WO2003063766A3 - Novel immunogenic compositions for the prevention and treatment of meningococcal disease - Google Patents
Novel immunogenic compositions for the prevention and treatment of meningococcal disease Download PDFInfo
- Publication number
- WO2003063766A3 WO2003063766A3 PCT/US2002/032369 US0232369W WO03063766A3 WO 2003063766 A3 WO2003063766 A3 WO 2003063766A3 US 0232369 W US0232369 W US 0232369W WO 03063766 A3 WO03063766 A3 WO 03063766A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- immunogenic compositions
- prevention
- treatment
- meningococcal disease
- novel immunogenic
- Prior art date
Links
- 230000002163 immunogen Effects 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000037941 meningococcal disease Diseases 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 241000588653 Neisseria Species 0.000 abstract 1
- 241000588677 Neisseria meningitidis serogroup B Species 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2414—Alpha-amylase (3.2.1.1.)
- C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2468—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on beta-galactose-glycoside bonds, e.g. carrageenases (3.2.1.83; 3.2.1.157); beta-agarase (3.2.1.81)
- C12N9/2471—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/22—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Neisseriaceae (F), e.g. Acinetobacter
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Abstract
Priority Applications (31)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2012002655A MX339524B (en) | 2001-10-11 | 2001-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease. |
IL16105202A IL161052A0 (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
EP02804818.9A EP1442047B1 (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
CN028233301A CN1578785B (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
ES02804818.9T ES2568895T3 (en) | 2001-10-11 | 2002-10-11 | New immunogenic compositions for the prevention and treatment of meningococcal disease |
KR1020047005313A KR101068318B1 (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
EP17156888.4A EP3199539B1 (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
KR1020117022199A KR101215664B1 (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
CA2463476A CA2463476C (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
JP2003563462A JP2005515771A (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic composition for prevention and treatment of meningitis disease |
KR1020107002131A KR101099916B1 (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
BRPI0212999A BRPI0212999B8 (en) | 2001-10-11 | 2002-10-11 | new immunogenic compositions for the prevention and treatment of meningococcal disease |
MXPA04003356A MXPA04003356A (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease. |
US10/492,427 US8101194B2 (en) | 2001-10-11 | 2002-10-11 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
IL161052A IL161052A (en) | 2001-10-11 | 2004-03-24 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US12/408,076 US20120034261A1 (en) | 2001-10-11 | 2009-03-20 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
US12/408,286 US9107873B2 (en) | 2001-10-11 | 2009-03-20 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US13/333,123 US8563006B2 (en) | 2001-10-11 | 2011-12-21 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US13/455,268 US9132182B2 (en) | 2001-10-11 | 2012-04-25 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US13/455,518 US20120308595A1 (en) | 2001-10-11 | 2012-04-25 | Novel Immunogenic Compositions For The Prevention And Treatment of Meningococcal Disease |
US13/455,326 US9623101B2 (en) | 2001-10-11 | 2012-04-25 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
MX2015018022A MX349481B (en) | 2001-10-11 | 2012-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease. |
US13/910,187 US8563007B1 (en) | 2001-10-11 | 2013-06-05 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
IL233545A IL233545A (en) | 2001-10-11 | 2014-07-08 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US14/639,543 US9168293B2 (en) | 2001-10-11 | 2015-03-05 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US14/820,452 US9757444B2 (en) | 2001-10-11 | 2015-08-06 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
IL245956A IL245956B (en) | 2001-10-11 | 2016-05-31 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
