WO2003057259A3 - Indocyanine green (icg) compositions - Google Patents

Indocyanine green (icg) compositions Download PDF

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Publication number
WO2003057259A3
WO2003057259A3 PCT/US2002/039613 US0239613W WO03057259A3 WO 2003057259 A3 WO2003057259 A3 WO 2003057259A3 US 0239613 W US0239613 W US 0239613W WO 03057259 A3 WO03057259 A3 WO 03057259A3
Authority
WO
WIPO (PCT)
Prior art keywords
icg
aqueous
composition
indocyanine green
compositions
Prior art date
Application number
PCT/US2002/039613
Other languages
French (fr)
Other versions
WO2003057259A2 (en
Inventor
Abu Alam
Ashok J Chavan
Robert W Flower
Original Assignee
Akorn Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akorn Inc filed Critical Akorn Inc
Priority to AU2002357158A priority Critical patent/AU2002357158A1/en
Publication of WO2003057259A2 publication Critical patent/WO2003057259A2/en
Publication of WO2003057259A3 publication Critical patent/WO2003057259A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure

Abstract

Aqueous indocyanine green (ICG) composition exhibiting enhanced stability, as well as enhanced ICG concentration, as compared to presently available ICG products. The composition comprises an aqueous ICG composition comprising ICG at a concentration of at least about 10 mg/ml and an aqueous diluent, wherein the composition is stable for at least 24 hours. Diagnostic and therapeutic methods for using these aqueous compositions are also contemplated, e.g., angiography, dye-enhanced photocoagulation, photodynamic therapy, for a variety of conditions, including Age-Related Macular Degeneration (ARMD), lesions and tumors.
PCT/US2002/039613 2001-12-27 2002-12-11 Indocyanine green (icg) compositions WO2003057259A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002357158A AU2002357158A1 (en) 2001-12-27 2002-12-11 Indocyanine green (icg) compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/034,432 US6944493B2 (en) 1999-09-10 2001-12-27 Indocyanine green (ICG) compositions and related methods of use
US10/034,432 2001-12-27

Publications (2)

Publication Number Publication Date
WO2003057259A2 WO2003057259A2 (en) 2003-07-17
WO2003057259A3 true WO2003057259A3 (en) 2003-09-18

Family

ID=21876377

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/039613 WO2003057259A2 (en) 2001-12-27 2002-12-11 Indocyanine green (icg) compositions

Country Status (3)

Country Link
US (1) US6944493B2 (en)
AU (1) AU2002357158A1 (en)
WO (1) WO2003057259A2 (en)

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Publication number Publication date
WO2003057259A2 (en) 2003-07-17
AU2002357158A1 (en) 2003-07-24
US6944493B2 (en) 2005-09-13
US20030060718A1 (en) 2003-03-27
AU2002357158A8 (en) 2003-07-24

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