WO2003054507A3 - Nanocrystals - Google Patents

Nanocrystals Download PDF

Info

Publication number
WO2003054507A3
WO2003054507A3 PCT/US2002/029429 US0229429W WO03054507A3 WO 2003054507 A3 WO2003054507 A3 WO 2003054507A3 US 0229429 W US0229429 W US 0229429W WO 03054507 A3 WO03054507 A3 WO 03054507A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluorescent nanocrystals
functionalized
compositions
nanocrystals
imidazole
Prior art date
Application number
PCT/US2002/029429
Other languages
French (fr)
Other versions
WO2003054507A2 (en
Inventor
Imad Naasani
Original Assignee
Biocrystal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocrystal Ltd filed Critical Biocrystal Ltd
Priority to AT02803277T priority Critical patent/ATE448077T1/en
Priority to JP2003555171A priority patent/JP2005513471A/en
Priority to AU2002365124A priority patent/AU2002365124A1/en
Priority to EP02803277A priority patent/EP1456022B1/en
Priority to DE60234382T priority patent/DE60234382D1/en
Publication of WO2003054507A2 publication Critical patent/WO2003054507A2/en
Publication of WO2003054507A3 publication Critical patent/WO2003054507A3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/25Web or sheet containing structurally defined element or component and including a second component containing structurally defined particles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2993Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2998Coated including synthetic resin or polymer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31721Of polyimide

Abstract

Provided herein are compositions of functionalized, fluorescent nanocrystals comprising fluorescent nanocrystals coated with an imidazole-containing compound; compositions of functionalized, fluorescent nanocrystals comprising fluorescent nanocrystals coated with an imidazole-containing compound and cross-linked with a phosphine cross-linking compound; compositions of functionalized fluorescent nanocrystals operably bound to molecular probe; a process of making functionalized, fluorescent nanocrystals; and a process of using functionalized, fluorescent nanocrystals in a detection system.
PCT/US2002/029429 2001-09-17 2002-09-17 Nanocrystals WO2003054507A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT02803277T ATE448077T1 (en) 2001-09-17 2002-09-17 NANOCRYSTALS
JP2003555171A JP2005513471A (en) 2001-09-17 2002-09-17 Nanocrystal
AU2002365124A AU2002365124A1 (en) 2001-09-17 2002-09-17 Nanocrystals
EP02803277A EP1456022B1 (en) 2001-09-17 2002-09-17 Nanocrystals
DE60234382T DE60234382D1 (en) 2001-09-17 2002-09-17 NANO CRYSTALS

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32298201P 2001-09-17 2001-09-17
US60/322,982 2001-09-17
US37920802P 2002-05-09 2002-05-09
US60/379,208 2002-05-09

Publications (2)

Publication Number Publication Date
WO2003054507A2 WO2003054507A2 (en) 2003-07-03
WO2003054507A3 true WO2003054507A3 (en) 2004-02-05

Family

ID=26983708

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/029429 WO2003054507A2 (en) 2001-09-17 2002-09-17 Nanocrystals

Country Status (7)

