WO2003090694A3 - Methods and compositions for diagnosing and monitoring auto immune and chronic inflammatory diseases - Google Patents

Methods and compositions for diagnosing and monitoring auto immune and chronic inflammatory diseases Download PDF

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Publication number
WO2003090694A3
WO2003090694A3 PCT/US2003/013015 US0313015W WO03090694A3 WO 2003090694 A3 WO2003090694 A3 WO 2003090694A3 US 0313015 W US0313015 W US 0313015W WO 03090694 A3 WO03090694 A3 WO 03090694A3
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WO
WIPO (PCT)
Prior art keywords
diagnosing
inflammatory diseases
chronic inflammatory
methods
auto immune
Prior art date
Application number
PCT/US2003/013015
Other languages
French (fr)
Other versions
WO2003090694A2 (en
Inventor
Jay Wohlgemuth
Kirk Fry
Robert Woodward
Ngoc Ly
Original Assignee
Expression Diagnostics Inc
Jay Wohlgemuth
Kirk Fry
Robert Woodward
Ngoc Ly
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Expression Diagnostics Inc, Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly filed Critical Expression Diagnostics Inc
Priority to US10/512,028 priority Critical patent/US7604936B2/en
Priority to JP2003587333A priority patent/JP4741191B2/en
Priority to AU2003231132A priority patent/AU2003231132A1/en
Publication of WO2003090694A2 publication Critical patent/WO2003090694A2/en
Publication of WO2003090694A3 publication Critical patent/WO2003090694A3/en
Priority to US12/561,213 priority patent/US7771950B2/en
Priority to US12/829,172 priority patent/US20110070584A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Methods of diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis and kits or systems containing the same are also described.
PCT/US2003/013015 2001-10-22 2003-04-24 Methods and compositions for diagnosing and monitoring auto immune and chronic inflammatory diseases WO2003090694A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/512,028 US7604936B2 (en) 2002-04-24 2003-04-24 Methods and compositions for diagnosis and monitoring auto immune and chronic inflammatory diseases
JP2003587333A JP4741191B2 (en) 2002-04-24 2003-04-24 Methods and compositions for diagnosing and monitoring autoimmune and chronic inflammatory diseases
AU2003231132A AU2003231132A1 (en) 2002-04-24 2003-04-24 Methods and compositions for diagnosing and monitoring auto immune and chronic inflammatory diseases
US12/561,213 US7771950B2 (en) 2002-04-24 2009-09-16 Methods and compositions for diagnosing and monitoring auto immune and chronic inflammatory diseases
US12/829,172 US20110070584A1 (en) 2001-10-22 2010-07-01 Methods and compositions for diagnosing and monitoring autoimmune and chronic inflammatory diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/131,827 2002-04-24
US10/131,827 US6905827B2 (en) 2001-06-08 2002-04-24 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/131,827 Continuation-In-Part US6905827B2 (en) 2001-06-08 2002-04-24 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/512,028 A-371-Of-International US7604936B2 (en) 2002-04-24 2003-04-24 Methods and compositions for diagnosis and monitoring auto immune and chronic inflammatory diseases
US12/561,213 Division US7771950B2 (en) 2001-10-22 2009-09-16 Methods and compositions for diagnosing and monitoring auto immune and chronic inflammatory diseases

Publications (2)

Publication Number Publication Date
WO2003090694A2 WO2003090694A2 (en) 2003-11-06
WO2003090694A3 true WO2003090694A3 (en) 2004-11-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/013015 WO2003090694A2 (en) 2001-10-22 2003-04-24 Methods and compositions for diagnosing and monitoring auto immune and chronic inflammatory diseases

Country Status (4)

Country Link
US (7) US6905827B2 (en)
JP (3) JP4741191B2 (en)
AU (1) AU2003231132A1 (en)
WO (1) WO2003090694A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102300874B (en) * 2008-12-08 2015-08-05 卡姆普根有限公司 TMEM154 polypeptide and polynucleotide and as the purposes of drug targets producing medicine and biological products
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy

Families Citing this family (262)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040146879A1 (en) * 1998-08-31 2004-07-29 Bayer Healthcare Llc Novel human genes and gene expression products
US7473528B2 (en) 1999-01-06 2009-01-06 Genenews Inc. Method for the detection of Chagas disease related gene transcripts in blood
US20080070243A1 (en) * 1999-06-28 2008-03-20 Michael Bevilacqua Gene expression profiling for identification, monitoring and treatment of multiple sclerosis
AU5662001A (en) * 2000-05-08 2001-11-20 Brainsgate Ltd. Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow
US7146209B2 (en) * 2000-05-08 2006-12-05 Brainsgate, Ltd. Stimulation for treating eye pathologies
US7117033B2 (en) * 2000-05-08 2006-10-03 Brainsgate, Ltd. Stimulation for acute conditions
US7432060B2 (en) 2000-11-09 2008-10-07 The Brigham And Women's Hospital, Inc. Methods for diagnosis of cardiovascular disease
JP2002300883A (en) * 2001-04-05 2002-10-15 Jenokkusu Soyaku Kenkyusho:Kk Method for testing steroid responsiveness
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
CA2459758A1 (en) * 2001-09-04 2003-03-13 International Business Machines Corporation A sampling approach for data mining of association rules
WO2003023056A2 (en) * 2001-09-12 2003-03-20 F. Hoffmann-La Roche Ag Specific markers for multiple sclerosis
EP2224003B1 (en) 2001-09-28 2018-04-18 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. MicroRNA molecules
US20030198959A1 (en) * 2002-03-28 2003-10-23 Kurnit David M. Methods and compositions for analysis of urine samples in the diagnosis and treatment of kidney diseases
US7684859B2 (en) * 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
US20050266099A1 (en) * 2002-04-25 2005-12-01 Alon Shalev Methods and apparatus for modifying properties of the bbb and cerebral circulation by using the neuroexcitatory and/or neuroinhibitory effects of odorants on nerves in the head
HUE027779T2 (en) 2002-05-09 2016-11-28 Brigham & Womens Hospital Inc 1L1RL-1 as a cardiovascular disease marker
US7221785B2 (en) * 2002-05-21 2007-05-22 Agilent Technologies, Inc. Method and system for measuring a molecular array background signal from a continuous background region of specified size
US20040137441A1 (en) * 2003-01-15 2004-07-15 Isis Pharmaceuticals Inc. Modulation of thyroid hormone receptor interactor 3 expression
CA2530108A1 (en) * 2002-06-20 2003-12-31 Mcgill University Oligonucleotide inhibitors of mbd2/dna demethylase and uses thereof
US20040043405A1 (en) * 2002-07-17 2004-03-04 Gene Logic, Inc. Nucleic acid detection assay control genes
US7118865B2 (en) * 2002-08-16 2006-10-10 Regents Of The University Of Minnesota Methods for diagnosing severe systemic lupus erythematosus
EP1545561B1 (en) * 2002-10-02 2010-04-28 The University of British Columbia Oligonucleotides for treatment of prostate and other cancers
US8722872B2 (en) 2002-10-02 2014-05-13 The University Of British Columbia Compositions and methods for treatment of prostate and other cancers
US7561919B2 (en) * 2002-11-14 2009-07-14 Brainsgate Ltd. SPG stimulation via the greater palatine canal
JP2006515999A (en) * 2002-11-14 2006-06-15 ブレインズゲート リミティド Surgical tools and techniques for stimulation
US20040143403A1 (en) * 2002-11-14 2004-07-22 Brandon Richard Bruce Status determination
US20040185481A1 (en) * 2003-02-06 2004-09-23 Canon Kabushiki Kaisha Testing method using DNA microarray
US7282331B2 (en) * 2003-03-18 2007-10-16 Advandx, Inc. Method for improved specificity in probe based assays
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20070248978A1 (en) * 2006-04-07 2007-10-25 Expression Diagnostics, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
US20050208518A1 (en) * 2003-05-16 2005-09-22 Longueville Francoise D Method and apparatus for determination of RNAi cell transfection effects by multiple gene expression analysis on micro-arrays
US20040229225A1 (en) * 2003-05-16 2004-11-18 Jose Remacle Determination of a general three-dimensional status of a cell by multiple gene expression analysis on micro-arrays
EP2264170B1 (en) 2003-05-21 2017-02-08 Andes Biotechnologies S.A. Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein
JP2007525195A (en) * 2003-06-02 2007-09-06 アレクシオン ファーマシューティカルズ， インコーポレイテッド Cell surface proteins associated with human chronic lymphocytic leukemia
US7947450B2 (en) 2003-07-10 2011-05-24 Universite Libre De Bruxelles Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed
WO2005005044A1 (en) * 2003-07-10 2005-01-20 Universite Libre De Bruxelles Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed
ITRM20030376A1 (en) 2003-07-31 2005-02-01 Univ Roma PROCEDURE FOR THE ISOLATION AND EXPANSION OF CARDIOC STAMIN CELLS FROM BIOPSIA.
