WO2003039598A8 - Selective norepinephrine serotonin reuptake inhibitors for treating fibromyalgia syndrome, chronic fatique syndrome and pain - Google Patents

Selective norepinephrine serotonin reuptake inhibitors for treating fibromyalgia syndrome, chronic fatique syndrome and pain

Info

Publication number
WO2003039598A8
WO2003039598A8 PCT/US2002/035396 US0235396W WO03039598A8 WO 2003039598 A8 WO2003039598 A8 WO 2003039598A8 US 0235396 W US0235396 W US 0235396W WO 03039598 A8 WO03039598 A8 WO 03039598A8
Authority
WO
WIPO (PCT)
Prior art keywords
syndrome
pain
serotonin reuptake
reuptake inhibitors
selective norepinephrine
Prior art date
Application number
PCT/US2002/035396
Other languages
French (fr)
Other versions
WO2003039598A1 (en
Inventor
Srinivas G Rao
Jay D Kranzler
Original Assignee
Cypress Bioscience Inc
Srinivas G Rao
Jay D Kranzler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cypress Bioscience Inc, Srinivas G Rao, Jay D Kranzler filed Critical Cypress Bioscience Inc
Priority to EP02793880A priority Critical patent/EP1463528B1/en
Priority to AT02793880T priority patent/ATE552856T1/en
Priority to CA002467356A priority patent/CA2467356C/en
Priority to ES02793880T priority patent/ES2395462T3/en
Publication of WO2003039598A1 publication Critical patent/WO2003039598A1/en
Publication of WO2003039598A8 publication Critical patent/WO2003039598A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention provides a method of treating, in a mammal, chronic fatigue syndrome (CFS), chronic fatigue syndrome (CFS) that is associated with depression, a combination of chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS), fibromyalgia syndrome (FMS) associated with depression, pain and pain associated with depression. The method includes administering a therapeutically effective amount of a dual serotonin norepinepbrine reuptake inhibitor compound or a pharmaceutically acceptable salt thereof.
PCT/US2002/035396 2001-11-05 2002-11-05 Selective norepinephrine serotonin reuptake inhibitors for treating fibromyalgia syndrome, chronic fatique syndrome and pain WO2003039598A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02793880A EP1463528B1 (en) 2001-11-05 2002-11-05 Selective norepinephrine serotonin reuptake inhibitors for treating fibromyalgia syndrome, chronic fatique syndrome and pain
AT02793880T ATE552856T1 (en) 2001-11-05 2002-11-05 SELECTIVE NOREPINEPHRINE-SEROTONIN REUPPOST INHIBITORS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME, CHRONIC FATIGUE SYNDROME AND PAIN
CA002467356A CA2467356C (en) 2001-11-05 2002-11-05 Selective norepinephrine serotonin reuptake inhibitors for treating fibromyalgia syndrome, chronic fatigue syndrome and pain
ES02793880T ES2395462T3 (en) 2001-11-05 2002-11-05 Selective norepinephrine-serotonin reuptake inhibitors for the treatment of fibromyalgia syndrome, chronic fatigue syndrome and pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/014,149 2001-11-05
US10/014,149 US6635675B2 (en) 2001-11-05 2001-11-05 Method of treating chronic fatigue syndrome

Publications (2)

Publication Number Publication Date
WO2003039598A1 WO2003039598A1 (en) 2003-05-15
WO2003039598A8 true WO2003039598A8 (en) 2004-06-03

Family

ID=21763814

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/035396 WO2003039598A1 (en) 2001-11-05 2002-11-05 Selective norepinephrine serotonin reuptake inhibitors for treating fibromyalgia syndrome, chronic fatique syndrome and pain

Country Status (7)