Country Link
US (2) US6955855B2 (en)
EP (2) EP1456022B1 (en)
JP (2) JP2005513471A (en)
AT (1) ATE448077T1 (en)
AU (1) AU2002365124A1 (en)
DE (1) DE60234382D1 (en)
WO (1) WO2003054507A2 (en)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1354064A2 (en) 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7214428B2 (en) 2001-09-17 2007-05-08 Invitrogen Corporation Highly luminescent functionalized semiconductor nanocrystals for biological and physical applications
US7205048B2 (en) * 2001-09-17 2007-04-17 Invitrogen Corporation Functionalized fluorescent nanocrystal compositions and methods of making
FR2834978B1 (en) * 2002-01-21 2004-04-09 Rhodia Elect & Catalysis MESOSTRUCTURE MATERIALS INCORPORATING NANOMETRIC CRYSTALLINE PARTICLES COMPRISING A METAL IN SOLID SOLUTION WITHIN THEIR CRYSTALLINE ARRAY
US7998923B2 (en) * 2002-05-07 2011-08-16 The Regents Of The University Of California Bioactivation of particles
JP2006502232A (en) * 2002-08-15 2006-01-19 モウンギ ジー. バウエンディ Stabilized semiconductor nanocrystals
GB0300427D0 (en) * 2003-01-09 2003-02-05 Univ Strathclyde Pharmaceutical composition
WO2004076056A2 (en) * 2003-02-26 2004-09-10 Lake Shore Cryotronics Inc. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
US8017235B2 (en) * 2003-09-04 2011-09-13 National Institute Of Advanced Industrial Science And Technology Method for manufacturing fine composite particles, apparatus for manufacturing fine composite particles, and fine composite particles
FR2862955B1 (en) * 2003-12-02 2006-03-10 Commissariat Energie Atomique INORGANIC NANOCRYSTALS WITH ORGANIC COATING LAYER, PROCESS FOR THEIR PREPARATION, AND MATERIALS THEREOF
US20060014175A1 (en) * 2004-05-17 2006-01-19 Imad Naasani Functionalized fluorescent nanocrystal detection system
WO2006093516A2 (en) 2004-06-22 2006-09-08 The Regents Of The University Of California Peptide-coated nanoparticles with graded shell compositions
US7229690B2 (en) * 2004-07-26 2007-06-12 Massachusetts Institute Of Technology Microspheres including nanoparticles
US7979358B1 (en) 2004-07-27 2011-07-12 Stamps.Com Inc. Quality assurance of image-customization of computer-based value-bearing items
US8805745B1 (en) 2004-07-27 2014-08-12 Stamps.Com Inc. Printing of computer-based value-bearing items
US8065239B1 (en) 2004-07-27 2011-11-22 Stamps.Com Inc. Customized computer-based value-bearing item quality assurance
US7243842B1 (en) 2004-07-27 2007-07-17 Stamps.Com Inc. Computer-based value-bearing item customization security
US7933845B1 (en) 2004-07-27 2011-04-26 Stamps.Com Inc. Image-customization of computer-based value-bearing items
US20060172133A1 (en) * 2004-08-17 2006-08-03 Imad Naasani Synthesis of highly luminescent colloidal particles
US7794600B1 (en) * 2004-08-27 2010-09-14 Nanosys, Inc. Purification of nanocrystal solutions by chromatography
WO2006029302A2 (en) * 2004-09-09 2006-03-16 Applera Corporation Dioxetane-nanoparticle assemblies for energy transfer detection systems, methods of making the assemblies, and methods of using the assemblies in bioassays
JP2006083219A (en) 2004-09-14 2006-03-30 Sharp Corp Fluorophor and light-emitting device using the same
ATE556126T1 (en) * 2004-10-29 2012-05-15 Life Technologies Corp FUNCTIONALIZED FLUORESCENT NANOCRYSTALS AND METHOD FOR THE PRODUCTION AND USE THEREOF
US7682782B2 (en) * 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
US9637682B2 (en) 2004-11-11 2017-05-02 Samsung Electronics Co., Ltd. Interfused nanocrystals and method of preparing the same
EP2292718A3 (en) * 2004-11-11 2011-06-22 Samsung Electronics Co., Ltd Interfused nanocrystals and method of preparing the same
CN101128737B (en) * 2005-01-17 2012-11-28 新加坡科技研究局 Novel water-solubility nanometer crystal and its preparing method