EP1668111A4 (en) * 2003-08-08 2008-07-02 Genenews Inc Osteoarthritis biomarkers and uses thereof
US7888497B2 (en) * 2003-08-13 2011-02-15 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
US8538704B2 (en) * 2003-10-06 2013-09-17 Cerner Innovation, Inc. Computerized method and system for inferring genetic findings for a patient
US7101679B2 (en) 2003-11-25 2006-09-05 Mayo Foundation For Medical Education And Research Marker for neuromyelitis optica
GB0400976D0 (en) * 2004-01-16 2004-02-18 Univ Cambridge Tech Methods of diagnosis
US8053182B2 (en) * 2004-01-30 2011-11-08 The Trustees Of The University Of Pennsylvania Predictors of transplant rejection determined by peripheral blood gene-expression profiling
US7666583B2 (en) 2004-02-19 2010-02-23 Yale University Identification of cancer protein biomarkers using proteomic techniques
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8055347B2 (en) 2005-08-19 2011-11-08 Brainsgate Ltd. Stimulation for treating brain events and other conditions
US8010189B2 (en) * 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US7552005B2 (en) * 2004-03-16 2009-06-23 Honeywell International Inc. Method for fault diagnosis of a turbine engine
JP2005314397A (en) * 2004-03-31 2005-11-10 Mitsubishi Chemicals Corp Anti-chondromodulin-1-specific antibody and its use
US7387877B2 (en) * 2004-04-06 2008-06-17 Oro Grande Technology Bio-sensor and bio-sensor reporting system
JP2007530075A (en) * 2004-04-23 2007-11-01 エグザジェン ダイアグノスティクス インコーポレイテッド Compositions and methods for prognosis of breast cancer
WO2005106471A2 (en) * 2004-04-30 2005-11-10 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with c-c chemokine receptor 4 (ccr4)
EP1765865A2 (en) * 2004-06-10 2007-03-28 ZymoGenetics, Inc. Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation
US20060094018A1 (en) * 2004-08-03 2006-05-04 Bauer A R Jr Discovery and a method for the early detection of pancreatic cancer and other disease conditions
US7820382B2 (en) * 2004-08-03 2010-10-26 Bauer A Robert Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation
US20080280282A1 (en) * 2004-08-03 2008-11-13 Bauer Jr A Robert Method for early detection of various cancers and gastrointestinal disease and monitoring of transplanted organs
US8080373B2 (en) * 2004-08-03 2011-12-20 Bauer Jr A Robert Method for the early detection of pancreatic cancer and other gastrointestinal disease conditions
WO2006021957A2 (en) * 2004-08-23 2006-03-02 Brainsgate Ltd. Concurrent bilateral spg modulation
US20060059145A1 (en) * 2004-09-02 2006-03-16 Claudia Henschke System and method for analyzing medical data to determine diagnosis and treatment
US20090083075A1 (en) * 2004-09-02 2009-03-26 Cornell University System and method for analyzing medical data to determine diagnosis and treatment
WO2006029184A2 (en) * 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
US7571055B2 (en) * 2004-10-13 2009-08-04 Regents Of The University Of Minnesota Systemic lupus erythematosus
US20060094028A1 (en) * 2004-11-04 2006-05-04 Welch Allyn, Inc. Rapid diagnostic assay
CA2586374A1 (en) * 2004-11-05 2007-01-25 The Government Of The United States Of America, As Represented By The Se Cretary Of The Navy Diagnosis and prognosis of infectious diseases clinical phenotypes and other physiologic states using host gene expression biomarkers in blood
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US20080311572A1 (en) * 2004-11-26 2008-12-18 Ahuja Sunil K Methods and Compositions For Correlating Ccl3l1/Ccr5 Genotypes With Disorders
AU2005332331A1 (en) * 2004-11-26 2006-12-07 Board Of Regents, The University Of Texas System Methods and compositions for correlating CCL3L1/CCR5 genotypes with disorders
US20060129324A1 (en) * 2004-12-15 2006-06-15 Biogenesys, Inc. Use of quantitative EEG (QEEG) alone and/or other imaging technology and/or in combination with genomics and/or proteomics and/or biochemical analysis and/or other diagnostic modalities, and CART and/or AI and/or statistical and/or other mathematical analysis methods for improved medical and other diagnosis, psychiatric and other disease treatment, and also for veracity verification and/or lie detection applications.
DE102006001780A1 (en) * 2005-01-14 2006-08-24 Siemens Corp. Research, Inc. Method for diagnosis of amylotrophic lateral sclerosis, comprising surface-enhanced desorption-ionisation mass spectrometry of proteins from patients and analysing peak values on an alternating decision tree
US7951078B2 (en) * 2005-02-03 2011-05-31 Maren Theresa Scheuner Method and apparatus for determining familial risk of disease
US20060194238A1 (en) * 2005-02-28 2006-08-31 Norman Latov Peripheral neuropathy diagnosis
US20060194237A1 (en) * 2005-02-28 2006-08-31 Norman Latov Method for diagnosing peripheral neuropathy
WO2006122295A2 (en) * 2005-05-11 2006-11-16 Expression Diagnostics, Inc. Methods of monitoring functional status of transplants using gene panels
WO2006130472A2 (en) * 2005-05-27 2006-12-07 The Regents Of The University Of California Identification of rac1b as a marker and mediator of matrix metalloproteinase-induced malignancy
JP2006333770A (en) * 2005-06-01 2006-12-14 Japan Science & Technology Agency Hemocyte-specific gene group in patient with angiitis
WO2006133399A1 (en) 2005-06-08 2006-12-14 Hitachi Chemical Research Center, Inc. METHOD FOR PREDICTING IMMUNE RESPONSE TO NEOPLASTIC DISEASE BASED ON mRNA EXPRESSION PROFILE IN NEOPLASTIC CELLS AND STIMULATED LEUKOCYTES
US20070099239A1 (en) * 2005-06-24 2007-05-03 Raymond Tabibiazar Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease
US7803932B2 (en) * 2005-07-15 2010-09-28 The Trustees Of Columbia University In The City Of New York Compositions and methods for inhibiting EB-1-mediated microtubule stability
US20070092890A1 (en) * 2005-08-05 2007-04-26 Genentech, Inc. Methods and compositions for detecting autoimmune disorders
WO2007030571A2 (en) * 2005-09-06 2007-03-15 Molecular Image Inc. Identification of targets and development of reagents for testing and molecular imaging of human disease
WO2007038501A2 (en) * 2005-09-27 2007-04-05 The Feinstein Institute For Medical Research Rheumatoid arthritis markers
US20070249533A1 (en) * 2005-09-28 2007-10-25 Levin Steven D Il-17a and il-17f antagonists and methods of using the same
WO2007044937A2 (en) * 2005-10-13 2007-04-19 President And Fellows Of Harvard College Compositions and methods to modulate memory