Country Link
US (1) US6635675B2 (en)
EP (2) EP2322225B1 (en)
AT (1) ATE552856T1 (en)
CA (1) CA2467356C (en)
ES (2) ES2433080T3 (en)
PT (2) PT2322225E (en)
WO (1) WO2003039598A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070117869A1 (en) * 2000-11-01 2007-05-24 Cognition Pharmaceuticals Llc Methods for treating coginitive impairment and improving cognition
US20050059743A1 (en) * 2000-11-01 2005-03-17 Sention, Inc. Methods for treating mild cognitive impairment and alzheimer's disease
WO2005000203A2 (en) * 2001-10-31 2005-01-06 Sention, Inc. Methods for treating cognitive impairment and improving cognition
US7619005B2 (en) * 2000-11-01 2009-11-17 Cognition Pharmaceuticals Llc Methods for treating cognitive impairment in humans with Multiple Sclerosis
US20030232890A1 (en) * 2000-11-01 2003-12-18 Sention, Inc. Methods for treating an impairment in memory consolidation
US20030119884A1 (en) * 2000-11-01 2003-06-26 Epstein Mel H. Methods and compositions for regulating memory consolidation
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
US20040034101A1 (en) * 2001-11-05 2004-02-19 Cypress Bioscience, Inc. Treatment and prevention of depression secondary to pain (DSP)
AU2003213009A1 (en) * 2002-02-12 2003-09-04 Cypress Bioscience, Inc. Methods of treating attention deficit/hyperactivity disorder (adhd)
CN1671368A (en) * 2002-07-24 2005-09-21 柏树生物科学公司 Treatment of depression secondary to pain (DSP)
MXPA05001705A (en) * 2002-08-14 2005-04-19 Pharmacia & Upjohn Co Llc Use of reboxetine for the treatment of hot flashes.
MXPA05003550A (en) * 2002-10-03 2006-01-24 Cypress Bioscience Inc Dosage escalation and divided daily dose of anti-depressants to treat neurological disorders.
US7704527B2 (en) * 2002-10-25 2010-04-27 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
EP1572187A1 (en) * 2002-12-13 2005-09-14 Warner-Lambert Company LLC Pregabalin and derivatives thereof for the treatment of fibromyalgia and other related disorders
FR2851163B1 (en) * 2003-02-14 2007-04-27 USE OF DEXTROGYAN ENANTIOMER OF MILNACIPRAN FOR THE PREPARATION OF A MEDICINAL PRODUCT
BRPI0407256A (en) * 2003-02-14 2006-01-31 Pf Medicament Use of the milnacipran enantiomer (1s, 2r) for the preparation of a medicament
CA2538412A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Combination comprising an alpha-2-delta ligand and an ssri and/or snri for treatment of depression and anxiety disorders
US20050181050A1 (en) * 2004-01-28 2005-08-18 Collegium Pharmaceutical, Inc. Dosage forms using drug-loaded ion exchange resins
GB0409744D0 (en) * 2004-04-30 2004-06-09 Pfizer Ltd Novel compounds
EP1745029A1 (en) * 2004-04-30 2007-01-24 Warner-Lambert Company LLC Substituted morpholine compounds for the treatment of central nervous system disorders
WO2006081518A2 (en) * 2005-01-28 2006-08-03 Collegium Pharmaceutical, Inc. Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents
US7956050B2 (en) 2005-07-15 2011-06-07 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
WO2008009663A1 (en) * 2006-07-19 2008-01-24 Boehringer Ingelheim International Gmbh Treatment of pain
EP2114868A2 (en) * 2007-02-28 2009-11-11 Ranbaxy Laboratories Limited Novel polymorphic forms of milnacipran hydrochloride
JP2010043063A (en) 2008-05-09 2010-02-25 Agency For Science Technology & Research Diagnosis and treatment of kawasaki disease
FR2944011B1 (en) 2009-04-03 2011-05-20 Pf Medicament AMINOCYCLOBUTANE OR AMINOCYCLOBUTENE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR USE AS MEDICAMENTS.
WO2010129689A1 (en) * 2009-05-05 2010-11-11 Forest Laboratories Holdings Limited Milnacipran formulations
JP5739415B2 (en) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー (S) -7-([1,2,4] triazolo [1,5-a] pyridin-6-yl) -4- (3,4-dichlorophenyl) -1,2,3,4-tetrahydroisoquinoline Crystal forms and uses thereof
DK2429296T3 (en) 2009-05-12 2018-03-12 Albany Molecular Res Inc 7 - ([1,2,4,] TRIAZOLO [1,5, -A] PYRIDIN-6-YL) -4- (3,4-DICHLORPHENYL) -1,2,3,4- TETRAHYDROISOQUINOLINE AND USE thereof
CA2779711C (en) * 2009-11-06 2016-11-01 Forest Laboratories Holding Limited Novel crystalline forms of (1s,2r)-2-(amino methyl)-n,n-diethyl-1-phenyl cyclopropane carboxamide
WO2012024397A2 (en) 2010-08-17 2012-02-23 Albany Molecular Research, Inc. 2,5-methano-and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
FR2978350B1 (en) 2011-07-28 2013-11-08 Pf Medicament LEVOMILNACIPRAN-BASED MEDICINAL PRODUCT FOR FUNCTIONAL REHABILITATION AFTER ACUTE NEUROLOGICAL ACCIDENT

