WO2003000343A3 - Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation - Google Patents

Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation Download PDF

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Publication number
WO2003000343A3
WO2003000343A3 PCT/US2002/009415 US0209415W WO03000343A3 WO 2003000343 A3 WO2003000343 A3 WO 2003000343A3 US 0209415 W US0209415 W US 0209415W WO 03000343 A3 WO03000343 A3 WO 03000343A3
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WO
WIPO (PCT)
Prior art keywords
administration
treatment
premature ejaculation
phosphodiesterase inhibitors
type
Prior art date
Application number
PCT/US2002/009415
Other languages
French (fr)
Other versions
WO2003000343A2 (en
Inventor
Leland F Wilson
Paul C Doherty Jr
Virgil A Place
William L Smith
Abdou Ali Ibrahim Abdel-Hamid
Original Assignee
Vivus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vivus Inc filed Critical Vivus Inc
Priority to JP2003506984A priority Critical patent/JP2005519851A/en
Priority to CA002451152A priority patent/CA2451152A1/en
Priority to EP02717729A priority patent/EP1418896A2/en
Publication of WO2003000343A2 publication Critical patent/WO2003000343A2/en
Publication of WO2003000343A3 publication Critical patent/WO2003000343A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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Abstract

A method is provided for treatment of premature ejaculation by administration of a phosphodiesterase inhibitor, e.g., an inhibitor of a Type III, Type IV, or Type V phosphodiesterase. In a preferred embodiment, administration is on as 'as needed' basis, i.e., the drug is administered immediately or several hours prior to sexual activity. Pharmaceutical formulations and packaged kits are also provided.
PCT/US2002/009415 2001-06-21 2002-03-25 Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation WO2003000343A2 (en)

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Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030077229A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs
US6476078B2 (en) * 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6743443B1 (en) * 1998-10-05 2004-06-01 Eisai Co., Ltd. Tablets immediately disintegrating in the oral cavity
UA67802C2 (en) * 1998-10-23 2004-07-15 Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. CONTROLLED-RELEASE FORMULATIONS FOR ORAL ADMINISTRATION CONTAINING cGMP PDE-5 INHIBITOR (VARIANTS), METHOD FOR ITS PREPARATION AND METHOD FOR TREATING ERECTILE DYSFUNCTION
US20040258750A1 (en) * 1999-06-28 2004-12-23 Gerard Alaux Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof
US7737147B2 (en) * 2000-07-27 2010-06-15 Thomas Nadackal Thomas Methods and compositions to enhance the efficacy of phosphodiesterase inhibitors
NZ524572A (en) * 2000-09-06 2004-08-27 Tanabe Seiyaku Co Oral compositions comprising phosphodiesterase inhibitors ( PDE inhibitor )and an acidic substance such as fumaric acid with improved drug efficacy due to decrease solubility in neutral and alkaline regions
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
JP3767392B2 (en) * 2001-02-05 2006-04-19 日産自動車株式会社 Engine camshaft rotation phase detection device and cylinder intake air amount calculation device
DE60211689T2 (en) 2001-03-16 2007-01-11 DMI Biosciences, Inc., Englewood Use of Tramadol to delay ejaculation
US6759029B2 (en) * 2001-05-24 2004-07-06 Alexza Molecular Delivery Corporation Delivery of rizatriptan and zolmitriptan through an inhalation route
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
EP1392258B1 (en) * 2001-05-24 2008-11-26 Alexza Pharmaceuticals, Inc. Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US6805853B2 (en) * 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
JP2005503425A (en) 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション Delivery of drug ester by the prescribed inhalation route
US20070122353A1 (en) * 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
