WO2003019145A3 - Non-fluorescent quencher compounds and biomolecular assays - Google Patents
Non-fluorescent quencher compounds and biomolecular assays Download PDFInfo
- Publication number
- WO2003019145A3 WO2003019145A3 PCT/US2002/027256 US0227256W WO03019145A3 WO 2003019145 A3 WO2003019145 A3 WO 2003019145A3 US 0227256 W US0227256 W US 0227256W WO 03019145 A3 WO03019145 A3 WO 03019145A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- quencher
- electron
- useful
- fluorescent
- diazo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
- C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
- C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
- C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
- C07C245/10—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
- C07C255/65—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms
- C07C255/67—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms having cyano groups and azido groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/141—Esters of phosphorous acids
- C07F9/1411—Esters of phosphorous acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002326774A AU2002326774A1 (en) | 2001-08-27 | 2002-08-27 | Non-fluorescent quencher compounds and biomolecular assays |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/942,342 US20030082547A1 (en) | 2001-08-27 | 2001-08-27 | Non-fluorescent quencher compounds and biomolecular assays |
US09/942,342 | 2001-08-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003019145A2 WO2003019145A2 (en) | 2003-03-06 |
WO2003019145A3 true WO2003019145A3 (en) | 2003-08-14 |
Family
ID=25477956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/027256 WO2003019145A2 (en) | 2001-08-27 | 2002-08-27 | Non-fluorescent quencher compounds and biomolecular assays |
Country Status (3)
Country | Link |
---|---|
US (7) | US20030082547A1 (en) |
AU (1) | AU2002326774A1 (en) |
WO (1) | WO2003019145A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9234233B2 (en) | 2010-03-26 | 2016-01-12 | Integrated Dna Technologies, Inc. | Methods for enhancing nucleic acid hybridization |
US9506057B2 (en) | 2010-03-26 | 2016-11-29 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
US9506059B2 (en) | 2010-03-26 | 2016-11-29 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6350253B1 (en) * | 1999-07-19 | 2002-02-26 | I-Flow Corporation | Catheter for uniform delivery of medication |
US7019129B1 (en) | 2000-05-09 | 2006-03-28 | Biosearch Technologies, Inc. | Dark quenchers for donor-acceptor energy transfer |
GB0111459D0 (en) * | 2001-05-10 | 2001-07-04 | Isis Innovation | Universal fluorescent sensors |
US20030082547A1 (en) * | 2001-08-27 | 2003-05-01 | Ewing Gregory J. | Non-fluorescent quencher compounds and biomolecular assays |
WO2004000995A2 (en) * | 2002-05-22 | 2003-12-31 | Marshall University | Methods, probes, and accessory molecules for detecting single nucleotide polymorphisms |
JP4694201B2 (en) * | 2002-09-20 | 2011-06-08 | インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド | Anthraquinone quenching dyes, their production and use |
US7927840B2 (en) * | 2006-09-11 | 2011-04-19 | Gen Probe Incorporated | Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region |
US7439341B2 (en) * | 2003-11-14 | 2008-10-21 | Integrated Dna Technologies, Inc. | Fluorescence quenching azo dyes, their methods of preparation and use |
US7635598B2 (en) | 2004-07-08 | 2009-12-22 | Biosearch Technologies, Inc. | Inducible fluorescence assay |
US7879986B2 (en) * | 2005-02-04 | 2011-02-01 | Berry & Associates, Inc. | Dark quenchers, probes and other conjugates incorporating the same, and their use |
EP1907560B1 (en) | 2005-05-20 | 2013-01-23 | Integrated DNA Technologies, Inc. | Compounds and methods for labeling oligonucleotides |
US20070218490A1 (en) * | 2006-03-15 | 2007-09-20 | Integrated Dna Technologies, Inc. | Nucleic acid monomers with 2'-chemical moieties |
AU2009225835B2 (en) * | 2008-03-15 | 2013-02-14 | Hologic, Inc. | Compositions and methods for analysis of nucleic acid molecules during amplification reactions |
