WO2004019906A3 - Method of manufacturing albumin microspheres comprising antisense oligonucleotides (oligomers) to nf-kb - Google Patents
Method of manufacturing albumin microspheres comprising antisense oligonucleotides (oligomers) to nf-kb Download PDFInfo
- Publication number
- WO2004019906A3 WO2004019906A3 PCT/US2003/026912 US0326912W WO2004019906A3 WO 2004019906 A3 WO2004019906 A3 WO 2004019906A3 US 0326912 W US0326912 W US 0326912W WO 2004019906 A3 WO2004019906 A3 WO 2004019906A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oligomers
- manufacturing
- antisense oligonucleotides
- albumin microspheres
- microspheres
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003270030A AU2003270030A1 (en) | 2002-08-29 | 2003-08-27 | Method of manufacturing albumin microspheres comprising antisense oligonucleotides (oligomers) to nf-kb |
JP2004531606A JP4621022B2 (en) | 2002-08-29 | 2003-08-27 | Microencapsulated materials and methods of making them |
CA002497142A CA2497142A1 (en) | 2002-08-29 | 2003-08-27 | Microencapsulated materials and method of making same |
EP03751924A EP1536773A2 (en) | 2002-08-29 | 2003-08-27 | Method of manufacturing albumin microspheres comprising antisense oligonucleotides (oligomers) to nf-kb |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/231,791 US7425543B2 (en) | 1992-11-16 | 2002-08-29 | Microencapsulated materials and method of making same |
US10/231,791 | 2002-08-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004019906A2 WO2004019906A2 (en) | 2004-03-11 |
WO2004019906A3 true WO2004019906A3 (en) | 2004-04-22 |
Family
ID=31976816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/026912 WO2004019906A2 (en) | 2002-08-29 | 2003-08-27 | Method of manufacturing albumin microspheres comprising antisense oligonucleotides (oligomers) to nf-kb |
Country Status (7)
Country | Link |
---|---|
US (2) | US7425543B2 (en) |
EP (1) | EP1536773A2 (en) |
JP (1) | JP4621022B2 (en) |
CN (1) | CN1756535A (en) |
AU (1) | AU2003270030A1 (en) |
CA (1) | CA2497142A1 (en) |
WO (1) | WO2004019906A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7425543B2 (en) * | 1992-11-16 | 2008-09-16 | The Corporation Of Mercer University | Microencapsulated materials and method of making same |
US20070243159A1 (en) * | 2003-04-30 | 2007-10-18 | Periasamy Selvaraj | Therapeutic Compositions and Vaccines By Glycosyl-Phosphatidylinositol (Gpi)-Anchored Cytokines and Immunostimulatory Molecules |
US7244765B2 (en) | 2004-06-25 | 2007-07-17 | Cytokine Pharmasciences, Inc | Guanylhydrazone salts, compositions, processes of making and methods of using |
BRPI0514452A8 (en) | 2004-08-17 | 2018-02-06 | Cytokine Pharmasciences Inc | COMPOSITIONS, MANUFACTURING METHODS AND USE OF GUANYLHYDRAZONE COMPOUNDS |
WO2009105584A1 (en) * | 2008-02-19 | 2009-08-27 | Jovesis Inc. | Microparticle compositions to modify cancer promoting cells |
US9149441B2 (en) * | 2008-09-29 | 2015-10-06 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
US11524058B2 (en) | 2008-09-29 | 2022-12-13 | The Corporation Of Mercer University | Oral dissolving films containing microencapsulated vaccines and methods of making same |
US10004790B2 (en) | 2008-09-29 | 2018-06-26 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
US10463608B2 (en) | 2008-09-29 | 2019-11-05 | The Corporation Of Mercer University | Microneedle-based transdermal delivery system and method of making same |
WO2014005596A1 (en) * | 2012-07-03 | 2014-01-09 | Aarhus Universitet | Modified payload molecules and their interactions and uses |
MX2014008314A (en) * | 2014-07-07 | 2016-01-06 | Andres Abelino Choza Romero | Nebulisation-based method for mixing substances. |
US11628208B2 (en) | 2015-10-05 | 2023-04-18 | The Corporation Of Mercer University | System and method for microneedle delivery of microencapsulated vaccine and bioactive proteins |
WO2017062463A1 (en) | 2015-10-05 | 2017-04-13 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
Citations (5)
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US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
WO1997047325A1 (en) * | 1996-06-11 | 1997-12-18 | Karolinska Innovations Ab | New composition and methods |
WO1998044908A1 (en) * | 1997-04-07 | 1998-10-15 | The Board Of Trustees Of The Leland Stanford Junior University | Method of regulating epithelial growth |
US20020006912A1 (en) * | 1992-05-22 | 2002-01-17 | The Scripps Research Institute | Suppression of nuclear factor-kappab dependent processes using oligonucleotides |
US20030105037A1 (en) * | 2001-10-06 | 2003-06-05 | Isis Pharmaceuticals Inc. | Antisense modulation of inhibitor-kappa B kinase-gamma expression |
