-25 | 2009-07-01 | Boston Scientific Limited | Injection of therapeutic into porous regions of a medical device |
DE102007034364A1 (en) | 2007-07-24 | 2009-01-29 | Biotronik Vi Patent Ag | Degradable metal stent with active ingredient-containing coating |
EP2323709A2 (en) | 2008-08-14 | 2011-05-25 | Boston Scientific Scimed, Inc. | Medical devices having electrodeposited conductive polymer coatings |
US20100057188A1 (en) | 2008-08-28 | 2010-03-04 | Boston Scientific Scimed, Inc. | Endoprostheses with porous regions and non-polymeric coating |
-
2001
- 2001-04-12 US US09/834,012 patent/US6764505B1/en not_active Expired - Lifetime
-
2002
- 2002-04-12 WO PCT/US2002/011581 patent/WO2002083039A1/en not_active Application Discontinuation
-
2004
- 2004-04-06 US US10/819,776 patent/US7674493B2/en not_active Expired - Fee Related
-
2010
- 2010-01-15 US US12/688,571 patent/US8119184B2/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0701803A1 (en) * | 1994-02-03 | 1996-03-20 | Ao-Forschungsinstitut Davos | Medical device for implantation into living bodies |
US5826586A (en) * | 1995-03-17 | 1998-10-27 | Smith & Nephew, Inc. | Methods for producing medical implants with roughened, particulate-free surfaces |
EP0972498A1 (en) * | 1995-12-05 | 2000-01-19 | Robert E. Fischell | Radioisotope stent with increased radiation field strength at the ends of the stent |
EP0850604A2 (en) * | 1996-12-30 | 1998-07-01 | SORIN BIOMEDICA S.p.A. | A stent for angioplasty and associated production process |
DE19916086A1 (en) * | 1998-04-11 | 1999-10-14 | Inflow Dynamics Inc | Vascular prosthesis/stent for stenosis reversal |
EP1103234A1 (en) * | 1999-11-23 | 2001-05-30 | SORIN BIOMEDICA CARDIO S.p.A. | A device for conveying radioactive agents on angioplasty stents, respective method and kit |
Cited By (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8066763B2 (en) | 1998-04-11 | 2011-11-29 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
EP2210626A1 (en) | 2001-05-11 | 2010-07-28 | Exogenesis Corporation | Medical devices having drugs adhered to the surface thereof. |
EP1393601A4 (en) * | 2001-05-11 | 2007-03-21 | Epion Corp | Method and system for improving the effectiveness of medical devices by adhering drugs to the surface thereof |
WO2002093988A1 (en) | 2001-05-11 | 2002-11-21 | Epion Corporation | Method and system for improving the effectiveness of medical devices by adhering drugs to the surface thereof |
EP1393601A1 (en) * | 2001-05-11 | 2004-03-03 | Epion Corporation | Method and system for improving the effectiveness of medical devices by adhering drugs to the surface thereof |
EP1416885A2 (en) * | 2001-07-26 | 2004-05-12 | Avantec Vascular Corporation | Methods and devices for delivery of therapeutic capable agents with variable release profile |
EP1416885A4 (en) * | 2001-07-26 | 2005-01-12 | Avantec Vascular Corp | Methods and devices for delivery of therapeutic capable agents with variable release profile |
WO2004026177A1 (en) * | 2002-09-20 | 2004-04-01 | Abbott Laboratories Vascular Enterprises Limited | Stent with rough surface and its manufacture |
EP1402849A1 (en) * | 2002-09-20 | 2004-03-31 | Abbott Laboratories Vascular Enterprises Limited | Stent with rough surface and its manufacturing method |
US7666223B2 (en) * | 2002-11-12 | 2010-02-23 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
US8367149B2 (en) | 2002-11-12 | 2013-02-05 | Advanced Cardiovascular System, Inc. | Method of coating a stent having variable drug release rate |
EP1547530A1 (en) * | 2003-12-17 | 2005-06-29 | Cordis Neurovascular, Inc. | Activatable bioactive vascular occlusive device and method of use |
US7294123B2 (en) | 2003-12-17 | 2007-11-13 | Corris Neurovascular, Inc. | Activatable bioactive vascular occlusive device and method of use |
WO2007103667A2 (en) * | 2006-03-06 | 2007-09-13 | Boston Scientific Limited | Medical device delivery systems |
WO2007103667A3 (en) * | 2006-03-06 | 2008-01-24 | Boston Scient Scimed Inc | Medical device delivery systems |
US8574615B2 (en) | 2006-03-24 | 2013-11-05 | Boston Scientific Scimed, Inc. | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