CN101208605A (en) * 2005-05-04 2008-06-25 新加坡科技研究局 New type water-solubility nanocrystalline containing low molecular weight coating agent and preparation method thereof
US9297092B2 (en) * 2005-06-05 2016-03-29 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
US8718437B2 (en) 2006-03-07 2014-05-06 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
US8845927B2 (en) * 2006-06-02 2014-09-30 Qd Vision, Inc. Functionalized nanoparticles and method
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
FR2908891B1 (en) * 2005-10-28 2017-04-21 Centre Nat De La Rech Scient - Cnrs ALUMINATE PERSISTENT LUMINESCENCE NANOPARTICLES FOR THEIR USE AS A DIAGNOSTIC AGENT FOR IN VIVO OPTICAL IMAGING
FR2892819B1 (en) * 2005-10-28 2008-02-01 Centre Nat Rech Scient PERSISTENT LUMINESCENCE NANOPARTICLES FOR THEIR USE AS A DIAGNOSTIC AGENT FOR IN VIVO OPTICAL IMAGING
ES2627998T3 (en) * 2005-11-16 2017-08-01 Exchange Imaging Technologies Gmbh Fluorescent nanoparticles
EP2308513A3 (en) * 2005-11-16 2011-11-23 Signalomics GmbH Fluorescent nanoparticles
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8849087B2 (en) * 2006-03-07 2014-09-30 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
US9874674B2 (en) 2006-03-07 2018-01-23 Samsung Electronics Co., Ltd. Compositions, optical component, system including an optical component, devices, and other products
WO2007112088A2 (en) * 2006-03-24 2007-10-04 Qd Vision, Inc. Hyperspectral imaging device
WO2007122651A1 (en) * 2006-04-24 2007-11-01 Nm Tech Ltd. Nanomaterials And Microdevices Technology Functional nanomaterials with antibacterial and antiviral activity
US7807265B2 (en) * 2006-05-12 2010-10-05 University Of Central Florida Research Foundation, Inc. Partially passivated quantum dots, process for making, and sensors therefrom
US7874593B1 (en) 2006-05-16 2011-01-25 Stamps.Com Inc. Rolls of image-customized value-bearing items and systems and methods for providing rolls of image-customized value-bearing items
US9212056B2 (en) * 2006-06-02 2015-12-15 Qd Vision, Inc. Nanoparticle including multi-functional ligand and method
WO2008020460A1 (en) 2006-06-14 2008-02-21 Nm Tech Ltd. Nanomaterials And Microdevices Technology Nanomaterial coatings for osteointegrated biomedical prostheses
US10839332B1 (en) 2006-06-26 2020-11-17 Stamps.Com Image-customized labels adapted for bearing computer-based, generic, value-bearing items, and systems and methods for providing image-customized labels
US20090280520A1 (en) * 2006-09-15 2009-11-12 Konica Minolta Medical & Graphic, Inc. Fluorescent semiconductor particles, method of manufacturing the same, biosubstance fluorescent labeling agent employing the same, and bioimaging method thereof
JP2008087096A (en) * 2006-09-29 2008-04-17 National Institute Of Advanced Industrial & Technology THIN FILM PATTERN OF Eu-DOPED YTTRIUM OXIDE NANOPARTICLE AND METHOD FOR PREPARING THE SAME
WO2008063658A2 (en) 2006-11-21 2008-05-29 Qd Vision, Inc. Semiconductor nanocrystals and compositions and devices including same
WO2008063657A2 (en) * 2006-11-21 2008-05-29 Qd Vision, Inc. Light emitting devices and displays with improved performance
WO2008063652A1 (en) 2006-11-21 2008-05-29 Qd Vision, Inc. Blue emitting semiconductor nanocrystals and compositions and devices including same
WO2008063653A1 (en) 2006-11-21 2008-05-29 Qd Vision, Inc. Semiconductor nanocrystals and compositions and devices including same
WO2008070459A2 (en) * 2006-11-22 2008-06-12 Alnis Biosciences, Inc. Coated nanoparticles for aqueous systems
DK2124880T3 (en) * 2006-12-18 2018-06-14 Exchange Imaging Tech Gmbh Fluorescent nanoparticles
