WO2002096350A3 - Immunogenic peptide composition for the prevention and treatment of alzheimer's disease - Google Patents
Immunogenic peptide composition for the prevention and treatment of alzheimer's disease Download PDFInfo
- Publication number
- WO2002096350A3 WO2002096350A3 PCT/US2002/010293 US0210293W WO02096350A3 WO 2002096350 A3 WO2002096350 A3 WO 2002096350A3 US 0210293 W US0210293 W US 0210293W WO 02096350 A3 WO02096350 A3 WO 02096350A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peptide
- alzheimer
- disease
- prevention
- treatment
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 230000002163 immunogen Effects 0.000 title abstract 5
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 4
- 230000002265 prevention Effects 0.000 title abstract 3
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 2
- 210000004556 brain Anatomy 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 210000004898 n-terminal fragment Anatomy 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002448171A CA2448171A1 (en) | 2001-05-25 | 2002-04-02 | Immunogenic peptide composition for the prevention and treatment of alzheimer's disease |
AT02731223T ATE474000T1 (en) | 2001-05-25 | 2002-04-02 | IMMUNOGENIC PEPTIDE COMPOSITION FOR THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE |
DE60237044T DE60237044D1 (en) | 2001-05-25 | 2002-04-02 | IMMUNOGENIC PEPTIDE COMPOSITION FOR THE PREVENTION AND TREATMENT OF ALZHEIMER DISEASE |
EP02731223A EP1497313B1 (en) | 2001-05-25 | 2002-04-02 | Immunogenic peptide composition for the prevention and treatment of alzheimer's disease |
MXPA03010631A MXPA03010631A (en) | 2001-05-25 | 2002-04-02 | Immunogenic peptide composition for the prevention and treatment of alzheimer's disease. |
DK02731223.0T DK1497313T3 (en) | 2001-05-25 | 2002-04-02 | Immunogenic peptide composition for the prevention and treatment of Alzheimer's disease |
JP2002592863A JP4440544B2 (en) | 2001-05-25 | 2002-04-02 | Immunogenic peptide composition for prevention and treatment of Alzheimer's disease |
AU2002303211A AU2002303211B2 (en) | 2001-05-25 | 2002-04-02 | Immunogenic peptide composition for the prevention and treatment of alzheimer's disease |
BR0210010-0 BRPI0210010B8 (en) | 2001-05-25 | 2002-04-02 | peptide immunogen, as well as composition and application comprising them |
CN028106210A CN1568329B (en) | 2001-05-25 | 2002-04-02 | Immunogenic peptide composition for the prevention and treatment of Alzheimer's disease |
ZA2003/08767A ZA200308767B (en) | 2001-05-25 | 2003-11-11 | Immunogenic peptide composition for the prevention and treatment of alzheimers disease |
HK05102035.8A HK1068215A1 (en) | 2001-05-25 | 2005-03-08 | Immunogenic peptide composition for the prevention and treatment of alzheimer's disease |
AU2008202270A AU2008202270B2 (en) | 2001-05-25 | 2008-05-22 | Immunogenic peptide composition for the prevention and treatment of Alzheimer's disease |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/865,294 US6906169B2 (en) | 2001-05-25 | 2001-05-25 | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
US09/865,294 | 2001-05-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002096350A2 WO2002096350A2 (en) | 2002-12-05 |
WO2002096350A3 true WO2002096350A3 (en) | 2004-11-11 |
Family
ID=25345158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/010293 WO2002096350A2 (en) | 2001-05-25 | 2002-04-02 | Immunogenic peptide composition for the prevention and treatment of alzheimer's disease |
Country Status (16)
Country | Link |
---|---|
US (3) | US6906169B2 (en) |
EP (2) | EP2123671B1 (en) |
JP (3) | JP4440544B2 (en) |
CN (2) | CN1568329B (en) |
AT (2) | ATE474000T1 (en) |
AU (2) | AU2002303211B2 (en) |
BR (1) | BRPI0210010B8 (en) |
CA (2) | CA2665748C (en) |
DE (2) | DE60237044D1 (en) |
DK (2) | DK2123671T3 (en) |
ES (2) | ES2360465T3 (en) |
HK (2) | HK1068215A1 (en) |
MX (1) | MXPA03010631A (en) |
TW (1) | TWI252233B (en) |
WO (1) | WO2002096350A2 (en) |
ZA (1) | ZA200308767B (en) |
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US8877190B2 (en) | 2006-11-30 | 2014-11-04 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9176150B2 (en) | 2003-01-31 | 2015-11-03 | AbbVie Deutschland GmbH & Co. KG | Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
CN110684122B (en) * | 2019-10-29 | 2021-03-02 | 中国人民解放军军事科学院军事医学研究院 | Recombinant Tau epitope chimeric polymer antigen, preparation method and application thereof |
