WO2004020026A1 - Frontloaded injection device - Google Patents

Frontloaded injection device Download PDF

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Publication number
WO2004020026A1
WO2004020026A1 PCT/DK2003/000548 DK0300548W WO2004020026A1 WO 2004020026 A1 WO2004020026 A1 WO 2004020026A1 DK 0300548 W DK0300548 W DK 0300548W WO 2004020026 A1 WO2004020026 A1 WO 2004020026A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge holder
cartridge
axial
injection device
holder
Prior art date
Application number
PCT/DK2003/000548
Other languages
French (fr)
Inventor
Michael Ejstrup Hansen
Claus Schmidt MØLLER
Christian Peter Enggaard
André LARSESN
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Priority to DE60306530T priority Critical patent/DE60306530T2/en
Priority to AU2003254638A priority patent/AU2003254638A1/en
Priority to JP2004531734A priority patent/JP2005536300A/en
Priority to EP03790757A priority patent/EP1539279B1/en
Publication of WO2004020026A1 publication Critical patent/WO2004020026A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546—Front-loading type injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2411—Ampoule inserted into the ampoule holder from the front
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump

Definitions

  • the invention relates to injection devices comprising a cartridge holder and a dose setting and injection part by which set doses can be apportioned from a cartridge in the cartridge holder as a piston rod is successively moved into a first end of said cartridge to press a piston closing said first end of the cartridge into the cartridge which has a second end closed by a membrane, whereby a liquid stored between the piston and the membrane can be pressed out through a hollow needle which is mounted on the device so that it pierces said membrane, access to the cartridge holder being obtained by opening a first end thereof through which the first end of the cartridge can be inserted with its piston facing the piston rod which extends into the cartridge holder from a second end thereof.
  • the cartridge holder may be unscrewed from the device to obtain access to the cartridge holder.
  • This will make the user stand with two parts: A cartridge holder with an empty cartridge; and a dose setting and injection part with a protruding piston rod.
  • the cartridge in the cartridge holder is then changed and the cartridge holder can be remounted on the dose setting and injection part.
  • the extending piston rod must be pushed or screwed back into the dose setting and injection part.
  • This returning of the projecting piston rod can cause some problems as an at- tempt to screw back a piston rod, which is designed to be pushed back, and visa versa, may damage the piston rod or components in the dose setting and injection system. Consequently an injection device in which the piston rod cannot be reached by the user is preferred.
  • the piston rod remains hidden by the cartridge holder when the front end of this holder is opened to change the cartridge.
  • the piston of this cartridge abuts the piston rod and press it backward into the device when the cartridge is pressed into the cartridge holder from the open first end of this cartridge holder.
  • the open first end of the cartridge holder may the be closed by a screw plug as it is described in EP 513 128.
  • a closing mechanism which is integrated in the device.
  • a device as described in the opening of this application which device is characterised in that at least one closing element is provided at the first end of the cartridge holder which closing element in its closed position forms a support for the second end of a cartridge to bar for an axial movement of the cartridge out of the cartridge holder and which closing element is displaceable in a radial direction relative to the cartridge holder so that said closing element can be moved to a position allowing a cartridge to pass axially into or out of the cartridge holder.
  • the cartridge holder may be provided with at least one axial element which has at its end at the second end of the cartridge holder an inward protrusion perpendicular to said axial element, which protrusions form the closure of the cartridge holder and may be moved in a radial direction relative to the cartridge holder by deflecting the end of the element carrying said inward protrusion away from its axial position and the cartridge holder
  • a closure at the second end of the cartridge holder may be formed by a number of axial elements arranged to form a cylinder accommodating a each axial element having an inward protrusion perpendicular to said axial element.
  • the said axial elements may be biased to be deflected outwardly and may be held in an axial position by an encompassing cartridge holder having an inner diameter corresponding to the outer diameter of the arrangement of the axial elements when these are in their axial position.
  • a longitudinal displacement of the cartridge holder may be obtained by a closing mechanism comprising a ring which is mounted on the device and can be rotated between to rotational positions, the ring having pins extending through slots in the cartridge holder and into tracks a tubular element on which the longitudinal elements are arraged, the tracks being helically designed so that the tubular element is displaced in an axial direction when the ring is rotated from one rotational position to the other.
  • At least one closing element is mounted at a front end of the cartridge holder axially displaceable relative to said cartridge holder.
  • a connection may be established between the locking device and the dose setting part of the device to set the piston free to be moved backward when the closure of the cartridge holder is opened and to lock it to the dose setting part to be governed by this part when the closure is closed.
  • Figure 1 shows schematically a side view of a front loadable syringe according to the invention
  • Figure 2 shows a sectional view along the line ll-ll in the syringe in figure 1 ,
