WO2003066661A3 - Human dr4 antibodies and uses thereof - Google Patents

Human dr4 antibodies and uses thereof Download PDF

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Publication number
WO2003066661A3
WO2003066661A3 PCT/US2002/020712 US0220712W WO03066661A3 WO 2003066661 A3 WO2003066661 A3 WO 2003066661A3 US 0220712 W US0220712 W US 0220712W WO 03066661 A3 WO03066661 A3 WO 03066661A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
human
kits
diagnosis
articles
Prior art date
Application number
PCT/US2002/020712
Other languages
French (fr)
Other versions
WO2003066661A2 (en
Inventor
Anan Chuntharapai
Kyung Jin Kim
Original Assignee
Genentech Inc
Anan Chuntharapai
Kyung Jin Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2003566032A priority Critical patent/JP4509570B2/en
Priority to AU2002366430A priority patent/AU2002366430B2/en
Priority to US10/480,730 priority patent/US7252994B2/en
Priority to EP02805988A priority patent/EP1409544B1/en
Priority to CA2451680A priority patent/CA2451680C/en
Priority to IL15952702A priority patent/IL159527A0/en
Priority to AT02805988T priority patent/ATE433996T1/en
Priority to DE60232660T priority patent/DE60232660D1/en
Application filed by Genentech Inc, Anan Chuntharapai, Kyung Jin Kim filed Critical Genentech Inc
Priority to DK02805988T priority patent/DK1409544T3/en
Publication of WO2003066661A2 publication Critical patent/WO2003066661A2/en
Publication of WO2003066661A3 publication Critical patent/WO2003066661A3/en
Priority to HK04107906.4A priority patent/HK1065323A1/en
Priority to US11/819,575 priority patent/US7744881B2/en
Priority to AU2008260311A priority patent/AU2008260311A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis

Abstract

Human Death Receptor 4 (DR4) antibodies are provided. The human DR4 antibodies may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treatment and diagnosis using the DR4 antibodies are also provided.
PCT/US2002/020712 2001-07-03 2002-06-29 Human dr4 antibodies and uses thereof WO2003066661A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AT02805988T ATE433996T1 (en) 2001-07-03 2002-06-29 HUMAN DR4 ANTIBODIES AND THEIR APPLICATIONS
US10/480,730 US7252994B2 (en) 2001-07-03 2002-06-29 Human DR4 antibodies and uses thereof
EP02805988A EP1409544B1 (en) 2001-07-03 2002-06-29 Human dr4 antibodies and uses thereof
CA2451680A CA2451680C (en) 2001-07-03 2002-06-29 Human dr4 antibodies and uses thereof
IL15952702A IL159527A0 (en) 2001-07-03 2002-06-29 Human dr4 antibodies and uses thereof
JP2003566032A JP4509570B2 (en) 2001-07-03 2002-06-29 Human DR4 antibody and method of use thereof
DE60232660T DE60232660D1 (en) 2001-07-03 2002-06-29 HUMAN DR4 ANTIBODIES AND ITS APPLICATIONS
AU2002366430A AU2002366430B2 (en) 2001-07-03 2002-06-29 Human DR4 antibodies and uses thereof
DK02805988T DK1409544T3 (en) 2001-07-03 2002-06-29 Human DR4 antibodies and uses thereof
HK04107906.4A HK1065323A1 (en) 2001-07-03 2004-10-14 Human dr4 antibodies and uses thereof
US11/819,575 US7744881B2 (en) 2001-07-03 2007-06-28 Human DR4 antibodies and uses thereof
AU2008260311A AU2008260311A1 (en) 2001-07-03 2008-12-18 Human DR4 antibodies and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30322001P 2001-07-03 2001-07-03
US60/303,220 2001-07-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/819,575 Continuation US7744881B2 (en) 2001-07-03 2007-06-28 Human DR4 antibodies and uses thereof

Publications (2)

Publication Number Publication Date
WO2003066661A2 WO2003066661A2 (en) 2003-08-14
WO2003066661A3 true WO2003066661A3 (en) 2003-11-27

Family

ID=27734188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/020712 WO2003066661A2 (en) 2001-07-03 2002-06-29 Human dr4 antibodies and uses thereof

Country Status (14)

Country Link
US (2) US7252994B2 (en)
EP (2) EP2192130A1 (en)
JP (1) JP4509570B2 (en)
AT (1) ATE433996T1 (en)
AU (2) AU2002366430B2 (en)
CA (1) CA2451680C (en)
CY (1) CY1110505T1 (en)
DE (1) DE60232660D1 (en)
DK (1) DK1409544T3 (en)
ES (1) ES2328234T3 (en)
HK (1) HK1065323A1 (en)
IL (1) IL159527A0 (en)
PT (1) PT1409544E (en)
WO (1) WO2003066661A2 (en)

