WO2003045280A1 - Helical insert for a conduit - Google Patents
Helical insert for a conduit Download PDFInfo
- Publication number
- WO2003045280A1 WO2003045280A1 PCT/GB2002/005276 GB0205276W WO03045280A1 WO 2003045280 A1 WO2003045280 A1 WO 2003045280A1 GB 0205276 W GB0205276 W GB 0205276W WO 03045280 A1 WO03045280 A1 WO 03045280A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- insert
- stent
- longitudinally extending
- helix
- extending member
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
- F15D—FLUID DYNAMICS, i.e. METHODS OR MEANS FOR INFLUENCING THE FLOW OF GASES OR LIQUIDS
- F15D1/00—Influencing flow of fluids
- F15D1/02—Influencing flow of fluids in pipes or conduits
- F15D1/04—Arrangements of guide vanes in pipe elbows or duct bends; Construction of pipe conduit elements or elbows with respect to flow, specially for reducing losses in flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2002/068—Modifying the blood flow model, e.g. by diffuser or deflector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0004—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable
- A61F2250/0013—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable for adjusting fluid pressure
Definitions
- This invention relates to an insert for a conduit, and especially, but not solely, an insert to modify flow in blood flow tubing such as veins and arteries of the human or animal body for the purpose of effecting helical flow therein.
- WO 00/38591 discloses modified blood flow tubing and stents for use in blood flow tubing with spiral configurations that induce spiral (or helical) flow in the tubing.
- spiral flow has a beneficial effect in reducing turbulence and dead flow spots in the tubing. It is believed that turbulence and dead flow spots contribute to the build up of plaque, or narrowing of blood vessels, which can result in blockage at or downstream of the tubing or stent.
- Stents are commonly used to open up and/or maintain open constricted arteries, and, as disclosed in WO 00/38591, can incorporate helical formations to induce the desired spiral flow.
- stents are already of some complexity, arising from the need to introduce them in compact form for easy passage through the artery to the target site, then to expand them to open the restriction or to fit a previously opened restriction.
- Introducing a helical flow inducing configuration is an added complication.
- an insert for a conduit the insert being adapted to effect helical flow in the conduit and comprising a longitudinally extending member defining at least a portion of a helix.
- the terms "helix”, “helical” and “spiral” as used herein cover the mathematical definition of helix and helical and any combination of the mathematical definitions of helical and spiral.
- the longitudinally extending member may be, in cross-section, flat. However, it may have an inwardly extending portion that extends inwardly of the helix and also extends lengthwise along the member. The inwardly extending portion may extend along an edge of the longitudinally extending member, or may extend, lengthwise, intermediate the edges of the longitudinally extending member.
- the longitudinally extending member may have two inwardly extending portions, and preferably, at least one may extend lengthwise along an edge of the longitudinally extending member.
- the inwardly extending portion, or portions is movable between the inwardly extended position and a collapsed position.
- the portion(s) can be moved to the collapsed position when the stent is collapsed to facilitate insertion of the stent.
- the inwardly extending portion, or portions are biased towards the extended position.
- the biasing of the inwardly extending portions to the extended position is enabled by an elastic deformation of the inwardly extending portion(s) to the collapsed position(s).
- the inwardly extending portion may be elastically compressible or elastically deflectable to the collapsed position.
- the longitudinally extending member is adapted to be attached to an internal side wall of a conduit, such as a stent, stent graft or graft.
- a conduit such as a stent, stent graft or graft.
- the longitudinally extending member defines a helix or helix/spiral combination around the longitudinal axis of the conduit.
- the longitudinally extending member may be so configured in relation to a conduit for which it is adapted that its cross-section at any position along the conduit is substantially on a diameter of the conduit cross- section.
- the insert may be adapted to lodge inside a vein or artery of the human or animal body, and may be adapted to lodge inside a stent in a vein or artery of the human or animal body, or a graft therein.
- the insert may have a pitch, in relation to its length, such that one end is angularly displaced from the other by less than one revolution.
- the revolution of the total length of the insert is at least 50%, and preferably at least 70% of one revolution. If multiple inserts are provided in the conduit, the revolution may be the combined total of the revolution of each insert.
- the insert comprises a biocompatible material, if it is to be left for any length of time.
- the insert may also be biodegradable, so that it can serve for a predetermined period of time without needing to be removed.
- a stent comprising a tubular body member and an insert mounted within the body member, the insert comprising a longitudinally extending member defining at least a portion of a helix.