  • Figure 3 shows a sectional view of the syringe in figure 2 rotated 90° about its axis
  • Figure 4 shows an exploded view of the syringe in figure 1 .
  • Figure 5 shows an enlarged view of the encircled part in figure 2
  • Figure 6 shows a detail of another embodiment of a front loaded device with its closure open
  • Figure 7 shows the embodiment in figure 6 with its closure closed.
  • FIG. 1 schematically shows a syringe according to the invention which syringe comprises a housing 1 for a dose setting and injection part, a cartridge holder 2 mounted on the housing 1 , and an operation ring 3 surrounding the housing at the transition between the housing 1 and the cartridge holder 2.
  • the housing 1 has a window 4 wherein a set dose is shown, but details of the dose setting and injection system are not shown.
  • the cartridge holder 2 has a window 5 through which a cartridge in the cartridge holder can be visually inspected.
  • the cartridge may be provided with a plastic top 6 onto which a not shown needle hub with an injection needle can be mounted. The possible provision of a needle is hinted by a needle cap 7.
  • FIG 2 and 3 shows sectional views of the syringe in figure 1 whereas figure 4 shows an exploded view of this syringe.
  • a cartridge 8 mounted in the cartridge holder 2 has a piston 9 which can be moved into the cartridge by a not shown piston rod which is successively moved outward from the dose setting and injection system when doses are set and injected.
  • the function of the dose setting system implies that the piston rod cannot rotate relative to the housing during dose setting and injection. When the piston rod is allowed to rotate the extending part of it can easily be pressed back into the dose setting and injection system.
  • the cartridge holder 2 is a tubular element provided with windows 5 for cartridge inspection and having at its end adjacent to the housing 1 of the dose setting and injection system a F-shaped cut out 11 which allows mounting of an operation ring 3 which has on its inner wall pins 10 with an axial distance corresponding to the distance between the horizontal parts of the F-shaped cut out.
  • the mounting is obtained by passing the pins 10 along the vertical part of the F-shaped cut out 11.
  • FIG 4 only one F-shaped cut out is seen but a similar cut out is provided rotationally displaced 180° from the shown cut out.
  • a clamping member 12 has a tubular bottom part which has diametrically opposed axial cut outs 13 in which correspondingly diametrically opposed protrusions 14 at the perimeter of a ring 15 are guided to form an axially displaceable bottom in the clamping member 12.
  • Said bottom part further has diametrically opposed cut outs 16 which are not perpendicular to the axis of the clamping member 12 but rather form apart of a helix.
  • the bottom part further carries two diametrically opposed tongues 17 which are biased to diverge outwardly away from the axis of the clamping member 12. At their outer ends the tongues 17 are provided with closing members 18 which are moved radial inward when the tongues 17 are forced to attain an axial direction.
  • the clamping member 12 is mounted in the cartridge holder 2 which has at its end opposite the dose setting and injection system longitudinal cut outs 19 in which ribs 20 at outer wall of the end of the tongues 17 can be guided.
  • the operation ring 3 is mounted so that a pair of diametrically opposed pins 10 on this ring grips through the upper vertical part of the F of the F-shaped cut out into the cut out 16 in the bottom part of the clamping member 12.
  • a coupling ring 21 having in its outer wall diametrically opposed recesses 22, each comprising two axially displaced parts perpendicular to the axis of the syringe connected by a part which is not perpendicular to said axis, is mounted in the cartridge holder 2 so that a set of diametrically opposed pins on the inner wall of the operation ring 3 grips through the lover vertical part of the F of the F-shaped cut outs into said recesses 22.
  • the coupling ring 21 further has at its outer cylindrical wall splines 23 which engage axial recesses in the cartridge holder to make the coupling ring inrotatable in the cartridge holder.
  • a spring 24 is mounted between the coupling ring 21 and the bottom ring 15 of the clamping member 12.
  • coupling ring 21 is at its end surface turning away from the cartridge holder provided with cir- cumferential three angled teeth which can cooperate with similar teeth on a piston rod guide ring 25 which has a not round central opening through which a correspondingly not round not shown piston rod projects from the dose setting and injection system.
  • this holder is by gluing or welding or any other method secured to the housing 1.
  • the syringe is ready for use with a cartridge held in the cartridge holder.
  • the operation ring 3 is in a position wherein its pins 10 gripping through the F-shaped cut out into the recess 16 of the syringe clamping member 12 engaging the parts at the foremost ends of these recesses 16 which parts are shaped as not helical landings which runs perpendicular to the axis of the clamping member 12.
  • the clamping member 12 is held in a retracted position in the cartridge holder in which position the closing members 18 is in their radially innermost position in which they grip over a neck part of the cartridge 8 and bar for an outward movement of said cartridge 8.
  • Figure 6 and 7 shows another embodiment of a front loaded injection device wherein a clos- ing element 30 can be moved relative to a second closing element which is integral with the device.
  • the closing element 30 is moved radially relative to a cartridge holder 31 providing an opening which allows insertion of a cartridge 32.
  • the cartridge is moved so far into the cartridge holder 31 that the closing element can be moved axially relative to the cartridge towards the second closing element so that the diameter of the opening formed by the two closing elements is smaller than the diameter of the cartridge which is in this way supported at its neck part.