US8771343B2 (en) | 2006-06-29 | 2014-07-08 | Boston Scientific Scimed, Inc. | Medical devices with selective titanium oxide coatings |
US8353949B2 (en) | 2006-09-14 | 2013-01-15 | Boston Scientific Scimed, Inc. | Medical devices with drug-eluting coating |
US7981150B2 (en) | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
US8932345B2 (en) | 2007-02-07 | 2015-01-13 | Cook Medical Technologies Llc | Medical device coatings for releasing a therapeutic agent at multiple rates |
US9656003B2 (en) | 2007-02-07 | 2017-05-23 | Cook Medical Technologies Llc | Medical device coatings for releasing a therapeutic agent at multiple rates |
WO2008097511A3 (en) * | 2007-02-07 | 2009-06-04 | Cook Inc | Medical device coatings for releasing a therapeutic agent at multiple rates |
WO2008106311A1 (en) * | 2007-02-27 | 2008-09-04 | Medtronic Vascular Inc. | Ion beam etching a surface of an implantable medical device |
US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
US8067054B2 (en) | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US9284409B2 (en) | 2007-07-19 | 2016-03-15 | Boston Scientific Scimed, Inc. | Endoprosthesis having a non-fouling surface |
US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
US8221822B2 (en) | 2007-07-31 | 2012-07-17 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
US8900292B2 (en) | 2007-08-03 | 2014-12-02 | Boston Scientific Scimed, Inc. | Coating for medical device having increased surface area |
US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8920491B2 (en) | 2008-04-22 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
US8932346B2 (en) | 2008-04-24 | 2015-01-13 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
US9005696B2 (en) | 2008-08-07 | 2015-04-14 | Exogenesis Corporation | Medical device for bone implant and method for producing such a device |
US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
US8678046B2 (en) | 2009-09-20 | 2014-03-25 | Medtronic Vascular, Inc. | Apparatus and methods for loading a drug eluting medical device |
JP2013541368A (en) * | 2010-09-17 | 2013-11-14 | メドトロニック ヴァスキュラー インコーポレイテッド | Apparatus and method for loading a drug eluting medical device |
CN103108614A (en) * | 2010-09-17 | 2013-05-15 | 美敦力瓦斯科尔勒公司 | Apparatus and methods for loading a drug eluting medical device |
WO2012036930A3 (en) * | 2010-09-17 | 2012-05-10 | Medtronic Vascular Inc. | Apparatus and methods for loading a drug eluting medical device |
Also Published As
Publication number | Publication date |
---|---|
US6764505B1 (en) | 2004-07-20 |
US20100116785A1 (en) | 2010-05-13 |
US8119184B2 (en) | 2012-02-21 |
US20040191404A1 (en) | 2004-09-30 |
US7674493B2 (en) | 2010-03-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6764505B1 (en) | Variable surface area stent | |
US6346110B2 (en) | Chamber for applying therapeutic substances to an implantable device | |
EP1781350B1 (en) | A method of making a coated medical device | |
KR100495875B1 (en) | Stent for percutaneous coronary intervention coated with drugs for the prevention of vascular restenosis | |
US7575593B2 (en) | Implantable device with reservoirs for increased drug loading | |
EP1539043B1 (en) | Expandable medical device with openings for delivery of multiple beneficial agents | |
EP1534181B1 (en) | Centering catheter | |
BRPI0717442B1 (en) | Method for producing a stent to reduce the occurrence and / or extent of restenosis or thrombosis and expandable stent | |
KR20070063511A (en) | Medical devices having nanoporous layers and methods for making the same | |
US20050159809A1 (en) | Implantable medical devices for treating or preventing restenosis | |
BRPI0717438B1 (en) | Method for producing a radially expandable endovascular stent and radially expandable endovascular stent | |
EP2211788A1 (en) | Stent made of wire having a spiral channel for drug delivery | |
CN101600463B (en) | Drug-delivery endovascular stent and method of use | |
WO2008024621A1 (en) | Systems for local bioactive material delivery | |
US20040204756A1 (en) | Absorbent article with improved liquid acquisition capacity | |
US20080189928A1 (en) | Stent Ring Surface Formation | |
WO2009158072A1 (en) | Methods and apparatus for multiple cured formulation coated stents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |