WO2003000777A3 - Multi-arm block copolymers as drug delivery vehicles - Google Patents

Multi-arm block copolymers as drug delivery vehicles Download PDF

Info

Publication number
WO2003000777A3
WO2003000777A3 PCT/US2002/021872 US0221872W WO03000777A3 WO 2003000777 A3 WO2003000777 A3 WO 2003000777A3 US 0221872 W US0221872 W US 0221872W WO 03000777 A3 WO03000777 A3 WO 03000777A3
Authority
WO
WIPO (PCT)
Prior art keywords
block copolymers
hydrophobic
drug delivery
delivery vehicles
polymer segment
Prior art date
Application number
PCT/US2002/021872
Other languages
French (fr)
Other versions
WO2003000777A2 (en
Inventor
Xuan Zhao
Original Assignee
Shearwater Corp
Xuan Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shearwater Corp, Xuan Zhao filed Critical Shearwater Corp
Priority to MXPA03006449A priority Critical patent/MXPA03006449A/en
Priority to DE60208172T priority patent/DE60208172T2/en
Priority to AT02761075T priority patent/ATE313586T1/en
Priority to AU2002326369A priority patent/AU2002326369B2/en
Priority to KR1020037009604A priority patent/KR100851270B1/en
Priority to EP02761075A priority patent/EP1373366B1/en
Priority to JP2003507177A priority patent/JP4078300B2/en
Priority to CA2435301A priority patent/CA2435301C/en
Publication of WO2003000777A2 publication Critical patent/WO2003000777A2/en
Publication of WO2003000777A3 publication Critical patent/WO2003000777A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/914—Polymers modified by chemical after-treatment derived from polycarboxylic acids and polyhydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
    • C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
    • C08G65/2609—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups containing aliphatic hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/22—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the initiator used in polymerisation
    • C08G2650/24—Polymeric initiators
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another

Abstract

The invention provides multi-arm block copolymers useful as drug delivery vehicles comprising a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, methods of making such copolymers and pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.
PCT/US2002/021872 2001-01-19 2002-01-22 Multi-arm block copolymers as drug delivery vehicles WO2003000777A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MXPA03006449A MXPA03006449A (en) 2001-01-19 2002-01-22 Multi-arm block copolymers as drug delivery vehicles.
DE60208172T DE60208172T2 (en) 2001-01-19 2002-01-22 MULTICOLORED BLOCK COPOLYMERS AND PHARMACEUTICAL COMPOSITION
AT02761075T ATE313586T1 (en) 2001-01-19 2002-01-22 MULTI-ARM BLOCK COPOLYMERS AND PHARMACEUTICAL COMPOSITION
AU2002326369A AU2002326369B2 (en) 2001-01-19 2002-01-22 Multi-arm block copolymers as drug delivery vehicles
KR1020037009604A KR100851270B1 (en) 2001-01-19 2002-01-22 Multi-arm block copolymers as drug delivery vehicles
EP02761075A EP1373366B1 (en) 2001-01-19 2002-01-22 Multi-arm block copolymers and pharmaceutical compositions
JP2003507177A JP4078300B2 (en) 2001-01-19 2002-01-22 Multi-arm block copolymers as drug delivery vehicles
CA2435301A CA2435301C (en) 2001-01-19 2002-01-22 Multi-arm block copolymers as drug delivery vehicles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26275401P 2001-01-19 2001-01-19
US60/262,754 2001-01-19

Publications (2)

Publication Number Publication Date
WO2003000777A2 WO2003000777A2 (en) 2003-01-03
WO2003000777A3 true WO2003000777A3 (en) 2003-05-01

Family

ID=22998880

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/021872 WO2003000777A2 (en) 2001-01-19 2002-01-22 Multi-arm block copolymers as drug delivery vehicles

Country Status (12)

Country Link
US (6) US6730334B2 (en)
EP (1) EP1373366B1 (en)
JP (1) JP4078300B2 (en)
KR (1) KR100851270B1 (en)
AT (1) ATE313586T1 (en)
AU (1) AU2002326369B2 (en)
CA (1) CA2435301C (en)
DE (1) DE60208172T2 (en)
ES (1) ES2254717T3 (en)
MX (1) MXPA03006449A (en)
TW (1) TWI246524B (en)
WO (1) WO2003000777A2 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906381B2 (en) 2008-10-12 2014-12-09 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IGG humoral response without T-cell antigen
US8932595B2 (en) 2008-10-12 2015-01-13 Massachusetts Institute Of Technology Nicotine immunonanotherapeutics
US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
US9233072B2 (en) 2008-10-12 2016-01-12 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
US9308280B2 (en) 2008-10-12 2016-04-12 Massachusetts Institute Of Technology Targeting of antigen presenting cells with immunonanotherapeutics
US9333179B2 (en) 2007-04-04 2016-05-10 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
US9381477B2 (en) 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US9474717B2 (en) 2007-10-12 2016-10-25 Massachusetts Institute Of Technology Vaccine nanotechnology
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals

Families Citing this family (191)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
TWI246524B (en) * 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US7265186B2 (en) * 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US7009033B2 (en) * 2001-07-02 2006-03-07 Polymer Source Inc. Heterofunctional polyethylene glycol and polyethylene oxide, process for their manufacture
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
KR20040040782A (en) * 2002-11-08 2004-05-13 선바이오(주) Novel hexa-arm polyethylene glycol and its derivatives and the methods of preparation thereof
EP2405015B1 (en) 2003-03-05 2016-01-06 Halozyme, Inc. Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
JP2005008614A (en) * 2003-03-28 2005-01-13 Nano Career Kk Drug delivery system for ophthalmology by using macromolecular micelle
US7482376B2 (en) * 2003-07-03 2009-01-27 3-Dimensional Pharmaceuticals, Inc. Conjugated complement cascade inhibitors
TWI248947B (en) * 2003-07-21 2006-02-11 Ind Tech Res Inst Biodegradable copolymer, and polymeric micelle composition containing the copolymer
EP1525890A1 (en) 2003-10-02 2005-04-27 Complex Biosystems GmbH Protein-Proteophore complexes
EP1670838B1 (en) * 2003-10-10 2015-12-09 Samyang Biopharmaceuticals Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
NZ586034A (en) 2004-02-02 2011-10-28 Ambrx Inc Modified human growth hormone polypeptides and their uses
US7354980B1 (en) 2004-03-12 2008-04-08 Key Medical Technologies, Inc. High refractive index polymers for ophthalmic applications
US7588745B2 (en) * 2004-04-13 2009-09-15 Si Options, Llc Silicon-containing products
ATE402971T1 (en) * 2004-05-05 2008-08-15 Firmenich & Cie BIODEGRADABLE GRAFT COPOLYMERS
WO2005118877A2 (en) * 2004-06-02 2005-12-15 Vicus Bioscience, Llc Producing, cataloging and classifying sequence tags
US7632924B2 (en) 2004-06-18 2009-12-15 Ambrx, Inc. Antigen-binding polypeptides and their uses
EP1773375A1 (en) 2004-07-14 2007-04-18 University of Utah Research Foundation Netrin-related compositions and uses
RU2393168C2 (en) 2004-07-19 2010-06-27 Биокон Лимитед Insulin-oligomer conjugates, preparations and use thereof
MX301374B (en) * 2004-10-08 2012-07-16 Firmenich & Cie Amphiphilic star block copolymers.
US7446157B2 (en) 2004-12-07 2008-11-04 Key Medical Technologies, Inc. Nanohybrid polymers for ophthalmic applications
US7736872B2 (en) 2004-12-22 2010-06-15 Ambrx, Inc. Compositions of aminoacyl-TRNA synthetase and uses thereof
KR101224781B1 (en) 2004-12-22 2013-01-21 암브룩스, 인코포레이티드 Formulations of human growth hormone comprising a non-naturally encoded amino acid
HUE048419T2 (en) 2004-12-22 2020-08-28 Nitto Denko Corp Drug carrier and drug carrier kit for inhibiting fibrosis
JP2008525032A (en) 2004-12-22 2008-07-17 アンブレツクス・インコーポレイテツド Methods for expressing and purifying recombinant human growth hormone
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
CA2594557C (en) 2004-12-22 2016-04-26 Ambrx, Inc. Modified human growth hormone
EP1871343A2 (en) 2005-04-12 2008-01-02 Wisconsin Alumni Research Foundation Micelle composition of polymer and passenger drug
US20060263328A1 (en) * 2005-05-19 2006-11-23 Sang Van Hydrophilic polymers with pendant functional groups and method thereof
KR100664558B1 (en) 2005-05-23 2007-01-03 박기동 Amphiphilic copolymer having multi functional group and preparation method thereof
JP2008541769A (en) 2005-06-03 2008-11-27 アンブレツクス・インコーポレイテツド Improved human interferon molecules and their use
CA2653541C (en) 2005-06-06 2014-12-23 The University Of British Columbia Polymer-based serum albumin substitute
EP1898955A2 (en) * 2005-06-17 2008-03-19 Nektar Therapeutics AL, Corporation Polymer-based compositions and conjugates of non-steroidal anti-inflammatory drugs
US20070009564A1 (en) * 2005-06-22 2007-01-11 Mcclain James B Drug/polymer composite materials and methods of making the same
KR100642220B1 (en) * 2005-07-12 2006-11-03 광주과학기술원 Conjugates of cyclodextrin and poly(oxyethylene) and process for preparation thereof
PL1909973T3 (en) 2005-07-15 2019-01-31 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
EP2412744B1 (en) 2005-07-18 2014-01-22 Nektar Therapeutics Method for preparing branched functionalised polymers using branched polyol cores
US20100272769A1 (en) * 2005-08-03 2010-10-28 Amcol International Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use
US20080184618A1 (en) * 2005-08-03 2008-08-07 Amcol International Virus-Interacting Layered Phyllosilicates and Methods of Use
US20070031512A1 (en) * 2005-08-03 2007-02-08 Amcol International Corporation Virus-interacting layered phyllosilicates and methods of inactivating viruses
ATE477291T1 (en) * 2005-10-25 2010-08-15 Evonik Degussa Gmbh PREPARATIONS COMPRISING HYPERBRANCHED POLYMERS
DE102005051342A1 (en) * 2005-10-25 2007-04-26 Goldschmidt Gmbh Encapsulation and controlled release of biologically active drugs with enzymatically degradable hyperbranched carrier polymers
CN101454461A (en) 2005-11-16 2009-06-10 Ambrx公司 Methods and compositions comprising non-natural amino acids
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
SI1979407T1 (en) 2006-01-19 2015-01-30 Allexcel, Inc. Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers
US9603941B2 (en) * 2006-01-24 2017-03-28 Minghui Chai Method of preparing dendritic drugs
US8309680B2 (en) * 2006-02-21 2012-11-13 Nektar Therapeutics Segmented degradable polymers and conjugates made therefrom
US8852625B2 (en) 2006-04-26 2014-10-07 Micell Technologies, Inc. Coatings containing multiple drugs
CA2652280C (en) * 2006-05-15 2014-01-28 Massachusetts Institute Of Technology Polymers for functional particles
US20100015068A1 (en) * 2006-07-06 2010-01-21 Massachusetts Institute Of Technology Methods and Compositions For Altering Biological Surfaces
US20100022481A1 (en) * 2006-08-02 2010-01-28 Dong Wang Drug Carriers, Their Synthesis, and Methods of Use Thereof
EP2046391A4 (en) * 2006-08-02 2013-03-20 Univ Nebraska Drug carriers, their synthesis, and methods of use thereof
DE102006038240A1 (en) * 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Process for the preparation of a composite of oligo- or polynucleotides and hydrophobic biodegradable polymers and composite obtained by the process
DK2061878T3 (en) 2006-09-08 2014-04-07 Ambrx Inc HYBRID SUPPRESSOR TRNA FOR ANIMAL CELLS
MX2009002526A (en) 2006-09-08 2009-04-16 Ambrx Inc Suppressor trna transcription in vertebrate cells.
JP5840345B2 (en) * 2006-09-08 2016-01-06 アンブルックス, インコーポレイテッドAmbrx, Inc. Modified human plasma polypeptides or modified human Fc scaffold proteins and uses thereof
US8636767B2 (en) 2006-10-02 2014-01-28 Micell Technologies, Inc. Surgical sutures having increased strength
CN102886326A (en) * 2006-10-23 2013-01-23 米歇尔技术公司 Holder for electrically charging a substrate during coating
US20080153982A1 (en) * 2006-12-20 2008-06-26 John Ta-Yuan Lai Vinyl-Thiocarbonate and Polyol Containing Block Copolymers
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
US9737642B2 (en) 2007-01-08 2017-08-22 Micell Technologies, Inc. Stents having biodegradable layers
JP5052919B2 (en) * 2007-03-08 2012-10-17 成均▲館▼大學校 産學協力團 PH and temperature sensitive block copolymer hydrogel
TWI407971B (en) 2007-03-30 2013-09-11 Nitto Denko Corp Cancer cells and tumor-related fibroblasts
KR101476472B1 (en) 2007-03-30 2015-01-05 암브룩스, 인코포레이티드 Modified fgf-21 polypeptides and their uses
JP5443336B2 (en) * 2007-04-17 2014-03-19 ミセル テクノロジーズ、インコーポレイテッド Stent with biodegradable layer
EP1982698A1 (en) * 2007-04-18 2008-10-22 Evonik Degussa GmbH Preparations for controlled release of natural bioactive materials
NZ580686A (en) 2007-05-02 2012-11-30 Ambrx Inc Modified interferon beta polypeptides and their uses
EP2431043A1 (en) 2007-05-23 2012-03-21 Amcol International Corporation Cholesterol-interacting layered phyllosilicates for suppressing gastrointestinal cholesterol absorption
EP2170418B1 (en) * 2007-05-25 2016-03-16 Micell Technologies, Inc. Polymer films for medical device coating
WO2008150845A1 (en) * 2007-05-31 2008-12-11 Vanderbilt University Screening for wnt pathway modulators and pyrvinium for the treatment of cance
US8178617B2 (en) 2007-07-16 2012-05-15 Allvivo Vascular, Inc. Antimicrobial constructs
US20110130822A1 (en) * 2007-07-20 2011-06-02 Orbusneich Medical, Inc. Bioabsorbable Polymeric Compositions and Medical Devices
EP2207570A2 (en) 2007-09-14 2010-07-21 Nitto Denko Corporation Drug carriers
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
WO2009051780A1 (en) * 2007-10-19 2009-04-23 Micell Technologies, Inc. Drug coated stents
CN101835496B (en) * 2007-10-23 2015-11-25 尼克塔治疗公司 The multiarm polymers of hydroxyapatite-targeting and the conjugate by its manufacture
