WO2003093418A3 - Keratinocytes expressing exogenous angiogenic growth factors - Google Patents
Keratinocytes expressing exogenous angiogenic growth factors Download PDFInfo
- Publication number
- WO2003093418A3 WO2003093418A3 PCT/US2003/013327 US0313327W WO03093418A3 WO 2003093418 A3 WO2003093418 A3 WO 2003093418A3 US 0313327 W US0313327 W US 0313327W WO 03093418 A3 WO03093418 A3 WO 03093418A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- growth factors
- angiogenic growth
- expressing exogenous
- keratinocytes
- skin tissue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
- C12N5/0698—Skin equivalents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/17—Angiopoietin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
- C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT03726524T ATE465242T1 (en) | 2002-04-30 | 2003-04-29 | EXOGENEOUS ANGIOGENIC GROWTH FACTORS EXPRESSING KERATINOCYTES |
IL16481703A IL164817A0 (en) | 2002-04-30 | 2003-04-29 | Keratinocytes expressing exogenous angiogenic growth factors |
EP03726524A EP1549738B1 (en) | 2002-04-30 | 2003-04-29 | Keratinocytes expressing exogenous angiogenic growth factors |
CA2483547A CA2483547C (en) | 2002-04-30 | 2003-04-29 | Keratinocytes expressing exogenous angiogenic growth factors |
NZ536205A NZ536205A (en) | 2002-04-30 | 2003-04-29 | Keratinocytes expressing exogenous angiogenic growth factors |
JP2004501554A JP4753577B2 (en) | 2002-04-30 | 2003-04-29 | Keratinocytes expressing exogenous angiogenic growth factors |
AU2003228755A AU2003228755B2 (en) | 2002-04-30 | 2003-04-29 | Keratinocytes expressing exogenous angiogenic growth factors |
DE60332256T DE60332256D1 (en) | 2002-04-30 | 2003-04-29 | EXOGENOUS ANGIOGENIC GROWTH FACTORS EXPRESSIVE KERATINOCYTES |
IL164817A IL164817A (en) | 2002-04-30 | 2004-10-25 | Composition comprising near diploid immortalized keratinocytes cells |
IL195518A IL195518A (en) | 2002-04-30 | 2008-11-25 | Skin graft composition comprising near diploid immortalized keratinocyte (niks) cells and uses thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37648802P | 2002-04-30 | 2002-04-30 | |
US60/376,488 | 2002-04-30 | ||
US10/425,784 | 2003-04-29 | ||
US10/425,784 US7498167B2 (en) | 2002-04-30 | 2003-04-29 | Keratinocytes expressing exogenous angiogenic growth factors |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003093418A2 WO2003093418A2 (en) | 2003-11-13 |
WO2003093418A3 true WO2003093418A3 (en) | 2005-04-21 |
Family
ID=29406758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/013327 WO2003093418A2 (en) | 2002-04-30 | 2003-04-29 | Keratinocytes expressing exogenous angiogenic growth factors |
Country Status (9)
Country | Link |
---|---|
US (5) | US7498167B2 (en) |
EP (1) | EP1549738B1 (en) |
JP (1) | JP4753577B2 (en) |
AT (1) | ATE465242T1 (en) |
CA (1) | CA2483547C (en) |
DE (1) | DE60332256D1 (en) |
IL (3) | IL164817A0 (en) |
NZ (1) | NZ536205A (en) |
WO (1) | WO2003093418A2 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60332256D1 (en) * | 2002-04-30 | 2010-06-02 | Stratatech Corp | EXOGENOUS ANGIOGENIC GROWTH FACTORS EXPRESSIVE KERATINOCYTES |
EP1858333B1 (en) * | 2005-03-01 | 2015-12-23 | Stratatech Corporation | Human skin equivalents expressing exogenous polypeptides |
EP2215212B1 (en) | 2007-11-14 | 2017-08-30 | Stratatech Corporation | Cold storage of organotypically cultured skin equivalents for clinical applications |
AU2009313656B2 (en) | 2008-11-04 | 2014-02-20 | Stratatech Corporation | Dried and irradiated skin equivalents for ready use |
WO2010135655A2 (en) | 2009-05-21 | 2010-11-25 | Stratatech Corporation | Human skin substitutes expressing il-12 |
TWI488966B (en) * | 2010-07-09 | 2015-06-21 | 優普生物科技股份有限公司 | Dna vaccine |
US8978234B2 (en) | 2011-12-07 | 2015-03-17 | MoMelan Technologies, Inc. | Methods of manufacturing devices for generating skin grafts |
US9597111B2 (en) | 2010-08-06 | 2017-03-21 | Kci Licensing, Inc. | Methods for applying a skin graft |