EP1795610A1 (en) * 2005-12-06 2007-06-13 Oligene GmbH A composition of nucleic acid sequences, specific for inflammatory disease, in particular rheumatoid arthritis
US20070238094A1 (en) * 2005-12-09 2007-10-11 Baylor Research Institute Diagnosis, prognosis and monitoring of disease progression of systemic lupus erythematosus through blood leukocyte microarray analysis
US20070231816A1 (en) * 2005-12-09 2007-10-04 Baylor Research Institute Module-Level Analysis of Peripheral Blood Leukocyte Transcriptional Profiles
EP1801234A1 (en) * 2005-12-22 2007-06-27 Stichting Sanquin Bloedvoorziening Diagnostic methods involving determining gene copy numbers and use thereof
US20080026386A1 (en) * 2006-03-31 2008-01-31 Behrens Timothy W Irf-5 haplotypes in systemic lupus erythematosus
ATE518011T1 (en) 2006-04-07 2011-08-15 Hitachi Chemical Co Ltd INCREASED EXPRESSION OF T-CELL RECEPTOR-MEDIATED TUMOR NECROSIS FACTOR SUPERFAMILY AND CHEMOKINE MRNA IN PERIPHERAL BLOOD LEUKOCYTES IN PATIENTS WITH CROHN'S DISEASE
CA2649509A1 (en) * 2006-04-20 2007-11-01 Glaxo Group Limited Novel compounds
EP3255432B1 (en) * 2006-04-24 2019-01-23 Critical Care Diagnostics, Inc. Predicting mortality and detecting severe disease
EP2537943B1 (en) 2006-04-24 2014-03-12 Genentech, Inc. Methods and compositions for detecting autoimmune disorders
US20090305265A1 (en) * 2006-04-27 2009-12-10 Critical Care Diagnostics, Inc. Interleukin-33 (il-33) for the diagnosis and prognosis of cardiovascular disease
EP3059594A1 (en) * 2006-05-01 2016-08-24 Critical Care Diagnostics, Inc. Prognosis of cardiovascular disease
DK2019965T3 (en) * 2006-05-02 2015-07-20 Critical Care Diagnostics Inc DIFFERENTIAL BETWEEN LUNG AND Cardiovascular Disease
JP5011830B2 (en) * 2006-06-09 2012-08-29 富士通セミコンダクター株式会社 DATA PROCESSING METHOD, DATA PROCESSING PROGRAM, RECORDING MEDIUM CONTAINING THE PROGRAM, AND DATA PROCESSING DEVICE
WO2008054561A2 (en) 2006-07-11 2008-05-08 University Of Medicine And Dentistry Of New Jersey Proteins, nucleic acids encoding the same and associated methods of use
GB0613844D0 (en) * 2006-07-12 2006-08-23 Progenika Biopharma Sa Methods and products for in vitro genotyping
CA2695935A1 (en) * 2006-08-11 2008-02-28 Baylor Research Institute Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections
US7993832B2 (en) * 2006-08-14 2011-08-09 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
US20090210026A1 (en) * 2006-08-17 2009-08-20 Brainsgate Ltd. Spg stimulation for enhancing neurogenesis and brain metabolism
US8053191B2 (en) 2006-08-31 2011-11-08 Westend Asset Clearinghouse Company, Llc Iterative nucleic acid assembly using activation of vector-encoded traits
CN101557818A (en) 2006-10-03 2009-10-14 新泽西医科和牙科大学 ATAP peptides, nucleic acids encoding the same and associated methods of use
EP2695896B1 (en) * 2006-10-06 2018-08-22 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Prevention of tissue ischemia, related methods and compositions
WO2008140484A2 (en) * 2006-11-09 2008-11-20 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US20100143372A1 (en) * 2006-12-06 2010-06-10 Medimmune, Llc Interferon alpha-induced pharmacodynamic markers
US9381209B2 (en) * 2007-03-05 2016-07-05 The University Of British Columbia Treatment of squamous cell carcinoma with HSP27 antisense oligonucleotides and radiotherapy
US20080227709A1 (en) * 2007-03-14 2008-09-18 Baylor Research Institute Gene expression in peripheral blood mononuclear cells from children with diabetes
US7844609B2 (en) 2007-03-16 2010-11-30 Expanse Networks, Inc. Attribute combination discovery
MX2009010273A (en) 2007-03-26 2009-10-12 Zymogenetics Inc Soluble il-17ra/rc fusion proteins and related methods.
EP1975252A1 (en) * 2007-03-29 2008-10-01 INSERM (Institut National de la Santé et de la Recherche Medicale) Methods for the prognosis or for the diagnosis of a thyroid disease
US20100129361A1 (en) * 2007-05-01 2010-05-27 The Brigham And Women's Hospital Immunosuppression with antibody against itm2a
US20100261172A1 (en) * 2007-05-03 2010-10-14 Medimmune, Llc Interferon alpha-induced pharmacodynamic markers
US20100183597A1 (en) * 2007-06-06 2010-07-22 Jiangping Wu Drak2 expression is associated with diabetes
CN101796197B (en) * 2007-06-08 2014-02-12 比奥根艾迪克Ma公司 Biomarkers for predicting anti-TNF responsiveness or non-responsiveness
US20110098309A1 (en) * 2007-07-12 2011-04-28 Acumen Pharmaceuticals, Inc. Methods of inhibiting the formation of amyloid-beta diffusable ligands using acylhydrazide compounds
US9006283B2 (en) 2007-07-12 2015-04-14 Acumen Pharmaceuticals, Inc. Methods of modifying amyloid β oligomers using non-peptidic compounds
US8962677B2 (en) * 2007-07-12 2015-02-24 Acumen Pharmaceuticals, Inc. Methods of restoring cognitive ability using non-peptidic compounds
US20100261613A1 (en) * 2007-07-26 2010-10-14 Michael Centola Methods for inflammatory disease management
US20090043752A1 (en) 2007-08-08 2009-02-12 Expanse Networks, Inc. Predicting Side Effect Attributes
EP2522755B1 (en) * 2007-08-13 2014-04-02 Baxter International Inc. IVIG modulation of chemokines for treatment of Multiple Sclerosis, Alzheimer's disease, and Parkinson's disease
DE102007041657A1 (en) * 2007-09-03 2009-03-05 Protagen Ag Marker sequences for multiple sclerosis and their use
NZ562237A (en) * 2007-10-05 2011-02-25 Pacific Edge Biotechnology Ltd Proliferation signature and prognosis for gastrointestinal cancer
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
JP2011502535A (en) 2007-11-14 2011-01-27 日立化成工業株式会社 Tumor necrosis factor superfamily mRNA expression through Fc receptors in peripheral blood leukocytes
US20090177450A1 (en) * 2007-12-12 2009-07-09 Lawrence Berkeley National Laboratory Systems and methods for predicting response of biological samples
JP2011509676A (en) 2008-01-18 2011-03-31 ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド Selective differentiation, identification and regulation of human Th17 cells
EP3779444A1 (en) 2008-01-18 2021-02-17 President and Fellows of Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
US9102983B2 (en) * 2008-01-30 2015-08-11 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Single nucleotide polymorphisms associated with renal disease
CN102014937A (en) 2008-03-03 2011-04-13 迈阿密大学 Allogeneic cancer cell-based immunotherapy
WO2009113649A1 (en) * 2008-03-14 2009-09-17 株式会社メディネット Antibody having an immune-enhancement function
DK2660599T3 (en) 2008-04-18 2014-12-08 Critical Care Diagnostics Inc PREDICTION OF RISK OF MAJOR ADVERSE HEART EVENTS