AU2008326324B9 (en) 2007-11-20 2012-11-15 Ambrx, Inc. Modified insulin polypeptides and their uses
US9801818B2 (en) 2007-12-31 2017-10-31 Samyang Biopharmaceuticals Corporation Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
KR101024742B1 (en) * 2007-12-31 2011-03-24 주식회사 삼양사 Amphiphilic Block Copolymer Micelle Composition Containing Taxane and Manufacturing Process of The Same
US9938333B2 (en) 2008-02-08 2018-04-10 Ambrx, Inc. Modified leptin polypeptides and their uses
TWI395593B (en) 2008-03-06 2013-05-11 Halozyme Inc In vivo temporal control of activatable matrix-degrading enzymes
KR101647932B1 (en) 2008-04-14 2016-08-11 할로자임, 아이엔씨 Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
AU2009251504B2 (en) 2008-04-17 2013-09-05 Micell Technologies, Inc. Stents having bioabsorbable layers
TWI394580B (en) 2008-04-28 2013-05-01 Halozyme Inc Super fast-acting insulin compositions
AU2009268528B2 (en) * 2008-07-09 2015-11-05 Board Of Regents Of The University Of Nebraska Functional micelles for hard tissue targeted delivery of chemicals
JP2011528275A (en) 2008-07-17 2011-11-17 ミセル テクノロジーズ，インク． Drug delivery medical device
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
ES2963062T3 (en) 2008-07-23 2024-03-25 Ambrx Inc Modified bovine G-CSF polypeptides and their uses
US9991391B2 (en) * 2008-07-25 2018-06-05 The Board Of Trustees Of The Leland Stanford Junior University Pristine and functionalized graphene materials
ES2744975T3 (en) 2008-09-23 2020-02-27 Nektar Therapeutics Metronome dosage method with camptothecin prodrugs (eg PEG-Irinotecan)
BRPI0919403A2 (en) 2008-09-26 2017-09-26 Ambrx Inc modified animal erythropoietin polypeptides and their uses
NZ592249A (en) 2008-09-26 2013-03-28 Ambrx Inc Non-natural amino acid replication-dependent microorganisms and vaccines
CN101724144A (en) 2008-11-03 2010-06-09 北京键凯科技有限公司 Novel multi-arm polyethylene glycol, preparation method and application thereof
PT3037529T (en) 2008-12-09 2019-05-31 Halozyme Inc Extended soluble ph20 polypeptides and uses thereof
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
WO2010111196A2 (en) * 2009-03-23 2010-09-30 Micell Technologies, Inc. Peripheral stents having layers
EP2411083A4 (en) 2009-03-23 2013-11-13 Micell Technologies Inc Drug delivery medical device
CA2756388C (en) * 2009-03-23 2015-10-27 Micell Technologies, Inc. Biodegradable polymers with low acidic impurity
CN102481195B (en) 2009-04-01 2015-03-25 米歇尔技术公司 Drug delivery medical device
EP2419058B1 (en) 2009-04-17 2018-02-28 Micell Technologies, Inc. Stents having controlled elution
CN101869712B (en) * 2009-04-21 2016-01-20 财团法人工业技术研究院 The polymeric micelle of encapsulation antitumor drug is used to be used for the treatment of the pharmaceutical composition of tumor
CN106137479B (en) 2009-05-14 2017-12-05 奥巴斯尼茨医学公司 Self-expandable stent with polygon transition region
US8013065B2 (en) * 2009-06-09 2011-09-06 International Business Machines Corporation Methods for making multi-branched polymers
DK2477603T3 (en) 2009-09-17 2016-06-13 Baxalta Inc STABLE CO-DEVELOPMENT OF hyaluronidase and Immunoglobulin, AND METHODS OF USE THEREOF
US20110070320A1 (en) * 2009-09-23 2011-03-24 Soonkap Hahn Biodegradable thermoresponsive 3-arm polyethylene glycol poly(lactide-co-glycolide) copolymer for ginseng administration
CN104017063A (en) 2009-12-21 2014-09-03 Ambrx公司 Modified porcine somatotropin polypeptides and their uses
CN107674121A (en) 2009-12-21 2018-02-09 Ambrx 公司 Bovine somatotropin polypeptide and its purposes by modification
EP2531140B1 (en) 2010-02-02 2017-11-01 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
WO2011106877A1 (en) 2010-03-01 2011-09-09 The University Of British Columbia Derivatized hyperbranched polyglycerols
US8795762B2 (en) * 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US8765098B2 (en) 2010-03-30 2014-07-01 International Business Machines Corporation Star polymers, methods of preparation thereof, and uses thereof
WO2011133655A1 (en) 2010-04-22 2011-10-27 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
JP2013533217A (en) 2010-05-17 2013-08-22 セビックス・インコーポレイテッド PEGylated C-peptide
EP2585533B1 (en) 2010-06-25 2017-05-17 E. I. du Pont de Nemours and Company Polyoxymethylene compositions with branched polymers