EP2351765A3 (en) * 2001-07-10 2012-02-22 Lakewood-Amedex, Inc Oligonucleotide-containing pharmacological compositions and their use
CA2457944C (en) * 2001-08-28 2009-09-29 Schering Corporation Polycyclic guanine phosphodiesterase v inhibitors
DE60233884D1 (en) * 2001-10-16 2009-11-12 Memory Pharmaceutical Corp 4 (4-ALKOXY-3-HYDROXYPHENYL) -2-PYRROLIDONE DERIVATIVES AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES
WO2003042216A1 (en) * 2001-11-09 2003-05-22 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
AU2002363947A1 (en) * 2001-11-21 2003-07-24 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
WO2003094900A1 (en) 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Delivery of drug amines through an inhalation route
US20060193788A1 (en) * 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
US20040220153A1 (en) * 2002-09-24 2004-11-04 Jost-Price Edward Roydon Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
US8133903B2 (en) * 2003-10-21 2012-03-13 Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases
US7754767B2 (en) * 2002-11-06 2010-07-13 Trinity Laboratories, Inc. Method for treatment of premature ejaculation in humans
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US20040105818A1 (en) * 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
AU2003294470B2 (en) * 2002-11-26 2009-09-17 Alexza Pharmaceuticals, Inc. Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain
JP2006514633A (en) * 2002-11-26 2006-05-11 アレックザ ファーマシューティカルズ， インコーポレイテッド Treatment of headache with antipsychotics delivered by inhalation
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
ATE463246T1 (en) * 2003-01-23 2010-04-15 Shire Holdings Ag FORMULATION AND METHOD FOR TREATING THROMBOCYTHEMIA
WO2004094375A2 (en) * 2003-04-16 2004-11-04 Memory Pharmaceuticals Corporation 4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors
RU2379292C2 (en) * 2003-04-18 2010-01-20 Мемори Фармасьютиклз Корпорейшн Pyrazole derivatives as phosphodiesterase 4 inhibitors
WO2004104490A1 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Self-contained heating unit and drug-supply unit employing same
AU2003903597A0 (en) * 2003-07-11 2003-07-24 Jakov Vaisman Treatment of premature ejaculation
US20050043343A1 (en) * 2003-07-28 2005-02-24 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a PDE IV inhibitor
WO2005023767A2 (en) 2003-09-10 2005-03-17 Brentwood Equities Ltd. Diastereomers of 4-aryloxy-3-hydroxypiperidines
WO2005058280A2 (en) * 2003-12-12 2005-06-30 Myogen, Inc. Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure
US7481997B1 (en) 2004-02-12 2009-01-27 Montana State University Snow mountain virus genome sequence, virus-like particles and methods of use
JP2007530566A (en) * 2004-03-22 2007-11-01 ミオゲン インコーポレイティッド (R) -Enoximone sulfoxide and its use in the treatment of PDE-III mediated diseases
EP1737448A1 (en) * 2004-03-22 2007-01-03 Myogen, Inc. (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
WO2005097210A1 (en) * 2004-03-26 2005-10-20 The University Of Utah Research Foundation Bioresponsive polymer system for delivery of microbicides
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US20060292213A1 (en) * 2004-06-23 2006-12-28 Myogen, Inc. Enoximone formulations and their use in the treatment of PDE-III mediated diseases
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
WO2006023703A2 (en) * 2004-08-20 2006-03-02 Cypress Bioscience, Inc. Method for treating sleep related breathing disorders
EP1799673A1 (en) 2004-10-15 2007-06-27 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
JP2008517066A (en) * 2004-10-20 2008-05-22 メモリー ファーマシューティカルス コーポレーション Phosphodiesterase 4 inhibitor
WO2006055854A2 (en) * 2004-11-17 2006-05-26 Cypress Bioscience, Inc. Methods for reducing the side effects associated with mirtazapine treatment
MX2008000087A (en) * 2005-06-23 2008-03-18 Schering Corp Rapidly absorbing oral formulations of pde5 inhibitors.