JP2012205516A (en) * | 2011-03-29 | 2012-10-25 | Osaka Univ | Method for producing artificial skin model, and artificial skin model |
US9663564B2 (en) | 2013-03-15 | 2017-05-30 | The Regents Of The University Of California | Vectors and methods to treat ischemia |
US20140065110A1 (en) * | 2012-08-31 | 2014-03-06 | The Regents Of The University Of California | Genetically modified msc and therapeutic methods |
EP2917336B1 (en) | 2012-11-09 | 2018-06-27 | Marco Archetti | Diffusible factors and cancer cells |
CA2905656C (en) | 2013-03-13 | 2020-04-14 | Stratatech Corporation | Cryopreservation of viable human skin substitutes |
JP6491188B2 (en) | 2013-03-14 | 2019-03-27 | ケーシーアイ ライセンシング インコーポレイテッド | Absorbent substrate for collecting skin grafts |
EP3089681B1 (en) | 2013-12-31 | 2021-09-08 | 3M Innovative Properties Company | Fluid-assisted skin graft harvesting |
US9993261B2 (en) | 2013-12-31 | 2018-06-12 | Kci Licensing, Inc. | Sensor systems for skin graft harvesting |
EP3280465B1 (en) | 2015-04-09 | 2020-12-16 | 3M Innovative Properties Company | Soft-tack, porous substrates for harvesting skin grafts |
EP3370630B1 (en) | 2015-11-03 | 2021-06-16 | 3M Innovative Properties Company | Device for creating an epidermal graft sheet |
US20180344448A1 (en) * | 2016-02-19 | 2018-12-06 | Kci Licensing, Inc. | Transfected epidermal grafts and methods of making the same |
CN110291188A (en) * | 2016-12-09 | 2019-09-27 | 芝加哥大学 | Organize organoid |
WO2021062359A1 (en) * | 2019-09-27 | 2021-04-01 | Stratatech Corporation | Methods for treating acute wounds and improving outcomes |
WO2021231775A1 (en) * | 2020-05-13 | 2021-11-18 | Stratatech Copporation | Viable bioengineered skin constructs |
EP4351603A1 (en) * | 2021-06-08 | 2024-04-17 | Stratatech Corporation | Viable bioengineered allogeneic cellularized skin constructs that secrete soluble factors associated with regenerative wound healing |
EP4340855A1 (en) * | 2021-08-13 | 2024-03-27 | Triovance Holding LLC | A skin substitute composition and methods of producing and using the same |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US448096A (en) * | 1891-03-10 | Hydrant | ||
US4485096A (en) * | 1982-02-26 | 1984-11-27 | Massachusetts Institute Of Technology | Tissue-equivalent and method for preparation thereof |
IL95429A (en) * | 1989-09-15 | 1997-09-30 | Organogenesis | Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production |
US5292655A (en) * | 1990-01-29 | 1994-03-08 | Wille Jr John J | Method for the formation of a histologically-complete skin substitute |
EP0526550B1 (en) * | 1990-04-24 | 1997-12-29 | EISENBERG, Mark | Composite living skin equivalents |
US5292566A (en) * | 1990-05-22 | 1994-03-08 | National Label Company | Battery label with non-shrinkable top layer |
IT1248934B (en) * | 1990-06-01 | 1995-02-11 | Fidia Spa | BIOCOMPATIBLE PERFORATED MEMBRANES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS A SUPPORT FOR THE IN VITRO GROWTH OF EPITHELIAL CELLS, ARTIFICIAL LEATHER THUS OBTAINED AND THEIR USE IN LEATHER TRANSPLANTS |
US5693332C1 (en) * | 1995-08-11 | 2001-01-09 | Univ California | Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure |
US5968546A (en) * | 1997-05-16 | 1999-10-19 | Baur; Marcus | Keratinocyte culture from precursor cells |
US20010048917A1 (en) * | 1998-03-09 | 2001-12-06 | Warren Hoeffler | Skin equivalent and methods of forming and using same |
US5989837A (en) * | 1998-07-13 | 1999-11-23 | Wisconsin Alumni Research Foundation | Immortalized human keratinocyte cell line |
US20030152562A1 (en) * | 2001-10-23 | 2003-08-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Vitro micro-organs, and uses related thereto |
US6458382B1 (en) * | 1999-11-12 | 2002-10-01 | Mirus Corporation | Nucleic acid transfer complexes |
JP2004527462A (en) * | 2000-11-01 | 2004-09-09 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | INVIVO stimulation of angiogenic activity |
JP4317366B2 (en) * | 2001-03-02 | 2009-08-19 | ストラタテック コーポレーション | Improved skin substitute and use thereof |