CA2805631C (en) 2010-07-16 2018-07-31 Micell Technologies, Inc. Drug delivery medical device
ES2661089T3 (en) 2010-07-20 2018-03-27 Halozyme Inc. Methods of treatment or prevention of adverse side effects associated with the administration of an anti-hyaluronan agent
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
EP2605789B1 (en) 2010-08-17 2019-06-05 Ambrx, Inc. Modified relaxin polypeptides and their uses
AR083006A1 (en) 2010-09-23 2013-01-23 Lilly Co Eli FORMULATIONS FOR THE STIMULATING FACTOR OF COLONIES OF GRANULOCITS (G-CSF) BOVINE AND VARIANTS OF THE SAME
WO2012070030A1 (en) * 2010-11-26 2012-05-31 University Of The Witwatersrand, Johannesburg A pharmaceutical composition
EP2658527B1 (en) 2010-12-30 2022-11-30 Micell Technologies, Inc. Nanoparticle and surface-modified particulate coatings, coated balloons, and methods therefore
WO2012109387A1 (en) 2011-02-08 2012-08-16 Halozyme, Inc. Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
WO2012142319A1 (en) 2011-04-13 2012-10-18 Micell Technologies, Inc. Stents having controlled elution
US10464100B2 (en) 2011-05-31 2019-11-05 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
US20130011378A1 (en) 2011-06-17 2013-01-10 Tzung-Horng Yang Stable formulations of a hyaluronan-degrading enzyme
WO2012174480A2 (en) 2011-06-17 2012-12-20 Halozyme, Inc. Continuous subcutaneous insulin infusion methods with a hyaluronan degrading enzyme
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
US8445577B2 (en) * 2011-07-25 2013-05-21 Iowa State University Research Foundation, Inc. Amphiphilic multi-arm copolymers and nanomaterials derived therefrom
WO2013040501A1 (en) 2011-09-16 2013-03-21 Pharmathene, Inc. Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
BR112014009797A2 (en) 2011-10-24 2020-10-27 Halozyme, Inc. Company diagnosis for anti-hyaluronan agent therapy and methods of its use
PT3130347T (en) 2011-12-30 2019-12-10 Halozyme Inc Ph20 polypeptide variants, formulations and uses thereof
BR112014024291B1 (en) 2012-03-30 2022-07-05 The Board Of Regents Of The University Of Oklahoma METHOD FOR THE RECOMBINANT PRODUCTION OF A HEPAROSAN POLYMER WITH HIGH MOLECULAR WEIGHT, USE OF SUCH TISSUE ANCREASEMENT POLYMER, ISOLATED POLYNUCLEOTIDE AND COMPOSITION OF BIOLOGICAL MATERIAL COMPRISING SUCH POLYMER
CA2986512C (en) 2012-04-04 2022-05-17 Halozyme, Inc. Combination therapy with an anti-hyaluronan agent and a tumor-targeted taxane
WO2013176739A1 (en) * 2012-05-25 2013-11-28 Regents Of The University Of Minnesota Biomaterials with a sustainable surface
US9738724B2 (en) 2012-06-08 2017-08-22 Sutro Biopharma, Inc. Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
EP2863955B1 (en) 2012-06-26 2016-11-23 Sutro Biopharma, Inc. Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
SI3584255T1 (en) 2012-08-31 2022-05-31 Sutro Biopharma, Inc Modified amino acids comprising an azido group
CN102861610B (en) * 2012-09-03 2014-05-07 宁波长阳科技有限公司 Hyperbranched amido pyridine contained catalyst, preparation methods of catalyst and application of catalyst
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
CN103910874A (en) * 2013-01-06 2014-07-09 张雅珍 Preparation and application of medicine-grafted polymer
CN104193987A (en) * 2013-01-21 2014-12-10 张雅珍 Preparation and uses of grafted medicine polymers
JP6330024B2 (en) 2013-03-12 2018-05-23 マイセル・テクノロジーズ，インコーポレイテッド Bioabsorbable biomedical implant
WO2014172261A1 (en) * 2013-04-15 2014-10-23 Kent State University Biodegradable side chain liquid crystal elastomers: smart responsive scaffolds (srs) for tissue regeneration
CN105377318A (en) 2013-05-15 2016-03-02 脉胜医疗技术公司 Bioabsorbable biomedical implants
TW201534726A (en) 2013-07-03 2015-09-16 Halozyme Inc Thermally stable PH20 hyaluronidase variants and uses thereof
ES2658039T3 (en) 2013-07-10 2018-03-08 Sutro Biopharma, Inc. Antibodies comprising multiple site-specific non-natural amino acid residues, methods for their preparation and methods of use
CN104910373A (en) * 2013-08-25 2015-09-16 张雅珍 New polymer, preparation and application thereof
CN104619246B (en) 2013-09-09 2016-11-30 甘布罗伦迪亚股份公司 In pressure signal, disturbing pulse separates with physiologic pulse
WO2015038966A1 (en) * 2013-09-12 2015-03-19 Regents Of The University Of Minnesota Semi-solid delivery systems
