WO2002083930A3 - Tauchsensor zur messung der konzentration eines analyten mit hilfe einer oxidase - Google Patents

Tauchsensor zur messung der konzentration eines analyten mit hilfe einer oxidase Download PDF

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Publication number
WO2002083930A3
WO2002083930A3 PCT/CH2002/000209 CH0200209W WO02083930A3 WO 2002083930 A3 WO2002083930 A3 WO 2002083930A3 CH 0200209 W CH0200209 W CH 0200209W WO 02083930 A3 WO02083930 A3 WO 02083930A3
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WO
WIPO (PCT)
Prior art keywords
oxygen
analyte
oxidase
channel
concentration
Prior art date
Application number
PCT/CH2002/000209
Other languages
English (en)
French (fr)
Other versions
WO2002083930A2 (de
Inventor
Peter Abel
Rudolf Ehwald
Uwe Beyer
Original Assignee
Disetronic Licensing Ag
Peter Abel
Rudolf Ehwald
Uwe Beyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Disetronic Licensing Ag, Peter Abel, Rudolf Ehwald, Uwe Beyer filed Critical Disetronic Licensing Ag
Publication of WO2002083930A2 publication Critical patent/WO2002083930A2/de
Priority to US10/687,529 priority Critical patent/US7335286B2/en
Publication of WO2002083930A3 publication Critical patent/WO2002083930A3/de
Priority to US12/032,456 priority patent/US8017314B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes

Abstract

Die Erfindung betriff die Messung der Konzentration von Analyten mit Hilfe einer Oxidase in einem Tauchsensor, der sich in einer Flüssigkeit oder flüssigkeitshaltigen Matrix befindet. Sauerstoff diffundiert in die Enzymschicht von innen aus einem gasgefüllten Raum, der mit der Atmosphäre bzw. einem Sauerstoffreservoir in Verbindung steht. Dies ermöglicht Sauerstoffsättigung der Oxidase in einem sauerstoffarmen oder sauerstofffreien Medium bzw. bei hoher Analytkonzentration. Die Diffusion der Analyten in die Enzymschicht erfolgt in einem diffusionslimitierenden wasserhaltigen Kanal oder mehreren solcher Kanäle, wobei der Kanal / die Kanäle an der Sensoroberfläche mit einer für Proteine undurchlässigen hydrophilen Matrix gefüllt ist / sind. Durch Vergrösserung des Kanalquerschnittes an der Sensoroberfläche und / oder durch Verbindung des Kanals / der Kanäle mit einer für Proteine undurchlässigen porösen hydrophilen Schicht an der Sensoroberfläche wird die Wirkung äusserer Ablagerungen auf den Diffusionswiderstand für den Analyten reduziert.
PCT/CH2002/000209 2001-04-18 2002-04-15 Tauchsensor zur messung der konzentration eines analyten mit hilfe einer oxidase WO2002083930A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/687,529 US7335286B2 (en) 2001-04-18 2003-10-16 Immersion sensor for measuring the concentration of an analyte with the help of an oxidase
US12/032,456 US8017314B2 (en) 2001-04-18 2008-02-15 Immersion sensor for measuring the concentration of an analyte with the help of an oxidase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10119036A DE10119036C1 (de) 2001-04-18 2001-04-18 Tauchsensor zur Messung der Konzentration eines Analyten mit Hilfe einer Oxidase
DE10119036.0 2001-04-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/687,529 Continuation US7335286B2 (en) 2001-04-18 2003-10-16 Immersion sensor for measuring the concentration of an analyte with the help of an oxidase

Publications (2)

Publication Number Publication Date
WO2002083930A2 WO2002083930A2 (de) 2002-10-24
WO2002083930A3 true WO2002083930A3 (de) 2003-11-27

Family

ID=7681874

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH2002/000209 WO2002083930A2 (de) 2001-04-18 2002-04-15 Tauchsensor zur messung der konzentration eines analyten mit hilfe einer oxidase

Country Status (3)

Country Link
US (2) US7335286B2 (de)
DE (1) DE10119036C1 (de)
WO (1) WO2002083930A2 (de)

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Also Published As

Publication number Publication date
US20080182286A1 (en) 2008-07-31
DE10119036C1 (de) 2002-12-12
US20040229302A1 (en) 2004-11-18
US8017314B2 (en) 2011-09-13
US7335286B2 (en) 2008-02-26
WO2002083930A2 (de) 2002-10-24

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