WO2003004006A2 - Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis - Google Patents
Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis Download PDFInfo
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- WO2003004006A2 WO2003004006A2 PCT/IB2002/003295 IB0203295W WO03004006A2 WO 2003004006 A2 WO2003004006 A2 WO 2003004006A2 IB 0203295 W IB0203295 W IB 0203295W WO 03004006 A2 WO03004006 A2 WO 03004006A2
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- kit
- inhibitor
- activated
- compounds
- cells
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- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/482,177 US20040266797A1 (en) | 2001-06-29 | 2002-06-28 | Use of potent,selective and non toxic c-kit inhibitors for treating tumor angiogensis |
JP2003510017A JP2004530730A (en) | 2001-06-29 | 2002-06-28 | Use of a potent, selective and non-toxic c-kit inhibitor for treating tumor angiogenesis |
CA002452366A CA2452366A1 (en) | 2001-06-29 | 2002-06-28 | Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis |
EP02755510A EP1401412A2 (en) | 2001-06-29 | 2002-06-28 | Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30140701P | 2001-06-29 | 2001-06-29 | |
US60/301,407 | 2001-06-29 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2003004006A2 true WO2003004006A2 (en) | 2003-01-16 |
WO2003004006A3 WO2003004006A3 (en) | 2003-05-30 |
WO2003004006A8 WO2003004006A8 (en) | 2003-08-21 |
Family
ID=23163212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2002/003295 WO2003004006A2 (en) | 2001-06-29 | 2002-06-28 | Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis |
Country Status (5)
Country | Link |
---|---|
US (1) | US20040266797A1 (en) |
EP (1) | EP1401412A2 (en) |
JP (1) | JP2004530730A (en) |
CA (1) | CA2452366A1 (en) |
WO (1) | WO2003004006A2 (en) |
Cited By (9)
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EP2366703A1 (en) | 2007-02-13 | 2011-09-21 | AB Science | Polymorph form of 2-amino (nitroaryl) thiazole derivative |
US8110591B2 (en) | 2003-10-23 | 2012-02-07 | Ab Science | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
WO2013014170A1 (en) | 2011-07-27 | 2013-01-31 | Ab Science | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) |
US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
US8658659B2 (en) | 2005-04-04 | 2014-02-25 | Ab Science | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors |
US8835435B2 (en) | 2002-08-02 | 2014-09-16 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
WO2020188015A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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EP1401413B1 (en) | 2001-06-29 | 2006-11-22 | AB Science | Use of tyrosine kinase inhibitions for treating allergic diseases |
DE60212627T2 (en) * | 2001-06-29 | 2007-06-14 | Ab Science | Use of tyrosine kinase inhibitors for the treatment of inflammatory diseases |
JP2005500041A (en) * | 2001-06-29 | 2005-01-06 | アブ サイエンス | Potent, selective and non-toxic C-KIT inhibitor |
JP2004537542A (en) * | 2001-06-29 | 2004-12-16 | アブ サイエンス | Use of a tyrosine kinase inhibitor for treating inflammatory bowel disease (IBD) |
WO2003024386A2 (en) * | 2001-09-20 | 2003-03-27 | Ab Science | Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis |
CA2461182A1 (en) * | 2001-09-20 | 2003-05-01 | Ab Science | Use of tyrosine kinase inhibitors for promoting hair growth |
PT1478380E (en) * | 2002-02-27 | 2006-12-29 | Ab Science | Use of tyrosine kinase inhibitors for treating cns disorders |
KR20210063782A (en) | 2019-11-25 | 2021-06-02 | 주식회사 노벨티노빌리티 | Antibodies Against c-kit and Uses Thereof |
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US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
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US8110591B2 (en) | 2003-10-23 | 2012-02-07 | Ab Science | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
US8658659B2 (en) | 2005-04-04 | 2014-02-25 | Ab Science | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors |
US8153792B2 (en) | 2007-02-13 | 2012-04-10 | Ab Science | Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors |
EP2366703A1 (en) | 2007-02-13 | 2011-09-21 | AB Science | Polymorph form of 2-amino (nitroaryl) thiazole derivative |
US8940894B2 (en) | 2007-02-13 | 2015-01-27 | Ab Science | Aminothiazole compounds as kinase inhibitors and methods of using the same |
WO2013014170A1 (en) | 2011-07-27 | 2013-01-31 | Ab Science | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) |
US9168245B2 (en) | 2011-07-27 | 2015-10-27 | Ab Science | Selective protein kinase inhibitors |
WO2020188015A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
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Also Published As
Publication number | Publication date |
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WO2003004006A3 (en) | 2003-05-30 |
EP1401412A2 (en) | 2004-03-31 |
JP2004530730A (en) | 2004-10-07 |
CA2452366A1 (en) | 2003-01-16 |
WO2003004006A8 (en) | 2003-08-21 |
US20040266797A1 (en) | 2004-12-30 |
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