WO2004034882A3 - Measuring a neurological event using clustering - Google Patents

Measuring a neurological event using clustering Download PDF

Info

Publication number
WO2004034882A3
WO2004034882A3 PCT/US2003/032940 US0332940W WO2004034882A3 WO 2004034882 A3 WO2004034882 A3 WO 2004034882A3 US 0332940 W US0332940 W US 0332940W WO 2004034882 A3 WO2004034882 A3 WO 2004034882A3
Authority
WO
WIPO (PCT)
Prior art keywords
detection cluster
therapy
treatment
intensity threshold
nervous system
Prior art date
Application number
PCT/US2003/032940
Other languages
French (fr)
Other versions
WO2004034882A2 (en
Inventor
Mark G Frei
Ivan Osorio
Nina M Graves
Scott F Schaffner
Mark T Rise
Jonathon E Giftakis
David L Carlson
Original Assignee
Medtronic Inc
Mark G Frei
Ivan Osorio
Nina M Graves
Scott F Schaffner
Mark T Rise
Jonathon E Giftakis
David L Carlson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc, Mark G Frei, Ivan Osorio, Nina M Graves, Scott F Schaffner, Mark T Rise, Jonathon E Giftakis, David L Carlson filed Critical Medtronic Inc
Priority to EP03779123.3A priority Critical patent/EP1583464B1/en
Priority to US10/687,571 priority patent/US7280867B2/en
Priority to AU2003285895A priority patent/AU2003285895A1/en
Publication of WO2004034882A2 publication Critical patent/WO2004034882A2/en
Publication of WO2004034882A3 publication Critical patent/WO2004034882A3/en
Priority to US11/837,987 priority patent/US7933646B2/en
Priority to US11/837,994 priority patent/US8738136B2/en
Priority to US14/262,634 priority patent/US9072832B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/361—Phantom sensations, e.g. tinnitus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7217—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/92—Computer assisted medical diagnostics

Abstract

Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
PCT/US2003/032940 2002-10-15 2003-10-15 Measuring a neurological event using clustering WO2004034882A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP03779123.3A EP1583464B1 (en) 2002-10-15 2003-10-15 Clustering of recorded patient neurological activity to determine length of a neurological event
US10/687,571 US7280867B2 (en) 2002-10-15 2003-10-15 Clustering of recorded patient neurological activity to determine length of a neurological event
AU2003285895A AU2003285895A1 (en) 2002-10-15 2003-10-15 Measuring a neurological event using clustering
US11/837,987 US7933646B2 (en) 2002-10-15 2007-08-13 Clustering of recorded patient neurological activity to determine length of a neurological event
US11/837,994 US8738136B2 (en) 2002-10-15 2007-08-13 Clustering of recorded patient neurological activity to determine length of a neurological event
US14/262,634 US9072832B2 (en) 2002-10-15 2014-04-25 Clustering of recorded patient neurological activity to determine length of a neurological event

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US41866602P 2002-10-15 2002-10-15
US41849602P 2002-10-15 2002-10-15
US60/418,496 2002-10-15
US50379403P 2003-09-19 2003-09-19
US50400003P 2003-09-19 2003-09-19
US60/503,794 2003-09-19

Publications (2)

Publication Number Publication Date
WO2004034882A2 WO2004034882A2 (en) 2004-04-29
WO2004034882A3 true WO2004034882A3 (en) 2005-08-11

Family

ID=38683551

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2003/032940 WO2004034882A2 (en) 2002-10-15 2003-10-15 Measuring a neurological event using clustering
PCT/US2003/032909 WO2004034880A2 (en) 2002-10-15 2003-10-15 Timed delay for redelivery of treatment therapy for a medical device system

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2003/032909 WO2004034880A2 (en) 2002-10-15 2003-10-15 Timed delay for redelivery of treatment therapy for a medical device system

Country Status (4)

Country Link
US (2) US7282030B2 (en)
EP (2) EP1583464B1 (en)
AU (2) AU2003301256A1 (en)
WO (2) WO2004034882A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8855775B2 (en) 2006-11-14 2014-10-07 Cyberonics, Inc. Systems and methods of reducing artifact in neurological stimulation systems
US9289595B2 (en) 2009-01-09 2016-03-22 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US9445730B2 (en) 2007-03-21 2016-09-20 Cyberonics, Inc. Implantable systems and methods for identifying a contra-ictal condition in a subject