CA2613617A1 (en) * 2005-06-27 2007-01-04 Daniel Drai Compositions and methods for enhancement of sexual function
KR20080055797A (en) * 2005-08-23 2008-06-19 닛산 가가쿠 고교 가부시키 가이샤 Sustained-release preparation
TW200738243A (en) * 2005-11-15 2007-10-16 Glaxo Group Ltd Novel process and formulations
WO2007070779A2 (en) * 2005-12-13 2007-06-21 Trinity Laboratories, Inc. A method to treat premature ejaculation in humans
US20090042972A1 (en) * 2006-05-19 2009-02-12 Somaxon Pharmaceuticals, Inc. Methods of using low-dose doxepin for the improvement of sleep
JP2009537554A (en) * 2006-05-19 2009-10-29 ソマクソン ファーマシューティカルズ インコーポレイテッド Low-dose doxepin formulations, including oral, sublingual and rapid-melt formulations, and uses thereof for treating insomnia
WO2007142810A2 (en) 2006-05-19 2007-12-13 Somaxon Pharmaceuticals, Inc. Methods of using low-dose doxepin for the improvement of sleep
US20100227916A1 (en) * 2006-05-19 2010-09-09 Somaxon Pharmaceuticals, Inc N-desmethyl-doxepin and methods of using the same to treat sleep disorders
US20100179215A1 (en) 2006-05-19 2010-07-15 Somaxon Pharmaceuticals, Inc. Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
US20080058408A1 (en) 2006-05-19 2008-03-06 Rogowski Roberta L Low-dose doxepin for treatment of sleep disorders in elderly patients
US20090042971A1 (en) * 2006-05-19 2009-02-12 Somaxon Pharmaceuticals, Inc. Method of using low-dose doxepin for the improvement of sleep
US20100179214A1 (en) 2006-05-19 2010-07-15 Somaxon Pharmaceuticals, Inc. Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
JP5230613B2 (en) 2006-05-23 2013-07-10 テラコス・インコーポレイテッド Glucose transporter inhibitor and method of use thereof
US7893053B2 (en) 2006-06-16 2011-02-22 Theracos, Inc. Treating psychological conditions using muscarinic receptor M1 antagonists
US8748419B2 (en) 2006-06-16 2014-06-10 Theracos, Inc. Treating obesity with muscarinic receptor M1 antagonists
US7915307B2 (en) 2006-07-20 2011-03-29 Somaxon Pharmaceuticals, Inc. Methods of improving the pharmacokinetics of doxepin
US20110165236A1 (en) * 2006-09-22 2011-07-07 Biokey, Inc. Controlled release hydrogel formulation
US20080075785A1 (en) * 2006-09-22 2008-03-27 San-Laung Chow Controlled release hydrogel formulation
WO2008085567A1 (en) * 2006-10-04 2008-07-17 Somaxon Pharmaceuticals, Inc. Methods of using low-dose doxepin for the improvement of sleep
US20100105614A1 (en) 2006-10-25 2010-04-29 Somaxon Pharmaceuticals, Inc. Ultra low dose doxepin and methods of using the same to treat sleep disorders
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
US20110077200A1 (en) * 2006-12-06 2011-03-31 Somaxon Pharmaceuticals, Inc. Combination therapy using low-dose doxepin for the improvement of sleep
BRPI0807282A2 (en) * 2007-02-12 2014-04-29 Dmi Biosciences Inc Early Ejaculation Treatment and Co-morbid Erectile Dysfunction
BRPI0807281A2 (en) * 2007-02-12 2014-04-29 Dmi Biosciences Inc REDUCING TRAMADOL SIDE EFFECTS
EP2121088B1 (en) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
AU2008232419B2 (en) 2007-04-02 2013-06-20 Theracos, Inc. Benzylic glycoside derivatives and methods of use
US20090074862A1 (en) 2007-04-13 2009-03-19 Luigi Schioppi Low-dose doxepin formulations and methods of making and using the same
WO2008157094A1 (en) * 2007-06-13 2008-12-24 Cypress Bioscience, Inc. Improving the tolerability of mirtazapine and a second active by using them in combination
DE102007028869A1 (en) * 2007-06-22 2008-12-24 Ratiopharm Gmbh A process for the preparation of a medicament containing tadalafil
PL2187742T3 (en) 2007-08-23 2018-06-29 Theracos Sub, Llc (2s,3r,4r,5s,6r)-2-(4-chloro-3-benzylphenyl)-6-(hydroxymethyl)tetrahydro-2h-pyran-3,4,5-triol derivatives for use in the treatment of diabetes
CA2698808A1 (en) 2007-09-13 2009-03-19 Concert Pharmaceuticals, Inc. Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
WO2009152344A2 (en) * 2008-06-11 2009-12-17 Comgenrx, Inc. Combination therapy using phosphodiesterase inhibitors
TWI523652B (en) 2008-07-15 2016-03-01 泰瑞克公司 Deuterated benzylbenzene derivatives and methods of use
AR073118A1 (en) 2008-08-22 2010-10-13 Theracos Inc PROCESSES FOR THE PREPARATION OF SGLT2 INHIBITORS AND CRYSTAL FORMS OF THE SAME.