Abstract

A frontloaded injection device comprising a cartridge holder into which a replaceable cartridge containing a fluid is inserted. The cartridge holder comprises a closing element such as a pair of claws which are displaceable in a radial direction. The closing element is provided at the front of the injection device and locks the cartridge by gripping at the neck part of the cartridge after the cartridge has been loaded into the cartridge holder from the front of the injection device. The closing element is preferably biased in an outwardly radial direction when the locking element is moved axially out of the cartridge holder

Description

Frontloaded injection device
The invention relates to injection devices comprising a cartridge holder and a dose setting and injection part by which set doses can be apportioned from a cartridge in the cartridge holder as a piston rod is successively moved into a first end of said cartridge to press a piston closing said first end of the cartridge into the cartridge which has a second end closed by a membrane, whereby a liquid stored between the piston and the membrane can be pressed out through a hollow needle which is mounted on the device so that it pierces said membrane, access to the cartridge holder being obtained by opening a first end thereof through which the first end of the cartridge can be inserted with its piston facing the piston rod which extends into the cartridge holder from a second end thereof.
By most known injection devices using changeable cartridges the cartridge holder may be unscrewed from the device to obtain access to the cartridge holder. This will make the user stand with two parts: A cartridge holder with an empty cartridge; and a dose setting and injection part with a protruding piston rod. The cartridge in the cartridge holder is then changed and the cartridge holder can be remounted on the dose setting and injection part. However, first the extending piston rod must be pushed or screwed back into the dose setting and injection part. This returning of the projecting piston rod can cause some problems as an at- tempt to screw back a piston rod, which is designed to be pushed back, and visa versa, may damage the piston rod or components in the dose setting and injection system. Consequently an injection device in which the piston rod cannot be reached by the user is preferred.
In a so-called front loaded device as the one described in the opening of this application the piston rod remains hidden by the cartridge holder when the front end of this holder is opened to change the cartridge. When a new cartridge is passed into the cartridge holder the piston of this cartridge abuts the piston rod and press it backward into the device when the cartridge is pressed into the cartridge holder from the open first end of this cartridge holder. The open first end of the cartridge holder may the be closed by a screw plug as it is described in EP 513 128.
As loose parts as screw plug offers possibility for skew mounting or loss of this part it is an objective of the invention to provide a closing mechanism which is integrated in the device. This is obtained by a device as described in the opening of this application, which device is characterised in that at least one closing element is provided at the first end of the cartridge holder which closing element in its closed position forms a support for the second end of a cartridge to bar for an axial movement of the cartridge out of the cartridge holder and which closing element is displaceable in a radial direction relative to the cartridge holder so that said closing element can be moved to a position allowing a cartridge to pass axially into or out of the cartridge holder.
The cartridge holder may be provided with at least one axial element which has at its end at the second end of the cartridge holder an inward protrusion perpendicular to said axial element, which protrusions form the closure of the cartridge holder and may be moved in a radial direction relative to the cartridge holder by deflecting the end of the element carrying said inward protrusion away from its axial position and the cartridge holder
In an embodiment a closure at the second end of the cartridge holder may be formed by a number of axial elements arranged to form a cylinder accommodating a each axial element having an inward protrusion perpendicular to said axial element.
The said axial elements may be biased to be deflected outwardly and may be held in an axial position by an encompassing cartridge holder having an inner diameter corresponding to the outer diameter of the arrangement of the axial elements when these are in their axial position.
A longitudinal displacement of the cartridge holder may be obtained by a closing mechanism comprising a ring which is mounted on the device and can be rotated between to rotational positions, the ring having pins extending through slots in the cartridge holder and into tracks a tubular element on which the longitudinal elements are arraged, the tracks being helically designed so that the tubular element is displaced in an axial direction when the ring is rotated from one rotational position to the other.
In another embodiment of the invention at least one closing element is mounted at a front end of the cartridge holder axially displaceable relative to said cartridge holder. A connection may be established between the locking device and the dose setting part of the device to set the piston free to be moved backward when the closure of the cartridge holder is opened and to lock it to the dose setting part to be governed by this part when the closure is closed.
In the following the invention is further described with references to the drawing, wherein
Figure 1 shows schematically a side view of a front loadable syringe according to the invention,
Figure 2 shows a sectional view along the line ll-ll in the syringe in figure 1 ,
Figure 3 shows a sectional view of the syringe in figure 2 rotated 90° about its axis,
Figure 4 shows an exploded view of the syringe in figure 1 ,
Figure 5 shows an enlarged view of the encircled part in figure 2,
Figure 6 shows a detail of another embodiment of a front loaded device with its closure open,
Figure 7 shows the embodiment in figure 6 with its closure closed.
Figure 1 schematically shows a syringe according to the invention which syringe comprises a housing 1 for a dose setting and injection part, a cartridge holder 2 mounted on the housing 1 , and an operation ring 3 surrounding the housing at the transition between the housing 1 and the cartridge holder 2. The housing 1 has a window 4 wherein a set dose is shown, but details of the dose setting and injection system are not shown. The cartridge holder 2 has a window 5 through which a cartridge in the cartridge holder can be visually inspected. The cartridge may be provided with a plastic top 6 onto which a not shown needle hub with an injection needle can be mounted. The possible provision of a needle is hinted by a needle cap 7. Figure 2 and 3 shows sectional views of the syringe in figure 1 whereas figure 4 shows an exploded view of this syringe. In figure 3 it is seen that a cartridge 8 mounted in the cartridge holder 2 has a piston 9 which can be moved into the cartridge by a not shown piston rod which is successively moved outward from the dose setting and injection system when doses are set and injected. The function of the dose setting system implies that the piston rod cannot rotate relative to the housing during dose setting and injection. When the piston rod is allowed to rotate the extending part of it can easily be pressed back into the dose setting and injection system.