- the tubular body member is movable between a collapsed position, during insertion of the stent, and an expanded position, when the stent is located in the desired position.
- the longitudinally extending member has an inwardly extending portion that extends inwardly away from the internal side-wails of the tubular body section.
- the inwardly extending portion is movable to a collapsed position.
- the stent comprises a single insert.
- the stent may comprise two or more inserts, typically, on the same cross-section of the tubular body member.
- the portion of a helix defined by the longitudinally extending member is at least 50% of one revolution, and preferably at least 70% of one revolution.
- the total portion of a helix defined by all the longitudinally extending members may be at least 50%, and preferably, at least 70% of one revolution.
- the insert has two inwardly extending portions extending along the length of the longitudinally extending member.
- the insert may have only one inwardly extending portion extending along the length of the longitudinally extending member.
- Figure 1 is a side view of a stent with a first insert
- Figure 2 is an end view of the stent of Figure 1 ;
- Figure 3 is a cross-section view of the first insert in an open position
- Figure 4 is a cross-section view of the first insert in a collapsed position
- Figure 5 is a cross-section al view of a second insert
- Figure 6 is a cross-sectional view of a third insert
- Figure 7 is a cross-sectional view of a fourth insert in an extended position
- Figure 8 is a cross-sectional view of the fourth insert in a collapsed position
- Figure 9 is a schematic diagram showing relative positions of a cuff and a stent in a carotid artery of a pig;
- Figure 10 is a section along the line CC of Figure 9 of a right carotid artery fitted with a prior art stent;
- Figure 11 is a section along the line CC of Figure 9 of a left carotid artery of a pig fitted with the stent shown in Figures 1 and 2.
- Figures 1 and 2 show a stent 1 having a main body 4 which is formed from a wire mesh material.
- the stent 1 could be formed from a tube with interruptions or a laser cut tube providing an expandable homogeneous structure.
- Attached to the internal side wall of the body 4 is an insert 2 which defines a helix.
- the insert 2 is typically manufactured from a biocompatible material, such as polyurethane, and may be attached to the internal side wall of the body 4 by injection moulding, insert moulding, glue or melting base portion 5 of the insert 2 onto the body 4 such that after cooling, the mesh structure of the body 4 is entrained with the base portion 5 of the insert 2.
- insert 2 also includes two fins 6, 7 extending from the base portion 5 at opposite edges of the base portion 5. It will be noted from Figures 1 and 2 that the fins 6, 7 extend along the length of the insert 2 and extend inwardly from the internal side walls of the main body 4.
- the stent 1 is inserted into a blood vessel in the human or animal body in a collapsed configuration and after it is located in the correct position, it is expanded to engage with the side walls of the blood vessel to locate the stent 1 in the desired position.
- the stent 1 is inserted on a balloon catheter with the stent 1 in the collapsed configuration around the collapsed balloon of the catheter.
- the balloon is then inflated by pumping fluid into the balloon through the catheter.
- the expansion of the balloon expands the stent 1 into engagement with the internal side walls of the blood vessel.
- the configuration of the stent 1 shown in Figure 1 is in the expanded position. That is, the configuration after it is engaged with the internal side walls of the vessels by expanding the balloon of a balloon catheter, and the balloon catheter is removed.
- the stent 1 may be formed from an expansible material that "self- expands" into position, for example, by thermal mending properties.
- the insert 2 When the stent 1 is collapsed onto the balloon of the catheter, or the stent delivery system, the insert 2 is designed such that the fins 6, 7 are bent inwardly so that the fins of the insert collapse so as to reduce the volume occupied by the insert 2 when the stent 1 is in the collapsed configuration.
- This is illustrated in Figure 4 where it can be seen that fin 7 bends inwardly to overlie the base 5 and fin 6 bends inwardly to overlie the fin 7.
- This feature is enabled by appropriate design of the base portion 5 and fins 6, 7 and a suitable choice of material for the insert 2.
- this is an elastically deformable material, such as a suitable plastic material, for example, polyurethane.
- the fins 6, 7 automatically return to the non-collapsed position, shown in Figure 2, after expansion of the stent 1 and removal of the balloon catheter.
- the insert 2 After insertion and placement in the desired blood vessel, the insert 2, due to its helical shape, acts on blood flowing through the stent 1 to generate a spiral flow component in the blood.