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508035A1 (en) 1981-06-23 1982-12-24 Fabre Sa Pierre ARYL-1-AMINOMETHYL-2 CYCLOPROPANES CARBOXAMIDE (Z) DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
IT1188212B (en) 1985-12-20 1988-01-07 Paolo Colombo SYSTEM FOR THE RELEASE SPEED OF ACTIVE SUBSTANCES
US4891223A (en) 1987-09-03 1990-01-02 Air Products And Chemicals, Inc. Controlled release delivery coating formulation for bioactive substances
FR2640972B1 (en) 1988-12-28 1991-04-19 Pf Medicament
IT1237904B (en) 1989-12-14 1993-06-18 Ubaldo Conte CONTROLLED SPEED RELEASE TABS OF ACTIVE SUBSTANCES
CA2041774C (en) 1990-11-27 1994-04-19 Mircea A. Mateescu Use of cross-linked amylose as a matrix for the slow release of biologically active compounds
US5603956A (en) 1990-11-27 1997-02-18 Labopharm Inc. Cross-linked enzymatically controlled drug release
US5326570A (en) 1991-07-23 1994-07-05 Pharmavene, Inc. Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine
GB9215043D0 (en) 1992-07-15 1992-08-26 Flow Inc K Fluid mass flow meters
US5260069A (en) 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
US5455046A (en) 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5773025A (en) 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
US5397574A (en) 1993-10-04 1995-03-14 Andrx Pharmaceuticals, Inc. Controlled release potassium dosage form
US5399358A (en) 1993-11-12 1995-03-21 Edward Mendell Co., Inc. Sustained release formulations for 24 hour release of metroprolol
US5419917A (en) 1994-02-14 1995-05-30 Andrx Pharmaceuticals, Inc. Controlled release hydrogel formulation
WO1995022521A1 (en) 1994-02-22 1995-08-24 Asahi Kasei Kogyo Kabushiki Kaisha Aminoalkylcyclopropane derivative
US5458887A (en) 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
US5458888A (en) 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
US5399359A (en) 1994-03-04 1995-03-21 Edward Mendell Co., Inc. Controlled release oxybutynin formulations
JP4157969B2 (en) 1994-03-18 2008-10-01 スパーナス ファーマシューティカルズ インコーポレイテッド Emulsified drug delivery system
US5399362A (en) 1994-04-25 1995-03-21 Edward Mendell Co., Inc. Once-a-day metoprolol oral dosage form
US5464633A (en) 1994-05-24 1995-11-07 Jagotec Ag Pharmaceutical tablets releasing the active substance after a definite period of time
US6103263A (en) 1994-11-17 2000-08-15 Andrx Pharmaceuticals, Inc. Delayed pulse release hydrogel matrix tablet
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US5567441A (en) 1995-03-24 1996-10-22 Andrx Pharmaceuticals Inc. Diltiazem controlled release formulation
US5824638A (en) 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
ATE192042T1 (en) * 1995-08-16 2000-05-15 Lilly Co Eli POTENTIATION OF SEROTONIN DRUG RESPONSE
