WO2003047503A3 - Delivery of medicaments to the nail - Google Patents

Delivery of medicaments to the nail Download PDF

Info

Publication number
WO2003047503A3
WO2003047503A3 PCT/US2002/033694 US0233694W WO03047503A3 WO 2003047503 A3 WO2003047503 A3 WO 2003047503A3 US 0233694 W US0233694 W US 0233694W WO 03047503 A3 WO03047503 A3 WO 03047503A3
Authority
WO
WIPO (PCT)
Prior art keywords
nail
medicament
present
compositions
medicaments
Prior art date
Application number
PCT/US2002/033694
Other languages
French (fr)
Other versions
WO2003047503A2 (en
Inventor
Michael A Repka
Original Assignee
Univ Mississippi
Michael A Repka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mississippi, Michael A Repka filed Critical Univ Mississippi
Priority to AU2002364893A priority Critical patent/AU2002364893A1/en
Priority to CA2468539A priority patent/CA2468539C/en
Publication of WO2003047503A2 publication Critical patent/WO2003047503A2/en
Publication of WO2003047503A3 publication Critical patent/WO2003047503A3/en
Priority to US10/830,730 priority patent/US7959904B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A61Q3/02—Nail coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Abstract

The present invention includes a method for delivering a medicament to a nail plate or nail bed that comprises providing a therapeutically effective amount of a medicament, etching the surface of the nail, and applying a medicament to surface of the nail. A preferred embodiment of the present invention is directed to a method of treating a fungal infection of the fingernail or toenail. Also included in the present invention are the compositions (i.e., the etching compositions and/or the medicament compositions) used to treat the nail in accordance with the methods of the present invention.
PCT/US2002/033694 2001-10-22 2002-10-22 Delivery of medicaments to the nail WO2003047503A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002364893A AU2002364893A1 (en) 2001-10-22 2002-10-22 Delivery of medicaments to the nail
CA2468539A CA2468539C (en) 2001-10-22 2002-10-22 Delivery of medicaments to the nail
US10/830,730 US7959904B2 (en) 2001-10-22 2004-04-22 Delivery of medicaments to the nail

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33041501P 2001-10-22 2001-10-22
US60/330,415 2001-10-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/830,730 Continuation-In-Part US7959904B2 (en) 2001-10-22 2004-04-22 Delivery of medicaments to the nail

Publications (2)

Publication Number Publication Date
WO2003047503A2 WO2003047503A2 (en) 2003-06-12
WO2003047503A3 true WO2003047503A3 (en) 2003-12-18

Family

ID=23289669

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/033694 WO2003047503A2 (en) 2001-10-22 2002-10-22 Delivery of medicaments to the nail

Country Status (4)

Country Link
US (1) US7959904B2 (en)
AU (1) AU2002364893A1 (en)
CA (1) CA2468539C (en)
WO (1) WO2003047503A2 (en)