- the length of the stent 1 is to a large extent dictated by enabling sufficient flexibility to ensure that the stent 1 can be inserted into the desired location in the human or animal body or the length of the narrowed artery requiring or able to be supported by the stent. That is, the length may depend on the length of the vessel needing treatment. Accordingly, the stent 1 typically has a length in the region of 10 mm to 100 mm. For certain vessels this may be normally approximately 20 mm to 40 mm in length. In order for the insert 2 to generate spiral flow of blood passing through the stent 1 , the helix angle of the helix defined by the insert 2 must not be too high.
- the insert 2 typically defines only a portion of one revolution of the helix that it defines. Preferably, this is at least 50% of one revolution and most preferably greater than 70% of one revolution. However, the effect may be enhanced by using a number of inserts 2 within the stent 1.
- a pig had the stent 1 inserted, on a balloon catheter delivery system, in the left carotid artery and a cuff applied surgically to the artery downstream of the stent.
- a prior art stent identical to the stent 1 , except for the absence of the insert 2 was inserted in a similar manner in the right carotid artery and a cuff was also applied surgically to the right carotid artery downstream of the prior art stent.
- the stent placements and the downstream cuffs were checked by intra-arterial contrast injection under X-ray (angiography).
- the cuffs 41 applied a moderate stenosis to each of the right and left carotid arteries 40 downstream of the stent.
- the cuffs 41 each produced a stenosis of approximately 75%.
- the relative positions of the stents in the carotid arteries 40 and the cuffs 41 are shown in Figure 9.
- the left and right carotid arteries 40 were explanted and examined grossly and histologically.
- the three sites along the carotid arteries 40 which were compared for the right and left carotid arteries 40 are indicated by the lines AA, BB and CC in Figure 9.
- the intimal and medial thickness and the intimal/medial thickness ratio were determined.
- the results are shown in Table 1 below and sections at site CC for the right and left carotid arteries are shown in Figures 10 and 11 , respectively.
- the insert 2 may be attached to a flexible material, such as a membrane, and that the flexible material is then attached to the inside and/or outside of the body 4.
- the flexible material may be a woven, knitted or spun polyester material, polyurethane material or extended PTFE material, and may be in the form of a tube which locates within the body 4 and is attached to the body 4 by a suitable means, such as adhesive or by stitching.
- the flexible material may be porous.
- the stent 1 Although in the stent 1 only one insert 2 is used, it is possible that multiple inserts may be used in either end-to-end and/or side-by-side relationship within the body 4. Where multiple inserts are used, the total portion of the helix defined by all the inserts is typically greater than 50% and preferably greater than 70%. This means that any one insert may define a portion of a helix that is less than 50%.
- Figure 5 shows a second example of an insert 10 that includes a base portion 11 with a fin 12 extending from one edge of the base portion 11. As with the insert 2, the fin 12 extends along the length of the insert 10.
- Figure 6 shows a third example of an insert 20 that includes a base portion 21 with a fin 22 extending centrally from the base portion 21. As with the inserts 2, 10 the fin 22 extends along the length of the insert 20.
- Figures 7 and 8 show a fourth example of an insert 24 that has a fin 23 formed from an elastically compressible foam material 25, such as a polyurethane foam.
- Figure 7 shows the insert 24 with the fin 23 in the extended position and
- Figure 8 shows the insert 24 with the foam material 25 compressed so that the fin 23 is collapsed.
- the inserts 10, 20, 24 may be used in the stent 1 in the same manner as the insert 2.
- the helical formations 2, 10, 20, 24 may each have a pitch, in relation to their length, such that one end is angularly displaced from the other by at least 50% of one revolution and preferably at least 70% of one revolution. This is found to impart favourable spiral flow to flow in a vein or artery, eliminating, or at least reducing, turbulence and dead spots with reduction of plaque formation.