WO1997035584A1 (en) * 1996-03-25 1997-10-02 Eli Lilly And Company Method for treating pain
FR2746314B1 (en) 1996-03-25 1998-06-12 Pf Medicament PRODUCT CONTAINING MILNACIPRAN AND IDAZOXAN AS A COMBINED PHARMACEUTICAL PREPARATION
FR2752732B1 (en) * 1996-08-28 1998-11-20 Pf Medicament EXTENDED RELEASE GALENIC FORM OF MILNACIPRAN
WO1998018452A1 (en) 1996-10-25 1998-05-07 Shire Laboratories, Inc. Soluble form osmotic dose delivery system
US5837379A (en) 1997-01-31 1998-11-17 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
FR2759906B1 (en) 1997-02-21 2004-06-04 Pf Medicament USE OF MILNACIPRAN AND DERIVATIVES THEREOF FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF CERTAIN PSYCHIATRIC DISEASES
CA2216215A1 (en) 1997-04-05 1998-10-05 Isa Odidi Controlled release formulations using intelligent polymers having opposing wettability characteristics of hydrophobicity and hydrophilicity
AU7706598A (en) 1997-05-30 1998-12-30 Laboratorios Phoenix U.S.A., Inc. Multi-layered osmotic device
US5885616A (en) 1997-08-18 1999-03-23 Impax Pharmaceuticals, Inc. Sustained release drug delivery system suitable for oral administration
US6096340A (en) 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US5916595A (en) 1997-12-12 1999-06-29 Andrx Pharmaceutials, Inc. HMG co-reductase inhibitor
US6099859A (en) 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
JP2002515435A (en) * 1998-05-21 2002-05-28 イーライ・リリー・アンド・カンパニー Combination therapy for treatment of depression
US6106862A (en) 1998-08-13 2000-08-22 Andrx Corporation Once daily analgesic tablet
US6099862A (en) 1998-08-31 2000-08-08 Andrx Corporation Oral dosage form for the controlled release of a biguanide and sulfonylurea
US6323242B1 (en) * 1998-12-02 2001-11-27 Peter Sterling Mueller Treatment of disorders secondary to organic impairments
AU3898000A (en) 1999-03-19 2000-10-09 Knoll Pharmaceutical Company Treatment of neuropathic pain or fibromyalgia
JP2003506484A (en) 1999-08-13 2003-02-18 ベラ・ファーマシューティカルズ・インコーポレイテッド Use of compositions for treating or preventing sleep disorders using very low doses of cyclobenzaprine
GB2355191A (en) 1999-10-12 2001-04-18 Laxdale Ltd Combination formulations for fatigue, head injury and strokes
JP2004517112A (en) * 2001-01-02 2004-06-10 ファルマシア・アンド・アップジョン・カンパニー New drug combination

Also Published As

Publication number Publication date
CA2467356C (en) 2008-06-17
CA2467356A1 (en) 2003-05-15
US6635675B2 (en) 2003-10-21
ES2395462T3 (en) 2013-02-12
PT2322225E (en) 2013-11-07
ES2433080T3 (en) 2013-12-09
EP1463528A1 (en) 2004-10-06
PT1463528E (en) 2012-06-27
EP1463528B1 (en) 2012-04-11
EP2322225B1 (en) 2013-07-31
ATE552856T1 (en) 2012-04-15
EP2322225A1 (en) 2011-05-18
WO2003039598A1 (en) 2003-05-15
US20030139476A1 (en) 2003-07-24

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