US9433638B1 (en) 2013-10-02 2016-09-06 University Of Kentucky Research Foundation Polymeric prodrug
WO2015054658A1 (en) 2013-10-11 2015-04-16 Sutro Biopharma, Inc. Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
CN107148265B (en) 2014-07-02 2019-04-05 纽约州立大学研究基金会 The micelle composition for having removed surfactant with high loaded article and surfactant ratio
WO2016033555A1 (en) 2014-08-28 2016-03-03 Halozyme, Inc. Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
JP6625627B2 (en) 2014-10-14 2019-12-25 ハロザイム インコーポレイテッド Compositions of adenosine deaminase-2 (ADA2), variants thereof and methods of using the same
KR20240024362A (en) 2014-10-24 2024-02-23 브리스톨-마이어스 스큅 컴퍼니 Modified fgf-21 polypeptides and uses thereof
CN105395483B (en) * 2015-12-21 2018-09-28 江南大学 One kind can deoxidization, degradation dissaving polymer nano-micelle and preparation method thereof
US10792477B2 (en) 2016-02-08 2020-10-06 Orbusneich Medical Pte. Ltd. Drug eluting balloon
CN110201242A (en) 2016-02-08 2019-09-06 祥丰医疗私人有限公司 A kind of medical device
CN105778021B (en) 2016-04-05 2018-07-10 华南理工大学 Beta-cyclodextrin base star polymer and preparation method and its unimolecular micelle diagnosis and treatment integral system
EP3512560A4 (en) * 2016-09-13 2020-05-27 Rasna Research Inc. Dactinomycin compositions and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
US20180085498A1 (en) 2016-09-23 2018-03-29 Micell Technologies, Inc. Prolonged drug-eluting products
US11027040B2 (en) 2016-12-29 2021-06-08 Industrial Technology Research Institute Method for manufacturing a porous film, porous film and method for tissue adhesion
MX2019008449A (en) 2017-02-08 2019-09-09 Bristol Myers Squibb Co Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof.
SG11201912071QA (en) 2017-06-22 2020-01-30 Catalyst Biosciences Inc Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
US10457759B2 (en) 2017-07-20 2019-10-29 International Business Machines Corporation Co-delivery of cholesterol lowering drugs and nutraceuticals
US11299587B2 (en) 2017-12-27 2022-04-12 Sanyo Chemical Industries, Ltd. Starting material, for bulk drug or additives for drug, and bulk drug or drug using same
CN108707212B (en) * 2018-05-02 2020-01-07 上海交通大学 Controllable preparation method of water-soluble conjugated polymer nanoparticles
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
SG11202102427XA (en) 2018-09-11 2021-04-29 Ambrx Inc Interleukin-2 polypeptide conjugates and their uses
EP3867265A1 (en) 2018-10-19 2021-08-25 Ambrx, Inc. Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
CN109608633A (en) * 2018-11-09 2019-04-12 北京诺康达医药科技股份有限公司 A kind of novel specific multi-arm polyethylene glycol derivative and preparation method thereof
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use
CA3176021A1 (en) 2018-12-28 2020-07-02 Catalyst Biosciences, Inc. Modified urokinase-type plasminogen activator polypeptides and methods of use
EP3680273B1 (en) * 2019-01-08 2022-03-09 Université de Montpellier Branched-block copolymer photo-crosslinker functionalized with photoreactive groups and its use for shaping degradable photo-crosslinked elastomers suitable for medical and tissue-engineering applications
JP2022520792A (en) 2019-02-12 2022-04-01 アンブルックス，インコーポレイテッド Compositions, Methods, and Uses Containing Antibody-TLR Agonist Conjugates
CN109929083B (en) * 2019-04-10 2020-04-28 浙江大学 Narrow molecular weight distribution multi-block copolymer and preparation method thereof
CN110078901A (en) * 2019-05-24 2019-08-02 上海典范医疗科技有限公司 A kind of poly-dl-lactide preparation method
EP3862032A1 (en) 2020-02-07 2021-08-11 Micell Technologies, Inc. Stents having biodegradable layers
IL296099A (en) 2020-03-11 2022-11-01 Ambrx Inc Interleukin-2 polypeptide conjugates and methods of use thereof
CN111759552A (en) 2020-07-06 2020-10-13 苏州莱诺医疗器械有限公司 Absorbable stent system
WO2022040596A1 (en) 2020-08-20 2022-02-24 Ambrx, Inc. Antibody-tlr agonist conjugates, methods and uses thereof
IL307282A (en) 2021-04-03 2023-11-01 Ambrx Inc Anti-her2 antibody-drug conjugates and uses thereof
CN113416302B (en) * 2021-07-08 2022-06-17 中国科学院兰州化学物理研究所 Mercaptan-acrylate biomaterial and preparation method and application thereof
CN114713206B (en) * 2022-03-15 2023-11-14 沈阳工业大学 Preparation and application of imidazole ionic liquid functionalized star-type block polymer stationary phase