Families Citing this family (222)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US9320900B2 (en) 1998-08-05 2016-04-26 Cyberonics, Inc. Methods and systems for determining subject-specific parameters for a neuromodulation therapy
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US9042988B2 (en) 1998-08-05 2015-05-26 Cyberonics, Inc. Closed-loop vagus nerve stimulation
US8762065B2 (en) 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US9375573B2 (en) 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US7209787B2 (en) 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US6678548B1 (en) * 2000-10-20 2004-01-13 The Trustees Of The University Of Pennsylvania Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device
US6892098B2 (en) * 2001-04-26 2005-05-10 Biocontrol Medical Ltd. Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders
US6907295B2 (en) 2001-08-31 2005-06-14 Biocontrol Medical Ltd. Electrode assembly for nerve control
US6684105B2 (en) 2001-08-31 2004-01-27 Biocontrol Medical, Ltd. Treatment of disorders by unidirectional nerve stimulation
US7885709B2 (en) 2001-08-31 2011-02-08 Bio Control Medical (B.C.M.) Ltd. Nerve stimulation for treating disorders
US7974693B2 (en) 2001-08-31 2011-07-05 Bio Control Medical (B.C.M.) Ltd. Techniques for applying, configuring, and coordinating nerve fiber stimulation
US8571653B2 (en) 2001-08-31 2013-10-29 Bio Control Medical (B.C.M.) Ltd. Nerve stimulation techniques
US7904176B2 (en) 2006-09-07 2011-03-08 Bio Control Medical (B.C.M.) Ltd. Techniques for reducing pain associated with nerve stimulation
US7734355B2 (en) * 2001-08-31 2010-06-08 Bio Control Medical (B.C.M.) Ltd. Treatment of disorders by unidirectional nerve stimulation
US7778703B2 (en) 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
US7778711B2 (en) 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Reduction of heart rate variability by parasympathetic stimulation
US7321793B2 (en) * 2003-06-13 2008-01-22 Biocontrol Medical Ltd. Vagal stimulation for atrial fibrillation therapy
US7844346B2 (en) 2002-05-23 2010-11-30 Biocontrol Medical Ltd. Electrode assembly for nerve control
US8204591B2 (en) 2002-05-23 2012-06-19 Bio Control Medical (B.C.M.) Ltd. Techniques for prevention of atrial fibrillation
US7885711B2 (en) 2003-06-13 2011-02-08 Bio Control Medical (B.C.M.) Ltd. Vagal stimulation for anti-embolic therapy
US20040093191A1 (en) * 2002-11-12 2004-05-13 The Boeing Company System and method for performing modal analysis of at least one remote structure
US7627384B2 (en) 2004-11-15 2009-12-01 Bio Control Medical (B.C.M.) Ltd. Techniques for nerve stimulation
US8880192B2 (en) 2012-04-02 2014-11-04 Bio Control Medical (B.C.M.) Ltd. Electrode cuffs
US8060197B2 (en) 2003-05-23 2011-11-15 Bio Control Medical (B.C.M.) Ltd. Parasympathetic stimulation for termination of non-sinus atrial tachycardia
US20050143589A1 (en) * 2003-11-09 2005-06-30 Donoghue John P. Calibration systems and methods for neural interface devices
US7317941B2 (en) * 2003-11-13 2008-01-08 Medtronic, Inc. Time syncrhonization of data
US9050469B1 (en) 2003-11-26 2015-06-09 Flint Hills Scientific, Llc Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals
EP1734941A2 (en) 2004-03-25 2006-12-27 The Feinstein Institute for Medical Research Neural tourniquet
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
DK1759536T3 (en) 2004-06-01 2011-09-05 Kwalata Trading Ltd In vitro techniques for use with stem cells
ATE547982T1 (en) * 2004-09-01 2012-03-15 Univ Monash METHOD AND SYSTEM FOR DETECTING NEURAL EVENTS
US7526340B2 (en) * 2004-10-29 2009-04-28 Medtronic, Inc. Division approximation for implantable medical devices
US7288066B2 (en) * 2004-11-01 2007-10-30 Medtronic, Inc. Data compression method for implantable medical devices
US8768446B2 (en) * 2004-11-02 2014-07-01 Medtronic, Inc. Clustering with combined physiological signals
US10201305B2 (en) * 2004-11-02 2019-02-12 Medtronic, Inc. Apparatus for data retention in an implantable medical device
US8024029B2 (en) * 2004-11-02 2011-09-20 Medtronic, Inc. Techniques for user-activated data retention in an implantable medical device
US7917199B2 (en) * 2004-11-02 2011-03-29 Medtronic, Inc. Patient event marking in combination with physiological signals
US20060129056A1 (en) * 2004-12-10 2006-06-15 Washington University Electrocorticography telemitter
US8214035B2 (en) * 2004-12-17 2012-07-03 Medtronic, Inc. System and method for utilizing brain state information to modulate cardiac therapy
US8485979B2 (en) 2004-12-17 2013-07-16 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
US20070239230A1 (en) * 2004-12-17 2007-10-11 Medtronic, Inc. System and method for regulating cardiac triggered therapy to the brain
US8108046B2 (en) * 2004-12-17 2012-01-31 Medtronic, Inc. System and method for using cardiac events to trigger therapy for treating nervous system disorders
US8108038B2 (en) * 2004-12-17 2012-01-31 Medtronic, Inc. System and method for segmenting a cardiac signal based on brain activity
US8041419B2 (en) * 2004-12-17 2011-10-18 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
US8112153B2 (en) 2004-12-17 2012-02-07 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
US8112148B2 (en) 2004-12-17 2012-02-07 Medtronic, Inc. System and method for monitoring cardiac signal activity in patients with nervous system disorders