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RU2372113C2 (en) 2003-07-14 2009-11-10 Пауэр Пэйпер Лтд. Method, apparatus and kit for onychomycosis treatment with using electrokinetic mass transport
CA2547990C (en) 2003-12-08 2011-08-02 Bentley Pharmaceuticals, Inc. Pharmaceutical compositions and methods for insulin treatment
US20050256553A1 (en) * 2004-02-09 2005-11-17 John Strisower Method and apparatus for the treatment of respiratory and other infections using ultraviolet germicidal irradiation
US20060078580A1 (en) 2004-10-08 2006-04-13 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
US7740875B2 (en) * 2004-10-08 2010-06-22 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
WO2006063350A2 (en) * 2004-12-10 2006-06-15 Talima Therapeutics, Inc. Compositions and methods for treating conditions of the nail unit
US20060275230A1 (en) 2004-12-10 2006-12-07 Frank Kochinke Compositions and methods for treating conditions of the nail unit
US8277495B2 (en) 2005-01-13 2012-10-02 Candela Corporation Method and apparatus for treating a diseased nail
US20090215888A1 (en) * 2006-03-02 2009-08-27 Singh Jagat Topical nail formulation
US20080107735A1 (en) * 2006-11-02 2008-05-08 Gyurik Robert J Macrocyclic formulations for transmembrane drug delivery
WO2008105038A1 (en) * 2007-02-23 2008-09-04 Nichiban Company Limited Adhesive patch for mycosis
US20080261986A1 (en) * 2007-03-30 2008-10-23 Friden Phillip M Pharmaceutical formulations for iontophoretic delivery of an anti-fungal drug
US20100291182A1 (en) * 2009-01-21 2010-11-18 Arsenal Medical, Inc. Drug-Loaded Fibers
US20100234925A1 (en) * 2009-03-16 2010-09-16 PinPoint U.S.A., Inc. Treatment of microbiological pathogens in a toe nail with antimicrobial light
GB0907553D0 (en) 2009-05-01 2009-06-10 Insense Ltd Treatment of human or animal body surface infection
US8814922B2 (en) * 2009-07-22 2014-08-26 New Star Lasers, Inc. Method for treatment of fingernail and toenail microbial infections using infrared laser heating and low pressure
US20110202016A1 (en) * 2009-08-24 2011-08-18 Arsenal Medical, Inc. Systems and methods relating to polymer foams
US9044580B2 (en) 2009-08-24 2015-06-02 Arsenal Medical, Inc. In-situ forming foams with outer layer
US9173817B2 (en) 2009-08-24 2015-11-03 Arsenal Medical, Inc. In situ forming hemostatic foam implants
US10420862B2 (en) 2009-08-24 2019-09-24 Aresenal AAA, LLC. In-situ forming foams for treatment of aneurysms
US20130089629A1 (en) * 2010-06-07 2013-04-11 Topical Pharma Ab Kit for the treatment of onychomycosis by nitric oxide
US8968626B2 (en) 2011-01-31 2015-03-03 Arsenal Medical, Inc. Electrospinning process for manufacture of multi-layered structures
US9034240B2 (en) 2011-01-31 2015-05-19 Arsenal Medical, Inc. Electrospinning process for fiber manufacture
US9194058B2 (en) 2011-01-31 2015-11-24 Arsenal Medical, Inc. Electrospinning process for manufacture of multi-layered structures
CN104010598B (en) 2011-09-05 2015-12-09 库尔诊疗公司 For causing, the hypothermic pogonip stomach of therapeutic is sent, dermal delivery or peritoneum are sent
US8993831B2 (en) 2011-11-01 2015-03-31 Arsenal Medical, Inc. Foam and delivery system for treatment of postpartum hemorrhage
EP2968886A1 (en) 2013-03-14 2016-01-20 Hallux, Inc. Method of treating infections, diseases or disorders of nail unit
KR20170027719A (en) 2014-05-29 2017-03-10 뉴 스킨 테라피스, 엘엘씨, 디/비/에이/ 엔에스티 컨설팅, 엘엘씨 Method and apparatus for non-thermal nail, foot, and hand fungus treatment
US11358002B2 (en) 2014-05-29 2022-06-14 Raymond R. Blanche Method and apparatus for non-thermal nail, foot, and hand fungus treatment
WO2019135123A1 (en) * 2018-01-02 2019-07-11 Nal Pharmaceutical Group Limited Liquid dosage form for topical application

Citations (4)

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US5947956A (en) * 1997-11-04 1999-09-07 Karell; Manuel Leon Laser apparatus for making holes and etchings
US6042845A (en) * 1994-12-22 2000-03-28 Johnson & Johnson Consumer Products, Inc. Anti fungal treatment of nails
US6143794A (en) * 1998-04-17 2000-11-07 Bertek Pharmaceuticals, Inc. Topical formulations for the treatment of nail fungal diseases
US6231875B1 (en) * 1998-03-31 2001-05-15 Johnson & Johnson Consumer Companies, Inc. Acidified composition for topical treatment of nail and skin conditions

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US4637930A (en) 1984-02-08 1987-01-20 Yamanouchi Pharmaceutical Co, Ltd. Transdermal formulation of nicardipine hydrochloride
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US6042845A (en) * 1994-12-22 2000-03-28 Johnson & Johnson Consumer Products, Inc. Anti fungal treatment of nails
US5947956A (en) * 1997-11-04 1999-09-07 Karell; Manuel Leon Laser apparatus for making holes and etchings
US6231875B1 (en) * 1998-03-31 2001-05-15 Johnson & Johnson Consumer Companies, Inc. Acidified composition for topical treatment of nail and skin conditions
US6143794A (en) * 1998-04-17 2000-11-07 Bertek Pharmaceuticals, Inc. Topical formulations for the treatment of nail fungal diseases

Also Published As

Publication number Publication date
AU2002364893A1 (en) 2003-06-17
WO2003047503A2 (en) 2003-06-12
US7959904B2 (en) 2011-06-14
US20040197280A1 (en) 2004-10-07
CA2468539C (en) 2013-01-08
CA2468539A1 (en) 2003-06-12
AU2002364893A8 (en) 2003-06-17

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