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3101374A (en) * 1958-08-19 1963-08-20 Wyandotte Chemicals Corp Polyoxyalkylene surface active agents having heteric polyoxyethylene solubilizing chains
US4278555A (en) * 1978-11-15 1981-07-14 Ethyl Corporation Lubricant composition
EP0462408A2 (en) * 1990-06-01 1991-12-27 Bayer Ag Functional aqueous liquids based on novel polyoxyalkylene polymers
US5429826A (en) * 1992-01-23 1995-07-04 Eastman Kodak Company Chemically fixed micelles
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
WO1999045964A1 (en) * 1998-03-12 1999-09-16 Shearwater Polymers, Incorporated Poly(ethylene glycol) derivatives with proximal reactive groups

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US673034A (en) * 1900-08-07 1901-04-30 Russel B Sigafoos Trussed ladder.
ZA801659B (en) 1979-03-21 1981-10-28 N Graham Controlled release compositions
JPS59155432A (en) 1983-02-22 1984-09-04 Rikagaku Kenkyusho Surface-modified polymer having molecular chain of large mobility
US5135751A (en) 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US6436425B1 (en) 1988-11-16 2002-08-20 Mdv Technologies, Inc. Method and non-gelling composition for inhibiting post-surgical adhesions
US5681576A (en) 1988-11-16 1997-10-28 Mdv Technologies, Inc. Method and composition for post surgical adhesion reduction
US5306501A (en) 1990-05-01 1994-04-26 Mediventures, Inc. Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers
WO1992000748A1 (en) 1990-07-06 1992-01-23 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
IE912365A1 (en) 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5965566A (en) 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5618528A (en) 1994-02-28 1997-04-08 Sterling Winthrop Inc. Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
EP0876165B1 (en) 1995-12-18 2006-06-21 Angiotech BioMaterials Corp. Crosslinked polymer compositions and methods for their use
US5610241A (en) 1996-05-07 1997-03-11 Cornell Research Foundation, Inc. Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
US6011042A (en) 1997-10-10 2000-01-04 Enzon, Inc. Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
AU740342B2 (en) 1997-12-12 2001-11-01 Samyang Corporation Biodegradable mixed polymeric micelles for gene delivery
ATE255422T1 (en) 1998-01-07 2003-12-15 Debio Rech Pharma Sa DEGRADABLE, HETEROBIFUNCTIONAL POLYETHYLENE GLYCOL ACRYLATES, AND GEL AND CONJUGATES THAT CAN BE PRODUCED THEM
US20030059465A1 (en) * 1998-05-11 2003-03-27 Unger Evan C. Stabilized nanoparticle formulations of camptotheca derivatives
US6328988B1 (en) 1999-04-23 2001-12-11 Rutgers, The State University Of New Jersey Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
US6348558B1 (en) 1999-12-10 2002-02-19 Shearwater Corporation Hydrolytically degradable polymers and hydrogels made therefrom
US20020041898A1 (en) * 2000-01-05 2002-04-11 Unger Evan C. Novel targeted delivery systems for bioactive agents
JP2003520210A (en) 2000-01-05 2003-07-02 イマレックス セラピューティクス， インコーポレイテッド Pharmaceutical formulations for delivery of drugs with low water solubility
US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
FI109162B (en) * 2000-06-30 2002-05-31 Nokia Corp Method and arrangement for decoding a convolution-coded codeword
TWI246524B (en) * 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US7265186B2 (en) 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3101374A (en) * 1958-08-19 1963-08-20 Wyandotte Chemicals Corp Polyoxyalkylene surface active agents having heteric polyoxyethylene solubilizing chains
US4278555A (en) * 1978-11-15 1981-07-14 Ethyl Corporation Lubricant composition
EP0462408A2 (en) * 1990-06-01 1991-12-27 Bayer Ag Functional aqueous liquids based on novel polyoxyalkylene polymers
US5429826A (en) * 1992-01-23 1995-07-04 Eastman Kodak Company Chemically fixed micelles
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
WO1999045964A1 (en) * 1998-03-12 1999-09-16 Shearwater Polymers, Incorporated Poly(ethylene glycol) derivatives with proximal reactive groups