- a biocompatible material will be selected, and a smooth structure with rounded ends will be preferred so as not to introduce any turbulence into the flow.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002343073A AU2002343073A1 (en) | 2001-11-21 | 2002-11-21 | Helical insert for a conduit |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0127888.6 | 2001-11-21 | ||
GB0127888A GB2382776A (en) | 2001-11-21 | 2001-11-21 | Helix shaped insert for flow modification in a duct or stent |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003045280A1 true WO2003045280A1 (en) | 2003-06-05 |
Family
ID=9926172
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2002/005242 WO2003045279A1 (en) | 2001-11-21 | 2002-11-21 | A helical formation for a conduit |
PCT/GB2002/005276 WO2003045280A1 (en) | 2001-11-21 | 2002-11-21 | Helical insert for a conduit |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2002/005242 WO2003045279A1 (en) | 2001-11-21 | 2002-11-21 | A helical formation for a conduit |
Country Status (9)
Country | Link |
---|---|
US (3) | US7331989B2 (en) |
EP (2) | EP1314406B1 (en) |
AT (2) | ATE366560T1 (en) |
AU (2) | AU2002343073A1 (en) |
DE (2) | DE60221085T2 (en) |
DK (1) | DK1446073T3 (en) |
ES (2) | ES2288540T3 (en) |
GB (2) | GB2382776A (en) |
WO (2) | WO2003045279A1 (en) |
Cited By (2)
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WO2005077305A1 (en) | 2004-02-06 | 2005-08-25 | Tayside Flow Technologies Ltd | A drug delivery device |
US8133277B2 (en) | 2004-10-21 | 2012-03-13 | Bard Peripheral Vascular, Inc. | Medical device for fluid flow and method of forming such device |
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US20040267349A1 (en) | 2003-06-27 | 2004-12-30 | Kobi Richter | Amorphous metal alloy medical devices |
US8382821B2 (en) | 1998-12-03 | 2013-02-26 | Medinol Ltd. | Helical hybrid stent |
GB9828696D0 (en) | 1998-12-29 | 1999-02-17 | Houston J G | Blood-flow tubing |
CN1172299C (en) | 1999-10-30 | 2004-10-20 | 三星电子株式会社 | Optical probe |
US7390331B2 (en) | 2001-05-22 | 2008-06-24 | Sanostec Corp | Nasal inserts |
US8403954B2 (en) | 2001-05-22 | 2013-03-26 | Sanostec Corp. | Nasal congestion, obstruction relief, and drug delivery |
GB2369797B (en) | 2001-11-20 | 2002-11-06 | Tayside Flow Technologies Ltd | Helical formations in tubes |
GB2382776A (en) | 2001-11-21 | 2003-06-11 | Tayside Flow Technologies Ltd | Helix shaped insert for flow modification in a duct or stent |
GB0227369D0 (en) * | 2002-11-23 | 2002-12-31 | Tayside Flow Technologies Ltd | A helical formation for a conduit |
US9039755B2 (en) * | 2003-06-27 | 2015-05-26 | Medinol Ltd. | Helical hybrid stent |
US9155639B2 (en) * | 2009-04-22 | 2015-10-13 | Medinol Ltd. | Helical hybrid stent |
GB0315714D0 (en) * | 2003-07-04 | 2003-08-13 | Tayside Flow Technologies Ltd | An internal formation for a conduit |
US8808354B2 (en) | 2004-09-22 | 2014-08-19 | Veryan Medical Limited | Helical stent |
GB2418362C (en) * | 2004-09-22 | 2010-05-05 | Veryan Medical Ltd | Stent |
US20060085065A1 (en) * | 2004-10-15 | 2006-04-20 | Krause Arthur A | Stent with auxiliary treatment structure |
US7988723B2 (en) | 2007-08-02 | 2011-08-02 | Flexible Stenting Solutions, Inc. | Flexible stent |
US8376053B2 (en) * | 2007-10-01 | 2013-02-19 | Premium Artificial Lift Systems Ltd. | Fluid flow conduit, method and use |
CN101854975A (en) | 2007-10-03 | 2010-10-06 | 桑诺斯泰克公司 | Nasal inserts |
US8398705B2 (en) * | 2008-06-11 | 2013-03-19 | Eric Mangiardi | Stent |
US9149376B2 (en) | 2008-10-06 | 2015-10-06 | Cordis Corporation | Reconstrainable stent delivery system |
DE102008050618B3 (en) * | 2008-10-09 | 2010-04-01 | Roland Kuffer | Device for absorbing electromagnetic radiation |
US20100298924A1 (en) * | 2009-05-19 | 2010-11-25 | Tayside Flow Technologies Ltd. | Vascular Graft |
