WO2004002394A3 - Dry powder dose filling systems and related methods - Google Patents

Dry powder dose filling systems and related methods Download PDF

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Publication number
WO2004002394A3
WO2004002394A3 PCT/US2003/020842 US0320842W WO2004002394A3 WO 2004002394 A3 WO2004002394 A3 WO 2004002394A3 US 0320842 W US0320842 W US 0320842W WO 2004002394 A3 WO2004002394 A3 WO 2004002394A3
Authority
WO
WIPO (PCT)
Prior art keywords
dry powder
dispensing
input signal
related methods
filling systems
Prior art date
Application number
PCT/US2003/020842
Other languages
French (fr)
Other versions
WO2004002394A2 (en
Inventor
Timothy M Crowder
Anthony J Hickey
Original Assignee
Oriel Therapeutics Inc
Timothy M Crowder
Anthony J Hickey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/434,009 external-priority patent/US6889690B2/en
Application filed by Oriel Therapeutics Inc, Timothy M Crowder, Anthony J Hickey filed Critical Oriel Therapeutics Inc
Priority to CN03820536A priority Critical patent/CN100591378C/en
Priority to CA2531055A priority patent/CA2531055C/en
Priority to SI200332333T priority patent/SI1534366T1/en
Priority to AU2003258985A priority patent/AU2003258985B2/en
Priority to JP2004549853A priority patent/JP4425795B2/en
Priority to EP03762314.7A priority patent/EP1534366B1/en
Publication of WO2004002394A2 publication Critical patent/WO2004002394A2/en
Publication of WO2004002394A3 publication Critical patent/WO2004002394A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D88/00—Large containers
    • B65D88/54—Large containers characterised by means facilitating filling or emptying
    • B65D88/64—Large containers characterised by means facilitating filling or emptying preventing bridge formation
    • B65D88/66—Large containers characterised by means facilitating filling or emptying preventing bridge formation using vibrating or knocking devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/001—Details of inhalators; Constructional features thereof with means for agitating the medicament using ultrasonic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0075—Mechanical counters having a display or indicator on a disc
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
    • B65B37/04—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged by vibratory feeders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G53/00—Conveying materials in bulk through troughs, pipes or tubes by floating the materials or by flow of gas, liquid or foam
    • B65G53/34—Details
    • B65G53/66—Use of indicator or control devices, e.g. for controlling gas pressure, for controlling proportions of material and gas, for indicating or preventing jamming of material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated

Abstract

Methods for flowably dispensing dry powders from a hopper having a dispensing port and a dry powder flow path can include: (a) generating a first non-linear vibration input signal, the first non-linear input signal comprising a plurality of different selected frequencies that correspond to a first dry powder formulation; (b) applying the first non-linear vibration input signal to a dispensing hopper having at least one dispensing port while the first dry powder formulation is flowing therethrough; and (c) dispensing a first meted quantity of the first dry powder through the dispensing port to a receiving member. Related devices and computer program products for dispensing dry powders are also described.
PCT/US2003/020842 2002-06-27 2003-06-26 Dry powder dose filling systems and related methods WO2004002394A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN03820536A CN100591378C (en) 2002-06-27 2003-06-26 Dry powder dose filling systems and related methods
CA2531055A CA2531055C (en) 2002-06-27 2003-06-26 Dry powder dose filling systems and related methods
SI200332333T SI1534366T1 (en) 2002-06-27 2003-06-26 Dry powder dose filling systems and related methods
AU2003258985A AU2003258985B2 (en) 2002-06-27 2003-06-26 Dry powder dose filling systems and related methods
JP2004549853A JP4425795B2 (en) 2002-06-27 2003-06-26 Method and system for dispensing dry powder
EP03762314.7A EP1534366B1 (en) 2002-06-27 2003-06-26 Dry powder dose filling systems and related methods

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US39267102P 2002-06-27 2002-06-27
US60/392,671 2002-06-27
US44051303P 2003-01-16 2003-01-16
US60/440,513 2003-01-16
US10/434,009 2003-05-08
US10/434,009 US6889690B2 (en) 2002-05-10 2003-05-08 Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
US11/179,163 US7428446B2 (en) 2002-05-10 2005-07-12 Dry powder dose filling systems and related methods

Publications (2)

Publication Number Publication Date
WO2004002394A2 WO2004002394A2 (en) 2004-01-08
WO2004002394A3 true WO2004002394A3 (en) 2005-03-17

Family

ID=56571089

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/020976 WO2004002395A2 (en) 2002-06-27 2003-06-26 Apparatus, systems and related methods for processing, dispensing and/or evaluating non-pharmaceutical dry powders
PCT/US2003/020843 WO2004003707A2 (en) 2002-06-27 2003-06-26 Apparatus and methods for dispensing dry powders
PCT/US2003/020842 WO2004002394A2 (en) 2002-06-27 2003-06-26 Dry powder dose filling systems and related methods

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2003/020976 WO2004002395A2 (en) 2002-06-27 2003-06-26 Apparatus, systems and related methods for processing, dispensing and/or evaluating non-pharmaceutical dry powders
PCT/US2003/020843 WO2004003707A2 (en) 2002-06-27 2003-06-26 Apparatus and methods for dispensing dry powders

Country Status (8)

Country Link
US (1) US7428446B2 (en)
EP (2) EP1534366B1 (en)
JP (2) JP2006507110A (en)
CN (1) CN100591378C (en)
AU (3) AU2003251760A1 (en)
CA (1) CA2531055C (en)
SI (2) SI1534366T1 (en)
WO (3) WO2004002395A2 (en)

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US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US9132246B2 (en) 2007-10-09 2015-09-15 Microdose Therapeutx, Inc. Inhalation device
US9162031B2 (en) 2004-02-24 2015-10-20 Microdose Therapeutx, Inc. Directional flow sensor inhaler

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CN107719723B (en) * 2017-08-24 2019-04-12 温州大学激光与光电智能制造研究院 A kind of high-speed, high precision dynamic weighing method suitable for powder packaging
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CN110153385B (en) * 2019-05-29 2021-09-14 湖南华菱涟钢特种新材料有限公司 Slag adding device
CN116119398A (en) * 2023-04-07 2023-05-16 营口德源碳素有限公司 Automatic charging and filling device for graphitized crucible

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AU2003258985B2 (en) 2008-07-03
WO2004002395A3 (en) 2004-10-07
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CA2531055C (en) 2011-12-06
WO2004002395A2 (en) 2004-01-08
WO2004002394A2 (en) 2004-01-08
EP1535349B1 (en) 2014-06-25
JP2006507110A (en) 2006-03-02
AU2003253792A1 (en) 2004-01-19
EP1534366A2 (en) 2005-06-01
AU2003258985A1 (en) 2004-01-19
JP2005536415A (en) 2005-12-02
AU2003253792A8 (en) 2004-01-19
WO2004003707A3 (en) 2005-03-17
JP4425795B2 (en) 2010-03-03
CA2531055A1 (en) 2004-01-08
SI1535349T1 (en) 2014-10-30
EP1535349A4 (en) 2009-11-11
CN100591378C (en) 2010-02-24
WO2004003707A2 (en) 2004-01-08
CN1688356A (en) 2005-10-26
US20050267628A1 (en) 2005-12-01
AU2003251760A1 (en) 2004-01-19
EP1535349A2 (en) 2005-06-01
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AU2003251760A8 (en) 2004-01-19
EP1534366A4 (en) 2011-03-02

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