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US6761888B1 (en) * | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US7179892B2 (en) * | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US20050059591A1 (en) * | 1998-04-07 | 2005-03-17 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US20030147882A1 (en) * | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
AU783144B2 (en) * | 2000-02-21 | 2005-09-29 | H. Lundbeck A/S | Novel method for down-regulation of amyloid |
CN1279971C (en) * | 2000-02-21 | 2006-10-18 | 法麦克萨有限公司 | Novel method for down-regulation of amyloid |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
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US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
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US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
US20040001848A1 (en) * | 2002-03-01 | 2004-01-01 | Szu-Yi Chou | Method of producing disease-specific antigens |
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JP4662719B2 (en) * | 2002-04-19 | 2011-03-30 | ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント | Immunological methods and compositions for the treatment of Alzheimer's disease |
EP1911765A3 (en) * | 2002-07-24 | 2008-04-23 | Innogenetics N.V. | Prevention, treatment and diagnosis of diseases associated with Beta-Amyloid formation and/or aggregation |
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MXPA06006821A (en) | 2003-12-17 | 2006-08-23 | Elan Pharm Inc | Abeta IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME. |
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Citations (7)
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WO1994028412A1 (en) * | 1993-05-28 | 1994-12-08 | The Miriam Hospital | Composition and method for in vivo imaging of amyloid deposits |
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-
2001
- 2001-05-25 US US09/865,294 patent/US6906169B2/en not_active Expired - Lifetime
-
2002
- 2002-03-18 TW TW091105087A patent/TWI252233B/en not_active IP Right Cessation
- 2002-04-02 DK DK09168110.6T patent/DK2123671T3/en active
- 2002-04-02 CN CN028106210A patent/CN1568329B/en not_active Expired - Lifetime
- 2002-04-02 WO PCT/US2002/010293 patent/WO2002096350A2/en active Search and Examination
- 2002-04-02 AT AT02731223T patent/ATE474000T1/en active
- 2002-04-02 CA CA2665748A patent/CA2665748C/en not_active Expired - Fee Related
- 2002-04-02 EP EP09168110A patent/EP2123671B1/en not_active Expired - Lifetime
- 2002-04-02 MX MXPA03010631A patent/MXPA03010631A/en active IP Right Grant
- 2002-04-02 AU AU2002303211A patent/AU2002303211B2/en not_active Ceased
- 2002-04-02 CN CN2008101692748A patent/CN101372511B/en not_active Expired - Fee Related
- 2002-04-02 BR BR0210010-0 patent/BRPI0210010B8/en not_active IP Right Cessation
- 2002-04-02 JP JP2002592863A patent/JP4440544B2/en not_active Expired - Fee Related
- 2002-04-02 AT AT09168110T patent/ATE496937T1/en active
- 2002-04-02 ES ES09168110T patent/ES2360465T3/en not_active Expired - Lifetime
- 2002-04-02 EP EP02731223A patent/EP1497313B1/en not_active Expired - Lifetime
- 2002-04-02 ES ES02731223T patent/ES2348975T3/en not_active Expired - Lifetime
- 2002-04-02 CA CA002448171A patent/CA2448171A1/en not_active Abandoned
- 2002-04-02 DE DE60237044T patent/DE60237044D1/en not_active Expired - Lifetime
- 2002-04-02 DE DE60239093T patent/DE60239093D1/en not_active Expired - Lifetime
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US9176150B2 (en) | 2003-01-31 | 2015-11-03 | AbbVie Deutschland GmbH & Co. KG | Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
US9540432B2 (en) | 2005-11-30 | 2017-01-10 | AbbVie Deutschland GmbH & Co. KG | Anti-Aβ globulomer 7C6 antibodies |
US8877190B2 (en) | 2006-11-30 | 2014-11-04 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US9359430B2 (en) | 2006-11-30 | 2016-06-07 | Abbvie Inc. | Abeta conformer selective anti-Abeta globulomer monoclonal antibodies |
US9394360B2 (en) | 2006-11-30 | 2016-07-19 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
CN110684122B (en) * | 2019-10-29 | 2021-03-02 | 中国人民解放军军事科学院军事医学研究院 | Recombinant Tau epitope chimeric polymer antigen, preparation method and application thereof |
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