WO2002088705A3 - Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties - Google Patents

Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties Download PDF

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Publication number
WO2002088705A3
WO2002088705A3 PCT/US2002/013947 US0213947W WO02088705A3 WO 2002088705 A3 WO2002088705 A3 WO 2002088705A3 US 0213947 W US0213947 W US 0213947W WO 02088705 A3 WO02088705 A3 WO 02088705A3
Authority
WO
WIPO (PCT)
Prior art keywords
measurement
optical properties
atherosclerotic plaque
determination
tissue optical
Prior art date
Application number
PCT/US2002/013947
Other languages
French (fr)
Other versions
WO2002088705A2 (en
Inventor
Guillermo J Tearney
Brett Eugene Bouma
Original Assignee
Gen Hospital Corp
Guillermo J Tearney
Brett Eugene Bouma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp, Guillermo J Tearney, Brett Eugene Bouma filed Critical Gen Hospital Corp
Priority to AT0929902A priority Critical patent/AT503309B1/en
Priority to GB0418870A priority patent/GB2408797B/en
Priority to CA2473587A priority patent/CA2473587C/en
Priority to DE10297689T priority patent/DE10297689B4/en
Publication of WO2002088705A2 publication Critical patent/WO2002088705A2/en
Publication of WO2002088705A3 publication Critical patent/WO2002088705A3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/02001Interferometers characterised by controlling or generating intrinsic radiation properties
    • G01B9/02012Interferometers characterised by controlling or generating intrinsic radiation properties using temporal intensity variation
    • G01B9/02014Interferometers characterised by controlling or generating intrinsic radiation properties using temporal intensity variation by using pulsed light
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163Optical arrangements
    • A61B1/00165Optical arrangements with light-conductive means, e.g. fibre optics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • A61B5/0066Optical coherence imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/02001Interferometers characterised by controlling or generating intrinsic radiation properties
    • G01B9/02007Two or more frequencies or sources used for interferometric measurement
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/02055Reduction or prevention of errors; Testing; Calibration
    • G01B9/0207Error reduction by correction of the measurement signal based on independently determined error sources, e.g. using a reference interferometer
    • G01B9/02072Error reduction by correction of the measurement signal based on independently determined error sources, e.g. using a reference interferometer by calibration or testing of interferometer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/02083Interferometers characterised by particular signal processing and presentation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/02083Interferometers characterised by particular signal processing and presentation
    • G01B9/02088Matching signals with a database
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/0209Low-coherence interferometers
    • G01B9/02091Tomographic interferometers, e.g. based on optical coherence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B2290/00Aspects of interferometers not specifically covered by any group under G01B9/02
    • G01B2290/70Using polarization in the interferometer

Abstract

Methods for diagnosing vulnerable atherosclerotic plaque using optical coherence tomography to measure tissue optical properties, including backreflectance of heterogeneous layers, such as plaque cap, lipid pool composition and macrophage presence. Methods also include measurement of spatially and temporally dependent reflectance, measurement of multiple wavelength reflectance, low coherence interferometry, polarization and quantification of macrophage content.
PCT/US2002/013947 2001-05-01 2002-05-01 Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties WO2002088705A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AT0929902A AT503309B1 (en) 2001-05-01 2002-05-01 DEVICE FOR DETERMINING ATHEROSCLEROTIC BEARING BY MEASURING OPTICAL TISSUE PROPERTIES
GB0418870A GB2408797B (en) 2001-05-01 2002-05-01 Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
CA2473587A CA2473587C (en) 2001-05-01 2002-05-01 Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
DE10297689T DE10297689B4 (en) 2001-05-01 2002-05-01 Method and device for the determination of atherosclerotic coating by measurement of optical tissue properties

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28789901P 2001-05-01 2001-05-01
US60/287,899 2001-05-01

Publications (2)

Publication Number Publication Date
WO2002088705A2 WO2002088705A2 (en) 2002-11-07
WO2002088705A3 true WO2002088705A3 (en) 2003-03-20

Family

ID=23104845

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/013947 WO2002088705A2 (en) 2001-05-01 2002-05-01 Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties

Country Status (7)

Country Link
US (3) US7865231B2 (en)
AT (1) AT503309B1 (en)
AU (1) AU2008249176B2 (en)
CA (1) CA2473587C (en)
DE (1) DE10297689B4 (en)
GB (1) GB2408797B (en)
WO (1) WO2002088705A2 (en)

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