US8505978B1 (en) 2006-12-20 2013-08-13 Stamps.Com Inc. Systems and methods for creating and providing shape-customized, computer-based, value-bearing items
WO2008157493A2 (en) * 2007-06-15 2008-12-24 The Research Foundation Of State University Of New York Stor Intellectual Property Division Use of zno nanocrystals for imaging and therapy
WO2009002551A1 (en) * 2007-06-26 2008-12-31 Qd Vision, Inc. Photovoltaic devices including quantum dot down-conversion materials useful for solar cells and materials including quantum dots
EP2207789B1 (en) * 2007-09-12 2014-06-11 QD Vision, Inc. Functionalized nanoparticles and method
US10373398B1 (en) 2008-02-13 2019-08-06 Stamps.Com Inc. Systems and methods for distributed activation of postage
WO2009145813A1 (en) * 2008-03-04 2009-12-03 Qd Vision, Inc. Particles including nanoparticles, uses thereof, and methods
US9525148B2 (en) 2008-04-03 2016-12-20 Qd Vision, Inc. Device including quantum dots
KR101995369B1 (en) 2008-04-03 2019-07-02 삼성 리서치 아메리카 인코포레이티드 Light-emitting device including quantum dots
US9978185B1 (en) 2008-04-15 2018-05-22 Stamps.Com Inc. Systems and methods for activation of postage indicia at point of sale
WO2009137053A1 (en) 2008-05-06 2009-11-12 Qd Vision, Inc. Optical components, systems including an optical component, and devices
US9207385B2 (en) 2008-05-06 2015-12-08 Qd Vision, Inc. Lighting systems and devices including same
EP2297762B1 (en) 2008-05-06 2017-03-15 Samsung Electronics Co., Ltd. Solid state lighting devices including quantum confined semiconductor nanoparticles
EP2323947B1 (en) 2008-08-06 2019-07-03 Life Technologies Corporation Water-dispersable nanoparticles
US8637082B2 (en) 2008-10-03 2014-01-28 Life Technologies Corporation Methods for preparation of ZnTe nanocrystals
US9937560B2 (en) 2008-10-03 2018-04-10 Life Technologies Corporation Methods for preparation of nanocrystals using a weak electron transfer agent and mismatched shell precursors
WO2010039897A2 (en) 2008-10-03 2010-04-08 Life Technologies Corporation Nanocrystals with functional ligands
CN102216202A (en) * 2008-10-03 2011-10-12 生命科技公司 Sulfonate modified nanocrystals
WO2010040074A2 (en) * 2008-10-03 2010-04-08 Life Technologies Corporation Compositions and methods for functionalizing or crosslinking ligands on nanoparticle surfaces
US9911246B1 (en) 2008-12-24 2018-03-06 Stamps.Com Inc. Systems and methods utilizing gravity feed for postage metering
WO2010111674A2 (en) 2009-03-27 2010-09-30 Life Technologies Corporation Methods and apparatus for single molecule sequencing using energy transfer detection
US8263639B2 (en) * 2009-04-21 2012-09-11 The United States Of America, As Represented By The Secretary Of The Navy Multifunctional metal-chelating ligands
PL220030B1 (en) 2009-08-11 2015-08-31 Nano Tech Spółka Z Ograniczoną Odpowiedzialnoscią Method for manufacturing nanocrystalline luminophores to record information and method for reading the information
US8894891B2 (en) * 2009-08-16 2014-11-25 Massachusetts Institute Of Technology Copolymer-associated nanomaterial
EP2475717A4 (en) 2009-09-09 2015-01-07 Qd Vision Inc Particles including nanoparticles, uses thereof, and methods
WO2011031876A1 (en) 2009-09-09 2011-03-17 Qd Vision, Inc. Formulations including nanoparticles
US9759727B2 (en) * 2010-03-23 2017-09-12 Massachusetts Institute Of Technology Ligands for semiconductor nanocrystals
US10202546B2 (en) 2010-03-23 2019-02-12 Massachusetts Institute Of Technology Ligands for semiconductor nanocrystals
US9914320B1 (en) 2011-04-21 2018-03-13 Stamps.Com Inc. Secure value bearing indicia using clear media
WO2012158832A2 (en) 2011-05-16 2012-11-22 Qd Vision, Inc. Method for preparing semiconductor nanocrystals