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US20030228309A1 (en) * 2000-11-08 2003-12-11 Theodora Salcedo Antibodies that immunospecifically bind to TRAIL receptors
US20060062786A1 (en) * 2000-11-08 2006-03-23 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20090226429A1 (en) * 2001-05-25 2009-09-10 Human Genome Sciences, Inc. Antibodies That Immunospecifically Bind to TRAIL Receptors
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US7361341B2 (en) * 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
US20050129616A1 (en) * 2001-05-25 2005-06-16 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20050214209A1 (en) * 2001-05-25 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
JP2005516958A (en) * 2001-12-20 2005-06-09 ヒューマン　ジノーム　サイエンシーズ，　インコーポレイテッド Antibodies that immunospecifically bind to TRAIL receptors
ES2239886B1 (en) * 2003-11-05 2006-12-16 Universidad De Barcelona METHOD AND APPLIANCE FOR THE DETERMINATION OF CELLULAR VIABILITY.
AU2012200602B2 (en) * 2004-08-06 2012-11-08 Genentech, Inc. Assays and methods using biomarkers
RU2431676C2 (en) 2004-08-06 2011-10-20 Дженентек, Инк. Analyses and methods with application of biomarkers
ATE508753T1 (en) * 2004-08-06 2011-05-15 Genentech Inc ASSAY AND METHODS USING BIOMARKERS
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US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
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JP5302012B2 (en) 2006-03-08 2013-10-02 タケダ カリフォルニア インコーポレイテッド Glucokinase activator
WO2007143434A2 (en) * 2006-05-31 2007-12-13 Takeda San Diego, Inc. Indazole and isoindole derivatives as glucokinase activating agents
WO2008079787A2 (en) 2006-12-20 2008-07-03 Takeda San Diego, Inc. Glucokinase activators
WO2008116107A2 (en) * 2007-03-21 2008-09-25 Takeda San Diego, Inc. Piperazine derivatives as glucokinase activators
US9044457B2 (en) 2010-06-16 2015-06-02 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Anti-DR4 agonist antibodies
KR102037541B1 (en) 2011-10-28 2019-10-29 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 Polypeptide constructs and uses thereof
EP2684896A1 (en) 2012-07-09 2014-01-15 International-Drug-Development-Biotech Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof
PT2992013T (en) 2013-04-29 2020-03-05 Teva Pharmaceuticals Australia Pty Ltd Anti-cd38 antibodies and fusions to attenuated interferon alpha-2b
US11117975B2 (en) 2013-04-29 2021-09-14 Teva Pharmaceuticals Australia Pty Ltd Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
UA119352C2 (en) 2014-05-01 2019-06-10 Тева Фармасьютикалз Острейліа Пті Лтд Combination of lenalidomide or pomalidomide and cd38 antibody-attenuated interferon-alpha constructs, and the use thereof
EA037749B1 (en) 2014-10-29 2021-05-18 Тева Фармасьютикалз Острэйлиа Пти Лтд INTERFERON 2b VARIANTS
CN109195626B (en) 2015-10-30 2022-09-13 银河生物技术有限责任公司 Antibodies that bind to death receptor 4 and death receptor 5
US20190144554A1 (en) 2015-12-01 2019-05-16 Genmab B.V. Anti-dr5 antibodies and methods of use thereof

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Also Published As

Publication number Publication date
CA2451680A1 (en) 2003-08-14
PT1409544E (en) 2009-09-16
US7252994B2 (en) 2007-08-07
JP4509570B2 (en) 2010-07-21
EP1409544A2 (en) 2004-04-21
JP2005517021A (en) 2005-06-09
AU2008260311A1 (en) 2009-01-15
AU2002366430A1 (en) 2003-09-02
EP1409544A4 (en) 2005-11-09
US20040147725A1 (en) 2004-07-29
ATE433996T1 (en) 2009-07-15
ES2328234T3 (en) 2009-11-11
AU2002366430B2 (en) 2008-09-18
US20080233646A1 (en) 2008-09-25
HK1065323A1 (en) 2005-02-18
EP2192130A1 (en) 2010-06-02
CA2451680C (en) 2011-04-19
WO2003066661A2 (en) 2003-08-14
CY1110505T1 (en) 2015-04-29
IL159527A0 (en) 2004-06-01
US7744881B2 (en) 2010-06-29
DE60232660D1 (en) 2009-07-30
DK1409544T3 (en) 2009-10-26
EP1409544B1 (en) 2009-06-17

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