EP2294216A4 (en) 2008-05-14 2011-11-23 Dermtech Int Diagnosis of melanoma and solar lentigo by nucleic acid analysis
US20100068711A1 (en) * 2008-07-18 2010-03-18 Xenomics, Inc. Methods of PCR-Based Detection of "Ultra Short" Nucleic Acid Sequences
US20100255467A1 (en) * 2008-07-22 2010-10-07 Los Alamos National Security, Llc Assays for determining exposure to multiwalled carbon nanotubes
US8285719B1 (en) 2008-08-08 2012-10-09 The Research Foundation Of State University Of New York System and method for probabilistic relational clustering
US10679749B2 (en) 2008-08-22 2020-06-09 International Business Machines Corporation System and method for virtual world biometric analytics through the use of a multimodal biometric analytic wallet
WO2010025310A2 (en) 2008-08-27 2010-03-04 Westend Asset Clearinghouse Company, Llc Methods and devices for high fidelity polynucleotide synthesis
US8200509B2 (en) 2008-09-10 2012-06-12 Expanse Networks, Inc. Masked data record access
US7917438B2 (en) 2008-09-10 2011-03-29 Expanse Networks, Inc. System for secure mobile healthcare selection
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
US8386519B2 (en) 2008-12-30 2013-02-26 Expanse Networks, Inc. Pangenetic web item recommendation system
US8108406B2 (en) * 2008-12-30 2012-01-31 Expanse Networks, Inc. Pangenetic web user behavior prediction system
TWI387750B (en) * 2009-02-10 2013-03-01 Nat Defense Medical Ct Biomarker and detection method for detecting kidney disease
US20120073585A1 (en) * 2009-04-08 2012-03-29 Cedars-Sinai Medical Center Methods of predicting complication and surgery in crohn's disease
WO2010141954A1 (en) * 2009-06-06 2010-12-09 Ceetox, Inc. Method for predicting respiratory toxicity of compounds
JP5996429B2 (en) 2009-09-03 2016-09-21 ジェネンテック， インコーポレイテッド Method for treatment, diagnosis and monitoring of rheumatoid arthritis
US10207240B2 (en) 2009-11-03 2019-02-19 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2011066185A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Microfluidic devices and methods for gene synthesis
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US9217144B2 (en) 2010-01-07 2015-12-22 Gen9, Inc. Assembly of high fidelity polynucleotides
JP5806122B2 (en) * 2010-02-08 2015-11-10 国立大学法人浜松医科大学 How to detect ulcerative colitis
US20110195854A1 (en) * 2010-02-09 2011-08-11 Cornell Research Foundation, Inc. Detecting and monitoring inflammatory neuropathy
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
EP2596353A4 (en) 2010-07-23 2014-01-15 Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
EP2596101B1 (en) 2010-07-23 2018-12-05 Sigma-Aldrich Co., LLC Genome editing using targeting endonucleases and single-stranded nucleic acids
AU2011281007A1 (en) * 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting kidney-associated diseases or conditions
CA2806293A1 (en) * 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
WO2012024236A1 (en) * 2010-08-14 2012-02-23 Biogen Idec Ma Inc. LTβR BLOCKADE: METHODS FOR OPTIMIZING THERAPEUTIC RESPONSIVENESS OF PATIENTS
WO2012035518A1 (en) 2010-09-17 2012-03-22 Compugen Ltd. Compositions and methods for treatment of drug resistant multiple myeloma
EP2441848A1 (en) * 2010-10-12 2012-04-18 Protagen AG Marker sequences for systematic lupus erythematodes and use of same
US10457935B2 (en) 2010-11-12 2019-10-29 Gen9, Inc. Protein arrays and methods of using and making the same
JP6118725B2 (en) 2010-11-12 2017-04-19 ジェン９・インコーポレイテッドＧｅｎ９，ＩＮＣ． Methods and devices for nucleic acid synthesis
US20120164642A1 (en) * 2010-12-22 2012-06-28 Erickson-Johnson Michele R Methods and materials for identifying nodular fasciitis
US9902996B2 (en) 2011-02-11 2018-02-27 Cedars-Sinai Medical Center Methods of predicting the need for surgery in crohn's disease
EP3605104B1 (en) 2011-03-17 2021-09-15 Critical Care Diagnostics, Inc. Methods predicting risk of an adverse clinical outcome
EP2697653B1 (en) * 2011-04-15 2016-03-30 Children's Medical Center Corporation Diagnostic markers and therapeutic targets of kawasaki disease
MX347514B (en) * 2011-05-25 2017-04-28 Innate Pharma Sa Anti-kir antibodies for the treatment of inflammatory disorders.
US9752176B2 (en) 2011-06-15 2017-09-05 Ginkgo Bioworks, Inc. Methods for preparative in vitro cloning
US9708643B2 (en) * 2011-06-17 2017-07-18 Affymetrix, Inc. Circulating miRNA biomaker signatures
JP2014526899A (en) 2011-08-26 2014-10-09 ジェン９・インコーポレイテッド Compositions and methods for high fidelity assembly of nucleic acids
EP2756103A4 (en) * 2011-09-12 2015-06-03 Univ Vanderbilt Characterizing multiple sclerosis
RU2459209C1 (en) * 2011-09-13 2012-08-20 Зарема Римовна Хисматуллина Method for prediction of acne severity level in patients with intestinal dysbiosis
EP2602621A1 (en) * 2011-12-08 2013-06-12 Julius-Maximilians-Universität Würzburg LASP-1, a novel urinary marker for transitional cell carcinoma detection
WO2013130674A1 (en) 2012-02-27 2013-09-06 Cellular Research, Inc. Compositions and kits for molecular counting
EP2820174B1 (en) * 2012-02-27 2019-12-25 The University of North Carolina at Chapel Hill Methods and uses for molecular tags
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
WO2013147606A1 (en) 2012-03-28 2013-10-03 Umc Utrecht Holding B.V. Combinatorial gamma 9 delta 2 t cell receptor chain exchange
EP4001427A1 (en) 2012-04-24 2022-05-25 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
UY34813A (en) 2012-05-18 2013-11-29 Amgen Inc ANTIGEN UNION PROTEINS DIRECTED AGAINST ST2 RECEIVER
US9884076B2 (en) 2012-06-05 2018-02-06 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
AU2013280661A1 (en) 2012-06-25 2015-01-22 Gen9, Inc. Methods for nucleic acid assembly and high throughput sequencing
JP6433896B2 (en) 2012-08-13 2018-12-05 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ Exosomes and microribonucleic acids for tissue regeneration
CN111834009A (en) 2012-08-21 2020-10-27 重症监护诊断股份有限公司 Multi-marker risk stratification
CN104797933A (en) 2012-09-07 2015-07-22 阿尔伯达大学董事会 Methods and compositions for diagnosis of inflammatory liver disease
JP2015529685A (en) 2012-09-17 2015-10-08 ザ・リサーチ・インスティテュート・アット・ネイションワイド・チルドレンズ・ホスピタルＴｈｅ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Ａｔｎａｔｉｏｎｗｉｄｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Compositions and methods for the treatment of amyotrophic lateral sclerosis
NZ771629A (en) 2013-03-09 2022-12-23 Harry Stylli Methods of detecting cancer
MX2015013703A (en) 2013-03-27 2016-08-11 Cedars Sinai Medical Center Treating fibrosis and inflammation by inhibiting tl1a.