US10713634B1 (en) 2011-05-18 2020-07-14 Stamps.Com Inc. Systems and methods using mobile communication handsets for providing postage
JP5440564B2 (en) * 2011-07-14 2014-03-12 信越半導体株式会社 Method for detecting crystal defects
WO2013028253A1 (en) 2011-08-19 2013-02-28 Qd Vision, Inc. Semiconductor nanocrystals and methods
US10373216B1 (en) 2011-10-12 2019-08-06 Stamps.Com Inc. Parasitic postage indicia
US10846650B1 (en) 2011-11-01 2020-11-24 Stamps.Com Inc. Perpetual value bearing shipping labels
US10922641B1 (en) 2012-01-24 2021-02-16 Stamps.Com Inc. Systems and methods providing known shipper information for shipping indicia
EP3033404B1 (en) * 2013-08-14 2018-11-28 Nanoco Technologies Ltd Quantum dot films utilizing multi-phase resins
CN103834385B (en) * 2014-02-25 2015-11-04 中国科学院理化技术研究所 Water-solubility nanocrystalline and chemosynthesis thereof and application
CN103897123B (en) * 2014-03-13 2016-04-13 复旦大学 A kind of rich surface contains preparation method and the application thereof of the core-shell magnetic composite microsphere of nickel ion
KR102046907B1 (en) * 2019-01-16 2019-11-20 주식회사 신아티앤씨 Quantum dots in which ionic liquids are ion-bonded and their preparation method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088994B1 (en) 1982-03-15 1991-06-19 Schering Corporation Hybrid dna, binding composition prepared thereby and processes therefor
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5151507A (en) * 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5789157A (en) * 1990-06-11 1998-08-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue selex
US5602240A (en) * 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
WO1992005186A1 (en) * 1990-09-20 1992-04-02 Gilead Sciences Modified internucleoside linkages
US5187085A (en) 1990-09-28 1993-02-16 Applied Biosystems, Inc. Nucleic acid sequence analysis with nucleoside-5'-o-(1-thiotriphosphates)
YU187991A (en) 1990-12-11 1994-09-09 Hoechst Aktiengesellschaft 3- (2) -AMINO-ALI THIOL-MODIFIED, FLUORESCENT-DYED NUCLEOSIDES, NUCLEOTIDS AND OLIGONUCLEOTIDES, PROCESS FOR THEIR OBTAINING AND THEIR USE
US5505928A (en) * 1991-11-22 1996-04-09 The Regents Of University Of California Preparation of III-V semiconductor nanocrystals
US5736137A (en) * 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5969135A (en) 1995-11-02 1999-10-19 Icn Pharmaceuticals, Inc. Oligonucleotide analogs with an amino acid or a modified amino alcohol residue
US5637258A (en) 1996-03-18 1997-06-10 Nanocrystals Technology L.P. Method for producing rare earth activited metal oxide nanocrystals
US5948386A (en) 1997-03-14 1999-09-07 The Curators Of The University Of Missouri Conjugate and method for forming aminomethyl phosphorus conjugates
EP1113986A2 (en) * 1998-09-18 2001-07-11 Massachusetts Institute Of Technology Inventory control
US6251303B1 (en) * 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6326144B1 (en) * 1998-09-18 2001-12-04 Massachusetts Institute Of Technology Biological applications of quantum dots
EP0990903B1 (en) * 1998-09-18 2003-03-12 Massachusetts Institute Of Technology Biological applications of semiconductor nanocrystals
US6306610B1 (en) * 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6221602B1 (en) * 1998-11-10 2001-04-24 Bio-Pixels Ltd. Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination
US6261779B1 (en) 1998-11-10 2001-07-17 Bio-Pixels Ltd. Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
US6179912B1 (en) 1999-12-20 2001-01-30 Biocrystal Ltd. Continuous flow process for production of semiconductor nanocrystals
US6306736B1 (en) * 2000-02-04 2001-10-23 The Regents Of The University Of California Process for forming shaped group III-V semiconductor nanocrystals, and product formed using process