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
US9381477B2 (en) 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
US9333179B2 (en) 2007-04-04 2016-05-10 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
US9474717B2 (en) 2007-10-12 2016-10-25 Massachusetts Institute Of Technology Vaccine nanotechnology
US9526702B2 (en) 2007-10-12 2016-12-27 Massachusetts Institute Of Technology Vaccine nanotechnology
US9539210B2 (en) 2007-10-12 2017-01-10 Massachusetts Institute Of Technology Vaccine nanotechnology
US9308280B2 (en) 2008-10-12 2016-04-12 Massachusetts Institute Of Technology Targeting of antigen presenting cells with immunonanotherapeutics
US9233072B2 (en) 2008-10-12 2016-01-12 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US9439859B2 (en) 2008-10-12 2016-09-13 Massachusetts Institute Of Technology Adjuvant incorporation in immunoanotherapeutics
US8906381B2 (en) 2008-10-12 2014-12-09 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IGG humoral response without T-cell antigen
US8932595B2 (en) 2008-10-12 2015-01-13 Massachusetts Institute Of Technology Nicotine immunonanotherapeutics

Also Published As

Publication number Publication date
KR20040032092A (en) 2004-04-14
AU2002326369B2 (en) 2007-03-15
US20090299050A1 (en) 2009-12-03
CA2435301C (en) 2010-04-13
US6730334B2 (en) 2004-05-04
EP1373366A2 (en) 2004-01-02
US20080234430A1 (en) 2008-09-25
US20120046422A1 (en) 2012-02-23
WO2003000777A2 (en) 2003-01-03
ES2254717T3 (en) 2006-06-16
US20040170595A1 (en) 2004-09-02
US20130144014A1 (en) 2013-06-06
ATE313586T1 (en) 2006-01-15
DE60208172T2 (en) 2006-07-13
US6838528B2 (en) 2005-01-04
US20020156047A1 (en) 2002-10-24
DE60208172D1 (en) 2006-01-26
US8071692B2 (en) 2011-12-06
JP2004531627A (en) 2004-10-14
EP1373366B1 (en) 2005-12-21
JP4078300B2 (en) 2008-04-23
KR100851270B1 (en) 2008-08-08
MXPA03006449A (en) 2004-10-15
US8586681B2 (en) 2013-11-19
CA2435301A1 (en) 2003-01-03
US7589157B2 (en) 2009-09-15
TWI246524B (en) 2006-01-01
US8338545B2 (en) 2012-12-25

Similar Documents

Publication Publication Date Title
WO2003000777A3 (en) Multi-arm block copolymers as drug delivery vehicles
WO2003044076A8 (en) Bioerodible poly(ortho esters) containing amine groups, and block copolymers containing them
MXPA05007146A (en) Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles.
CA2430481A1 (en) Compositions for sustained delivery of hydrophobic drugs and process for the preparation thereof
WO2001049258A3 (en) Methods and compositions for improved delivery devices
WO2004009664A3 (en) Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from
WO2006094737A3 (en) Gastroresistant pharmaceutical formulations containing rifaximin
WO2001047562A3 (en) Hydrolytically degradable carbamate derivatives of poly(ethylene glycol)
CA2348016A1 (en) Controlled release liquid delivery compositions with low initial drug burst
CA2379672A1 (en) Biodegradable poly(alkylene oxide)-poly(p-dioxanone) block copolymer soluble in organic solvents, and drug delivery composition comprising same
CA2523987A1 (en) Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
WO2005011813A3 (en) Treatment of ocular disease
EP1832289A3 (en) Compositions and coatings for implantable medical devices
CA2439500A1 (en) Drug delivery system for hydrophobic drugs
SI1638539T1 (en) Pharmaceutical compositions comprising ph-sensitive block copolymers and a hydrophobic drug
CA2416109A1 (en) Solid dose nanoparticulate compositions
WO2004082628A3 (en) Improved bioavailability and improved delivery of acidic pharmaceutical drugs
WO2004112713A3 (en) Drug polymer complexes
WO1997025052A3 (en) Compositions comprising pvp having an average molecular weight in the range of 3,000 to 14,000 daltons
CA2395077A1 (en) Liquid composition of biodegradable block copolymer for drug delivery system and process for the preparation thereof
TW200610540A (en) Pharmaceutical compositions
CA2308520A1 (en) Strictly alternating poly(alkylene oxide ether) copolymers
WO2004046328A3 (en) Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
DK1392254T3 (en) Micelle drug delivery system for hydrophobic drugs
EP2014307A3 (en) Micellar drug delivery vehicles and uses thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2435301

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PA/a/2003/006449

Country of ref document: MX

Ref document number: 2003507177

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 1020037009604

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2002326369

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2002761075

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2002761075

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020037009604

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 2002761075

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 2002326369

Country of ref document: AU