WO2015010108A1 (en) 2013-07-19 2015-01-22 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
US20150032681A1 (en) * 2013-07-23 2015-01-29 International Business Machines Corporation Guiding uses in optimization-based planning under uncertainty
WO2015031691A1 (en) 2013-08-28 2015-03-05 Cellular Research, Inc. Massively parallel single cell analysis
CN105745528A (en) 2013-10-07 2016-07-06 赛卢拉研究公司 Methods and systems for digitally counting features on arrays
US9725719B2 (en) 2013-11-05 2017-08-08 The Research Institute At Nationwide Children's Hospital Compositions and methods for inhibiting NF-κB and SOD-1 to treat amyotrophic lateral sclerosis
EP2878335B1 (en) 2013-11-10 2018-01-03 Brainsgate Ltd. Implant and delivery system for neural stimulator
CN112646812A (en) 2013-12-27 2021-04-13 株式会社博纳克 Artificial matching type miRNA for controlling gene expression and application thereof
US20170298402A1 (en) * 2014-10-03 2017-10-19 President And Fellows Of Harvard College Self-labeling nucleic acids and methods of use
WO2016054591A1 (en) 2014-10-03 2016-04-07 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
US10417225B2 (en) 2015-09-18 2019-09-17 Splunk Inc. Entity detail monitoring console
CA2971827A1 (en) 2014-12-27 2016-06-30 Bonac Corporation Naturally occuring mirna for controlling gene expression, and use of same
EP3259371B1 (en) 2015-02-19 2020-09-02 Becton, Dickinson and Company High-throughput single-cell analysis combining proteomic and genomic information
US9727810B2 (en) 2015-02-27 2017-08-08 Cellular Research, Inc. Spatially addressable molecular barcoding
US11142769B2 (en) 2015-03-27 2021-10-12 Bonac Corporation Single-stranded nucleic acid molecule having delivery function and gene expression regulating ability
CN107406888A (en) 2015-03-30 2017-11-28 赛卢拉研究公司 For combining the method and composition of bar coding
EP3286326A1 (en) 2015-04-23 2018-02-28 Cellular Research, Inc. Methods and compositions for whole transcriptome amplification
WO2016175776A1 (en) 2015-04-29 2016-11-03 Hewlett Packard Enterprise Development Lp Trend correlations
EP3093043B1 (en) 2015-05-13 2018-11-14 Brainsgate Ltd. Implant and delivery system for neural stimulator
WO2016196229A1 (en) 2015-06-01 2016-12-08 Cellular Research, Inc. Methods for rna quantification
JP6624704B2 (en) 2015-08-31 2019-12-25 日立化成株式会社 Molecular methods for assessing urothelial disease
JP6940484B2 (en) 2015-09-11 2021-09-29 セルラー リサーチ， インコーポレイテッド Methods and compositions for library normalization
CA3009769C (en) * 2015-12-29 2021-01-12 National University Corporation Hokkaido University Single-stranded nucleic acid molecule inhibiting expression of prorenin gene or prorenin receptor gene, and use thereof
US11253551B2 (en) 2016-01-11 2022-02-22 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
KR20220153109A (en) 2016-03-17 2022-11-17 세다르스-신나이 메디칼 센터 Methods of diagnosing inflammatory bowel disease through rnaset2
EP3452614B1 (en) 2016-05-02 2023-06-28 Becton, Dickinson and Company Accurate molecular barcoding
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
CN109074430B (en) 2016-05-26 2022-03-29 贝克顿迪金森公司 Molecular marker counting adjustment method
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
WO2017212072A1 (en) * 2016-06-10 2017-12-14 Umc Utrecht Holding B.V. Human leukocyte antigen restricted gamma delta t cell receptors and methods of use thereof
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
AU2017331459B2 (en) 2016-09-26 2023-04-13 Becton, Dickinson And Company Measurement of protein expression using reagents with barcoded oligonucleotide sequences
AU2017359047A1 (en) 2016-11-08 2019-05-02 Becton, Dickinson And Company Methods for cell label classification
CN109952612B (en) 2016-11-08 2023-12-01 贝克顿迪金森公司 Method for classifying expression profiles
US10722880B2 (en) 2017-01-13 2020-07-28 Cellular Research, Inc. Hydrophilic coating of fluidic channels
CN110382708A (en) 2017-02-01 2019-10-25 赛卢拉研究公司 Selective amplification is carried out using blocking property oligonucleotides
AU2018255346A1 (en) 2017-04-19 2019-11-07 Capricor, Inc. Methods and compositions for treating skeletal muscular dystrophy
CN110719959B (en) 2017-06-05 2021-08-06 贝克顿迪金森公司 Sample indexing for single cells
WO2019009606A1 (en) * 2017-07-05 2019-01-10 고려대학교 산학협력단 Pharmaceutical composition containing mir-4507 microrna as active ingredient for prevention or treatment of dermatitis
CN107463879A (en) * 2017-07-05 2017-12-12 成都数联铭品科技有限公司 Human bodys' response method based on deep learning
US11106442B1 (en) 2017-09-23 2021-08-31 Splunk Inc. Information technology networked entity monitoring with metric selection prior to deployment
US11093518B1 (en) 2017-09-23 2021-08-17 Splunk Inc. Information technology networked entity monitoring with dynamic metric and threshold selection
US11159397B2 (en) 2017-09-25 2021-10-26 Splunk Inc. Lower-tier application deployment for higher-tier system data monitoring
WO2019126209A1 (en) 2017-12-19 2019-06-27 Cellular Research, Inc. Particles associated with oligonucleotides
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
JP2021511019A (en) * 2018-01-24 2021-05-06 ジェネンテック， インコーポレイテッド Diagnostic and therapeutic methods for the treatment of rheumatoid arthritis (RA)
JP7358388B2 (en) 2018-05-03 2023-10-10 ベクトン・ディキンソン・アンド・カンパニー Molecular barcoding at opposite transcript ends
AU2019262048A1 (en) 2018-05-03 2020-11-12 Becton, Dickinson And Company High throughput multiomics sample analysis
CA3099275A1 (en) 2018-05-09 2019-11-14 Dermtech, Inc. Novel gene classifiers and uses thereof in autoimmune diseases
US10769543B2 (en) 2018-08-01 2020-09-08 Forcepoint Llc Double-layered image classification endpoint solution
WO2020072380A1 (en) 2018-10-01 2020-04-09 Cellular Research, Inc. Determining 5' transcript sequences
JP2022506546A (en) 2018-11-08 2022-01-17 ベクトン・ディキンソン・アンド・カンパニー Single-cell whole transcriptome analysis using random priming
US11492660B2 (en) 2018-12-13 2022-11-08 Becton, Dickinson And Company Selective extension in single cell whole transcriptome analysis
US11371076B2 (en) 2019-01-16 2022-06-28 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
EP4242322A3 (en) 2019-01-23 2023-09-20 Becton, Dickinson and Company Oligonucleotides associated with antibodies
AU2020247911A1 (en) 2019-03-26 2021-11-11 Dermtech, Inc. Novel gene classifiers and uses thereof in skin cancers
MX2021013858A (en) * 2019-05-14 2022-03-22 Univ Monash Modulators and modulation of the receptor for advanced glycation end-products rna.
US11939622B2 (en) 2019-07-22 2024-03-26 Becton, Dickinson And Company Single cell chromatin immunoprecipitation sequencing assay
US20220146527A1 (en) * 2019-09-17 2022-05-12 Chang Gung University Method of creating characteristic profiles of mass spectra and identification model for analyzing and identifying features of microorganisms
WO2021092386A1 (en) 2019-11-08 2021-05-14 Becton Dickinson And Company Using random priming to obtain full-length v(d)j information for immune repertoire sequencing
EP4090763A1 (en) 2020-01-13 2022-11-23 Becton Dickinson and Company Methods and compositions for quantitation of proteins and rna
CN115605614A (en) 2020-05-14 2023-01-13 贝克顿迪金森公司（Us） Primers for immune repertoire profiling
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
EP4247967A1 (en) 2020-11-20 2023-09-27 Becton, Dickinson and Company Profiling of highly expressed and lowly expressed proteins
US11676072B1 (en) 2021-01-29 2023-06-13 Splunk Inc. Interface for incorporating user feedback into training of clustering model
CN113435168B (en) * 2021-06-10 2024-03-22 上海美吉生物医药科技有限公司 Automatic editing method, system, terminal and medium for glue pattern
WO2023012356A2 (en) * 2021-08-06 2023-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to diagnose inflammatory diseases
WO2023235773A1 (en) * 2022-06-01 2023-12-07 Genentech, Inc. Method to identify a patient with an increased likelihood of chronic spontaneous urticaria
CN117153316A (en) * 2023-09-05 2023-12-01 中普达科技股份有限公司 Management system of medical information acquisition terminal for multiple users

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0217102A1 (en) * 1985-08-28 1987-04-08 Yeda Research And Development Company, Ltd. Interferon-induced (2'-5') oligo a synthetase gene, mRNA, cDNA and enzymes having (2'-5') oligo a synthetase activity
US6274312B1 (en) * 1996-12-11 2001-08-14 Schering Corporation Intracellular regulatory molecules; related reagents

Family Cites Families (224)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981481A (en) 1974-12-06 1999-11-09 The Johns Hopkins University Human C3b/C4b receptor (CR1)
US5212071A (en) 1988-04-01 1993-05-18 The Johns Hopkins University Nucleic acids encoding a human C3b/C4b receptor (CR1)
US4350593A (en) 1977-12-19 1982-09-21 Becton, Dickinson And Company Assembly, compositions and method for separating blood
US4190535A (en) 1978-02-27 1980-02-26 Corning Glass Works Means for separating lymphocytes and monocytes from anticoagulated blood
US4215051A (en) 1979-08-29 1980-07-29 Standard Oil Company (Indiana) Formation, purification and recovery of phthalic anhydride
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4358535A (en) 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US4762780A (en) 1984-04-17 1988-08-09 The Regents Of The University Of California Method and composition for screening and diagnosing "HCMV"
US4582789A (en) 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives
US4818418A (en) 1984-09-24 1989-04-04 Becton Dickinson And Company Blood partitioning method
US4751001A (en) 1984-09-24 1988-06-14 Becton Dickinson And Company Blood partitioning apparatus
US5264351A (en) 1984-11-05 1993-11-23 The Board Of Regents For The University Of Oklahoma Monoclonal antibodies against autoimmune RNA proteins
US5053134A (en) 1984-12-04 1991-10-01 Becton Dickinson And Company Lymphocyte collection tube
US6197563B1 (en) * 1985-03-28 2001-03-06 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences
US6040166A (en) * 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5011684A (en) 1985-09-05 1991-04-30 Beth Israel Hospital Association Lysing or blocking unwanted cells with IL-2 receptor-specific binding substance
US4789630A (en) 1985-10-04 1988-12-06 Cetus Corporation Ionic compounds containing the cationic meriquinone of a benzidine
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5604099A (en) 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US6127155A (en) * 1986-08-22 2000-10-03 Roche Molecular Systems, Inc. Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
US5693517A (en) 1987-06-17 1997-12-02 Roche Molecular Systems, Inc. Reagents and methods for coupled high temperature reverse transcription and polymerase chain reactions
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5374553A (en) 1986-08-22 1994-12-20 Hoffmann-La Roche Inc. DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima
US5795762A (en) 1986-08-22 1998-08-18 Roche Molecular Systems, Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US5455170A (en) 1986-08-22 1995-10-03 Hoffmann-La Roche Inc. Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05
US5405774A (en) 1986-08-22 1995-04-11 Hoffmann-La Roche Inc. DNA encoding a mutated thermostable nucleic acid polymerase enzyme from thermus species sps17
US5310652A (en) 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
US5407800A (en) 1986-08-22 1995-04-18 Hoffmann-La Roche Inc. Reverse transcription with Thermus thermophilus polymerase
US5079352A (en) 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US5352600A (en) 1986-08-22 1994-10-04 Hoffmann-La Roche Inc. Purified thermostable enzyme
US5561058A (en) 1986-08-22 1996-10-01 Hoffmann-La Roche Inc. Methods for coupled high temperatures reverse transcription and polymerase chain reactions
US5466591A (en) 1986-08-22 1995-11-14 Hoffmann-La Roche Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US5618711A (en) 1986-08-22 1997-04-08 Hoffmann-La Roche Inc. Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
CA1297431C (en) 1987-04-24 1992-03-17 F. Hoffmann-La Roche Ag Process for the isolation of nucleic acids
US5063162A (en) 1987-04-24 1991-11-05 Hoffmann-La Roche Inc. Process for isolating nucleic acids utilizing protease digestion
US4908318A (en) 1987-09-04 1990-03-13 Integrated Genetics, Inc. Nucleic acid extraction methods
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US5120525A (en) 1988-03-29 1992-06-09 Immunomedics, Inc. Radiolabeled antibody cytotoxic therapy of cancer
US5693760A (en) * 1988-04-14 1997-12-02 Incyte Pharmaceuticals, Inc. Method of causing selective immunosuppression using HL-60 related lectins
US5142033A (en) 1988-09-23 1992-08-25 Hoffmann-La Roche Inc. Structure-independent DNA amplification by the polymerase chain reaction
US5075216A (en) 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US5066584A (en) 1988-09-23 1991-11-19 Cetus Corporation Methods for generating single stranded dna by the polymerase chain reaction
US5091310A (en) 1988-09-23 1992-02-25 Cetus Corporation Structure-independent dna amplification by the polymerase chain reaction
US5389512A (en) 1988-10-07 1995-02-14 Hoffman-La Roche Inc. Method for determining the relative amount of a viral nucleic acid segment in a sample by the polymerase chain reaction
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5219727A (en) 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
US5340720A (en) 1989-11-29 1994-08-23 University Of Kansas Methods of diagnosing and monitoring rheumatic diseases
US5215882A (en) 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
CA2033692A1 (en) 1990-01-25 1991-07-26 Wilhelm Bannwarth Energy transfer systems
CA2075050C (en) 1990-02-16 1998-10-06 Will Bloch Specificity and convenience of the polymerase chain reaction
US5344755A (en) 1990-04-21 1994-09-06 The United States Of America As Represented By The Department Of Health And Human Services Method for detecting immune system dysfunction in asymptomatic, HIV-scropositive individuals
US5350683A (en) * 1990-06-05 1994-09-27 Immunex Corporation DNA encoding type II interleukin-1 receptors
US5130423A (en) 1990-07-13 1992-07-14 Microprobe Corporation Non-corrosive compositions and methods useful for the extraction of nucleic acids
DK0540693T3 (en) 1990-07-24 1999-09-13 Hoffmann La Roche Reduction of non-specific amplification during in vitro nucleic acid amplification using modified nucleic acid
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
JP2582980B2 (en) 1990-09-28 1997-02-19 エフ．ホフマン−ラ ロシュ アクチェンゲゼルシャフト Purified thermostable nucleic acid polymerase from Agrobacterium guinea pig
DE4034036C2 (en) 1990-10-26 1994-03-03 Diagen Inst Molekularbio Device and method for isolating nucleic acids from cell suspensions
ES2078733T3 (en) 1991-01-22 1995-12-16 Akzo Nobel Nv METHOD FOR THE DETECTION OF ANTI-RNA ANTIBODIES.
EP0585257A4 (en) * 1991-03-28 1995-02-22 Univ Minnesota Dna and amino acid sequence specific for natural killer cells.
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
EP0519338B1 (en) 1991-06-20 1996-08-28 F. Hoffmann-La Roche Ag Improved methods for nucleic acid amplification
US5445940A (en) 1991-08-28 1995-08-29 Brigham & Women's Hospital Methods and compositions for detecting and treating a subset of human patients having an autoimmune disease
HUT69725A (en) 1991-10-01 1995-09-28 Gen Hospital Corp Process for producing compositions for preventing allograft rejection
US5346994A (en) 1992-01-28 1994-09-13 Piotr Chomczynski Shelf-stable product and process for isolating RNA, DNA and proteins
ES2082256T3 (en) 1992-03-23 1996-03-16 Hoffmann La Roche DNA DETECTION METHOD.
WO1993025713A1 (en) 1992-06-17 1993-12-23 Arch Development Corporation Compositions and methods for detecting gene rearrangements and translocations
GB2268935B (en) 1992-06-24 1996-10-23 Nat Heart & Lung Inst Diagnosis of rejection of transplanted organs
DK88892D0 (en) * 1992-07-06 1992-07-06 Novo Nordisk As CONNECTION
ES2194843T3 (en) 1992-09-11 2003-12-01 Hoffmann La Roche DETECTION OF NUCLEIC ACIDS IN BLOOD.