CN102037144B (en) | 2008-04-01 | 2013-09-25 | 生物检索技术股份有限公司 | Stabilized nucleic acid dark quencher-fluorophore probes |
KR101834574B1 (en) | 2009-01-29 | 2018-03-05 | 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 | Measuring g protein coupled receptor activation |
WO2010090756A2 (en) * | 2009-02-06 | 2010-08-12 | Anaspec, Inc. | Fret-assays, methods for performing the assays and compounds relevant to the assays |
NZ701769A (en) | 2009-09-16 | 2016-06-24 | Genentech Inc | Coiled coil and/or tether containing protein complexes and uses thereof |
TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
CN103384825B (en) | 2010-12-23 | 2017-05-24 | 霍夫曼-拉罗奇有限公司 | Detection of a posttranslationally modified polypeptide by a bi-valent binding agent |
SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
US10112988B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide |
US10112987B2 (en) * | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide |
KR20150023889A (en) | 2012-06-27 | 2015-03-05 | 에프. 호프만-라 로슈 아게 | Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof |
WO2014001325A1 (en) | 2012-06-27 | 2014-01-03 | F. Hoffmann-La Roche Ag | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
ITFI20130093A1 (en) | 2013-04-29 | 2014-10-30 | Univ Firenze | DYES NATURALIZED WITH THE UNIT 6¿-DEOSSI-6¿- (PIPERAZINIL) LACTOSE. |
EP3227332B1 (en) | 2014-12-03 | 2019-11-06 | F.Hoffmann-La Roche Ag | Multispecific antibodies |
SG11201708480YA (en) * | 2015-04-15 | 2017-12-28 | Biosearch Tech Inc | Dual quencher probes |
CN105254517B (en) * | 2015-09-30 | 2017-08-25 | 上海安诺其集团股份有限公司 | A kind of naphthalene cycle compound and preparation method thereof |
IL291323B2 (en) | 2016-07-15 | 2023-09-01 | Am Chemicals Llc | Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis |
EP3592757A2 (en) | 2017-03-09 | 2020-01-15 | ELITechGroup, Inc. | Nitrodiarylethenes as fluorescence quenchers for nucleic acid probes |
US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
US10677728B2 (en) | 2017-08-17 | 2020-06-09 | Elitechgroup B.V. | Duplex stabilizing fluorescence quenchers for nucleic acid probes |
WO2023095166A1 (en) * | 2021-11-23 | 2023-06-01 | Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) | Substituted diazenylanilines as fluorescence quencher and use thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999064431A2 (en) * | 1998-06-10 | 1999-12-16 | Intergen Company | Purines and pyrimidines linked to a quencher |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2830943A (en) | 1955-11-03 | 1958-04-15 | Gen Electric | Method for controlling the irradiation of polyethylene |
US2945849A (en) | 1957-03-04 | 1960-07-19 | Bayer Ag | Disazo compounds containing a quaternary ammonium group |
US3369013A (en) | 1965-07-12 | 1968-02-13 | Eastman Kodak Co | Disazo dyes |
US3445452A (en) | 1965-12-10 | 1969-05-20 | Eastman Kodak Co | Azobenzene-azo-aniline dyestuffs containing a pyrrolidinono,a piperidono or a phthalimidono group |
DE1930261C3 (en) | 1969-06-13 | 1979-05-03 | Bayer Ag, 5090 Leverkusen | Disazo dyes and their use for dyeing nitrogen-containing fiber materials |
US4069012A (en) | 1974-03-26 | 1978-01-17 | Cassella Farbwerke Mainkur Aktiengesellschaft | Dyeing of polyester fabric with disazo dye |
US4313872A (en) | 1976-02-02 | 1982-02-02 | Cassella Aktiengesellschaft | Azo coupling in two-phase water-alcohol mixtures |
EP0098522B1 (en) | 1982-06-30 | 1989-06-07 | Hitachi, Ltd. | Liquid crystal composition |
US4623716A (en) | 1984-11-01 | 1986-11-18 | Usv Pharmaceutical Corp. | Process for the preparation and purification of peptides |
US4888385A (en) | 1987-04-30 | 1989-12-19 | Millipore Corporation | BOP reagent for solid phase peptide synthesis |
US4965349A (en) | 1987-12-24 | 1990-10-23 | Applied Biosystems, Inc. | Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports |
US5492821A (en) * | 1990-11-14 | 1996-02-20 | Cargill, Inc. | Stabilized polyacrylic saccharide protein conjugates |
US5384411A (en) | 1991-06-20 | 1995-01-24 | Hewlett-Packard Company | Immobilization of PH-sensitive dyes to solid supports |