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US3137631A (en) | 1959-12-01 | 1964-06-16 | Faberge Inc | Encapsulation in natural products |
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US3429827A (en) | 1962-11-23 | 1969-02-25 | Moore Business Forms Inc | Method of encapsulation |
US3663685A (en) | 1968-04-01 | 1972-05-16 | Minnesota Mining & Mfg | Biodegradable radioactive particles |
US3663686A (en) | 1968-04-24 | 1972-05-16 | Minnesota Mining & Mfg | Biodegradable radioactive particles |
US3663687A (en) | 1968-06-26 | 1972-05-16 | Minnesota Mining & Mfg | Biodegradable parenteral microspherules |
US3758678A (en) | 1968-09-26 | 1973-09-11 | Minnesota Mining & Mfg | Biodegradable radioactive polysaccharide particles |
US3937668A (en) | 1970-07-15 | 1976-02-10 | Ilse Zolle | Method for incorporating substances into protein microspheres |
US3962414A (en) | 1972-04-27 | 1976-06-08 | Alza Corporation | Structured bioerodible drug delivery device |
CA1077842A (en) | 1975-10-09 | 1980-05-20 | Minnesota Mining And Manufacturing Company | Albumin medicament carrier system |
US4169804A (en) | 1976-08-19 | 1979-10-02 | Minnesota Mining And Manufacturing Company | Magnetically responsive composite microparticle |
US4357259A (en) * | 1977-08-01 | 1982-11-02 | Northwestern University | Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres |
US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
US4230687A (en) | 1978-05-30 | 1980-10-28 | Griffith Laboratories U.S.A., Inc. | Encapsulation of active agents as microdispersions in homogeneous natural polymeric matrices |
JPS5632417A (en) | 1979-08-27 | 1981-04-01 | Seisan Nipponsha Kk | Storage of livestock semen |
US4349530A (en) | 1980-12-11 | 1982-09-14 | The Ohio State University | Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal |
US4671954A (en) | 1983-12-13 | 1987-06-09 | University Of Florida | Microspheres for incorporation of therapeutic substances and methods of preparation thereof |
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US4674480A (en) | 1984-05-25 | 1987-06-23 | Lemelson Jerome H | Drug compositions and methods of applying same |
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US5017379A (en) | 1984-05-25 | 1991-05-21 | Lemelson Jerome H | Drug units and methods for treating blood clots |
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JPH0729042B2 (en) * | 1987-10-29 | 1995-04-05 | 雪印乳業株式会社 | Method for producing microcapsules by spraying method |
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US20040005569A1 (en) * | 2002-07-02 | 2004-01-08 | Isis Pharmaceuticals Inc. | Antisense modulation of NF-kappa-B p50 subunit expression |
US8957034B2 (en) * | 2004-01-28 | 2015-02-17 | Johns Hopkins University | Drugs and gene carrier particles that rapidly move through mucous barriers |
-
2002
- 2002-08-29 US US10/231,791 patent/US7425543B2/en not_active Expired - Lifetime
-
2003
- 2003-08-27 JP JP2004531606A patent/JP4621022B2/en not_active Expired - Fee Related
- 2003-08-27 AU AU2003270030A patent/AU2003270030A1/en not_active Abandoned
- 2003-08-27 WO PCT/US2003/026912 patent/WO2004019906A2/en active Application Filing
- 2003-08-27 EP EP03751924A patent/EP1536773A2/en not_active Withdrawn
- 2003-08-27 CN CNA038247526A patent/CN1756535A/en active Pending
- 2003-08-27 CA CA002497142A patent/CA2497142A1/en not_active Abandoned
-
2008
- 2008-09-08 US US12/206,415 patent/US20090081306A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
US20020006912A1 (en) * | 1992-05-22 | 2002-01-17 | The Scripps Research Institute | Suppression of nuclear factor-kappab dependent processes using oligonucleotides |
WO1997047325A1 (en) * | 1996-06-11 | 1997-12-18 | Karolinska Innovations Ab | New composition and methods |
WO1998044908A1 (en) * | 1997-04-07 | 1998-10-15 | The Board Of Trustees Of The Leland Stanford Junior University | Method of regulating epithelial growth |
US20030105037A1 (en) * | 2001-10-06 | 2003-06-05 | Isis Pharmaceuticals Inc. | Antisense modulation of inhibitor-kappa B kinase-gamma expression |
Also Published As
Publication number | Publication date |
---|---|
JP4621022B2 (en) | 2011-01-26 |
AU2003270030A8 (en) | 2004-03-19 |
US20090081306A1 (en) | 2009-03-26 |
JP2006511461A (en) | 2006-04-06 |
CA2497142A1 (en) | 2004-03-11 |
EP1536773A2 (en) | 2005-06-08 |
CN1756535A (en) | 2006-04-05 |
WO2004019906A2 (en) | 2004-03-11 |
AU2003270030A1 (en) | 2004-03-19 |
US20040043079A1 (en) | 2004-03-04 |
US7425543B2 (en) | 2008-09-16 |
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