WO2003077858A3 - Humanized antibodies that recognize beta amyloid peptide - Google Patents
Humanized antibodies that recognize beta amyloid peptide Download PDFInfo
- Publication number
- WO2003077858A3 WO2003077858A3 PCT/US2003/007715 US0307715W WO03077858A3 WO 2003077858 A3 WO2003077858 A3 WO 2003077858A3 US 0307715 W US0307715 W US 0307715W WO 03077858 A3 WO03077858 A3 WO 03077858A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- humanized antibodies
- amyloid peptide
- beta amyloid
- recognize beta
- recognize
- Prior art date
Links
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003575912A JP2006503549A (en) | 2002-03-12 | 2003-03-12 | Humanized antibody that recognizes β-amyloid peptide |
EA200401170A EA010902B1 (en) | 2002-03-12 | 2003-03-12 | Humanized immunoglobulin, that recognizes beta amyloid peptide, pharmaceutical composition and method for producing thereof |
MXPA04008740A MXPA04008740A (en) | 2002-03-12 | 2003-03-12 | Humanized antibodies that recognize beta amyloid peptide. |
IL16362603A IL163626A0 (en) | 2002-03-12 | 2003-03-12 | Humanized antibodies that recognize beta amyloid peptide |
NZ535769A NZ535769A (en) | 2002-03-12 | 2003-03-12 | Humanized antibodies that recognize beta amyloid peptide |
AU2003214152A AU2003214152B2 (en) | 2002-03-12 | 2003-03-12 | Humanized antibodies that recognize beta amyloid peptide |
CA2478049A CA2478049C (en) | 2002-03-12 | 2003-03-12 | Humanized antibodies that recognize beta amyloid peptide |
CN038058162A CN1703426B (en) | 2002-03-12 | 2003-03-12 | Humanized antibodies that recognize beta amyloid peptide |
BRPI0308143-5A BR0308143A (en) | 2002-03-12 | 2003-03-12 | light chain, heavy chain, immunoglobulin, humanized antibody. pharmaceutical and therapeutic composition, isolated polypeptide and peptide, polypeptide variant, isolated nucleic acid molecule, vector, host cell, transgenic animal, use of the variable region sequence presented as sequence id: 2 or sequence id. 4 and methods of preventing or treating an amyloidogenic disease associated with amyloid deposition of fir trees in a patient's brain and alzheimer's disease, of producing an antibody or fragment thereof, of identifying residues sensitive to substitution in a variable frame region of immunoglobulin , imaging of amyloid deposits in a patient's brain and reducing plaque, neuter and beta amyloid peptide (fir) load and neuritically dystrophy |
ES03711559T ES2389541T3 (en) | 2002-03-12 | 2003-03-12 | Humanized antibodies that recognize beta-amyloid peptide |
EP03711559A EP1554311B1 (en) | 2002-03-12 | 2003-03-12 | Humanized antibodies that recognize beta amyloid peptide |
IL163626A IL163626A (en) | 2002-03-12 | 2004-08-19 | Humanized antibodies that recognize beta amyloid peptide |
NO20043992A NO20043992L (en) | 2002-03-12 | 2004-09-23 | Humanized antibodies that recognize beta amyloid peptide |
IS7499A IS7499A (en) | 2002-03-12 | 2004-10-11 | Human antibodies against beta-amyloid peptides |
HR20040950A HRP20040950A2 (en) | 2002-03-12 | 2004-10-12 | Humanized antibodies that recognize beta amyloid peptide |
HK06105249.2A HK1085222A1 (en) | 2002-03-12 | 2006-05-03 | Humanized antibodies that recognize beta amyloid peptide |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36375102P | 2002-03-12 | 2002-03-12 | |
US60/363751 | 2002-03-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003077858A2 WO2003077858A2 (en) | 2003-09-25 |
WO2003077858A3 true WO2003077858A3 (en) | 2005-05-19 |
Family
ID=28041806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/007715 WO2003077858A2 (en) | 2002-03-12 | 2003-03-12 | Humanized antibodies that recognize beta amyloid peptide |
Country Status (30)
Country | Link |
---|---|
US (2) | US7256273B2 (en) |
EP (1) | EP1554311B1 (en) |
JP (1) | JP2006503549A (en) |
KR (2) | KR101122871B1 (en) |
CN (1) | CN1703426B (en) |
AR (1) | AR038953A1 (en) |
AU (1) | AU2003214152B2 (en) |
BR (1) | BR0308143A (en) |
CA (1) | CA2478049C (en) |
CO (1) | CO5611164A2 (en) |
EA (1) | EA010902B1 (en) |
EC (1) | ECSP045314A (en) |
ES (1) | ES2389541T3 (en) |
GE (1) | GEP20084474B (en) |
HK (1) | HK1085222A1 (en) |
HR (1) | HRP20040950A2 (en) |
IL (2) | IL163626A0 (en) |
IS (1) | IS7499A (en) |
MX (1) | MXPA04008740A (en) |
MY (1) | MY139983A (en) |
NO (1) | NO20043992L (en) |
NZ (1) | NZ535769A (en) |
PE (1) | PE20040207A1 (en) |
PL (1) | PL215258B1 (en) |
SG (1) | SG180018A1 (en) |
TW (1) | TWI328116B (en) |
UA (1) | UA89469C2 (en) |
UY (1) | UY27721A1 (en) |
WO (1) | WO2003077858A2 (en) |
ZA (1) | ZA200406616B (en) |
Cited By (20)
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---|---|---|---|---|
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US7871615B2 (en) | 2003-05-30 | 2011-01-18 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US7893214B2 (en) | 1997-12-02 | 2011-02-22 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
US8034339B2 (en) | 1997-12-02 | 2011-10-11 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidogenic disease |
US8128928B2 (en) | 2002-03-12 | 2012-03-06 | Wyeth Llc | Humanized antibodies that recognize beta amyloid peptide |
US8318164B2 (en) | 2005-01-28 | 2012-11-27 | Janssen Alzheimer Immunotherapy | Anti A beta antibody formulation |
US8613920B2 (en) | 2007-07-27 | 2013-12-24 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US8877190B2 (en) | 2006-11-30 | 2014-11-04 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
US8916165B2 (en) | 2004-12-15 | 2014-12-23 | Janssen Alzheimer Immunotherapy | Humanized Aβ antibodies for use in improving cognition |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
US9146244B2 (en) | 2007-06-12 | 2015-09-29 | Ac Immune S.A. | Polynucleotides encoding an anti-beta-amyloid monoclonal antibody |
US9176150B2 (en) | 2003-01-31 | 2015-11-03 | AbbVie Deutschland GmbH & Co. KG | Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
US9221900B2 (en) | 2010-07-30 | 2015-12-29 | Ac Immune S.A. | Methods for identifying safe and functional humanized antibodies |
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US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US7179892B2 (en) * | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
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US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
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US20060024667A1 (en) | 2004-07-29 | 2006-02-02 | Karen Manucharyan | Compositions and methods for Alzheimer's disease |
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