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems

Also Published As

Publication number Publication date
US20050112376A1 (en) 2005-05-26
EP1456022A2 (en) 2004-09-15
WO2003054507A2 (en) 2003-07-03
EP1456022A4 (en) 2005-03-09
JP5254928B2 (en) 2013-08-07
AU2002365124A1 (en) 2003-07-09
JP2010048812A (en) 2010-03-04
AU2002365124A8 (en) 2003-07-09
EP2159044B1 (en) 2012-05-16
EP2159044A1 (en) 2010-03-03
ATE448077T1 (en) 2009-11-15
US20030059635A1 (en) 2003-03-27
DE60234382D1 (en) 2009-12-24
US6955855B2 (en) 2005-10-18
EP1456022B1 (en) 2009-11-11
JP2005513471A (en) 2005-05-12
US7198847B2 (en) 2007-04-03

Similar Documents

Publication Publication Date Title
WO2003054507A3 (en) Nanocrystals
EP1281070A4 (en) Methods, articles and kits for labeling polymer gels
EP1927635A3 (en) Primer composition and bonding method
AU2004697A (en) Biodegradable poly (amino acid)s, derivatized amino acid polymers and methods for making same
DE69940561D1 (en) RESIN COMPOSITION, POLYMER AND METHOD FOR THE PRODUCTION THEREOF
AU3361899A (en) Catalyst composition for polymerizing monomers
AU7845000A (en) Catalyst compositions and method of polymerization therewith
DE69910511D1 (en) POLYBUTENE-1 (CO) POLYMERS AND METHOD FOR THE PRODUCTION THEREOF
AU2023199A (en) Methods, systems, and kits for intravascular nucleic acid delivery
EP1153942A4 (en) Polymer, processes for producing polymer, and composition
AU6192299A (en) Functionalized derivatives of hyaluronic acid and formation of hydrogels in situusing same
EP1019365A4 (en) Novel compositions for the delivery of negatively charged molecules
AU5742200A (en) Electronic statement, bill presentment and payment system and method
DE59603014D1 (en) METHOD FOR PRODUCING LOW MOLECULAR, HIGHLY REACTIVE POLYISOBUTEN
ID20314A (en) POLYMER PROPILENON ADMINISTRATION, PRODUCTION PROCESS AND POLYPROPHYLENE RESIN COMPOSITION
AU5272901A (en) Method for producing identification code, and method and system for giving electronic notice service and electronic meter reading service by using the same
ATE336547T1 (en) POLYMER COMPOSITION CONTAINING AT LEAST ONE MEDIUM MOLECULAR REACTIVE POLYISOBUTENE
AU2002349732A1 (en) Water-base composition and crosslinking agent for water-soluble polymers
AU2468601A (en) Polymerization catalyst systems, methods of making and uses therefor
WO2000066650A3 (en) Carboxyl functional additive for condensing polyamides
AU2003229311A1 (en) Short chain polymer for enhancing the bioadhesiveness of polymers on mucosal membrane
WO2004029137A3 (en) Cross-linked polymer matrices, and methods of making and using same
AU2708999A (en) Cellulose/polymer composite enthalpy exchanger and method for its manufacture
AU2002363823A1 (en) Modified covalently cross-linked polymers
AU3219400A (en) Methods and reagents for molecular detection of hiv-1 groups m, n and

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2003555171

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2002803277

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002803277

Country of ref document: EP