As it is seen in figure 4, the cartridge holder 2 is a tubular element provided with windows 5 for cartridge inspection and having at its end adjacent to the housing 1 of the dose setting and injection system a F-shaped cut out 11 which allows mounting of an operation ring 3 which has on its inner wall pins 10 with an axial distance corresponding to the distance between the horizontal parts of the F-shaped cut out. The mounting is obtained by passing the pins 10 along the vertical part of the F-shaped cut out 11. In figure 4 only one F-shaped cut out is seen but a similar cut out is provided rotationally displaced 180° from the shown cut out.
A clamping member 12 has a tubular bottom part which has diametrically opposed axial cut outs 13 in which correspondingly diametrically opposed protrusions 14 at the perimeter of a ring 15 are guided to form an axially displaceable bottom in the clamping member 12. Said bottom part further has diametrically opposed cut outs 16 which are not perpendicular to the axis of the clamping member 12 but rather form apart of a helix. The bottom part further carries two diametrically opposed tongues 17 which are biased to diverge outwardly away from the axis of the clamping member 12. At their outer ends the tongues 17 are provided with closing members 18 which are moved radial inward when the tongues 17 are forced to attain an axial direction.
The clamping member 12 is mounted in the cartridge holder 2 which has at its end opposite the dose setting and injection system longitudinal cut outs 19 in which ribs 20 at outer wall of the end of the tongues 17 can be guided. The operation ring 3 is mounted so that a pair of diametrically opposed pins 10 on this ring grips through the upper vertical part of the F of the F-shaped cut out into the cut out 16 in the bottom part of the clamping member 12. A coupling ring 21 having in its outer wall diametrically opposed recesses 22, each comprising two axially displaced parts perpendicular to the axis of the syringe connected by a part which is not perpendicular to said axis, is mounted in the cartridge holder 2 so that a set of diametrically opposed pins on the inner wall of the operation ring 3 grips through the lover vertical part of the F of the F-shaped cut outs into said recesses 22. The coupling ring 21 further has at its outer cylindrical wall splines 23 which engage axial recesses in the cartridge holder to make the coupling ring inrotatable in the cartridge holder. A spring 24 is mounted between the coupling ring 21 and the bottom ring 15 of the clamping member 12. Finally the coupling ring 21 is at its end surface turning away from the cartridge holder provided with cir- cumferential three angled teeth which can cooperate with similar teeth on a piston rod guide ring 25 which has a not round central opening through which a correspondingly not round not shown piston rod projects from the dose setting and injection system.
When the described components has been mounted in the cartridge holder 2 this holder is by gluing or welding or any other method secured to the housing 1.
In the figures 2 and 3 the syringe is ready for use with a cartridge held in the cartridge holder. The operation ring 3 is in a position wherein its pins 10 gripping through the F-shaped cut out into the recess 16 of the syringe clamping member 12 engaging the parts at the foremost ends of these recesses 16 which parts are shaped as not helical landings which runs perpendicular to the axis of the clamping member 12. Thereby the clamping member 12 is held in a retracted position in the cartridge holder in which position the closing members 18 is in their radially innermost position in which they grip over a neck part of the cartridge 8 and bar for an outward movement of said cartridge 8. At the same time the pins gripping through the lover vertical part of the F of the F-shaped cut out into the recess 22 of the coupling ring 21 keep this ring 21 in a position wherein its triangular teeth engages the teeth of the piston rod guide ring 25 through which the not shown piston rod is guided, and this way the piston rod is locked against rotation relative to the housing 1.
When in figure 4 the operation ring 3 is rotated to the left the, pins engaging the recess 16 of the clamping member will move this member outward in the cartridge holder. The tongues 17 which were forced to their axial position by the cartridge holder will now diverge bringing the closing members away from the cartridge and provide an opening through which the cartridge can be drawn out through the end of the cartridge holder 2. At the same time the other set of pins 10 which engages the recesses of the coupling ring 21 will against the force of the spring 24 move this ring away from the dose setting and injection system and bring its teeth out of engagement with the teeth of the piston rod guide ring 25. This will allow the piston rod guide ring 25 and the not shown piston rod to rotate so that the piston rod can by the insertion of a new cartridge be pressed back in to the dose setting and injection system. When a new cartridge has been moved into the cartridge holder, the operation ring 3 is rotated rightward whereby its pins 10 engaging the helical cut out 16 will draw the clamping member 12 into the cartridge holder and the closing members 18 will be moved radially inward in front of the cartridge to maintain it in the cartridge holder. At the same time the coupling ring 21 is by the other set of pins which engage the recesses 22 in this coupling ring moved toward the housing 1 whereby the coupling teeth of this ring is brought into engagement with the teeth on the piston rod guide ring 25. This will lock the piston rod against rotation whereby dose setting and injection is again allowed.
Figure 6 and 7 shows another embodiment of a front loaded injection device wherein a clos- ing element 30 can be moved relative to a second closing element which is integral with the device. The closing element 30 is moved radially relative to a cartridge holder 31 providing an opening which allows insertion of a cartridge 32. By pressing the plastic top 33 mounted on a neck part of the cartridge, the cartridge is moved so far into the cartridge holder 31 that the closing element can be moved axially relative to the cartridge towards the second closing element so that the diameter of the opening formed by the two closing elements is smaller than the diameter of the cartridge which is in this way supported at its neck part.