US20100048607A1 (en) * 2008-08-25 2010-02-25 Chandrashekhar Kocherlakota Formulations comprising palonosetron
US8198268B2 (en) * 2008-10-31 2012-06-12 Janssen Biotech, Inc. Tianeptine sulfate salt forms and methods of making and using the same
AU2009324894B2 (en) 2008-11-25 2015-04-09 University Of Rochester MLK inhibitors and methods of use
US8355927B2 (en) 2010-11-05 2013-01-15 Genomind, Llc Neuropsychiatric test reports
EP2316435A1 (en) * 2009-10-22 2011-05-04 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Pharmaceutical compositions of PDE-5 inhibitors and dapoxetine
DE102009058321A1 (en) * 2009-12-15 2011-06-16 Ratiopharm Gmbh Orodispersible tablet containing dapoxetine
CA2800176C (en) 2010-05-24 2018-08-28 University Of Rochester Bicyclic heteroaryl kinase inhibitors and methods of use
WO2011156405A2 (en) * 2010-06-07 2011-12-15 Novadel Pharma Inc. Oral spray formulations and methods for administration of sildenafil
WO2011153712A1 (en) 2010-06-12 2011-12-15 Theracos, Inc. Crystalline form of benzylbenzene sglt2 inhibitor
US20120009125A1 (en) * 2010-07-06 2012-01-12 Lombard Jay L Apoe4 and apoj biomarker-based prevention and treatment of dementia
CN102958513A (en) * 2010-07-06 2013-03-06 株式会社那笔制药 Time-delayed sustained release pharmaceutical composition comprising dapoxetine for oral administration
US9592288B2 (en) 2011-02-18 2017-03-14 The Scripps Research Institute Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
US8524664B2 (en) 2011-06-02 2013-09-03 Colorado Seminary, Which owns and Operates The Univeristy of Denver Methods of treating overproduction of cortisol using ACTH antagonist peptides
BR112013033475A2 (en) * 2011-06-28 2017-12-19 Ctc Bio Inc pharmaceutical composition for treating, preventing or improving premature ejaculation and method for treating, preventing or improving premature ejaculation
WO2013030789A1 (en) * 2011-08-30 2013-03-07 Ranbaxy Laboratories Limited Pharmaceutical oral solid dosage form containing a poorly water soluble pde - iv inhibitor
CN103100085A (en) * 2011-11-09 2013-05-15 上海兰蒂斯生物医药科技有限公司 Pharmaceutical composition
DE102011122363B4 (en) 2011-12-23 2019-03-21 Thomas Magnete Gmbh Electric control for electromagnets
US20150320677A1 (en) 2012-08-17 2015-11-12 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Effervescent tablet formulations of dapoxetine and a pde5 inhibitor
WO2014027979A2 (en) 2012-08-17 2014-02-20 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Tablet formulations comprising tadalafil and dapoxetine
US20150231092A1 (en) 2012-08-17 2015-08-20 Sanovell IIac Sanayi Ve Ticaret Anonim Sirketi Novel effervescent sachet formulations of dapoxetine and a pde5 inhibitor
WO2014027975A2 (en) * 2012-08-17 2014-02-20 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Novel orally administered pharmaceutical formulations
WO2014027980A1 (en) 2012-08-17 2014-02-20 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Oral film formulations comprising dapoxetine and tadalafil
TR201309037A2 (en) 2012-08-17 2014-03-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Novel effervescent sachet formulations of dapoxetine and a pde5 inhibitor
WO2014085795A1 (en) 2012-11-30 2014-06-05 University Of Rochester Mixed lineage kinase inhibitors for hiv/aids therapies
WO2014190063A1 (en) * 2013-05-21 2014-11-27 Wynberg Jason B Methods for the treatment of premature ejaculation
MX2016008729A (en) 2013-12-31 2017-02-28 Ctc Bio Inc Pharmaceutical composition containing clomipramine and preparation method therefor.
