WO2003024957A1 - Derives de benzimidazole - Google Patents

Derives de benzimidazole Download PDF

Info

Publication number
WO2003024957A1
WO2003024957A1 PCT/JP2002/009551 JP0209551W WO03024957A1 WO 2003024957 A1 WO2003024957 A1 WO 2003024957A1 JP 0209551 W JP0209551 W JP 0209551W WO 03024957 A1 WO03024957 A1 WO 03024957A1
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic effect
benzimidazole derivatives
difference
individuals
compounds
Prior art date
Application number
PCT/JP2002/009551
Other languages
English (en)
French (fr)
Inventor
Masaaki Nagasawa
Hiroyasu Nishioka
Kazuyasu Asami
Naoyoshi Miura
Yutaka Shinozaki
Hitoshi Morita
Original Assignee
Zeria Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharmaceutical Co., Ltd. filed Critical Zeria Pharmaceutical Co., Ltd.
Priority to US10/380,158 priority Critical patent/US6884810B2/en
Priority to AU2002332178A priority patent/AU2002332178B2/en
Priority to KR10-2003-7014459A priority patent/KR20040025677A/ko
Priority to EP02767961A priority patent/EP1428825A4/en
Priority to JP2003528804A priority patent/JP4020076B2/ja
Priority to CA002445513A priority patent/CA2445513A1/en
Publication of WO2003024957A1 publication Critical patent/WO2003024957A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
PCT/JP2002/009551 2001-09-18 2002-09-18 Derives de benzimidazole WO2003024957A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/380,158 US6884810B2 (en) 2001-09-18 2002-09-18 Benzimidazole derivatives
AU2002332178A AU2002332178B2 (en) 2001-09-18 2002-09-18 Benzimidazole derivatives
KR10-2003-7014459A KR20040025677A (ko) 2001-09-18 2002-09-18 벤즈이미다졸 유도체
EP02767961A EP1428825A4 (en) 2001-09-18 2002-09-18 benzimidazole derivatives
JP2003528804A JP4020076B2 (ja) 2001-09-18 2002-09-18 ベンズイミダゾール誘導体
CA002445513A CA2445513A1 (en) 2001-09-18 2002-09-18 Benzimidazole derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001282918 2001-09-18
JP2001-282918 2001-09-18
JP2002096101 2002-03-29
JP2002-96101 2002-03-29

Publications (1)

Publication Number Publication Date
WO2003024957A1 true WO2003024957A1 (fr) 2003-03-27

Family

ID=26622397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/009551 WO2003024957A1 (fr) 2001-09-18 2002-09-18 Derives de benzimidazole

Country Status (8)

Country Link
US (1) US6884810B2 (ja)
EP (1) EP1428825A4 (ja)
JP (1) JP4020076B2 (ja)
KR (1) KR20040025677A (ja)
CN (1) CN1243749C (ja)
AU (1) AU2002332178B2 (ja)
CA (1) CA2445513A1 (ja)
WO (1) WO2003024957A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004077367A1 (ja) * 2003-02-25 2004-09-10 Zeria Pharmaceutical Co. Ltd. 四環系スルフェンアミド化合物
JP2007522182A (ja) * 2004-02-12 2007-08-09 イスティチュート スペリオーレ ディ サニータ プロトンポンプ阻害剤の新規使用
JP2008534446A (ja) * 2005-03-25 2008-08-28 リブゾン ファーマシューティカル グループ インク． 置換スルホキシド化合物、その調製方法、およびその使用方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2003082854A1 (ja) * 2002-03-29 2005-08-04 ゼリア新薬工業株式会社 １−ｎ−アミノベンズイミダゾール誘導体
CN101492459B (zh) * 2008-01-25 2011-04-27 山东轩竹医药科技有限公司 含烷氧乙酰基二氢异噁唑并吡啶化合物
EP2514841A1 (en) * 2008-01-25 2012-10-24 Theranostics Laboratory Methods and compositions for the assessment of drug response

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689333A (en) * 1984-08-16 1987-08-25 Takeda Chemical Industries, Ltd. 2-(2-pyridylmethylthio (sulfinyl)) benzimidazoles
EP0268956A2 (en) * 1986-11-13 1988-06-01 Eisai Co., Ltd. Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same
EP0356143A1 (en) * 1988-08-18 1990-02-28 Takeda Chemical Industries, Ltd. Injectable solutions
EP0382489A2 (en) * 1989-02-10 1990-08-16 Takeda Chemical Industries, Ltd. Use of benzimidazole derivatives as antibacterial agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
ZA854287B (en) 1984-06-16 1986-02-26 Byk Gulden Lomberg Chem Fab Dialkoxypyridines,process for their preparation,their use and medicaments containing them
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
US4738975A (en) 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
JPH0717631B2 (ja) 1986-03-04 1995-03-01 武田薬品工業株式会社 ピリジニウム誘導体およびその製造法
JPH0674272B2 (ja) 1986-11-13 1994-09-21 エーザイ株式会社 ピリジン誘導体及びそれを含有する潰瘍治療剤
US5223515A (en) * 1988-08-18 1993-06-29 Takeda Chemical Industries, Ltd. Injectable solution containing a pyridyl methylsulfinylbenzimidazole
US5877192A (en) * 1993-05-28 1999-03-02 Astra Aktiebolag Method for the treatment of gastric acid-related diseases and production of medication using (-) enantiomer of omeprazole
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689333A (en) * 1984-08-16 1987-08-25 Takeda Chemical Industries, Ltd. 2-(2-pyridylmethylthio (sulfinyl)) benzimidazoles
EP0268956A2 (en) * 1986-11-13 1988-06-01 Eisai Co., Ltd. Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same
EP0356143A1 (en) * 1988-08-18 1990-02-28 Takeda Chemical Industries, Ltd. Injectable solutions
EP0382489A2 (en) * 1989-02-10 1990-08-16 Takeda Chemical Industries, Ltd. Use of benzimidazole derivatives as antibacterial agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KUBO K. ET AL.: "Synthesis of 2-(((4-fluoroalkoxy-2-pyridyl)methyl)sulfonyl)-1H-benzimidazoles as antiulcer agents", CHEMICAL AND PARMACEUTICAL BULLETIN, vol. 38, no. 10, October 1990 (1990-10-01), TOKYO, JP, pages 2853 - 2858, XP002150630 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004077367A1 (ja) * 2003-02-25 2004-09-10 Zeria Pharmaceutical Co. Ltd. 四環系スルフェンアミド化合物
JP2007522182A (ja) * 2004-02-12 2007-08-09 イスティチュート スペリオーレ ディ サニータ プロトンポンプ阻害剤の新規使用
JP2008534446A (ja) * 2005-03-25 2008-08-28 リブゾン ファーマシューティカル グループ インク． 置換スルホキシド化合物、その調製方法、およびその使用方法
JP4837722B2 (ja) * 2005-03-25 2011-12-14 リブゾン ファーマシューティカル グループ インク． 置換スルホキシド化合物、その調製方法、およびその使用方法

Also Published As

Publication number Publication date
JPWO2003024957A1 (ja) 2004-12-24
US6884810B2 (en) 2005-04-26
AU2002332178B2 (en) 2005-12-08
EP1428825A4 (en) 2005-03-23
CN1243749C (zh) 2006-03-01
JP4020076B2 (ja) 2007-12-12
CA2445513A1 (en) 2003-03-27
CN1511153A (zh) 2004-07-07
US20030236411A1 (en) 2003-12-25
EP1428825A1 (en) 2004-06-16
KR20040025677A (ko) 2004-03-24

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