WO2003064677A3 - Long-acting follicle stimulating hormone analogues and uses thereof - Google Patents

Long-acting follicle stimulating hormone analogues and uses thereof Download PDF

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Publication number
WO2003064677A3
WO2003064677A3 PCT/US2003/002957 US0302957W WO03064677A3 WO 2003064677 A3 WO2003064677 A3 WO 2003064677A3 US 0302957 W US0302957 W US 0302957W WO 03064677 A3 WO03064677 A3 WO 03064677A3
Authority
WO
WIPO (PCT)
Prior art keywords
long
stimulating hormone
follicle stimulating
hormone analogues
acting
Prior art date
Application number
PCT/US2003/002957
Other languages
French (fr)
Other versions
WO2003064677A2 (en
Inventor
Joyce Lustbader
Original Assignee
Univ Columbia
Joyce Lustbader
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Joyce Lustbader filed Critical Univ Columbia
Priority to AU2003207775A priority Critical patent/AU2003207775A1/en
Publication of WO2003064677A2 publication Critical patent/WO2003064677A2/en
Publication of WO2003064677A3 publication Critical patent/WO2003064677A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

This invention provides FSH analogues having increased serum half-life relative to FSH. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject.
PCT/US2003/002957 2002-01-31 2003-01-31 Long-acting follicle stimulating hormone analogues and uses thereof WO2003064677A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003207775A AU2003207775A1 (en) 2002-01-31 2003-01-31 Long-acting follicle stimulating hormone analogues and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6291002A 2002-01-31 2002-01-31
US10/062,910 2002-01-31
US10/112,321 2002-03-27
US10/112,321 US7081446B2 (en) 2002-01-31 2002-03-27 Long-acting follicle stimulating hormone analogues and uses thereof

Publications (2)

Publication Number Publication Date
WO2003064677A2 WO2003064677A2 (en) 2003-08-07
WO2003064677A3 true WO2003064677A3 (en) 2007-04-05

Family

ID=27667767

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/002957 WO2003064677A2 (en) 2002-01-31 2003-01-31 Long-acting follicle stimulating hormone analogues and uses thereof

Country Status (3)

Country Link
US (3) US7081446B2 (en)
AU (1) AU2003207775A1 (en)
WO (1) WO2003064677A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103554268B (en) * 2013-11-01 2015-04-01 广州联康生物科技有限公司 Long-acting recombinant follicle-stimulating hormone and application thereof

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7081446B2 (en) * 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
CA2529246A1 (en) * 2003-06-20 2004-12-29 Serum Biomedical Institute Method of producing recombinant dna molecules
KR100533794B1 (en) * 2003-10-02 2005-12-07 주식회사 프로젠 Method for mass production of human Follicle Stimulating Hormone
CN1926237A (en) * 2004-01-28 2007-03-07 森托尼克斯制药有限公司 Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8304386B2 (en) * 2006-02-03 2012-11-06 Prolor Biotech, Inc. Long-acting growth hormone and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US7553940B2 (en) 2006-02-03 2009-06-30 Modigene Inc Long-acting EPO polypeptides and derivatives thereof and methods thereof
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US8476234B2 (en) * 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
FI1996220T4 (en) † 2006-03-06 2023-11-09 Amunix Pharmaceuticals Inc Unstructured recombinant polymers and uses thereof
WO2008098169A2 (en) * 2007-02-08 2008-08-14 Aspenbio Pharma, Inc. Compositions and methods including expression and bioactivity of bovine follicle stimulating hormone
ES2693697T3 (en) * 2007-11-30 2018-12-13 Aspenbio Pharma, Inc. Activity of the recombinant equine follicle stimulating hormone
CN102348715B (en) 2009-02-03 2017-12-08 阿穆尼克斯运营公司 Extension recombinant polypeptide and the composition for including the extension recombinant polypeptide
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
PE20142405A1 (en) 2012-04-19 2015-01-25 Opko Biolog Ltd LONG-ACTING OXYTOMODULIN VARIANTS AND METHODS OF PRODUCING THEM
US9808534B2 (en) * 2012-11-20 2017-11-07 Opko Biologics Ltd. Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
CN103539862B (en) * 2013-11-01 2015-04-01 广州联康生物科技有限公司 Long-acting recombinant follicle-stimulating hormone and application thereof
CN103539860B (en) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 Long-acting recombinant human follicle-stimulating hormone-Fc fusion protein (hFSH-Fc)
CN104152457B (en) * 2014-07-14 2017-02-15 林静静 Preparation method of veterinary follicle-stimulating hormone analogue
KR102473014B1 (en) 2015-06-19 2022-11-30 옵코 바이오로직스 리미티드 Long-acting coagulation factors and methods of producing same
CN106279437B (en) 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 Hyperglycosylated human coagulation factor VIII fusion proteins and preparation method thereof and purposes
EP3502143A4 (en) * 2016-08-19 2020-07-15 Ampsource Biopharma Shanghai Inc. Linker peptide for constructing fusion protein
CN107759697B (en) 2016-08-19 2023-03-24 安源医药科技（上海）有限公司 Method for producing fusion protein
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN108531508B (en) * 2018-03-20 2021-07-16 西北民族大学 Preparation method for sheep follicle-stimulating hormone gene recombinant expression
CN112679601A (en) * 2021-01-20 2021-04-20 长春生物制品研究所有限责任公司 Preparation method of high specific activity recombinant human follicle stimulating hormone