US9657020B2 (en) 2015-01-20 2017-05-23 Xoc Pharmaceuticals, Inc. Ergoline compounds and uses thereof
BR112017015510A2 (en) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc compound of formula (i), method of treatment and / or prevention, d2 receptor agonizing method in one individual, d3 receptor antagonizing method in one individual, 5-ht1d receptor agonizing method in one individual, 5-ht1a receptor agonization in one individual, selective 5-ht1d receptor agonizing method instead of 5-ht1b receptor in one individual, 5-ht2c re-receptor selective agonizing method instead of 5-ht2a or 5 receptor -ht2b in one individual, method of 5-ht2c receptor agonization in one individual, method of providing functional antagonist activity at 5-ht2b receptor or 5-ht7 receptor, and, method of providing functional antagonist activity at adrenergic receptors in one individual
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
WO2017201071A1 (en) * 2016-05-16 2017-11-23 Foster Howell Combination therapy for male sexual dysfunction
US10726443B2 (en) 2016-07-11 2020-07-28 Samsung Electronics Co., Ltd. Deep product placement
US10575067B2 (en) 2017-01-04 2020-02-25 Samsung Electronics Co., Ltd. Context based augmented advertisement
WO2018223065A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine
US11682045B2 (en) 2017-06-28 2023-06-20 Samsung Electronics Co., Ltd. Augmented reality advertisements on objects
EP3723743A4 (en) * 2017-12-15 2021-09-08 Montero Gida Sanayi Ve Ticaret Anonim Sirketi The pharmaceutical combination comprising dapoxetine, phosphodiesterase type-5 inhibitor and anti-emetic agent
EP3646871A1 (en) 2018-10-30 2020-05-06 SEROJAC PME Handels GmbH Treatment and prevention of premature ejaculation (pe)
US20210178106A1 (en) * 2019-08-23 2021-06-17 NOTA Laboratories, LLC Nitric oxide generating systems for inhalation

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019978A1 (en) * 1994-01-21 1995-07-27 Laboratoires Glaxo Wellcome S.A. Tetracyclic derivatives, process of preparation and use
WO1999024433A1 (en) * 1997-11-12 1999-05-20 Bayer Aktiengesellschaft 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
GB2340037A (en) * 1998-07-30 2000-02-16 Glaxo Group Ltd Compositions comprising bupropion for the treatment of premature ejaculation
US6037346A (en) * 1997-10-28 2000-03-14 Vivus, Inc. Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6127363A (en) * 1997-10-28 2000-10-03 Vivus, Inc. Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6156753A (en) * 1997-10-28 2000-12-05 Vivus, Inc. Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction
WO2001019802A1 (en) * 1999-09-16 2001-03-22 Tanabe Seiyaku Co., Ltd. Aromatic nitrogenous six-membered ring compounds
EP1097711A2 (en) * 1999-11-02 2001-05-09 Pfizer Limited Treatment of pulmonary hypertension
WO2001041807A2 (en) * 1999-12-10 2001-06-14 Vivus, Inc. Transmucosal composition containing a phosphodiesterase inhibitors for the treatment of erectile dysfunction
WO2001070211A2 (en) * 2000-03-23 2001-09-27 The Regents Of The University Of California L-arginine and phosphodiesterase (pde) inhibitor synergism
WO2002003995A2 (en) * 2000-07-06 2002-01-17 Pfizer Limited Treatment of male sexual dysfunction
WO2002018333A1 (en) * 2000-08-31 2002-03-07 Pfizer Limited Phenoxybenzylamine derivatives as selective serotonin re-uptake inhibitors
WO2002040027A1 (en) * 2000-11-20 2002-05-23 Pfizer Limited Treatment of premature ejaculation

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507323A (en) 1984-07-25 1985-03-26 Burroughs Wellcome Co. Treatment of psychosexual dysfunctions
US4666908A (en) 1985-04-05 1987-05-19 Warner-Lambert Company 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
