WO2002088370A3 - Autogene nucleic acids encoding a secretable rna polymerase - Google Patents

Autogene nucleic acids encoding a secretable rna polymerase Download PDF

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Publication number
WO2002088370A3
WO2002088370A3 PCT/CA2002/000670 CA0200670W WO02088370A3 WO 2002088370 A3 WO2002088370 A3 WO 2002088370A3 CA 0200670 W CA0200670 W CA 0200670W WO 02088370 A3 WO02088370 A3 WO 02088370A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
rna polymerase
autogene
acids encoding
secretable rna
Prior art date
Application number
PCT/CA2002/000670
Other languages
French (fr)
Other versions
WO2002088370A2 (en
Inventor
John Finn
Ian Maclachlan
Original Assignee
Protiva Biotherapeutics Inc
John Finn
Ian Maclachlan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protiva Biotherapeutics Inc, John Finn, Ian Maclachlan filed Critical Protiva Biotherapeutics Inc
Publication of WO2002088370A2 publication Critical patent/WO2002088370A2/en
Publication of WO2002088370A3 publication Critical patent/WO2002088370A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The invention provides methods, nucleic acids, compounds, and compositions for expressing a product of interest in a cell that involve a secretable RNA Polymerase.
PCT/CA2002/000670 2001-04-30 2002-04-30 Autogene nucleic acids encoding a secretable rna polymerase WO2002088370A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28797401P 2001-04-30 2001-04-30
US60/287,974 2001-04-30

Publications (2)

Publication Number Publication Date
WO2002088370A2 WO2002088370A2 (en) 2002-11-07
WO2002088370A3 true WO2002088370A3 (en) 2003-09-25

Family

ID=23105194

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/000670 WO2002088370A2 (en) 2001-04-30 2002-04-30 Autogene nucleic acids encoding a secretable rna polymerase

Country Status (2)

Country Link
US (1) US7364750B2 (en)
WO (1) WO2002088370A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7364750B2 (en) 2001-04-30 2008-04-29 The University Of British Columbia Autogene nucleic acids encoding a secretable RNA polymerase
US20040142892A1 (en) * 2001-04-30 2004-07-22 The University Of British Columbia Autogene nucleic acids encoding a secretable RNA polymerase
HUE038099T2 (en) 2004-12-21 2018-09-28 Musc Found For Res Dev Compositions and methods for promoting wound healing and tissue regeneration
WO2008157840A2 (en) * 2007-06-21 2008-12-24 Musc Foundation For Research Development Alpha connexin c-terminal (act) peptides for treating age-related macular degeneration
US9408381B2 (en) 2004-12-21 2016-08-09 Musc Foundation For Research Development Alpha Connexin c-Terminal (ACT) peptides for use in transplant
US20060264413A1 (en) * 2005-04-18 2006-11-23 Sri International Method and composition for inhibiting cell proliferation and angiogenesis
US9273300B2 (en) * 2007-02-07 2016-03-01 Strike Bio, Inc Methods and compositions for modulating sialic acid production and treating hereditary inclusion body myopathy
KR102038948B1 (en) 2012-03-01 2019-11-26 퍼스트스트링 리서치 인코포레이티드 Topical Gels Containing Alpha Connexin C-Terminal (ACT) Peptides
CN114010788A (en) 2014-08-22 2022-02-08 奥克兰联合服务有限公司 Channel modulators
US20220118112A1 (en) 2018-10-09 2022-04-21 The University Of British Columbia Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto
TW202317598A (en) * 2021-09-01 2023-05-01 美商艾姆麥克斯治療股份有限公司 Peptides with antimicrobial activities

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041243A2 (en) * 1996-04-26 1997-11-06 University Of Pittsburgh A cytoplasmic gene expression system which utilizes a prokaryotic rna polymerase autogene
WO2001015511A2 (en) * 1999-09-01 2001-03-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, dna and viruses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3377363D1 (en) * 1982-03-31 1988-08-18 Ajinomoto Kk Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells
US7422902B1 (en) * 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US6773920B1 (en) * 1999-03-31 2004-08-10 Invitrogen Corporation Delivery of functional protein sequences by translocating polypeptides
CA2368998A1 (en) 1999-03-31 2000-10-05 Invitrogen Corporation Delivery of functional protein sequences by translocating polypeptides
US7364750B2 (en) 2001-04-30 2008-04-29 The University Of British Columbia Autogene nucleic acids encoding a secretable RNA polymerase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041243A2 (en) * 1996-04-26 1997-11-06 University Of Pittsburgh A cytoplasmic gene expression system which utilizes a prokaryotic rna polymerase autogene
WO2001015511A2 (en) * 1999-09-01 2001-03-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, dna and viruses

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEN XIAOZHUO ET AL: "A SELF-INITIATING EUKARYOTIC TRANSIENT GENE EXPRESSION SYSTEM BASED ON COTRANSFECTION OF BACTERIOPHAGE T7 TNA POLYMERASE AND DNA VECTORS CONTAINING A T7 AUTOGENE", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 22, no. 11, 11 June 1994 (1994-06-11), pages 2114 - 2120, XP002029322, ISSN: 0305-1048 *
DEROSSI D (REPRINT) ET AL: "Trojan peptides: the penetratin system for intracellular delivery", TRENDS IN CELL BIOLOGY, ELSEVIER SCIENCE LTD, XX, vol. 8, no. 2, February 1998 (1998-02-01), pages 84 - 87, XP002122131, ISSN: 0962-8924 *
ELROY-STEIN O ET AL: "CYTOPLASMIC EXPRESSION SYSTEM BASED ON CONSTITUTIVE SYNTHESIS OF BACTERIOPHAGE T7 POLYMERASE IN MAMMALIAN CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 87, no. 17, 1 September 1990 (1990-09-01), pages 6743 - 6747, XP000563742, ISSN: 0027-8424 *
GAO X ET AL: "CYTOPLASMIC EXPRESSION OF A REPORTER GENE BY CO-DELIVERY OF T7 RNA POLYMERASE AND T7 PROMOTER SEQUENCE WITH CATIONIC LIPOSOMES", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 21, no. 12, 25 June 1993 (1993-06-25), pages 2867 - 2872, XP000572618, ISSN: 0305-1048 *
LINDGREN M M ET AL: "Cell-penetrating peptides", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 21, no. 3, March 2000 (2000-03-01), pages 99 - 103, XP004202572, ISSN: 0165-6147 *

Also Published As

Publication number Publication date
WO2002088370A2 (en) 2002-11-07
US20030108886A1 (en) 2003-06-12
US7364750B2 (en) 2008-04-29

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