Claims

Claims
1 An injection device comprising a cartridge holder and a dose setting and injection part by which set doses can be apportioned from a cartridge in the cartridge holder as a piston rod is successively moved into a first end of said cartridge to press a piston closing said first end of the cartridge into the cartridge which has a second end closed by a membrane, whereby a liquid stored between the piston and the membrane can be pressed out through a hollow needle which is mounted on the device so that it pierces said membrane, access to the cartridge holder being obtained by opening a first end thereof through which the first end of the cartridge can be inserted with its piston facing the piston rod which extends into the cartridge holder from a second end thereof characterized in that, at least one closing element is provided at the first end of the cartridge holder which closing element in its closed position forms a support for the second end of a cartridge to bar for an axial movement of the cartridge out of the cartridge holder and which closing element is displaceable in a radial direction relative to the cartridge holder so that said closing element can be moved to a position allowing a cartridge to pass axially into or out of the cartridge holder.
2. An injection device according to claim 1 , characterized in that the cartridge holder is provided with at least one axial element which has at its end at the second end of the cartridge holder an inward protrusion perpendicular to said axial element, which protrusions form the closure of the cartridge holder and may be moved in a radial direction relative to the cartridge holder by deflecting the end of the element carrying said inward protrusion away from its axial position and the cartridge holder.
3. An injection device according to claim 2, characterized in that the closure at the second end of the cartridge holder is formed of by number of axial elements each having an inward protrusion perpendicular to the respective axial element.
4. An injection device according to claim 3, characterized in that the said axial elements are biased to be deflected outwardly and are held in an axial position by an encompassing cartridge holder having an inner diameter corresponding to the outer diameter of the arrangement of the axial elements when these are in their axial position, and that the axial elements is designed to be moved axially out of the cartridge holder to be deflected outward by their bios.
5. An injection device according to claim 4, characterized in that the closing mechanism comprises a ring which is mounted on the device and can be rotated between to rotational positions, the ring having pins extending through slots in the cartridge holder and into tracks in a tubular element on which the longitudinal elements are arranged, the tracks being heli- cally designed so that the tubular element is displaced in an axial direction when the ring is rotated from one rotational position to the other.
7. An injection device according to claim 1 , characterized in that at least one closing element is mounted at a front end of the cartridge holder axially displaceable relative to said cartridge holder.
PCT/DK2003/000548 2002-08-29 2003-08-19 Frontloaded injection device WO2004020026A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE60306530T DE60306530T2 (en) 2002-08-29 2003-08-19 INJECTION DEVICE WITH FRONT LOADING
AU2003254638A AU2003254638A1 (en) 2002-08-29 2003-08-19 Frontloaded injection device
JP2004531734A JP2005536300A (en) 2002-08-29 2003-08-19 Forward retractable injection device
EP03790757A EP1539279B1 (en) 2002-08-29 2003-08-19 Frontloaded injection device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200201269 2002-08-29
DKPA200201269 2002-08-29