US6849718B2 (en) * | 2001-03-20 | 2005-02-01 | Dana Farber Cancer Institute, Inc. | Muteins of hypoxia inducible factor alpha and methods of use thereof |
WO2003018621A2 (en) * | 2001-08-23 | 2003-03-06 | Oxford Biomedica (Uk) Limited | Genes |
US6838430B2 (en) * | 2001-09-28 | 2005-01-04 | The Regents Of The University Of California | Use of HIF-1a variants to accelerate wound healing |
US20040190793A1 (en) * | 2002-03-01 | 2004-09-30 | Rorvig Mark E. | Method for retrieving images by content measure metadata encoding |
DE60332256D1 (en) * | 2002-04-30 | 2010-06-02 | Stratatech Corp | EXOGENOUS ANGIOGENIC GROWTH FACTORS EXPRESSIVE KERATINOCYTES |
EP1546392A4 (en) * | 2002-08-02 | 2006-05-24 | Stratatech Corp | Species specific dna detection |
US20050186185A1 (en) * | 2003-05-30 | 2005-08-25 | Paul Conrad | Room temperature storage of organs |
EP1660632B1 (en) * | 2003-08-01 | 2014-02-19 | Stratatech Corporation | Human skin equivalents expressing exogenous polypeptides |
-
2003
- 2003-04-29 DE DE60332256T patent/DE60332256D1/en not_active Expired - Lifetime
- 2003-04-29 WO PCT/US2003/013327 patent/WO2003093418A2/en active Application Filing
- 2003-04-29 US US10/425,784 patent/US7498167B2/en not_active Expired - Lifetime
- 2003-04-29 NZ NZ536205A patent/NZ536205A/en not_active IP Right Cessation
- 2003-04-29 IL IL16481703A patent/IL164817A0/en unknown
- 2003-04-29 EP EP03726524A patent/EP1549738B1/en not_active Expired - Lifetime
- 2003-04-29 JP JP2004501554A patent/JP4753577B2/en not_active Expired - Lifetime
- 2003-04-29 AT AT03726524T patent/ATE465242T1/en not_active IP Right Cessation
- 2003-04-29 CA CA2483547A patent/CA2483547C/en not_active Expired - Lifetime
-
2004
- 2004-05-19 US US10/848,646 patent/US7807148B2/en not_active Expired - Lifetime
- 2004-10-25 IL IL164817A patent/IL164817A/en active IP Right Grant
-
2008
- 2008-11-25 IL IL195518A patent/IL195518A/en active IP Right Grant
-
2009
- 2009-02-25 US US12/392,221 patent/US7915042B2/en not_active Expired - Lifetime
-
2010
- 2010-09-21 US US12/886,976 patent/US7988959B2/en not_active Expired - Lifetime
-
2011
- 2011-08-01 US US13/195,614 patent/US8808685B2/en not_active Expired - Lifetime
Non-Patent Citations (3)
Title |
---|
ALLEN-HOFFMANN ET ALL: "Normal Growth and Differentiation in a Spontaneously Immunortalized Near-diploid Human Keratinocyte Cell Line, NIKS", J INVEST DERMATOL, vol. 114, no. 3, March 2004 (2004-03-01), pages 444 - 455, XP002964029 * |
DETMAR M. ET AL: "Hypoxia Regulates the Expression of Vascular Permeability Factor/vascular Endothelial Growth Factor (VPF/VEGF) and Its Receptors in Human Skin", J INVEST DERMATOL, vol. 108, no. 3, March 1997 (1997-03-01), pages 263 - 268, XP002924630 * |
RIO M.D ET AL: "Nonviral Transfer of Genes to Pig Primary Keratinocytes. Induction of Angiogenesisby Composite Grafts of Modified Keratinocytes Overexpressing VEGF Driven by a Keratin Promotor", GENE THERAPY, vol. 6, October 1999 (1999-10-01), pages 1734 - 1741, XP008049910 * |
Also Published As
Publication number | Publication date |
---|---|
DE60332256D1 (en) | 2010-06-02 |
EP1549738A2 (en) | 2005-07-06 |
US7498167B2 (en) | 2009-03-03 |
IL164817A0 (en) | 2005-12-18 |
US20040009591A1 (en) | 2004-01-15 |
ATE465242T1 (en) | 2010-05-15 |
US20050013807A1 (en) | 2005-01-20 |
US7988959B2 (en) | 2011-08-02 |
EP1549738B1 (en) | 2010-04-21 |
US7915042B2 (en) | 2011-03-29 |
WO2003093418A2 (en) | 2003-11-13 |
AU2003228755A1 (en) | 2003-11-17 |
CA2483547C (en) | 2012-03-20 |
NZ536205A (en) | 2008-04-30 |
US20090169528A1 (en) | 2009-07-02 |
EP1549738A4 (en) | 2006-11-02 |
US8808685B2 (en) | 2014-08-19 |
CA2483547A1 (en) | 2003-11-13 |
JP2006509529A (en) | 2006-03-23 |
US20110059057A1 (en) | 2011-03-10 |
IL164817A (en) | 2010-12-30 |
US20110286985A1 (en) | 2011-11-24 |
US7807148B2 (en) | 2010-10-05 |
IL195518A (en) | 2012-08-30 |
JP4753577B2 (en) | 2011-08-24 |
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