WO2004012576A3 - A method for detecting a functional signal in retinal images - Google Patents

A method for detecting a functional signal in retinal images Download PDF

Info

Publication number
WO2004012576A3
WO2004012576A3 PCT/US2003/023930 US0323930W WO2004012576A3 WO 2004012576 A3 WO2004012576 A3 WO 2004012576A3 US 0323930 W US0323930 W US 0323930W WO 2004012576 A3 WO2004012576 A3 WO 2004012576A3
Authority
WO
WIPO (PCT)
Prior art keywords
retina
light source
signal
retinal
stimulation
Prior art date
Application number
PCT/US2003/023930
Other languages
French (fr)
Other versions
WO2004012576A2 (en
Inventor
Peter Soliz
Eduardo Barriga
Original Assignee
Kestrel Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kestrel Corp filed Critical Kestrel Corp
Priority to AU2003257064A priority Critical patent/AU2003257064A1/en
Publication of WO2004012576A2 publication Critical patent/WO2004012576A2/en
Publication of WO2004012576A3 publication Critical patent/WO2004012576A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14555—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for the eye fundus

Abstract

A system and method for detecting a functional signal in retinal images. An optical imaging device (100) comprises a stimulation light source (120), an interrogating light source (125), and a detector (120). The retina is stimulated by the stimulation light source. The retina is then illuminated by an interrogation light, and the reflected intensity from the retina is measured at an interrogating spectral band that indicates the state of hemoglobin saturation before and after visual stimulation. The optical changes that result from retinal neuronal activity are captured by the detector. The signal representing the state of hemoglobin saturation before and after visual stimulation is isolated. In an embodiment of the present invention, this signal is isolated using principle components analysis (PCA). In another embodiment of the present invention, blind source separation (BSS) and independent component analysis (ICA) algorithms such as extended spatial decorrelation and fast-ICA are used to isolate the functional signal from the retinal videos.
PCT/US2003/023930 2002-08-05 2003-07-31 A method for detecting a functional signal in retinal images WO2004012576A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003257064A AU2003257064A1 (en) 2002-08-05 2003-07-31 A method for detecting a functional signal in retinal images

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40122402P 2002-08-05 2002-08-05
US60/401,224 2002-08-05

Publications (2)

Publication Number Publication Date
WO2004012576A2 WO2004012576A2 (en) 2004-02-12
WO2004012576A3 true WO2004012576A3 (en) 2004-07-01

Family

ID=31495943

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/023930 WO2004012576A2 (en) 2002-08-05 2003-07-31 A method for detecting a functional signal in retinal images

Country Status (3)