Publications (1)

Publication Number Publication Date
WO2004020026A1 true WO2004020026A1 (en) 2004-03-11

Family

ID=31970209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2003/000548 WO2004020026A1 (en) 2002-08-29 2003-08-19 Frontloaded injection device

Country Status (8)

Country Link
US (1) US7175055B2 (en)
EP (1) EP1539279B1 (en)
JP (1) JP2005536300A (en)
CN (1) CN100358593C (en)
AT (1) ATE331542T1 (en)
AU (1) AU2003254638A1 (en)
DE (1) DE60306530T2 (en)
WO (1) WO2004020026A1 (en)

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WO2013110769A2 (en) 2012-01-25 2013-08-01 Novo Nordisk A/S Drug delivery device with cartridge fixation feature
WO2013124119A1 (en) 2012-02-24 2013-08-29 Novo Nordisk A/S Drug delivery device with cartridge snap holding feature
WO2013156350A3 (en) * 2012-04-18 2014-02-20 Carebay Europe Ltd Medicament delivery device
WO2014187813A1 (en) 2013-05-21 2014-11-27 Novo Nordisk A/S Frontloaded drug delivery device with dynamic axial stop feature
WO2014187814A1 (en) 2013-05-21 2014-11-27 Novo Nordisk A/S Frontloaded drug delivery device with actuated cartridge holder and piston rod coupling
WO2015055641A1 (en) * 2013-10-16 2015-04-23 Novo Nordisk A/S Drug delivery device with front loading feature
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
EP2999504A1 (en) * 2013-05-21 2016-03-30 Novo Nordisk A/S Drug delivery device with piston rod coupling
RU2608437C1 (en) * 2012-04-18 2017-01-18 Кэрбей Юроп Лтд Drug delivery device
US9713678B2 (en) 2011-12-08 2017-07-25 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US10434258B2 (en) 2011-12-08 2019-10-08 Sanofi-Aventis Deutschland Gmbh Syringe carrier
EP1998831B1 (en) 2006-01-23 2020-10-28 The Medical House Limited Improved autoinjector supporting the syringe at the front
US10918803B2 (en) 2015-06-03 2021-02-16 Sanofi-Aventis Deutschland Gmbh Syringe carrier for an autoinjector and method of assembling
US11103649B2 (en) 2015-06-03 2021-08-31 Sanofi-Aventis Deutschland Gmbh Autoinjector and method of assembling
US11642462B2 (en) 2006-01-23 2023-05-09 Shl Medical Ag Injection device