IL245955A IL245955B (en) | 2001-10-11 | 2016-05-31 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US15/443,618 US10300122B2 (en) | 2001-10-11 | 2017-02-27 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US16/270,067 US20190151431A1 (en) | 2001-10-11 | 2019-02-07 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US16/736,619 US11116829B2 (en) | 2001-10-11 | 2020-01-07 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32810101P | 2001-10-11 | 2001-10-11 | |
US60/328,101 | 2001-10-11 | ||
US40693402P | 2002-08-30 | 2002-08-30 | |
US60/406,934 | 2002-08-30 |
Related Child Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10492427 A-371-Of-International | 2002-10-11 | ||
US10/492,427 A-371-Of-International US8101194B2 (en) | 2001-10-11 | 2002-10-11 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US12/408,076 Division US20120034261A1 (en) | 2001-10-11 | 2009-03-20 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
US12/408,286 Division US9107873B2 (en) | 2001-10-11 | 2009-03-20 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US13/333,123 Division US8563006B2 (en) | 2001-10-11 | 2011-12-21 | Immunogenic compositions for the prevention and treatment of meningococcal disease |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003063766A2 WO2003063766A2 (en) | 2003-08-07 |
WO2003063766A3 true WO2003063766A3 (en) | 2004-01-08 |
Family
ID=27668840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/032369 WO2003063766A2 (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
Country Status (19)
Country | Link |
---|---|
US (13) | US8101194B2 (en) |
EP (14) | EP2332961B1 (en) |
JP (6) | JP2005515771A (en) |
KR (4) | KR101215664B1 (en) |
CN (4) | CN105617372A (en) |
AU (3) | AU2009213040C1 (en) |
BE (3) | BE2017C057I2 (en) |
BR (1) | BRPI0212999B8 (en) |
CA (5) | CA2894296C (en) |
DK (10) | DK2371838T3 (en) |
ES (14) | ES2781213T3 (en) |
FR (4) | FR15C0056I2 (en) |
HK (2) | HK1178429A1 (en) |
IL (5) | IL161052A0 (en) |
LU (4) | LU92786I2 (en) |
MX (3) | MX339524B (en) |
NL (3) | NL300897I2 (en) |
PT (10) | PT2348036E (en) |
WO (1) | WO2003063766A2 (en) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2261339B1 (en) | 1998-05-01 | 2017-03-22 | GlaxoSmithKline Biologicals SA | Neisseria meningitidis antigens and compositions |
EP2258851A1 (en) | 1999-05-19 | 2010-12-08 | Novartis Vaccines and Diagnostics S.r.l. | Combination neisserial compositions |
BR0015137A (en) | 1999-10-29 | 2003-03-25 | Chiron Spa | Neisserial antigenic peptides |
RU2279889C2 (en) | 2000-01-17 | 2006-07-20 | Чирон С.Р.Л. | OUTER MEMBRANE VESICLE VACCINE (OMV) CONTAINING PROTEINS OF SEROGROUP B N.Meningitis OUTER MEMBRANE |
CA2689666C (en) | 2000-02-28 | 2015-02-24 | Novartis Vaccines And Diagnostics S.R.L. | Heterologous expression of neisserial proteins |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
MX339524B (en) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Novel immunogenic compositions for the prevention and treatment of meningococcal disease. |
SI1549338T1 (en) | 2002-10-11 | 2011-04-29 | Novartis Vaccines & Diagnostic | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
PT2191844E (en) | 2003-01-30 | 2014-06-04 | Novartis Ag | Injectable vaccines against multiple meningococcal serogroups |
CA2522751A1 (en) * | 2003-04-16 | 2004-11-04 | Wyeth Holdings Corporation | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
DE602004032481D1 (en) | 2003-10-02 | 2011-06-09 | Novartis Vaccines & Diagnostic | Combination vaccines against meningitis |
GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
GB0419408D0 (en) | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
KR102564388B1 (en) | 2005-04-08 | 2023-08-08 | 와이어쓰 엘엘씨 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
CN102526723B (en) | 2005-06-27 | 2017-07-07 | 葛兰素史密丝克莱恩生物有限公司 | Immunogenic composition |
AU2013201318B2 (en) * | 2005-11-25 | 2015-11-19 | Glaxosmithkline Biologicals Sa | Chimeric, hybrid and tandem polypeptides of meningococcal NMB 1870 |
GB0524066D0 (en) * | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
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2013
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2014
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2018
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1999057280A2 (en) * | 1998-05-01 | 1999-11-11 | Chiron Corporation | Neisseria meningitidis antigens and compositions |
WO2001064922A2 (en) * | 2000-02-28 | 2001-09-07 | Chiron Spa | Heterologous expression of neisserial proteins |
WO2001064920A2 (en) * | 2000-02-28 | 2001-09-07 | Chiron Spa | Hybrid expression of neisserial proteins |
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