WO2003083077A3 - Antibody libraries - Google Patents

Antibody libraries Download PDF

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Publication number
WO2003083077A3
WO2003083077A3 PCT/US2003/009662 US0309662W WO03083077A3 WO 2003083077 A3 WO2003083077 A3 WO 2003083077A3 US 0309662 W US0309662 W US 0309662W WO 03083077 A3 WO03083077 A3 WO 03083077A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibody libraries
present
libraries
relates
antibody
Prior art date
Application number
PCT/US2003/009662
Other languages
French (fr)
Other versions
WO2003083077A2 (en
Inventor
Robert D Bremel
Kurt Eakle
Michael Imboden
Original Assignee
Gala Design Inc
Robert D Bremel
Kurt Eakle
Michael Imboden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gala Design Inc, Robert D Bremel, Kurt Eakle, Michael Imboden filed Critical Gala Design Inc
Priority to DE60324779T priority Critical patent/DE60324779D1/en
Priority to EP03745659A priority patent/EP1495146B1/en
Priority to AU2003226127A priority patent/AU2003226127A1/en
Publication of WO2003083077A2 publication Critical patent/WO2003083077A2/en
Publication of WO2003083077A3 publication Critical patent/WO2003083077A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to the production of antibody libraries. In particular, the present invention relates to the use of integrating retroviral vectors to generate libraries comprising a plurality of combinations of antibody light chains and heavy chains. The present invention thus provides improved methods of generating and screening antibody libraries comprising large numbers of unique antibodies.
PCT/US2003/009662 2002-03-28 2003-03-28 Antibody libraries WO2003083077A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE60324779T DE60324779D1 (en) 2002-03-28 2003-03-28 ANTIBODY LIBRARIES
EP03745659A EP1495146B1 (en) 2002-03-28 2003-03-28 Antibody libraries
AU2003226127A AU2003226127A1 (en) 2002-03-28 2003-03-28 Antibody libraries

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36880802P 2002-03-28 2002-03-28
US60/368,808 2002-03-28
US37129902P 2002-04-10 2002-04-10
US60/371,299 2002-04-10

Publications (2)

Publication Number Publication Date
WO2003083077A2 WO2003083077A2 (en) 2003-10-09
WO2003083077A3 true WO2003083077A3 (en) 2003-12-11

Family

ID=28678256

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/009662 WO2003083077A2 (en) 2002-03-28 2003-03-28 Antibody libraries

Country Status (6)

Country Link
US (2) US20040038304A1 (en)
EP (1) EP1495146B1 (en)
AT (1) ATE414795T1 (en)
AU (1) AU2003226127A1 (en)
DE (1) DE60324779D1 (en)
WO (1) WO2003083077A2 (en)

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US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20060195935A1 (en) 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
CA2581422C (en) * 2004-11-08 2012-05-22 Chromagenics B.V. Selection of host cells expressing protein at high levels
SI1809750T1 (en) 2004-11-08 2012-08-31 Chromagenics Bv Selection of host cells expressing protein at high levels
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CN101646688A (en) * 2006-10-24 2010-02-10 特鲁比昂药品公司 Materials and methods for improved immunoglycoproteins
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CA2762837C (en) 2009-05-20 2021-08-03 Novimmune S.A. Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants
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Also Published As

Publication number Publication date
AU2003226127A1 (en) 2003-10-13
ATE414795T1 (en) 2008-12-15
US20040038304A1 (en) 2004-02-26
AU2003226127A8 (en) 2003-10-13
DE60324779D1 (en) 2009-01-02
EP1495146A2 (en) 2005-01-12
EP1495146A4 (en) 2006-06-07
EP1495146B1 (en) 2008-11-19
WO2003083077A2 (en) 2003-10-09
US8222188B2 (en) 2012-07-17
US20100009869A1 (en) 2010-01-14

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