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1243578C (en) 1998-01-30 2006-03-01 诺沃挪第克公司 An injection syringe
TW453884B (en) 1999-09-16 2001-09-11 Novo Nordisk As Dose setting limiter
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
EP2210634A1 (en) 2009-01-22 2010-07-28 Sanofi-Aventis Deutschland GmbH Drug delivery device dose setting mechanism
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0308267D0 (en) * 2003-04-10 2003-05-14 Dca Design Int Ltd Improvements in and relating to a pen-type injector
WO2006045526A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US20080208142A1 (en) * 2005-02-28 2008-08-28 Novo Nordisk A/S Dose Setting Mechanism for an Injection Device
GB0503990D0 (en) 2005-02-28 2005-04-06 Spofforth Leonard M Hypodermic syringe mechanism
WO2006114396A1 (en) 2005-04-24 2006-11-02 Novo Nordisk A/S Injection device
DE102006004561A1 (en) * 2006-01-17 2007-07-26 Tecpharma Licensing Ag Injection device with secured knob
DE102006004563A1 (en) * 2006-01-17 2007-07-19 Tecpharma Licensing Ag Injection device for administering medication has a casing, a delivery element moving in relation to the casing and a locking element
DE102006004562A1 (en) * 2006-01-17 2007-07-19 Tecpharma Licensing Ag Feed rod with coupling element
CN101400393B (en) 2006-03-10 2011-09-14 诺沃-诺迪斯克有限公司 An injection device and a method of changing a cartridge in the device
CN101400394B (en) * 2006-03-10 2012-07-04 诺沃-诺迪斯克有限公司 An injection device having a gearing arrangement
JP5226508B2 (en) * 2006-05-16 2013-07-03 ローツェ株式会社 Shuttle type transfer device
ATE458517T1 (en) 2006-05-16 2010-03-15 Novo Nordisk As TRANSMISSION MECHANISM FOR AN INJECTION DEVICE
CN101500630B (en) 2006-07-03 2012-05-30 诺沃-诺迪斯克有限公司 Coupling for injection devices
BRPI0806854B8 (en) 2007-02-05 2021-06-22 Novo Nordisk As push-button and push-button connection for an injection device
AU2008231897B2 (en) 2007-03-23 2012-11-29 Novo Nordisk A/S An injection device comprising a locking nut
EP2401009B1 (en) * 2009-02-26 2012-11-28 Tecpharma Licensing AG Product container holder for an injection device and for receiving a product container
CA2769102C (en) * 2009-07-31 2017-09-19 3M Innovative Properties Company Hollow microneedle arrays
EP2311513A1 (en) * 2009-10-16 2011-04-20 Sanofi-Aventis Deutschland GmbH Cartridge holder assembly for a drug delivery device
TR201902092T4 (en) 2010-02-01 2019-03-21 Sanofi Aventis Deutschland A method of fixing a cartridge in a cartridge holder, a drug delivery device, and a cartridge holder.
CA2695265A1 (en) * 2010-03-02 2011-09-02 Duoject Medical Systems Inc. Injection device
EP2560705B1 (en) * 2010-04-23 2018-12-05 Sanofi-Aventis Deutschland GmbH Coded cartridge holder system for a fluid delivery device
CN103140249A (en) * 2010-08-06 2013-06-05 赛诺菲-安万特德国有限公司 Method and system for retaining a cartridge in a holder
TWI459986B (en) * 2010-11-08 2014-11-11 Shl Group Ab Container holder assembly
EP2601990A1 (en) * 2011-12-08 2013-06-12 Sanofi-Aventis Deutschland GmbH Syringe carrier
EP2601989A1 (en) * 2011-12-08 2013-06-12 Sanofi-Aventis Deutschland GmbH Syringe carrier
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
US8834449B2 (en) 2012-01-23 2014-09-16 Ikomed Technologies, Inc. Mixing syringe
US9751056B2 (en) 2012-01-23 2017-09-05 Merit Medical Systems, Inc. Mixing syringe
EP2834185B1 (en) * 2012-04-03 2017-01-18 Synthes GmbH Device and method for opening an ampoule
US20160089500A1 (en) * 2013-05-21 2016-03-31 Novo Nordisk A/S Drug Delivery Device with Means for Disabling Activation of Expelling Mechanism
US10751470B2 (en) * 2014-02-10 2020-08-25 E3D A.C.A.L Ltd Semi disposable auto injector
CN106999667B (en) * 2014-12-12 2019-12-03 艾斯曲尔医疗公司 Dosing mechanism and medicament delivery device including the dosing mechanism
US10206852B2 (en) * 2014-12-18 2019-02-19 Orbit Biomedical Limited Vial holder devices and systems
AU2015364416A1 (en) * 2014-12-18 2017-06-29 Orbit Biomedical Limited Vial holder devices, methods and systems
CA3009221A1 (en) * 2014-12-23 2016-06-30 Automed Pty Ltd Delivery apparatus, system and associated methods
PE20211202A1 (en) 2017-08-24 2021-07-05 Novo Nordisk As COMPOSITIONS OF GLP-1 AND ITS USES
EP3597237A1 (en) * 2018-07-18 2020-01-22 Sanofi Cartridge assembly for a drug delivery device and drug delivery device
EP4106724A1 (en) 2020-02-18 2022-12-28 Novo Nordisk A/S Glp-1 compositions and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3144178A (en) * 1962-03-12 1964-08-11 Stanley J Sarnoff Cartridge holder
WO1991010460A1 (en) * 1990-01-22 1991-07-25 Novo Nordisk A/S A process and apparatus for mixing and injecting a medicine
US5078698A (en) * 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
WO1997007841A2 (en) * 1995-08-25 1997-03-06 Medrad, Inc. Front load pressure jacket system with syringe holder