Country Link
US (2) US7222961B2 (en)
AU (1) AU2003257064A1 (en)
WO (1) WO2004012576A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7222961B2 (en) * 2002-08-05 2007-05-29 Kestrel Corporation Method for detecting a functional signal in retinal images
US20040218794A1 (en) * 2003-05-01 2004-11-04 Yi-Hsuan Kao Method for processing perfusion images
US9471978B2 (en) * 2004-10-04 2016-10-18 Banner Health Methodologies linking patterns from multi-modality datasets
GB0612096D0 (en) 2006-06-19 2006-07-26 Greater Glasgow Nhs Board Functional imaging of the retina
GB0700770D0 (en) * 2007-01-15 2007-02-21 Univ Aberdeen Apparatus for detecting retinal neuropathy
US8515201B1 (en) * 2008-09-18 2013-08-20 Stc.Unm System and methods of amplitude-modulation frequency-modulation (AM-FM) demodulation for image and video processing
DE102009015598B4 (en) * 2009-04-02 2015-10-01 Carl Zeiss Meditec Ag Method and device for finding functional tissue areas in a tissue area
US8303115B2 (en) * 2009-05-28 2012-11-06 Annidis Health Systems Corp. Method and system for retinal health management
JP4902721B2 (en) * 2009-10-23 2012-03-21 キヤノン株式会社 Optical tomographic image generation apparatus and optical tomographic image generation method
DE102009053905B4 (en) * 2009-11-20 2012-05-24 Roland Consult Stasche & Finger Gmbh Method and device for detecting reaction signals for an eye to be examined
US7884933B1 (en) 2010-05-05 2011-02-08 Revolutionary Business Concepts, Inc. Apparatus and method for determining analyte concentrations
US8600213B2 (en) * 2011-10-26 2013-12-03 Xerox Corporation Filtering source video data via independent component selection
US20140125642A1 (en) * 2012-11-05 2014-05-08 Broadcom Corporation Display System Ocular Imaging
US9179834B2 (en) * 2013-02-01 2015-11-10 Kabushiki Kaisha Topcon Attenuation-based optic neuropathy detection with three-dimensional optical coherence tomography
GB2519315B (en) * 2013-10-16 2020-12-16 Canon Kk Method and apparatus for identifying actual signal sources among a plurality of signal sources with artefacts detection
USD734470S1 (en) 2013-12-13 2015-07-14 Henry Ford Health System Vision assessment chart
US9526412B2 (en) 2014-01-21 2016-12-27 Kabushiki Kaisha Topcon Geographic atrophy identification and measurement
USD745169S1 (en) * 2014-01-28 2015-12-08 The Eye Tribe Aps Eye tracking apparatus
USD844145S1 (en) 2014-12-22 2019-03-26 Henry Ford Health System Vision assessment chart
US10117568B2 (en) 2015-01-15 2018-11-06 Kabushiki Kaisha Topcon Geographic atrophy identification and measurement
WO2018095994A1 (en) * 2016-11-22 2018-05-31 Delphinium Clinic Ltd. Method and system for classifying optic nerve head
CN108597531B (en) * 2018-03-28 2021-05-28 南京大学 Method for improving dual-channel blind signal separation through multi-sound-source activity detection
CN108670192B (en) * 2018-04-21 2019-08-16 重庆贝奥新视野医疗设备有限公司 A kind of multispectral eyeground imaging system and method for dynamic vision stimulation
USD948724S1 (en) 2019-04-16 2022-04-12 Henry Ford Health System Vision assessment chart
WO2021189144A1 (en) * 2020-03-26 2021-09-30 Diamentis Inc. Systems and methods for processing retinal signal data and identifying conditions
CN115316960B (en) * 2022-10-13 2023-03-31 浙江大学医学中心(余杭) Brain nerve activity regulation and control and brain information synchronous reading system

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4922919A (en) * 1988-03-22 1990-05-08 Duke University Method for measuring ocular oxidative metabolism
US5219400A (en) * 1991-06-11 1993-06-15 The United States Of America As Represented By The Secretary Of The Army Noninvasive method for quantitation of oxyhemoglobin saturation by near-infrared reflectance spectrophotometry
US5297554A (en) * 1989-04-26 1994-03-29 Glynn Christopher J Device for use in real-time monitoring of human or animal bodily function
US5308919A (en) * 1992-04-27 1994-05-03 Minnich Thomas E Method and apparatus for monitoring the arteriovenous oxygen difference from the ocular fundus
US6086206A (en) * 1998-01-05 2000-07-11 Sutter; Erich E. Analysis method for enhancing and extracting second order nonlinear response components of the multi-area electroretinogram
US6478424B1 (en) * 1998-07-31 2002-11-12 Yeda Research And Development Co., Ltd. Non-invasive imaging of retinal function

