WO2002102303A3 - Crystals and structure of synagis fab - Google Patents

Crystals and structure of synagis fab Download PDF

Info

Publication number
WO2002102303A3
WO2002102303A3 PCT/US2002/013583 US0213583W WO02102303A3 WO 2002102303 A3 WO2002102303 A3 WO 2002102303A3 US 0213583 W US0213583 W US 0213583W WO 02102303 A3 WO02102303 A3 WO 02102303A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystals
synagis fab
synagis
fab
subsets
Prior art date
Application number
PCT/US2002/013583
Other languages
French (fr)
Other versions
WO2002102303A2 (en
Inventor
Leslie S Johnson
Bradford Braden
Original Assignee
Medimmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Inc filed Critical Medimmune Inc
Priority to AU2002327171A priority Critical patent/AU2002327171A1/en
Publication of WO2002102303A2 publication Critical patent/WO2002102303A2/en
Publication of WO2002102303A3 publication Critical patent/WO2002102303A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Abstract

The present invention provides machine readable media embedded with the three-dimensional atomic structure coordinates of Synagis Fab, and subsets thereof, and methods of using them.
PCT/US2002/013583 2001-05-01 2002-04-29 Crystals and structure of synagis fab WO2002102303A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002327171A AU2002327171A1 (en) 2001-05-01 2002-04-29 Crystals and structure of synagis fab

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28800501P 2001-05-01 2001-05-01
US60/288,005 2001-05-01

Publications (2)

Publication Number Publication Date
WO2002102303A2 WO2002102303A2 (en) 2002-12-27
WO2002102303A3 true WO2002102303A3 (en) 2003-12-04

Family

ID=23105344

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/013583 WO2002102303A2 (en) 2001-05-01 2002-04-29 Crystals and structure of synagis fab

Country Status (3)

Country Link
US (2) US6955717B2 (en)
AU (1) AU2002327171A1 (en)
WO (1) WO2002102303A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550143B2 (en) 2005-04-06 2009-06-23 Ibc Pharmaceuticals, Inc. Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
IL156618A0 (en) * 2000-12-28 2004-01-04 Altus Biologics Inc Crystals of whole antibodies and fragments thereof, methods for the preparation thereof and diagnostic kits utilizing the same
US6955717B2 (en) 2001-05-01 2005-10-18 Medimmune Inc. Crystals and structure of Synagis Fab
WO2011050168A2 (en) 2009-10-21 2011-04-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Rsv immunogens, antibodies and compositions thereof
EP2625194B1 (en) 2010-10-06 2015-08-12 University Of Washington Through Its Center For Commercialization Polypeptides and their use in treating and limiting respiratory syncytial virus infection
US9701720B2 (en) 2012-04-05 2017-07-11 University Of Washington Through Its Center For Commercialization Epitope-scaffold immunogens against respiratory syncytial virus (RSV)
CN107108054B (en) 2014-10-31 2020-10-13 免疫医疗有限责任公司 Improved manufacturing method
CA2972990A1 (en) 2015-01-20 2016-07-28 Beatrice Tien-Yi WANG Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof
AR103726A1 (en) 2015-02-27 2017-05-31 Merck Sharp & Dohme HUMAN ANTI-PD-1 MONOCLONAL ANTIBODY CRYSTALS
EP3359191A4 (en) 2015-10-05 2019-05-29 Merck Sharp & Dohme Corp. Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors
EP3359194A4 (en) 2015-10-06 2019-04-24 Merck Sharp & Dohme Corp. Antibody drug conjugate for anti-inflammatory applications
WO2017132103A2 (en) 2016-01-29 2017-08-03 Merck Sharp & Dohme Corp. Phosphonate linkers and their use to facilitate cellular retention of compounds
JOP20190260A1 (en) 2017-05-02 2019-10-31 Merck Sharp & Dohme Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040252A1 (en) * 1995-06-07 1996-12-19 Idec Pharmaceuticals Corporation High affinity human monoclonal antibodies specific for rsv f-protein
US5994511A (en) * 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
US6113898A (en) * 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
US6129914A (en) * 1992-03-27 2000-10-10 Protein Design Labs, Inc. Bispecific antibody effective to treat B-cell lymphoma and cell line
WO2000061618A1 (en) * 1999-04-13 2000-10-19 University Of Toronto Fab-EPITOPE COMPLEX FROM THE HIV-1 CROSS-NEUTRALIZING MONOCLONAL ANTIBODY 2F5

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6424082B1 (en) 2000-08-03 2002-07-23 Hypertherm, Inc. Apparatus and method of improved consumable alignment in material processing apparatus
US6955717B2 (en) 2001-05-01 2005-10-18 Medimmune Inc. Crystals and structure of Synagis Fab

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6129914A (en) * 1992-03-27 2000-10-10 Protein Design Labs, Inc. Bispecific antibody effective to treat B-cell lymphoma and cell line
WO1996040252A1 (en) * 1995-06-07 1996-12-19 Idec Pharmaceuticals Corporation High affinity human monoclonal antibodies specific for rsv f-protein
US6113898A (en) * 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
US5994511A (en) * 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
WO2000061618A1 (en) * 1999-04-13 2000-10-19 University Of Toronto Fab-EPITOPE COMPLEX FROM THE HIV-1 CROSS-NEUTRALIZING MONOCLONAL ANTIBODY 2F5

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CRYSTAL SCREEN, HAMPTON RESEARCH, USER GUIDE, 1991, pages 1 - 8, XP002961681 *
JOHNSON ET AL.: "Development of humanized monoclonal antibody with potent in vitro and in vivo activity against respiratory syntical virus", THE JOURNAL OF INFECTIOUS DISEASES, 1997, pages 1215 - 1224, XP002175659 *
MEISSNER ET AL.: "Immunoprophylaxix with palvizumab, a humanized respiratory respiratory, syncytical virus monoclonal antibody, for preventing of respiratory syntical virtus infection in high risk infants; a consensus opinion", PEDIATRIC INFECT. DIS. J., vol. 18, no. 3, 1999, pages 223 - 231, XP002962232 *

Also Published As

Publication number Publication date
US20060241285A1 (en) 2006-10-26
US6955717B2 (en) 2005-10-18
AU2002327171A1 (en) 2003-01-02
US7229618B2 (en) 2007-06-12
WO2002102303A2 (en) 2002-12-27
US20030097974A1 (en) 2003-05-29

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