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2392196A (en) * 1945-02-24 1946-01-01 Arthur E Smith Syringe
US2956563A (en) * 1958-10-02 1960-10-18 Cartrix Corp Hypodermic syringe devices
US3115135A (en) * 1962-03-12 1963-12-24 Stanley J Sarnoff Aspirating piston and plunger coupling
US3556099A (en) * 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
US3880162A (en) * 1973-04-25 1975-04-29 Lee G Simmons Pole-syringe for injecting from a remote distance
US4314556A (en) * 1980-04-21 1982-02-09 Ma Austin C Emergency syringe
US4973318A (en) * 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
US5244465A (en) * 1988-10-19 1993-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Reusable injection device for distributing a preselected dose
US4990142A (en) * 1989-10-23 1991-02-05 Gte Products Corporation Hypodermic syringe
US5002537A (en) * 1989-10-23 1991-03-26 Gte Products Corporation Hypodermic syringe
US5383865A (en) * 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5496286A (en) * 1994-08-17 1996-03-05 Sterling Winthrop Hypodermic syringe holder with disposable body
US6036675A (en) * 1999-02-03 2000-03-14 Specialized Health Products, Inc. Safety sterile cartride unit apparatus and methods
BR0112825A (en) * 2000-07-28 2003-07-01 Mdc Invest Holdings Inc Process for injecting medicine from a medical device that has a needle with a sharp tip and medical device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3144178A (en) * 1962-03-12 1964-08-11 Stanley J Sarnoff Cartridge holder
WO1991010460A1 (en) * 1990-01-22 1991-07-25 Novo Nordisk A/S A process and apparatus for mixing and injecting a medicine
US5078698A (en) * 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
WO1997007841A2 (en) * 1995-08-25 1997-03-06 Medrad, Inc. Front load pressure jacket system with syringe holder

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11642462B2 (en) 2006-01-23 2023-05-09 Shl Medical Ag Injection device
EP1998831B1 (en) 2006-01-23 2020-10-28 The Medical House Limited Improved autoinjector supporting the syringe at the front
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
JP2013505037A (en) * 2009-09-18 2013-02-14 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Latching and control device for integration in medical devices
US11400223B2 (en) 2011-12-08 2022-08-02 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US9713678B2 (en) 2011-12-08 2017-07-25 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US11400222B2 (en) 2011-12-08 2022-08-02 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US10646656B2 (en) 2011-12-08 2020-05-12 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US10441719B2 (en) 2011-12-08 2019-10-15 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US11511043B2 (en) 2011-12-08 2022-11-29 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US10434258B2 (en) 2011-12-08 2019-10-08 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US11406763B2 (en) 2011-12-08 2022-08-09 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US11400221B2 (en) 2011-12-08 2022-08-02 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US11406764B2 (en) 2011-12-08 2022-08-09 Sanofi-Aventis Deutschland Gmbh Syringe carrier
WO2013110769A2 (en) 2012-01-25 2013-08-01 Novo Nordisk A/S Drug delivery device with cartridge fixation feature
WO2013110769A3 (en) * 2012-01-25 2013-12-05 Novo Nordisk A/S Drug delivery device with cartridge fixation feature
WO2013124119A1 (en) 2012-02-24 2013-08-29 Novo Nordisk A/S Drug delivery device with cartridge snap holding feature
WO2013124118A1 (en) 2012-02-24 2013-08-29 Novo Nordisk A/S Drug delivery device with front loading feature
US11103640B2 (en) 2012-02-24 2021-08-31 Novo Nordisk A/S Drug delivery device with front loading feature
WO2013156350A3 (en) * 2012-04-18 2014-02-20 Carebay Europe Ltd Medicament delivery device
RU2608437C1 (en) * 2012-04-18 2017-01-18 Кэрбей Юроп Лтд Drug delivery device
CN104394912A (en) * 2012-04-18 2015-03-04 卡贝欧洲有限公司 Medicament delivery device
WO2014187814A1 (en) 2013-05-21 2014-11-27 Novo Nordisk A/S Frontloaded drug delivery device with actuated cartridge holder and piston rod coupling
US10080845B2 (en) 2013-05-21 2018-09-25 Novo Nordisk A/S Drug delivery device with piston rod coupling
US9956349B2 (en) 2013-05-21 2018-05-01 Novo Nordisk A/S Frontloaded drug delivery device with dynamic axial stop feature
EP2999504A1 (en) * 2013-05-21 2016-03-30 Novo Nordisk A/S Drug delivery device with piston rod coupling
WO2014187813A1 (en) 2013-05-21 2014-11-27 Novo Nordisk A/S Frontloaded drug delivery device with dynamic axial stop feature
WO2015055641A1 (en) * 2013-10-16 2015-04-23 Novo Nordisk A/S Drug delivery device with front loading feature
US11103649B2 (en) 2015-06-03 2021-08-31 Sanofi-Aventis Deutschland Gmbh Autoinjector and method of assembling
US10918803B2 (en) 2015-06-03 2021-02-16 Sanofi-Aventis Deutschland Gmbh Syringe carrier for an autoinjector and method of assembling

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AU2003254638A1 (en) 2004-03-19
CN1678361A (en) 2005-10-05
US7175055B2 (en) 2007-02-13
US20040108339A1 (en) 2004-06-10
EP1539279A1 (en) 2005-06-15
ATE331542T1 (en) 2006-07-15
CN100358593C (en) 2008-01-02
DE60306530T2 (en) 2007-01-04
JP2005536300A (en) 2005-12-02
EP1539279B1 (en) 2006-06-28

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