CA2176348C (en) | 1993-11-12 | 2004-11-02 | Sanjay Tyagi | Hybridization probes for nucleic acid detection, universal stems, methods and kits |
US5925517A (en) * | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
US5736626A (en) | 1996-01-29 | 1998-04-07 | The Perkin-Elmer Corporation | Solid support reagents for the direct synthesis of 3'-labeled polynucleotides |
WO1997039008A1 (en) * | 1996-04-12 | 1997-10-23 | The Public Health Research Institute Of The City Of New York, Inc. | Detection probes, kits and assays |
EP0816326B1 (en) * | 1996-07-02 | 2000-05-10 | Bayer Ag | Process for preparing mono- and polyspartic acid esters |
US5866336A (en) * | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
US5821356A (en) | 1996-08-12 | 1998-10-13 | The Perkin Elmer Corporation | Propargylethoxyamino nucleotides |
US5770716A (en) * | 1997-04-10 | 1998-06-23 | The Perkin-Elmer Corporation | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
US5846726A (en) * | 1997-05-13 | 1998-12-08 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
US5928869A (en) * | 1997-05-30 | 1999-07-27 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
US6008379A (en) | 1997-10-01 | 1999-12-28 | The Perkin-Elmer Corporation | Aromatic-substituted xanthene dyes |
US6080868A (en) * | 1998-01-23 | 2000-06-27 | The Perkin-Elmer Corporation | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds |
US6037130A (en) * | 1998-07-28 | 2000-03-14 | The Public Health Institute Of The City Of New York, Inc. | Wavelength-shifting probes and primers and their use in assays and kits |
WO2000075378A1 (en) | 1999-06-09 | 2000-12-14 | Biosearch Technologies, Inc. | Fluorescence energy transfer probes with stabilized conformations |
US6472153B1 (en) | 1999-10-26 | 2002-10-29 | Epoch Biosciences, Inc. | Hybridization-triggered fluorescent detection of nucleic acids |
US6660845B1 (en) | 1999-11-23 | 2003-12-09 | Epoch Biosciences, Inc. | Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
US6727356B1 (en) | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
US7019129B1 (en) | 2000-05-09 | 2006-03-28 | Biosearch Technologies, Inc. | Dark quenchers for donor-acceptor energy transfer |
US20030082547A1 (en) * | 2001-08-27 | 2003-05-01 | Ewing Gregory J. | Non-fluorescent quencher compounds and biomolecular assays |
-
2001
- 2001-08-27 US US09/942,342 patent/US20030082547A1/en not_active Abandoned
-
2002
- 2002-08-27 AU AU2002326774A patent/AU2002326774A1/en not_active Abandoned
- 2002-08-27 WO PCT/US2002/027256 patent/WO2003019145A2/en not_active Application Discontinuation
-
2003
- 2003-04-30 US US10/425,674 patent/US20040005607A1/en not_active Abandoned
-
2004
- 2004-07-23 US US10/897,583 patent/US20050164225A1/en not_active Abandoned
-
2008
- 2008-04-04 US US12/098,378 patent/US20090105452A1/en not_active Abandoned
-
2010
- 2010-12-16 US US12/970,829 patent/US20110245462A1/en not_active Abandoned
-
2012
- 2012-02-01 US US13/363,594 patent/US20120220751A1/en not_active Abandoned
- 2012-09-27 US US13/629,021 patent/US8637658B2/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999064431A2 (en) * | 1998-06-10 | 1999-12-16 | Intergen Company | Purines and pyrimidines linked to a quencher |
US6117986A (en) * | 1998-06-10 | 2000-09-12 | Intergen Company, L.P. | Pyrimidines linked to a quencher |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9234233B2 (en) | 2010-03-26 | 2016-01-12 | Integrated Dna Technologies, Inc. | Methods for enhancing nucleic acid hybridization |
US9506057B2 (en) | 2010-03-26 | 2016-11-29 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
US9506059B2 (en) | 2010-03-26 | 2016-11-29 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
Also Published As
Publication number | Publication date |
---|---|
US20050164225A1 (en) | 2005-07-28 |
US20120220751A1 (en) | 2012-08-30 |
US20130123475A1 (en) | 2013-05-16 |
WO2003019145A2 (en) | 2003-03-06 |
US20030082547A1 (en) | 2003-05-01 |
AU2002326774A1 (en) | 2003-03-10 |
US8637658B2 (en) | 2014-01-28 |
US20110245462A1 (en) | 2011-10-06 |
US20040005607A1 (en) | 2004-01-08 |
US20090105452A1 (en) | 2009-04-23 |
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