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6198532B1 (en) * 1991-02-22 2001-03-06 Applied Spectral Imaging Ltd. Spectral bio-imaging of the eye
AUPM537994A0 (en) * 1994-04-29 1994-05-26 Australian National University, The Early detection of glaucoma
AUPP266198A0 (en) * 1998-03-30 1998-04-23 Australian National University, The Simultaneous binocular assessment of multiple optic nerve and cortical regions in diseases affecting nerve conduction
US6276798B1 (en) * 1998-09-29 2001-08-21 Applied Spectral Imaging, Ltd. Spectral bio-imaging of the eye
US6430431B1 (en) * 1999-11-11 2002-08-06 Mcw Research Foundation, Inc. MRI system for measuring vision capabilities
US7222961B2 (en) * 2002-08-05 2007-05-29 Kestrel Corporation Method for detecting a functional signal in retinal images

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4922919A (en) * 1988-03-22 1990-05-08 Duke University Method for measuring ocular oxidative metabolism
US5297554A (en) * 1989-04-26 1994-03-29 Glynn Christopher J Device for use in real-time monitoring of human or animal bodily function
US5219400A (en) * 1991-06-11 1993-06-15 The United States Of America As Represented By The Secretary Of The Army Noninvasive method for quantitation of oxyhemoglobin saturation by near-infrared reflectance spectrophotometry
US5308919A (en) * 1992-04-27 1994-05-03 Minnich Thomas E Method and apparatus for monitoring the arteriovenous oxygen difference from the ocular fundus
US6086206A (en) * 1998-01-05 2000-07-11 Sutter; Erich E. Analysis method for enhancing and extracting second order nonlinear response components of the multi-area electroretinogram
US6478424B1 (en) * 1998-07-31 2002-11-12 Yeda Research And Development Co., Ltd. Non-invasive imaging of retinal function

Also Published As

Publication number Publication date
AU2003257064A8 (en) 2004-02-23
AU2003257064A1 (en) 2004-02-23
US20040114109A1 (en) 2004-06-17
WO2004012576A2 (en) 2004-02-12
US20070211211A1 (en) 2007-09-13
US7222961B2 (en) 2007-05-29

Similar Documents

Publication Publication Date Title
WO2004012576A3 (en) A method for detecting a functional signal in retinal images
US20230346238A1 (en) Method and system using biological information detection device using second light from target onto which dots formed by first light are projected to detect status of living body
US20210264598A1 (en) Human detection device equipped with light source projecting at least one dot onto living body
Magdalena Nowara et al. SparsePPG: Towards driver monitoring using camera-based vital signs estimation in near-infrared
CA2372376C (en) Apparatus and method of monitoring a subject's eyes using two different wavelengths of light
Lewandowska et al. Measuring pulse rate with a webcam
US11727709B2 (en) Detecting device, detecting method, and recording medium
US9204843B2 (en) Optical distance measurement system and operation method thereof
US10379035B2 (en) Appearance inspection apparatus and appearance inspection method
Yang et al. Motion robust remote photoplethysmography in CIELab color space
WO2009158662A2 (en) Method of reducing visibility of illimination while acquiring high quality imagery
US20130342756A1 (en) Enabling hybrid video capture of a scene illuminated with unstructured and structured illumination sources
JP2006242909A (en) System for discriminating part of object
US11956868B2 (en) Systems, devices, and methods for implementing spectral reflectance imaging using narrow band emitters
Jeanne et al. Camera-based heart rate monitoring in highly dynamic light conditions
US11187580B2 (en) Spectral-spatial imaging device
KR20170094256A (en) Camera based photoplethysmogram estimation
WO2002002001A3 (en) Epithelial diagnostic aid
US20090324021A1 (en) Method of Identification of a Person on the Iris of the Eye (Embodiments)
CA2816058A1 (en) Iris identification method of a person (alternatives)
RU2407435C1 (en) Method of identification of personality by iris (its versions)
KR102242293B1 (en) Non-contact system of measuring oxygen saturation and its way to working
RU2417735C1 (en) Method of iris identification of personality (versions)
KR100459014B1 (en) Method and apparatus for distribution analysis of surface color
Bui et al. Measuring Heart Rate by using the Contact Free Video Imaging on a Built-In Camera of a Smartphone

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP