WO2004017857A1 - Implantat zur implantation in knochengewebe oder in durch knochenersatzmaterial ergänztem knochengewebe - Google Patents
Implantat zur implantation in knochengewebe oder in durch knochenersatzmaterial ergänztem knochengewebe Download PDFInfo
- Publication number
- WO2004017857A1 WO2004017857A1 PCT/CH2003/000550 CH0300550W WO2004017857A1 WO 2004017857 A1 WO2004017857 A1 WO 2004017857A1 CH 0300550 W CH0300550 W CH 0300550W WO 2004017857 A1 WO2004017857 A1 WO 2004017857A1
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- WIPO (PCT)
- Prior art keywords
- implant
- surface areas
- type
- bone
- bone tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0016—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy polymeric material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
- A61F2/447—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4611—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
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- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0019—Blade implants
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30032—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in absorbability or resorbability, i.e. in absorption or resorption time
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- A61F2/02—Prostheses implantable into the body
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- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
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- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2002/4625—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use
- A61F2002/4627—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use with linear motion along or rotating motion about the instrument axis or the implantation direction, e.g. telescopic, along a guiding rod, screwing inside the instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2002/4681—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor by applying mechanical shocks, e.g. by hammering
- A61F2002/4683—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor by applying mechanical shocks, e.g. by hammering by applying ultrasonic vibrations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0071—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof thermoplastic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/008—Phase change materials [PCM], e.g. for storing latent heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Definitions
- the invention is in the field of medical technology and relates to an implant according to the preamble of the first independent claim.
- the implant is implanted in particular in human or animal bone tissue, but can also be implanted in bone tissue supplemented with bone substitute material.
- the implant according to the invention is, for example, a dental implant that takes over the function of a natural tooth root in a jawbone and, for example, has a fixing point at its proximal end for attaching an artificial tooth crown, a bridge or a denture, which after implantation in the area of the Bone surface is arranged.
- the dental implant can also represent a complete denture, that is to say also have a crown area in addition to a root area to be implanted.
- the implant can also have a different function and be suitable for implantation in another human or animal bone.
- the implant can therefore serve in general to connect a bone part to another tissue part, in particular a bone part, or to an artificial part, the artificial part being able to support or replace a bone part (for example an artificial joint ball or socket) or a therapeutic auxiliary device. direction (eg drug release device, drainage device or stimulator for electrical or chemical stimulation).
- a bone part for example an artificial joint ball or socket
- a therapeutic auxiliary device for example drug release device, drainage device or stimulator for electrical or chemical stimulation.
- the implant itself can also be such a therapeutic auxiliary device. It can also serve as a placeholder for missing and possibly replaceable bone tissue (eg after removal of a tumor) or as an augmentation element for a desired bone enlargement.
- Denture structures (individual teeth, groups of teeth, partial dentures or entire dentures) that are based on the above-mentioned dental implants with fixation sites are created according to the prior art, for example in the following steps: after the natural tooth root has been removed, the patient waits until the opening in the jawbone has filled with bone tissue through natural bone regeneration. An opening adapted to the implant is created in the area of the regenerated bone tissue. The implant is inserted into the opening, the opening being so deep that the implant can be accommodated entirely in it, ie it does not protrude beyond the opening. An internal thread defining the fixation point on the face of the implant is closed with a cover screw.
- the gums are sewn together over the cover screw and the patient waits until the bone tissue has grown together with the implant and thus has sufficient stability (secondary stability) for the expected load. Then, in a further step, the gums are opened above the implant and the cover screw is replaced by a spacer, the spacer projecting above the gums. Only when the gums around the spacer have healed is the denture structure attached to them.
- the briefly described procedure means a treatment time of up to 12 to 18 months for the patient. Of this, two to three months fall between the time of implantation and a point in time when the implant has grown into or overgrown with the bone tissue for a load.
- the first waiting time (regeneration of the bone tissue in an opening in the jawbone) can be avoided or shortened if implants are used which are shaped as closely as possible to the original opening, as described, for example, in publication US Pat. No. 6,132,214 (Suhonen et al .) is described.
- the dental implants used according to the prior art usually consist of pure titanium or titanium alloys. These metals show a very high biological compatibility and there are also various methods known to design the surfaces of implants made of these metals for an even better osseointegration. In many cases, the implants also have macroscopic structures that allow ingrowth of the bone tissue or growth through with the bone tissue. These known dental implants only have a stability that is sufficient for a full load after complete osseointegration, that is, only when they are closely surrounded by the bone tissue, or have grown together with the bone tissue or have grown through them (secondary stability). In osteoporotic or soft bone, as well as in poorly regenerating bone tissue, for example from older patients, it may not be possible to achieve sufficient implant stability at all.
- the primary stability of the dental implants described above that is to say their stability immediately after the implantation, is very limited. For this reason, the above-mentioned waiting time between implantation and further assembly is inserted.
- the primary stability of the implants mentioned differs depending on the shape of the implant, but is often not sufficient for full loading. Pin-shaped implants with a thread are limited to tension and pressure and can be loaded with transverse forces, especially if they are used in such a way that at least one thread is in the area of the cortex. They are not very resilient to torsion. Implants that have a non-round cross-section, for example, whose shape is adapted to a natural tooth root, are better subjected to torsion. cash, less on train. The same applies to plate-shaped dental implants, which can also have several fixing points.
- the primary stability in particular the resilience to tension or pressure, is increased by correspondingly designed threads (US-3499222), by expandable elements (eg US-5766009, EP-1184006) or by collar-shaped elements .
- Anchor-shaped implants which are used in particular for fastening wires and sutures, are equipped with barb-like surface structures to increase the primary and secondary stability for tensile loads (US-4360343).
- the object of the invention is therefore to create an implant to be implanted in bone tissue or bone substitute material that has very good primary stability, so that it can be loaded immediately after implantation, but which also has other clinical functions, for example support osseointegration, passage of particles or molecules in one direction or another (release of therapeutic substances or drainage ge), electrical or chemical stimulation etc., also takes place immediately after the implantation.
- the additional clinical functions should not be significantly limited clinically by the required primary stability.
- the implant has a load-bearing function, for example a dental implant
- the implant according to the invention nor its implantation should be more complex than is the case for implants according to the prior art.
- the surfaces of the implant according to the invention which adjoin the bone tissue after the implantation and, for example, should grow around or grow together with the bone tissue, have areas of a first type and areas of a second type different from the first type.
- the surface areas of the first type are equipped in a manner known per se for one or more predetermined clinical functions.
- predetermined clinical functions are the promotion or at least enabling of osseointegration for good, secondary stability, the release of therapeutically active substances into the tissue surrounding the implant, the removal of undesired substances (drainage) from the tissue surrounding the implant or the electrical or chemical stimulation of tissue surrounding the implant.
- the surface areas of the first type therefore have structures which are suitable for stable growth or growth with the vital tissue and are at least biologically active with regard to osseointegration.
- substances with, for example, osseointegrative, anti-inflammatory, infection-fighting or growth-promoting effects can be released through the surface areas of the first type or they can be equipped for the transmission of stimulating impulses with a therapeutic effect.
- the surface areas of the first type are, for example, biologically compatible surfaces (e.g. made of titanium) and can form macroscopic structures into which the bone tissue can grow.
- Such surfaces can additionally be coated, for example, with calcium phosphate-containing compounds, they can be modified, for example, with phosphonates or peptide sequences, and / or they can have gels or polymers in which, for example, growth factors are incorporated.
- the surface areas of the second type are equipped for the creation of primary stability.
- these surface areas have a material which can be liquefied by means of mechanical vibrations, for example a thermoplastic material (thermoplastic material or composite material with a thermoplastic component) or a thixotropic cement, this liquefiable material during implantation using mechanical vibrations, for example ultrasound , liquefied and pressed into bumps, pores or created geometries in the bone tissue surrounding the implant.
- a material which can be liquefied by means of mechanical vibrations for example a thermoplastic material (thermoplastic material or composite material with a thermoplastic component) or a thixotropic cement, this liquefiable material during implantation using mechanical vibrations, for example ultrasound , liquefied and pressed into bumps, pores or created geometries in the bone tissue surrounding the implant.
- the material forming the surface areas of the second type already forms parts of the outer surface of the implant before the implantation, or it is located inside the implant and is pressed during the implantation in the liquefied state through corresponding openings on the outer surface of the implant, where it is then in situ forms the surface areas of the second type.
- the surface areas of the second type are arranged such that they come into contact with the bone tissue when the implant is positioned in the bone.
- the surface areas of the second type protrude at least locally, for example, from the surface areas of the first type or they are located on implant edges, bulges, etc.
- the openings are on implants that carry the material forming the surface areas of the first type before the implantation , through which the liquefiable material is pressed out, advantageously arranged at precisely the same locations.
- the surface areas of the two different types are arranged in such a way and the liquefiable material and / or the liquefaction are applied in such a metered manner that the surface areas of the first type of liquefied material remain as free as possible.
- This ensures that the further clinical functions of these surface areas of the first type are not hindered immediately after implantation, or at most to a limited extent not clinically relevant.
- the separation of the two types of implant surfaces is achieved, for example, for implants that are moved in an implantation direction relative to the bone tissue during the implantation, in that the two types of surface areas are arranged essentially parallel to one another in the implantation direction.
- the implant according to the invention is implanted in an opening made specifically for the implant in the previously regenerated bone tissue (e.g. the jaw), this opening being able to accommodate the entire implant (root area) or the implant being self-tapping deeper than the opening in the bone tissue can be introduced.
- the opening can therefore only affect the cortex layer, for example, or if the implant is designed accordingly, it can be missing at all.
- the shape of the implant according to the invention can also be adapted in the form of a replica to an irregular opening in the bone tissue, that is to say, for example, it can have the shape of a removed, natural tooth root and can be implanted directly into this irregular opening.
- the implant according to the invention is thus, for example, a dental implant and has the shape of a pin or a natural tooth root and has a fixing point at its proximal end (for example a blind hole with an internal thread or a point at which the dental surgeon can create such a blind hole) or an artificial crown area on. It can be chisel-shaped at its distal end and / or be equipped laterally with self-tapping or furrowing structures. It can also be plate, disc or blade-shaped and have one or more fixing points or it can have the shape of an anchor to which, for example, a wire or a suture material can be fastened.
- the implant according to the invention is in one piece and has the different surface areas defined above, which consist for example of different materials, or it has the liquefiable material in its interior, openings being provided through which the material in its liquefied state leads to the outside of the Implant can be pressed.
- the implant can also be in two or more parts, the surgeon combining two or more parts made of different materials to form an implant.
- the implant according to the invention is positioned in an opening in a bone (or bone tissue supplemented with bone substitute material), for example in a jaw bone, or optionally on the bone and then subjected to mechanical vibrations, for example with ultrasound, and at the same time pressed against the bone ,
- a bone or bone tissue supplemented with bone substitute material
- mechanical vibrations for example with ultrasound
- the implant is advanced in the bone tissue at the same time as it liquefies (direction of implantation).
- the sonotrode of an ultrasound device is placed on its proximal end.
- the frequency of the vibrations is between 2 and 200 kHz.
- Implants according to the invention with a load-bearing function have, for example, a central implant part which covers the surface riches of the first kind and that, for example, made of metal (e.g. steel, titanium, cobalt / chrome alloys), made of ceramic or glass-like material (e.g. aluminum oxide, zirconium oxide, silicates, calcium phosphate ceramics or glasses), made of thermosetting or high-temperature thermoplastic Plastics (polyetheraryl ketones, polyfluoro- or polychlorethylene, polyetherimides, polyether sulfones, polyvinyl chloride, polyurethanes, polysulfones, polyester) .
- metal e.g. steel, titanium, cobalt / chrome alloys
- ceramic or glass-like material e.g. aluminum oxide, zirconium oxide, silicates, calcium phosphate ceramics or glasses
- thermosetting or high-temperature thermoplastic Plastics polyetheraryl ketones, polyfluoro- or polychlorethylene, polyether
- the implant parts can be connected to one another by the manufacturer or can only be connected to one another by the surgeon immediately before or during the implantation.
- Implants according to the invention without any significant load-bearing function can also have a central implant part and a peripheral implant part made of at least partially liquefiable material, the mechanical stability (load-bearing function) required for the implantation is necessary, can be taken over by the peripheral part and in such a case the central part has only a low mechanical stability.
- a central implant part can be, for example, a permeable container, for example made of porous calcium phosphate or other mechanically unstable bone substitute material or made of a thin membrane, the release or drainage or stimulation taking place through the container wall.
- the central implant part can also be a body made of, for example, porous calcium phosphate or other bone substitute material, the function of which is to prevent the formation of missing or additionally to initiate or support the desired bone material. Even in the case of a mechanically unstable central implant part, it is possible to provide the liquefiable material in the interior of the central implant part and to press it in the liquefied state through corresponding openings of the central implant part on the outside thereof during the implantation.
- the implant according to the invention can also consist of only a single material if it meets the requirements for the mechanical strength of the implant and, if applicable, a fixing point, the requirements and the demands made by the further clinical functions of the surface areas of the first type (eg biological integration or secondary stability) can meet the requirements of liquefiability through mechanical vibrations.
- the single material may be filled to different degrees (e.g., fibers, whiskers, or particles) in different areas of the implant, or it may be filled with different materials in different areas.
- the surface areas to be integrated in the bone tissue are appropriately configured so that the surface areas of the second type or the liquefied material come into contact with the bone tissue in particular during implantation and that the liquefied material does not or only does so are applied to the surface areas of the first type at a clinically irrelevant degree.
- the liquefiable material is advantageously at least partially biodegradable (resorbable), so that the primary stability created by the form fit between the implant and the bone tissue is gradually replaced by the secondary stability of the Osseointegration, which advantageously increases to the same extent as the liquefiable material is absorbed, that is, the primary stability is reduced.
- the liquefiable material is advantageously at least partially absorbable if the implant is to be removed after a predetermined time or if it is to be completely replaced by bone tissue. If the primary stability is to be maintained, the liquefiable material is not or only partially absorbable.
- Suitable liquefiable materials are, for example, resorbable polymers, for example based on lactic and / or glycolic acid (PLA, PLLA, PGA, PLGA etc.) or polyhydroxyalkanoates (PHA), polycaprolactones (PCL), polysaccharides, polydioxanones (PD) polyanhydrides, polypeptides or corresponding copolymers or mixed polymers or composite materials containing the named polymers as components.
- PHA lactic and / or glycolic acid
- PHA polyhydroxyalkanoates
- PCL polycaprolactones
- PD polysaccharides
- PD polydioxanones
- polypeptides or corresponding copolymers or mixed polymers or composite materials containing the named polymers as components are, for example, resorbable polymers, for example based on lactic and / or glycolic acid (PLA, PLLA, PGA, PLGA etc.) or polyhydroxyalkanoates (
- thermoplastics such as polyolefins (eg polyethylene), polyacrylates, polymetacrylates, polycarbonates, polyamides, polyesters, polyurethanes, polysulfones, polyaryl ketones, polyimides, polyphenylsulfides or liquid crystal polymers (liquid crystal polymers LCPs), polyacetals, Halogenated polymers, in particular halogenated polyolefins, polypropylene sulfides, polysulfones, polyethers or corresponding copolymers and copolymers or the above-mentioned polymers as component-containing composite materials.
- polyolefins eg polyethylene
- polyacrylates eg polymetacrylates
- polycarbonates e.g polyamides, polyesters, polyurethanes, polysulfones, polyaryl ketones, polyimides, polyphenylsulfides or liquid crystal polymers (liquid crystal polymers LCPs), polyacetals
- Halogenated polymers in particular
- Applicable thixotropic systems are resorbable, partially resorbable or non-resorbable, polymeric, ceramic or hydraulic cements (eg Norian® from Synthes or Sulfix® from Centerpulse).
- the liquefiable material can contain foreign phases or other substances for further functions.
- the liquefiable material can be reinforced by adding fibers or whiskers (eg calcium phosphate ceramics or glasses) (composite material). It can also contain in situ swelling or soluble (pore-forming) components (e.g. polyesters, polysaccharides, hydrogels, sodium phosphate) or substances to be released in situ with therapeutic effects, for example to promote healing and regeneration (e.g. growth factors, antibiotics, anti-inflammatories or buffers such as sodium phosphate) against adverse effects of acidic degradation). If the liquefiable material is absorbable, such substances are released with a delay.
- the part of the implant that is not made of the liquefiable material is not resorbable if the implant remains in the body or is to be surgically removed. However, it can also consist at least partially of a resorbable material that is gradually replaced by vital tissue after the implantation.
- the design of the implant and the choice of the liquefiable material must be coordinated with one another in such a way that the strength of the positive connection can meet the expected load, and in such a way that the liquefaction entails a responsible, that is to say the least possible release of heat.
- liquefiable materials with a relatively high softening temperature it is advantageous to ensure that the implant as a whole (including the liquefiable material) conducts the mechanical vibrations in the manner of a resonator, so that the liquefiable material is only very local, for example only in the Areas of correspondingly provided energy direction sensors are liquefied in the surface areas of the second type. In this way, the amount of heat released can be kept within an acceptable range.
- Liquefaction also takes place inside the liquefiable material (through strong damping of the stimulating vibrations) or at points of contact between the central and peripheral implant part.
- the heat load on the tissue during the implantation can be further reduced by the central implant part having materials with a high thermal conductivity and / or a high heat capacity (e.g. silicon carbide) and optionally provided with cooling channels through which a cooling medium is passed.
- materials with a high thermal conductivity and / or a high heat capacity e.g. silicon carbide
- FIGS. 1, 2A, 2B and 2C show three first, exemplary embodiments of an essentially pin-shaped implant according to the invention (e.g. dental implant) with a central and a peripheral implant part as a side view (FIG. 1) and in cross section (FIGS. 2A to 2C);
- an essentially pin-shaped implant according to the invention e.g. dental implant
- FIGS. 2A to 2C show three first, exemplary embodiments of an essentially pin-shaped implant according to the invention (e.g. dental implant) with a central and a peripheral implant part as a side view (FIG. 1) and in cross section (FIGS. 2A to 2C);
- Figure 3 shows a second, exemplary embodiment of an implant according to the invention (e.g. dental implant) with a central and a peripheral implant
- the shape of the implant being adapted to an existing cavity in a bone (e.g. opening in the jaw bone created by removal of a natural tooth root);
- FIGS. 4 and 5 show two further embodiments of an implant according to the invention (for example a dental implant) with a central and peripheral implant part, the central implant part being adapted to an existing cavity in a bone (for example reproduction of a natural tooth root) and having a self-separating or grooving (cross section );
- FIG. 6 shows a further, essentially pin-shaped embodiment of an implant according to the invention (for example a dental implant) with a central and a peripheral implant part (side view);
- FIGS. 7 and 8 show an exemplary embodiment of an implant according to the invention in the form of an anchor as a side view (FIG. 7) and in cross section (FIG. 8);
- FIGS. 9 and 10 show an exemplary embodiment of a plate-shaped, disc-shaped or blade-shaped implant according to the invention (e.g. dental implant with two fixing points) as a side view (FIG. 9) and top view (FIG. 10);
- a plate-shaped, disc-shaped or blade-shaped implant according to the invention e.g. dental implant with two fixing points
- FIGS. 9 and 10 show an exemplary embodiment of a plate-shaped, disc-shaped or blade-shaped implant according to the invention (e.g. dental implant with two fixing points) as a side view (FIG. 9) and top view (FIG. 10);
- FIGS. 11 and 12 show an exemplary embodiment of an essentially pin-shaped implant according to the invention (e.g. dental implant) with a hollow central implant part as a longitudinal section (FIG. 11) and top view (FIG. 12).
- an essentially pin-shaped implant according to the invention e.g. dental implant
- FIGS. 11 and 12 show an exemplary embodiment of an essentially pin-shaped implant according to the invention (e.g. dental implant) with a hollow central implant part as a longitudinal section (FIG. 11) and top view (FIG. 12).
- FIG. 13 shows an exemplary embodiment of the implant according to the invention with a central implant part without substantial mechanical stability
- Figures 15 and 16 (each A, B and C) two embodiments of implants for
- Figures 1 and 2A to 2C show an exemplary pin-shaped embodiment of the implant according to the invention, which has a load-bearing function, that is, for example, a dental implant but also an implant for orthopedic use, for example for stabilizing a broken bone or for fixing a plate or a Shaft of a joint prosthesis (e.g. hip joint, knee joint, shoulder joint or finger joint).
- the implant has a central implant part 1 and a peripheral implant part 2, the central implant part at its proximal end, for example, a fixing point 3, for example a blind hole with an internal thread, or a point at which the surgeon (for example a dental surgeon) can create such a blind hole, having.
- the distal end is chiseled, for example, for a self-tapping effect.
- the implant can also have, for example, axially extending, self-tapping or grooving elements 9.
- the central implant part 1 has surface areas 4 of the first type extending parallel to the implantation direction A (for example with osseointegrative, anti-inflammatory, infection-fighting and / or growth-promoting properties) and between the surface areas 4 of the first type surfaces which are suitable for connection to the peripheral implant part 2 suitable.
- the connection between the peripheral implant part 2 and the central implant part can be an adhesive connection 5 (FIG. 2A) or a form-fitting, for example individual grooves 5 ′ (FIGS.
- the peripheral implant part 2 has fingers 6 which fit, for example, into the grooves 5 'or onto the surface areas 5 "and which form at least part of the surface areas 8 of the second type.
- the invention does not actually impose any conditions on the cross section of the pin-shaped implants according to the invention, so that this can be selected depending on the function.
- Cross sections other than those shown in the three figures are therefore also conceivable, for example with a central implant part a round cross section and fingers 6 sitting thereon, as shown in FIG. 2A.
- the implant illustrated in FIG. 2C can be driven into the bone tissue largely self-tapping, for example. So that the liquefied material is not driven onto the surface areas 4 of the first type, the surface areas of the first and second types (4 and 8) extend side by side parallel to the implantation direction A. In the proximal area, where the implantation path is only short, the fingers can 6 open into a ring 6 ', which extends around the central implant part 1 and is advantageously also held in a groove in the central implant part 1.
- the ring 6 not only combines the fingers 6 to form a coherent, peripheral implant part 2, which may be advantageous for a connection to the central implant part by the surgeon, but it also becomes a more intimate one, possibly in the region of the cortex primary stabilization between implant and bone tissue created, in particular against tension and torsion. If necessary, a thread or a similar structure must be created in the cortex so that the ring 6 'can be positively connected to this relatively dense layer of bone.
- the surface areas of the first and second types can also be arranged differently for an implant that is positioned in a deeper opening and is not or only slightly advanced during the exposure to the mechanical vibrations.
- the surface areas 8 of the second type can, for example, form a pattern of dots or of intersecting lines.
- the arrangement of the surface areas 8 of the second type must therefore be adapted to the type of implantation.
- it has to be adapted to the primary stability that can be achieved by the liquefied material, which cannot be given by the shape of the implant.
- the two implant parts 1 and 2 of the implants shown in FIGS. 1 and 2A to 2C can be connected to one another by the manufacturer.
- the peripheral implant part 2 can be produced, for example, by injection molding directly on the central implant part 1.
- the two implant parts 1 and 2 can also be manufactured separately and only assembled by the surgeon immediately before the implantation. It is advantageous to achieve the positive or adhesive connection between the two materials during the implantation, for example, by liquefying the material of the peripheral implant part 2 and pressing it, for example, into the openings or grooves according to FIG. 2B of the central implant part.
- the inside of the peripheral implant part 2 or the corresponding surface of the central implant part 1 may have to be provided with energy directors.
- the advantage of assembling on the consumer side is that the two parts can be sterilized separately and, if necessary, in different processes that are adapted to the different functionalities of the parts. Sterilization of the assembled implant is not necessary.
- the assembly of the implant on the consumer side also makes it possible for the surgeon to be provided with a set with central implant parts that differ from one another, for example in terms of length and diameter, and peripheral implant parts that differ from one another, for example with regard to material or finger thickness, so that the surgeon makes a precise choice for a present case can put together a suitable implant yourself (greater variability with a smaller number of system components).
- a device eg sonotrode of an ultrasound device
- the pin-shaped implants according to FIGS. 1 and 2A to 2C, the distal end of which is essentially matched to the proximal end face of the implant. If necessary, a coupling between the sonotrode and the implant element inserted.
- the vibration energy is advantageously coupled in via the central implant part.
- FIG. 3 shows a dental implant according to the invention, which is designed in principle like the implant according to FIG. 1, but the shape of which is not modeled on the known pin-shaped or screw-shaped implants, but of the shape of an existing cavity in a bone, in the present case is adapted to a natural tooth root.
- the central implant part 1 is provided with structures 10 between the surface areas 8 of the second type, which are formed by the peripheral implant part 2, that is to say in the surface areas 4 of the first type, which, like a thread, have better anchoring in the regenerated bone tissue (secondary stability ) enables.
- FIGS. 4 and 5 show in cross section two further embodiments of the implant according to the invention which are suitable for implantation in an existing cavity in a bone, for example in that by removing a natural tooth root. They are adapted to the corresponding cavity for this application and have axially running self-tapping or grooving elements 9.
- the central implant part 1 of the two implants consists of a pin part 1.1, which for example carries a fixing point 3 or an artificial tooth crown, and a molded part 1.2.
- the molded part 1.2 is made ex situ in the sense of a replica, for example on the basis of a tooth root removed from a jaw, as described, for example, in publication US Pat. No. 6,132,214 (Suhonen et al.), Or in situ, i.e. molded in the appropriate cavity.
- the molded part 1.2 according to FIG. 4 forms the surface areas 4 of the first type
- the peripheral implant part 2 is limited to the self-tapping or grooving elements 9, into which, for example, pin-shaped parts made of the liquefiable material are embedded.
- the implant according to FIG. 4 can also be implanted in two steps. First, an existing cavity is filled with a piece of bone substitute material (molded part 1.2) and then the pin part 1.1 is inserted, the anchoring using liquefiable material (peripheral implant part 2) at least partially affecting the bone substitute material. Such cases are indicated in FIG. 4 with dash-dotted lines.
- the molded part 1.2 according to FIG. 5 is surrounded by a relatively thin and as flexible as possible layer of the liquefiable material, that is to say by the peripheral implant part 2, which forms the surface 8 of the second type.
- a membrane which is at least partially coated with the liquefiable material can also be provided.
- the axially extending, self-tapping or grooving elements 9 have the surfaces 4 of the first type.
- the molded part 1.2 consists of a plastic, hardenable material, for example of a bone cement that can be hardened by means of light, ultrasound or heat, and which advantageously has thixotropic properties. When inserted into the bone cavity, the molded part 1.2 adapts to this cavity.
- the liquefiable material of the surface areas 8 of the second type When mechanical vibrations are applied, not only is the liquefiable material of the surface areas 8 of the second type pressed into pores and unevenness of the surrounding bone tissue, but also the shaped body is adapted to the opening in the jaw bone and, if necessary, hardened.
- the flowable material is advantageously resorbable, so that the primary stability created by the surface areas 8 of the second type is replaced by a secondary stability first due to the osseointegration of the molded body 1.2 and after its absorption by an osseointegration of the pin part 1.1.
- Implants designed as dental implants according to FIGS. 4 and 5 can be implanted in the jawbone essentially immediately after removal of a natural tooth root, since their shape can be adapted to the opening created by the removal. Thanks to the primary stability achieved by the surface areas 8 of the second type, they can also be loaded immediately, which results in micro-movements with physiological dimensions that accelerate the osseointegration in the surface areas of the first type. Such dental implants thus shorten the treatment time even more than the implants according to FIGS. 1 to 3. The same naturally also applies to implants that are to be implanted in a predetermined cavity by people other than jawbones.
- FIG. 6 shows a further, pin-shaped embodiment of the implant according to the invention (eg dental implant, fixation of broken bones, attachment of stabilizing plates, shaft of joint prostheses) with a central implant part and a peripheral implant part 2.
- the central implant part 1 has continuous and / or non-continuous openings 11 for growing through with bone tissue, in which, for example, held in place by friction, pins 12 made of the liquefiable material and protrude beyond the surface of the central implant part 1.
- the pins 12 together form the peripheral implant part 2, the pin ends projecting from the openings 11 form the surfaces 8 of the second type.
- Figures 7 and 8 show a side view and in cross section an anchor-shaped
- Embodiment of the implant according to the invention the fixing point 3 of which is designed, for example, as an eyelet.
- the anchor has a known shape and has a slot running along its length, in which a pin made of the liquefiable material (peripheral implant part 2) is arranged in a form-fitting manner.
- the pin 13 protrudes on both sides over the anchor surface.
- the anchor-shaped implant can additionally have barbs 14 which are pressed into the bone tissue when subjected to tension and which supplement the form-fitting anchoring by the peripheral implant part 2.
- Such barbs or similar means can also be completely absent.
- the design of the anchor edges as cutting blades facilitates the implantation without first creating a corresponding opening in the bone tissue or with creating an opening that only affects the cortex.
- FIGS. 9 and 10 show, as a further exemplary embodiment of the implant according to the invention, a plate-shaped, disc-shaped or blade-shaped dental implant which has, for example, two fixing points 3 or two artificial tooth crowns and whose peripheral implant part 2 consists of a plurality of pin-shaped parts 13, which in the area the plate, disc or blade are arranged in through openings and in the area of the fixing points in grooves of the central implant part.
- the plate-shaped, disc-shaped or blade-shaped dental implants are usually inserted into the jaw from the alveolar ridge like the pin-shaped dental implants, or are driven into the jaw during exposure to mechanical vibrations ( Implantation direction A, Figure 9). If necessary, they can also be implanted into the jawbone from the side (implantation direction A ', FIG. 10), for which part of the jawbone has to be removed and repositioned after the implantation. Plate, disc or blade-shaped implants are used not only in the dental field but also, as is known, in the orthopedic field, with their proximal region then being designed accordingly.
- FIGS. 11 and 12 show a further pin-shaped embodiment of an implant according to the invention (e.g. dental implant or implant for orthopedic use) in a longitudinal section and as a top view.
- the central implant part 1 is designed as a sleeve with an inner cavity 2 ', in which the liquefiable material is presented.
- the sleeve wall has through openings or slots 20, which are arranged, for example, in axial rows or extend axially.
- the implant according to FIGS. 11 and 12 can also be driven into the bone tissue (at least cancellous bone) without opening.
- a ring-shaped sonotrode 22 is suitable for this. As soon as the implant has reached the predetermined position in the jawbone, the sonotrode 21 is used.
- the peripheral implant part is actually only created after the implant has been positioned in the bone tissue, that is to say in situ.
- the liquefiable material presented in the inner cavity 2 'of the central implant part can, like the liquefiable material arranged on the outside of the central implant part, be a thermoplastic material or advantageously a highly viscous polymeric or hydraulic cement with thixotropic properties, which after implantation can be caused, for example, by ultraviolet light, heat, mechanical Vibrations or can be easily hardened by time.
- thermoplastic is used as the liquefiable material presented in the inner cavity 2 'of the central implant part 1
- energy directors may have to be arranged on the inner surfaces of the central implant part 1 or on the surfaces of the thermoplastic.
- the liquefiable material can also be provided by the manufacturer in the central implant part 1 for an implant according to FIGS. 11 and 12. However, it can also be presented by the surgeon in any number of individual portions, or it can be pressed into the central implant part 1 essentially continuously through the sonotrode.
- FIG. 13 shows a further exemplary embodiment of the implant according to the invention, which, in contrast to the implants shown in the previous figures, does not assume a load-bearing function, the function of which, for example, the release of a therapeutically active substance, drainage or electrical or chemical stimulation of tissue or Organs or the like.
- the peripheral implant part 2 which at least partially consists of the liquefiable material (surface areas 8 of the second type), is designed like a cage, this cage having mechanical stability sufficient for the implantation. has wise.
- the implant is positioned in an opening in the bone tissue and then subjected to vibration energy by means of a device (sonotrode of an ultrasound device) adapted to the proximal end face of the implant.
- the sonotrode 22 is, for example, a hollow cylinder.
- the central implant part 1 of the implant according to FIG. 14, which forms the surface areas 4 of the first type, has, for example, an osseointegrative function and consists, for example, of a highly porous calcium phosphate, of bone chips (patient's own cancellous bone) or of a gel.
- it can also be a device through which particles or molecules are released into the environment (delivery device) or absorbed from the environment (drainage device) or a stimulator, this device being designed, for example, as a correspondingly permeable container and the container walls form the surface areas 4 of the first type.
- the cage according to FIG. 13 can be provided with a central implant part by the manufacturer or can be filled with bone chips in the operating room, for example. It is also conceivable to implant the cage empty and to provide it with a central implant part in situ, wherein a cover element holding the central implant part can also be attached in situ by means of ultrasonic welding.
- FIG. 14 shows, as a further example of the implant according to the invention, an augmentation element 31 which can be used to produce bone tissue which is desired in addition to the natural bone tissue, for example for widening a jaw ridge 32.
- the alveolar ridge 32 and the augmentation element ment 31 are shown in section after the implantation.
- the augmentation element 31 in turn has a central implant part 1, which consists of a material that promotes bone growth, for example a highly porous calcium phosphate. Pins of the liquefiable material are arranged in, for example, through openings (inner cavities 2 ') of the central implant part 1.
- the augmentation element 31 is positioned on the appropriately prepared alveolar ridge 32 such that the pins are directed against the alveolar ridge 32, for example. Vibration energy is then coupled into the pins using a sonotrode 21 which is matched to the pin cross section, and these are pressed against the alveolar ridge 32.
- the liquefiable material is at least partially liquefied and pressed into the alveolar ridge and the central implant part, as a result of which the augmentation element 31 is attached to the alveolar ridge 32 at certain points and the central implantation part (surface areas of the first type) is in intensive contact with the bone tissue of the alveolar ridge, so that Immediately after implantation, cells from the natural bone can migrate into the central part of the implant and have a bone-forming effect.
- the liquefiable material is advantageously resorbable in the present case.
- FIGS. 15A to 15C and 16A to 16C show two embodiments of the implant according to the invention which can be used to connect two vertebral bodies.
- the implants in turn have a central implantation part 1, which here has a load-bearing framework 1.3 and a filler 1.4 arranged in this framework and equipped with bone tissue for growth, for example made from highly porous calcium phosphate, from bone chips or from a gel.
- the shape of the central implant part is adapted to a natural intervertebral disc and has one or more combs 40 at the top and bottom, which run in the direction of implantation A and fit into corresponding grooves to be created in the vertebral bodies 41.