DE102009024960A1 (en) * | 2009-06-12 | 2010-12-16 | Dietrich Wetzel Kg | Self-cleaning and / or conveying device and / or pressure and / or friction loss-influencing structure |
US9095420B2 (en) * | 2011-01-24 | 2015-08-04 | Tufts Medical Center, Inc. | Endovascular stent |
GB2498581A (en) * | 2012-01-23 | 2013-07-24 | Rolls Royce Plc | Pipe inspection probing cable having an external helical track |
GB2514135B (en) | 2013-05-14 | 2015-04-15 | Cook Medical Technologies Llc | Implantable flow diverter |
GB2519932B (en) | 2013-08-13 | 2015-10-21 | Cook Medical Technologies Llc | Implantable flow adjuster |
US9561320B2 (en) | 2014-06-05 | 2017-02-07 | Cook Medical Technologies Llc | Device for promoting fistula patency and method |
EP2952142B1 (en) | 2014-06-06 | 2017-09-06 | Cook Medical Technologies LLC | Device for forming fistula between blood vessels |
US10022252B2 (en) | 2015-06-10 | 2018-07-17 | Cook Medical Technologies Llc | Spiral blood flow device with diameter independent helix angle |
US11491002B2 (en) * | 2015-08-14 | 2022-11-08 | Indian Institute Of Technology Bombay | Implantable cardio-vascular flow streamliner |
CN110645237B (en) * | 2019-09-02 | 2022-01-14 | 厦门理工学院 | Pipeline guiding device |
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-
2001
- 2001-11-21 GB GB0127888A patent/GB2382776A/en not_active Withdrawn
- 2001-11-21 GB GB0305703A patent/GB2384189A/en not_active Withdrawn
-
2002
- 2002-11-21 US US10/301,257 patent/US7331989B2/en not_active Expired - Lifetime
- 2002-11-21 WO PCT/GB2002/005242 patent/WO2003045279A1/en not_active Application Discontinuation
- 2002-11-21 EP EP02258031A patent/EP1314406B1/en not_active Expired - Lifetime
- 2002-11-21 ES ES02258031T patent/ES2288540T3/en not_active Expired - Lifetime
- 2002-11-21 AU AU2002343073A patent/AU2002343073A1/en not_active Abandoned
- 2002-11-21 DE DE60221085T patent/DE60221085T2/en not_active Expired - Lifetime
- 2002-11-21 DK DK02779716T patent/DK1446073T3/en active
- 2002-11-21 DE DE60231423T patent/DE60231423D1/en not_active Expired - Lifetime
- 2002-11-21 AU AU2002343055A patent/AU2002343055A1/en not_active Abandoned
- 2002-11-21 US US10/496,212 patent/US7185677B2/en not_active Expired - Lifetime
- 2002-11-21 WO PCT/GB2002/005276 patent/WO2003045280A1/en not_active Application Discontinuation
- 2002-11-21 AT AT02258031T patent/ATE366560T1/en not_active IP Right Cessation
- 2002-11-21 AT AT02779716T patent/ATE424158T1/en active
- 2002-11-21 EP EP02779716A patent/EP1446073B1/en not_active Expired - Lifetime
- 2002-11-21 ES ES02779716T patent/ES2321385T3/en not_active Expired - Lifetime
-
2008
- 2008-01-17 US US12/009,269 patent/US8021415B2/en not_active Expired - Fee Related
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005077305A1 (en) | 2004-02-06 | 2005-08-25 | Tayside Flow Technologies Ltd | A drug delivery device |
US8133277B2 (en) | 2004-10-21 | 2012-03-13 | Bard Peripheral Vascular, Inc. | Medical device for fluid flow and method of forming such device |
Also Published As
Publication number | Publication date |
---|---|
US7185677B2 (en) | 2007-03-06 |
GB0127888D0 (en) | 2002-01-16 |
EP1314406B1 (en) | 2007-07-11 |
AU2002343055A1 (en) | 2003-06-10 |
US20030139807A1 (en) | 2003-07-24 |
GB2382776A (en) | 2003-06-11 |
DE60221085D1 (en) | 2007-08-23 |
US20050061380A1 (en) | 2005-03-24 |
EP1314406A2 (en) | 2003-05-28 |
US20080114448A1 (en) | 2008-05-15 |
DE60231423D1 (en) | 2009-04-16 |
EP1314406A3 (en) | 2004-04-21 |
US7331989B2 (en) | 2008-02-19 |
EP1446073B1 (en) | 2009-03-04 |
WO2003045279A1 (en) | 2003-06-05 |
US8021415B2 (en) | 2011-09-20 |
EP1446073A1 (en) | 2004-08-18 |
ATE366560T1 (en) | 2007-08-15 |
ATE424158T1 (en) | 2009-03-15 |
DE60221085T2 (en) | 2008-03-20 |
ES2288540T3 (en) | 2008-01-16 |
GB2384189A (en) | 2003-07-23 |
ES2321385T3 (en) | 2009-06-05 |
GB0305703D0 (en) | 2003-04-16 |
AU2002343073A1 (en) | 2003-06-10 |
DK1446073T3 (en) | 2009-06-22 |
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