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242580B1 (en) * 1994-02-18 2001-06-05 Washington University Single-chain forms of the glycoprotein hormone quartet

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE10199028I2 (en) 1983-11-02 2004-07-01 Applied Research Systems Products and methods for the production of a heterodimeric human LH with a Met42 Val55 alpha subunit.
US5359033A (en) 1985-10-30 1994-10-25 Biogen, Inc. Cleaved dimers of mullerian inhibiting substance-like polypeptides
US5260421A (en) 1987-12-21 1993-11-09 Applied Research Systems Ars Holding N.V. Site-directed mutagenesis modified glycoprotein hormones
US5661126A (en) 1989-01-19 1997-08-26 The General Hospital Corporation Use of mullerian inhibiting substance for treating certain tumors and for modulating class I major histocompatibility antigen expression
US7081445B2 (en) * 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
ATE148171T1 (en) 1989-02-21 1997-02-15 Univ Washington MODIFIED FORMS OF REPRODUCTIVE HORMONES
US5935815A (en) 1989-10-25 1999-08-10 Katholieke Universiteit Leuven Process for micro biological production of proteins
US5270181A (en) 1991-02-06 1993-12-14 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
US5272070A (en) 1991-03-08 1993-12-21 Board Of Regents, The University Of Texas System Method for the preparation of cell lines producing Man3 GlcNac 2 asparagine-linked gylcans and cell lines produced thereby
US5932211A (en) 1991-11-12 1999-08-03 Women's And Children's Hospital Glycosylation variants of iduronate 2-sulfatase
US5985611A (en) * 1992-04-30 1999-11-16 Washington University Recombinant production of gonadotropins in secretory cells
EP0690871A4 (en) 1993-01-12 1999-10-20 Univ Johns Hopkins Med Growth differentiation factor-5
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6040157A (en) 1994-03-08 2000-03-21 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
BR9506313A (en) * 1994-08-12 1997-08-05 Univ Washington Single chain forms of the glycoprotein hormone quartet
AU2728297A (en) 1996-04-15 1997-11-07 Board Of Trustees Of The Leland Stanford Junior University Soluble 7-transmembrane domain G-protein-coupled receptor compositions and me thods
US6103501A (en) 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
US6635256B1 (en) 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US20030012792A1 (en) 1998-05-22 2003-01-16 Holaday John W. Compositions and methods for inhibiting endothelial cell proliferation and regulating angiogenesis using cancer markers
US6265393B1 (en) 1998-08-07 2001-07-24 Heinrichs William Leroy Prevention of endometriosis signs or symptons
US20020127652A1 (en) * 2000-02-11 2002-09-12 Schambye Hans Thalsgard Follicle stimulating hormones
CA2405912A1 (en) * 2000-04-12 2001-10-18 Human Genome Sciences, Inc. Albumin fusion proteins
US7163681B2 (en) 2000-08-07 2007-01-16 Centocor, Inc. Anti-integrin antibodies, compositions, methods and uses
US6987172B2 (en) 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
US20020128190A1 (en) 2001-03-09 2002-09-12 Leslie Lobel Expression of properly folded and soluble extracellular domain of a gonadotropin receptor
US7173113B2 (en) 2002-01-31 2007-02-06 The Trustees Of Columbia University In The City Of New York Long-acting hormone and growth factor compositions and uses thereof
US7081446B2 (en) 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
WO2003103725A1 (en) 2002-06-07 2003-12-18 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP1572972A4 (en) 2002-11-21 2007-11-21 Genentech Inc Therapy of non-malignant diseases or disorders with anti-erbb2 antibodies
US20080039372A1 (en) 2005-07-21 2008-02-14 The Trustees Of Columbia University In The City Of New York Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation
WO2007076501A2 (en) 2005-12-23 2007-07-05 The Burnham Institute For Medical Research Endometriosis cell targeting peptide and uses thereof
WO2009052119A1 (en) 2007-10-14 2009-04-23 Columbia University A method for treating endometriosis by administering mullerian inhibiting substance
WO2010017290A1 (en) 2008-08-05 2010-02-11 The Trustees Of Columbia University In The City Of New York Müllerian inhibiting substance (mis) analogues

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242580B1 (en) * 1994-02-18 2001-06-05 Washington University Single-chain forms of the glycoprotein hormone quartet

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BAIRD D.T. ET AL.: "Is there a place for different isoforms of FSH in clinical medicine? IV. The clinician's point of view", HUMAN REPRODUCTION, vol. 16, no. 7, pages 1316 - 1318, XP003010057 *
ULLOA-AGUIRRE ET AL., ARCHIVES OF MEDICAL RESEARCH, vol. 32, 2001, pages 520 - 532, XP003010058 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103554268B (en) * 2013-11-01 2015-04-01 广州联康生物科技有限公司 Long-acting recombinant follicle-stimulating hormone and application thereof

Also Published As

Publication number Publication date
US7202215B2 (en) 2007-04-10
AU2003207775A8 (en) 2007-05-17
US7807620B2 (en) 2010-10-05
US7081446B2 (en) 2006-07-25
WO2003064677A2 (en) 2003-08-07
US20030143694A1 (en) 2003-07-31
AU2003207775A1 (en) 2003-09-02
US20080234186A1 (en) 2008-09-25
US20030211580A1 (en) 2003-11-13

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