US5565339A (en) 1992-10-08 1996-10-15 Hoffmann-La Roche Inc. Compositions and methods for inhibiting dimerization of primers during storage of polymerase chain reaction reagents
WO1994018156A1 (en) 1993-02-01 1994-08-18 University Of Iowa Research Foundation Quartenary amine surfactants and methods of using same in isolation of rna
AU669420B2 (en) * 1993-03-26 1996-06-06 Minnesota Mining And Manufacturing Company Oily mist resistant electret filter media
US6403304B1 (en) * 1993-04-06 2002-06-11 Forsyth Dental Infirmary For Children Human osteoclast-specific and -related DNA sequences
US5643765A (en) 1993-04-06 1997-07-01 University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5491086A (en) 1993-05-14 1996-02-13 Hoffmann-La Roche Inc. Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
US6045996A (en) * 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US5459037A (en) 1993-11-12 1995-10-17 The Scripps Research Institute Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
JPH08508415A (en) 1993-12-14 1996-09-10 ユニバーシティー オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション Systemic gene therapy for connective tissue disease
US5527884A (en) * 1993-12-21 1996-06-18 President And Fellows Of Harvard College Mediators of chronic allograft rejection and DNA molecules encoding them
DK145393D0 (en) 1993-12-23 1993-12-23 Stig Haunsoe PROTEIN MARKETS FOR THE PREVENTION OF ACUTE ALLOTRANGE PLANTS
US5811284A (en) 1993-12-29 1998-09-22 Schering Corporation Nucleic acids encoding kp43 protein and antigenic fragments thereof
US5512462A (en) 1994-02-25 1996-04-30 Hoffmann-La Roche Inc. Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
US6190872B1 (en) * 1994-05-06 2001-02-20 Gus J. Slotman Method for identifying and monitoring patients at risk for systemic inflammatory conditions and apparatus for use in this method
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5658744A (en) 1994-07-22 1997-08-19 The United States Of America As Represented By The Department Of Health And Human Services Methods of identifying patients having an altered immune status
US6010953A (en) * 1994-08-02 2000-01-04 Micron Technology, Inc. Method for forming a semiconductor buried contact with a removable spacer
US6010847A (en) 1994-08-18 2000-01-04 Akzo Nobel N.V. Oligonucleotides that can be used in the amplification and detection of CMV nucleic acid
US5491063A (en) 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5571673A (en) 1994-11-23 1996-11-05 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5506145A (en) 1994-12-02 1996-04-09 Bull; Brian S. Determination of an individual's inflammation index from whole blood fibrinogen and hematocrit or hemoglobin measurements
FR2729637B1 (en) * 1995-01-19 1997-04-18 Semt Pielstick DEVICE AND METHOD FOR ADJUSTING THE SPEED OF A VESSEL
US6139832A (en) * 1995-02-08 2000-10-31 Human Genome Sciences, Inc. Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides
US5834248A (en) * 1995-02-10 1998-11-10 Millennium Pharmaceuticals Inc. Compositions and methods using rchd534, a gene uregulated by shear stress
US6066322A (en) 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
EP0735144B1 (en) 1995-03-28 2002-06-05 Japan Science and Technology Corporation Method for molecular indexing of genes using restriction enzymes
US6251597B1 (en) * 1996-03-29 2001-06-26 Millennium Pharmaceuticals, Inc. Methods for detecting fohy030
US5569583A (en) 1995-04-25 1996-10-29 Health Research Inc. Rapid and sensitive detection of cytomegalovirus
WO1996039536A1 (en) 1995-06-06 1996-12-12 T Cell Diagnostics, Inc. UNIVERSAL CHEMISTRY ENZYME-LINKED IMMUNOSORBENT ASSAY FOR DETECTION OF mRNA EXPRESSION
US5635365A (en) 1995-08-07 1997-06-03 Emory University Noninvasive diagnosis for allograft rejection
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US5665551A (en) 1995-09-13 1997-09-09 Roche Molecular Systems, Inc. Purified nucleic acid encoding a thermostable pyrophosphatase
US5765585A (en) * 1995-10-12 1998-06-16 Peterson; Roger Sample decade dilution system and procedure
US5750345A (en) 1995-10-31 1998-05-12 Evanston Hospital Corporation Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US5973137A (en) 1996-02-13 1999-10-26 Gentra Systems, Inc. Low pH RNA isolation reagents, method, and kit
US6068933A (en) * 1996-02-15 2000-05-30 American National Can Company Thermoformable multilayer polymeric film
US6099823A (en) 1996-02-16 2000-08-08 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
WO1997030065A1 (en) 1996-02-16 1997-08-21 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
US5922184A (en) 1997-07-21 1999-07-13 Bio-Rad Laboratories, Inc. Computer-directed detection of paraproteins
US5719787A (en) * 1996-05-15 1998-02-17 Cornell Research Foundation, Inc. Method for on-line dynamic contingency screening of electric power systems
US5958342A (en) 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
CZ293215B6 (en) 1996-08-06 2004-03-17 F. Hoffmann-La Roche Ag Enzyme of thermally stable DNA polymerase, process of its preparation and a pharmaceutical composition and a kit containing thereof
US6146828A (en) 1996-08-14 2000-11-14 Exact Laboratories, Inc. Methods for detecting differences in RNA expression levels and uses therefor
US8212004B2 (en) 1999-03-02 2012-07-03 Human Genome Sciences, Inc. Neutrokine-alpha fusion proteins
AU722819B2 (en) 1996-12-06 2000-08-10 Urocor, Inc. Diagnosis of disease state using mRNA profiles
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
EP0866071B1 (en) 1997-03-20 2004-10-20 F. Hoffmann-La Roche Ag Modified primers
US6190857B1 (en) * 1997-03-24 2001-02-20 Urocor, Inc. Diagnosis of disease state using MRNA profiles in peripheral leukocytes
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
US5958688A (en) 1997-04-28 1999-09-28 The Trustees Of The University Of Pennsylvania Characterization of mRNA patterns in neurites and single cells for medical diagnosis and therapeutics
US5994076A (en) 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
US6010853A (en) 1997-05-29 2000-01-04 Dana-Farber Cancer Institute Siva genes, novel genes involved in CD27-mediated apoptosis
US6228628B1 (en) * 1997-07-09 2001-05-08 Roche Molecular Systems Mutant chimeric DNA polymerase
US6040168A (en) * 1997-08-06 2000-03-21 The Rockefeller University DNA encoding the human synapsin III gene and uses thereof
AU9200398A (en) * 1997-08-22 1999-03-16 Yale University A process to study changes in gene expression in granulocytic cells
EP0996726B1 (en) 1997-08-29 2003-12-10 Brigham And Women's Hospital T-cell membrane protein (tirc7), peptides and antibodies derived therefrom and uses thereof
WO1999011822A1 (en) 1997-09-03 1999-03-11 Gene Logic Inc. Method for predicting prognosis and treatment response for genetically based abnormalities
SK3382000A3 (en) * 1997-09-09 2000-10-09 Procter & Gamble A compound having structure of aromatic substituted prostaglandins and its use for the treatment of bone disorders
US20030104371A1 (en) 1997-09-24 2003-06-05 Strom Terry B. Methods of evaluating transplant rejection
US6187534B1 (en) * 1997-09-24 2001-02-13 Cornell Research Foundation, Inc. Methods of evaluating transplant rejection
DE69829402T2 (en) * 1997-10-31 2006-04-13 Affymetrix, Inc. (a Delaware Corp.), Santa Clara EXPRESSION PROFILES IN ADULTS AND FOLDS ORGANS
US6248528B1 (en) * 1998-04-06 2001-06-19 Millennium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
US6864227B1 (en) 1998-04-13 2005-03-08 California Institute Of Technology Artery-and vein-specific proteins and uses therefor
US6048695A (en) * 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
CA2326827A1 (en) 1998-05-05 1999-11-11 Gene Logic, Inc. A process to study changes in gene expression in t lymphocytes
US6117644A (en) * 1998-06-04 2000-09-12 Ottawa Heart Institute Research Corporation Predicting and detecting cardiac allograft rejection
US6218122B1 (en) * 1998-06-19 2001-04-17 Rosetta Inpharmatics, Inc. Methods of monitoring disease states and therapies using gene expression profiles
CA2334040C (en) 1998-07-17 2011-02-08 William M. Switzer Methods and devices for detection of xenogeneic graft persistence and infectious agents
US6056322A (en) * 1998-08-03 2000-05-02 Lupi; Louis A. Combination sample medication payment check and medication prescription device
AU5583799A (en) 1998-08-25 2000-03-14 Human Genome Sciences, Inc. 49 human secreted proteins
GB2340939B (en) 1998-08-27 2003-11-12 Addenbrooke S Nhs Trust Improvements in or relating to diagnosis of disease
US6410319B1 (en) * 1998-10-20 2002-06-25 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
US6248527B1 (en) * 1998-10-21 2001-06-19 Millennium Pharmaceuticals, Inc. Method of detecting risk of type II diabetes based on mutations found in carboxypeptidase E
US6203987B1 (en) * 1998-10-27 2001-03-20 Rosetta Inpharmatics, Inc. Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
US6406884B1 (en) 1999-06-18 2002-06-18 Millennium Pharmaceuticals, Inc. Secreted proteins and uses thereof
AU1724000A (en) * 1998-11-12 2000-05-29 Nyxis, Inc. Diagnostic assay for cancer
JP2002530077A (en) 1998-11-18 2002-09-17 インサイト・ファーマスーティカルズ・インコーポレイテッド Inflammation related genes
US6177254B1 (en) * 1998-12-15 2001-01-23 Jerome Bernard Rattner Nucleolus autoantigenic marker for systemic lupus erthyematosus
US6222093B1 (en) * 1998-12-28 2001-04-24 Rosetta Inpharmatics, Inc. Methods for determining therapeutic index from gene expression profiles
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
WO2000046372A2 (en) 1999-02-05 2000-08-10 Chiron Corporation Pancreatic islet genes regulated by glucose
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US6150121A (en) 1999-02-16 2000-11-21 Wisconsin Alumni Research Foundation Assessing immunological state of transplant recipients
AU3387700A (en) 1999-03-02 2000-09-21 Chiron Corporation Microarrays for identifying pathway activation or induction
AU3899700A (en) 1999-03-17 2000-10-04 Alphagene, Inc. Secreted proteins and polynucleotides encoding them
US6280941B1 (en) 1999-03-29 2001-08-28 Cedars-Sinai Medical Center Genetic marker test for lupus
WO2000058473A2 (en) 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
US6242185B1 (en) * 1999-04-01 2001-06-05 Incyte Genomics, Inc. Purified nucleic acid encoding transcription factor regulatory protein
US6162604A (en) 1999-04-01 2000-12-19 Jacob; Chaim O. Methods for determining genetic predisposition to autoimmune diseases by genotyping apoptotic genes
GB9908807D0 (en) 1999-04-16 1999-06-09 Celltech Therapeutics Ltd Synthetic signalling molecules
US6245526B1 (en) * 1999-05-26 2001-06-12 Incyte Pharmaceuticals, Inc. Lipid metabolism transcription factor
US6132997A (en) 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
WO2000073498A1 (en) 1999-06-02 2000-12-07 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of immune disorders
US6168933B1 (en) * 1999-06-08 2001-01-02 Incyte Pharmaceuticals, Inc. Phospholipid transfer protein
JP2004528526A (en) 1999-06-28 2004-09-16 ソース・プリシジョン・メディシン・インク Systems and methods for characterizing biological states or agents using calibrated gene expression profiles
US6245527B1 (en) * 1999-06-30 2001-06-12 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
CA2383456C (en) 1999-08-23 2016-06-07 Clive Wood Pd-1, a receptor for b7-4, and uses therefor
US6225093B1 (en) * 1999-09-07 2001-05-01 Decode Genetics Ehf. Detection of C4A deletion by long range PCR
JP2003509053A (en) 1999-09-15 2003-03-11 インサイト・ゲノミックス・インコーポレイテッド Protein phosphatase and protein kinase
WO2001023564A1 (en) 1999-09-27 2001-04-05 Scios Inc. Secreted factors
WO2001023426A2 (en) 1999-09-30 2001-04-05 Varian Associates, Inc. Hypoxia-related human genes, proteins, and uses thereof
IL143936A0 (en) 1999-10-21 2002-04-21 Univ Case Western Reserve Gene expression profiling of inflammatory bowel disease
JP2004507206A (en) 1999-11-04 2004-03-11 インサイト・ゲノミックス・インコーポレイテッド Tissue-specific genes important for diagnosis
WO2001038585A2 (en) 1999-11-24 2001-05-31 The Regents Of The University Of California Polymer arrays and methods of using labeled probe molecules to identify and quantify target molecule expression
GB9928136D0 (en) 1999-11-29 2000-01-26 Rose Marlene L Organ rejection and associated conditions
WO2001047944A2 (en) 1999-12-28 2001-07-05 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
US20020132753A1 (en) * 2000-01-31 2002-09-19 Rosen Craig A. Nucleic acids, proteins, and antibodies
AU3095801A (en) 2000-01-31 2001-08-07 Human Genome Sciences Inc Nucleic acids, proteins, and antibodies
WO2001055312A2 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
EP1290217A2 (en) 2000-02-04 2003-03-12 Aeomica, Inc. Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
WO2001060860A2 (en) 2000-02-17 2001-08-23 Millennium Predictive Medicine, Inc. Genes differentially expressed in human prostate cancer and their use
CZ20023203A3 (en) 2000-03-24 2003-08-13 Micromet Ag Multifunctional polypeptides comprising a binding site to an epitope of the NKG2D receptor complex
US6900015B2 (en) * 2000-04-24 2005-05-31 Beth Israel Deaconess Medical Center, Inc. Measurement of protective genes in allograft rejection
DE10021834A1 (en) 2000-05-06 2001-11-15 Lynx Therapeutics Gmbh New mRNA indicative of T cell activation and functional status, useful for diagnosis and therapy e.g. of autoimmunity or transplant rejection
US6797263B2 (en) * 2000-05-12 2004-09-28 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for achieving immune suppression
WO2002000677A1 (en) 2000-06-07 2002-01-03 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2002028999A2 (en) 2000-10-03 2002-04-11 Gene Logic, Inc. Gene expression profiles in granulocytic cells
JP2002118661A (en) * 2000-10-06 2002-04-19 Nec Corp Cellular phone system having message recording function
NZ525336A (en) 2000-10-20 2006-03-31 Expression Diagnostics Inc Leukocyte expression profiling
JP2002300883A (en) 2001-04-05 2002-10-15 Jenokkusu Soyaku Kenkyusho:Kk Method for testing steroid responsiveness
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
EP1410011B1 (en) * 2001-06-18 2011-03-23 Rosetta Inpharmatics LLC Diagnosis and prognosis of breast cancer patients
AU2002316552A1 (en) 2001-07-02 2003-01-21 Yale University Inhibitor of t cell activation
WO2003040404A1 (en) 2001-11-09 2003-05-15 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US20030225526A1 (en) 2001-11-14 2003-12-04 Golub Todd R. Molecular cancer diagnosis using tumor gene expression signature
CN1310652C (en) 2001-11-29 2007-04-18 特拉科斯有限公司 Methods for pretreating a subject with extracorporeal photopheresis and/or apoptotic cells
EP1319717A1 (en) * 2001-12-11 2003-06-18 Roche Diagnostics GmbH Method for detection of inflammatory processes
US20040072181A1 (en) * 2002-01-22 2004-04-15 Whitehead Alexander Steven Methods for determining drug responsiveness
WO2003072035A2 (en) 2002-02-22 2003-09-04 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
DE10234524A1 (en) 2002-07-24 2004-02-12 Oligene Gmbh Array of probes derived from monocyte-macrophage genes, useful e.g. for diagnosis, prognosis and therapeutic monitoring of rheumatoid arthritis and other inflammatory diseases
US7118865B2 (en) * 2002-08-16 2006-10-10 Regents Of The University Of Minnesota Methods for diagnosing severe systemic lupus erythematosus
US8741557B2 (en) 2003-02-14 2014-06-03 Beth Israel Deaconess Medical Center, Inc. Predicting graft rejection
WO2005016235A2 (en) * 2003-04-14 2005-02-24 The Regents Of The University Of California Combined use of impdh inhibitors with toll-like receptor agonists
US7892745B2 (en) 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20070248978A1 (en) 2006-04-07 2007-10-25 Expression Diagnostics, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
CA2528162A1 (en) 2003-06-04 2004-12-16 The Government Of The United States As Represented By The Secretary Of T He Department Of Health And Human Services, Centers For Disease Control Pni microarray and uses
WO2005108428A2 (en) 2004-02-26 2005-11-17 Compugen Ltd. Cd40 splice variants and their uses
WO2006029184A2 (en) * 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
WO2006122295A2 (en) 2005-05-11 2006-11-16 Expression Diagnostics, Inc. Methods of monitoring functional status of transplants using gene panels
US7993832B2 (en) * 2006-08-14 2011-08-09 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0217102A1 (en) * 1985-08-28 1987-04-08 Yeda Research And Development Company, Ltd. Interferon-induced (2'-5') oligo a synthetase gene, mRNA, cDNA and enzymes having (2'-5') oligo a synthetase activity
US6274312B1 (en) * 1996-12-11 2001-08-14 Schering Corporation Intracellular regulatory molecules; related reagents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NETO E.D. ET AL: "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags", PNAS, vol. 97, no. 7, 28 March 2000 (2000-03-28), pages 3491 - 3496, XP002932604 *
ZHANG L. ET AL: "IRF-7, a new Interferon Regulatory Factor associated with Epstein-Barr virus latency", MOLECULAR AND CELLULAR BIOLOGY, vol. 17, no. 10, October 1997 (1997-10-01), pages 5748 - 5757, XP002110967 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102300874B (en) * 2008-12-08 2015-08-05 卡姆普根有限公司 TMEM154 polypeptide and polynucleotide and as the purposes of drug targets producing medicine and biological products
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy

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US20110262914A1 (en) 2011-10-27
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US7579148B2 (en) 2009-08-25
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US20090263796A1 (en) 2009-10-22
US20070037167A1 (en) 2007-02-15
US7771950B2 (en) 2010-08-10
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