- the peripheral implant part 2 is arranged on the combs 40 and, according to FIGS. 16, is presented in the inner cavities 2 ′ of the central implant part 1, openings 40 being provided in the area of the combs.
- the implant according to FIG. 15A is, as shown in FIG. 15B, driven between two appropriately prepared vertebral bodies 41 by means of sonotrode 30, the liquefiable material of the peripheral implant part 2 liquefying and being pressed into the bone tissue of the vertebral bodies and thereby anchoring the implant therein becomes, as shown in Figure 15C.
- the sonotrode 30 to be used is essentially matched to the proximal face of the implant.
- the implant according to FIG. 16A is positioned between the vertebral bodies 41, as shown in FIG. 16B, for example with a sonotrode 30, which is essentially matched to the proximal end face of the load-bearing framework 1.3 of the central implant part 1.
- a sonotrode which is matched to the proximal end face of the inner cavity 2 ', couples vibrational energy into this material, as a result of which the material is pressed through the openings 20 and into the bone tissue of the vertebral bodies 41 and thus the implant in anchored to the vertebral bodies, as shown in FIG. 17C.
- the implants according to FIGS. 15 and 16 are firmly connected to the vertebral bodies 41 immediately after the implantation (primary stability), so that there is no need to fix the vertebrae involved, as is necessary according to the prior art. This makes the implants ideal for minimally invasive interventions.
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03792085A EP1530446B1 (de) | 2002-08-23 | 2003-08-15 | Implantat zur implantation in knochengewebe oder in durch knochenersatzmaterial ergänztem knochengewebe |
MXPA05002109A MXPA05002109A (es) | 2002-08-23 | 2003-08-15 | Implante para la implantacion en el tejido oseo suplementado con materia osea sustituida. |
IL16674203A IL166742A0 (en) | 2002-08-23 | 2003-08-15 | Implant for implanting in bone tissue or in bone tissue supplemented with bone substitute material |
NZ538336A NZ538336A (en) | 2002-08-23 | 2003-08-15 | Implant for implanting in bone tissue or in bone tissue supplemented with bone substitute material |
DE50311713T DE50311713D1 (de) | 2002-08-23 | 2003-08-15 | Implantat zur implantation in knochengewebe oder in durch knochenersatzmaterial ergänztem knochengewebe |
BR0313641-8A BR0313641A (pt) | 2002-08-23 | 2003-08-15 | Implante para ser implantado em tecido ósseo ou em tecido ósseo suplementado com material substituto de osso |
JP2004529639A JP4384599B2 (ja) | 2002-08-23 | 2003-08-15 | 骨組織、または骨代用材料で補われる骨組織に移植されるべきインプラント |
CA2496119A CA2496119C (en) | 2002-08-23 | 2003-08-15 | An implant to be implanted in bone tissue or in bone tissue supplemented with bone substitute material |
DK03792085T DK1530446T3 (da) | 2002-08-23 | 2003-08-15 | Implantat til implantation i knoglevæv eller i knoglevæv suppleret med knogleerstatningsmateriale |
AU2003250711A AU2003250711B2 (en) | 2002-08-23 | 2003-08-15 | Implant for implanting in bone tissue or in bone tissue supplemented with bone substitute material |
IL166742A IL166742A (en) | 2002-08-23 | 2005-02-08 | Implant for implanting in bone tissue or in bone tissue supplemented with bone substitute material |
NO20051530A NO339825B1 (no) | 2002-08-23 | 2005-03-22 | Tannimplantat for implantasjon i benvev eller i benvev som er supplert med benerstatningsmateriale |
HK05110439.3A HK1079416A1 (en) | 2002-08-23 | 2005-11-18 | Implant for implanting in bone tissue or in bone tissue supplemented with bone substitute material |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH14522002 | 2002-08-23 | ||
CH1452/02 | 2002-08-23 |
Publications (1)
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WO2004017857A1 true WO2004017857A1 (de) | 2004-03-04 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/CH2003/000550 WO2004017857A1 (de) | 2002-08-23 | 2003-08-15 | Implantat zur implantation in knochengewebe oder in durch knochenersatzmaterial ergänztem knochengewebe |
Country Status (20)
Country | Link |
---|---|
US (2) | US7008226B2 (de) |
EP (5) | EP1530446B1 (de) |
JP (1) | JP4384599B2 (de) |
KR (1) | KR100996990B1 (de) |
CN (1) | CN100506186C (de) |
AU (1) | AU2003250711B2 (de) |
BR (1) | BR0313641A (de) |
CA (1) | CA2496119C (de) |
DE (1) | DE50311713D1 (de) |
DK (1) | DK1530446T3 (de) |
ES (4) | ES2620126T3 (de) |
HK (1) | HK1079416A1 (de) |
IL (2) | IL166742A0 (de) |
MX (1) | MXPA05002109A (de) |
NO (1) | NO339825B1 (de) |
NZ (1) | NZ538336A (de) |
PL (1) | PL206534B1 (de) |
RU (1) | RU2355352C2 (de) |
WO (1) | WO2004017857A1 (de) |
ZA (1) | ZA200501343B (de) |
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