US4940731A (en) 1989-08-30 1990-07-10 Pfizer Inc. Method of treating premature ejaculation using sertraline
US5250534A (en) 1990-06-20 1993-10-05 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
GB9114760D0 (en) 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
US5151448A (en) 1991-07-12 1992-09-29 Crenshaw Roger T Method for treating premature ejaculation
US5276042A (en) 1993-04-16 1994-01-04 Crenshaw Roger T Treatment of premature ejaculation
GB9301192D0 (en) 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
IT1264965B1 (en) 1993-11-12 1996-10-17 Giorgio Cavallini USE OF ALFA 1-BLOCCANTI IN THE TREATMENT OF EARLY EJACULATION
DE4338948A1 (en) 1993-11-15 1995-05-18 Carlen Judith Treating erectile dysfunction without causing side-effects
GB9423910D0 (en) 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
GB9514473D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
DE19603321A1 (en) 1996-01-31 1997-08-07 Byk Gulden Lomberg Chem Fab New phenanthridine derivatives
US5874437A (en) 1996-11-01 1999-02-23 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
IT1291890B1 (en) 1997-04-23 1999-01-21 Pera Giuseppe CATHETER FOR DIAGNOSIS AND TREATMENT OF EARLY EJACULATION
GB9722520D0 (en) 1997-10-24 1997-12-24 Pfizer Ltd Compounds
US6228864B1 (en) 1997-10-28 2001-05-08 Vivus, Inc. Administration of 5-HT receptor agonists and antagonists, to treat premature ejaculation
AU734734B2 (en) 1997-10-28 2001-06-21 Vivus, Inc. Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6037360A (en) 1997-10-28 2000-03-14 Vivus, Incorporated Administration of 5-HT3 receptor antagonists to treat premature ejaculation
US5922341A (en) 1997-10-28 1999-07-13 Vivus, Incorporated Local administration of pharmacologically active agents to treat premature ejaculation
CA2306837C (en) 1997-10-28 2007-05-08 Asivi, Llc. Treatment of female sexual dysfunction
AUPP010397A0 (en) 1997-10-30 1997-11-20 Vaisman, Jakov Method and composition for treatment of sexual dysfunction
EP0934933A1 (en) 1998-02-06 1999-08-11 Byk Gulden Lomberg Chemische Fabrik GmbH Phthalazinones
TW542719B (en) 1998-02-23 2003-07-21 Pfizer Res & Dev Method of treating impotence due to spinal cord injury
AU3328499A (en) 1998-03-14 1999-10-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone pde iii/iv inhibitors
BR9908716A (en) 1998-05-01 2000-11-21 Neal R Cutler Treatment of sexual dysfunction in certain groups of patients
US6200591B1 (en) 1998-06-25 2001-03-13 Anwar A. Hussain Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
DE19834506A1 (en) 1998-07-31 2000-02-03 Hexal Ag Transmucosal therapeutic system for the use of sildenafil
DE19838300A1 (en) 1998-08-24 2000-03-02 Bayer Ag 9-dialkylaminopurinone derivatives
US6077841A (en) 1998-09-04 2000-06-20 Janssen Pharmaceutica, N.V. 5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction
EP1144410A2 (en) 1999-01-20 2001-10-17 Arzneimittelwerk Dresden Gmbh Use of imidazo 1,5-a]-pyrido 3,2-e]-pyrazinones as medicaments
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
AU3724400A (en) 1999-03-08 2000-09-28 Merck & Co., Inc. Methods and compositions for treating erectile dysfunction
AU765128B2 (en) 1999-03-22 2003-09-11 Bristol-Myers Squibb Company Fused pyridopyridazine inhibitors of cGMP phosphodiesterase
FR2792635B1 (en) 1999-04-20 2001-06-01 Synthelabo CYCLOBUTENE-3,4-DIONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
AU4982300A (en) 1999-05-06 2000-11-21 Pentech Pharmaceuticals, Inc. Regimen and kit for amelioration of premature ejaculation
ES2256032T3 (en) 1999-09-03 2006-07-16 Apbi Holdings, Llc USE OF DAPOXETINE, A SELECTIVE INHIBITOR OF RECOVERY OF SEROTONINE, FOR THE TREATMENT OF A SEXUAL DYSFUNCTION.
ATE524767T1 (en) 2007-07-20 2011-09-15 Zeiss Carl Smt Gmbh METHOD FOR TESTING A WAFER FOR A CONTAMINATION LIMIT AND EUV PROJECTION EXPOSURE SYSTEM

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019978A1 (en) * 1994-01-21 1995-07-27 Laboratoires Glaxo Wellcome S.A. Tetracyclic derivatives, process of preparation and use
US20020004498A1 (en) * 1997-10-28 2002-01-10 Doherty Paul C. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6037346A (en) * 1997-10-28 2000-03-14 Vivus, Inc. Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6127363A (en) * 1997-10-28 2000-10-03 Vivus, Inc. Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6156753A (en) * 1997-10-28 2000-12-05 Vivus, Inc. Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction
WO1999024433A1 (en) * 1997-11-12 1999-05-20 Bayer Aktiengesellschaft 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
GB2340037A (en) * 1998-07-30 2000-02-16 Glaxo Group Ltd Compositions comprising bupropion for the treatment of premature ejaculation
WO2001019802A1 (en) * 1999-09-16 2001-03-22 Tanabe Seiyaku Co., Ltd. Aromatic nitrogenous six-membered ring compounds
EP1219609A1 (en) * 1999-09-16 2002-07-03 Tanabe Seiyaku Co., Ltd. Aromatic nitrogenous six-membered ring compounds
EP1097711A2 (en) * 1999-11-02 2001-05-09 Pfizer Limited Treatment of pulmonary hypertension
WO2001041807A2 (en) * 1999-12-10 2001-06-14 Vivus, Inc. Transmucosal composition containing a phosphodiesterase inhibitors for the treatment of erectile dysfunction
WO2001070211A2 (en) * 2000-03-23 2001-09-27 The Regents Of The University Of California L-arginine and phosphodiesterase (pde) inhibitor synergism
WO2002003995A2 (en) * 2000-07-06 2002-01-17 Pfizer Limited Treatment of male sexual dysfunction
WO2002018333A1 (en) * 2000-08-31 2002-03-07 Pfizer Limited Phenoxybenzylamine derivatives as selective serotonin re-uptake inhibitors
WO2002040027A1 (en) * 2000-11-20 2002-05-23 Pfizer Limited Treatment of premature ejaculation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NORMAN P: "IC-351 ICOS CORP", CURRENT OPINION IN CPNS INVESTIGATIONAL DRUGS, PHARMA PRESS, LONDON,, GB, vol. 1, no. 2, 1999, pages 268 - 271, XP001021217, ISSN: 1464-844X *
SORBERA L A ET AL: "VARDENAFIL TREATMENT OF ERECTILE DYSFUNCTION PHOSPHODIESTERASE 5 INHIBITOR", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 26, no. 2, 2001, pages 141 - 144, XP001096442, ISSN: 0377-8282 *
SORBERA L A: "IC-351 TREATMENT OF ERECTILE DYSFUNCTION TREATMENT OF FEMALE SEXUAL SYSFUNCTION PHOSPHODIESTERASE 5 INHIBITOR GF-196960 CIALIS(TM)", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 26, no. 1, 2001, pages 15 - 19, XP001021114, ISSN: 0377-8282 *

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