US8209019B2 (en) * 2004-12-17 2012-06-26 Medtronic, Inc. System and method for utilizing brain state information to modulate cardiac therapy
US8209009B2 (en) * 2004-12-17 2012-06-26 Medtronic, Inc. System and method for segmenting a cardiac signal based on brain stimulation
US11207518B2 (en) 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
EP1833559B1 (en) 2004-12-27 2010-11-24 The Feinstein Institute for Medical Research Treating inflammatory disorders by electrical vagus nerve stimulation
US8609082B2 (en) 2005-01-25 2013-12-17 Bio Control Medical Ltd. Administering bone marrow progenitor cells or myoblasts followed by application of an electrical current for cardiac repair, increasing blood supply or enhancing angiogenesis
US20070055320A1 (en) * 2005-09-07 2007-03-08 Northstar Neuroscience, Inc. Methods for treating temporal lobe epilepsy, associated neurological disorders, and other patient functions
US8165682B2 (en) 2005-09-29 2012-04-24 Uchicago Argonne, Llc Surface acoustic wave probe implant for predicting epileptic seizures
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US8868172B2 (en) 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US7657310B2 (en) * 2006-01-26 2010-02-02 Cyberonics, Inc. Treatment of reproductive endocrine disorders by vagus nerve stimulation
TW200734462A (en) 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
US8190251B2 (en) * 2006-03-24 2012-05-29 Medtronic, Inc. Method and apparatus for the treatment of movement disorders
US7761146B2 (en) * 2006-04-21 2010-07-20 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US7764989B2 (en) * 2006-04-21 2010-07-27 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US8165683B2 (en) 2006-04-21 2012-04-24 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US7761145B2 (en) * 2006-04-21 2010-07-20 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US20080269835A1 (en) * 2006-04-21 2008-10-30 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US20070249953A1 (en) * 2006-04-21 2007-10-25 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US20070249956A1 (en) * 2006-04-21 2007-10-25 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US7359837B2 (en) * 2006-04-27 2008-04-15 Medtronic, Inc. Peak data retention of signal data in an implantable medical device
US7764988B2 (en) 2006-04-27 2010-07-27 Medtronic, Inc. Flexible memory management scheme for loop recording in an implantable device
US7610083B2 (en) * 2006-04-27 2009-10-27 Medtronic, Inc. Method and system for loop recording with overlapping events
US7856272B2 (en) * 2006-04-28 2010-12-21 Flint Hills Scientific, L.L.C. Implantable interface for a medical device system
US20070299317A1 (en) * 2006-06-13 2007-12-27 Hoyme Kenneth P System and method for programming customized data collection for an autonomous medical device
EP2034885A4 (en) 2006-06-23 2010-12-01 Neurovista Corp Minimally invasive monitoring systems and methods
US9119633B2 (en) 2006-06-28 2015-09-01 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US11389232B2 (en) 2006-06-28 2022-07-19 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US20080058664A1 (en) * 2006-08-29 2008-03-06 Neuropace, Inc. Patient event recording and reporting apparatus, system, and method
US20090281518A1 (en) * 2006-09-13 2009-11-12 Koninklijke Philips Electronics N.V. Device for automatic adjustment of the dose of melatonin and/or delivery of melatonin
WO2008092119A2 (en) 2007-01-25 2008-07-31 Neurovista Corporation Systems and methods for identifying a contra-ictal condition in a subject
EP2124734A2 (en) 2007-01-25 2009-12-02 NeuroVista Corporation Methods and systems for measuring a subject's susceptibility to a seizure
US7869884B2 (en) 2007-04-26 2011-01-11 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US7962214B2 (en) 2007-04-26 2011-06-14 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US7904175B2 (en) 2007-04-26 2011-03-08 Cyberonics, Inc. Trans-esophageal vagus nerve stimulation
US8000788B2 (en) 2007-04-27 2011-08-16 Medtronic, Inc. Implantable medical device for treating neurological conditions including ECG sensing
US8594779B2 (en) * 2007-04-30 2013-11-26 Medtronic, Inc. Seizure prediction
US9788750B2 (en) * 2007-04-30 2017-10-17 Medtronic, Inc. Seizure prediction
WO2008133626A1 (en) * 2007-04-30 2008-11-06 Medtronic, Inc. Seizure prediction
US9521955B2 (en) * 2007-05-03 2016-12-20 Cornell Research Foundtion, Inc. Subdural electro-optical sensor
US20090005831A1 (en) * 2007-06-01 2009-01-01 Wilson Lon P Method, apparatus and protocol for screening appropriate patient candidates and for cardiac resychronization therapy (crt), determining cardiac functional response to adjustments of ventricular pacing devices and follow-up of crt patient outcomes
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
WO2009029614A1 (en) 2007-08-27 2009-03-05 The Feinstein Institute For Medical Research Devices and methods for inhibiting granulocyte activation by neural stimulation
US8376943B2 (en) * 2007-09-24 2013-02-19 Medtronic, Inc. Patient event information
US10561845B2 (en) 2007-09-24 2020-02-18 Medtronic, Inc. Therapy adjustment based on patient event indication
US9529972B2 (en) * 2007-09-24 2016-12-27 Medtronic, Inc. Patient event indication
US20090093686A1 (en) * 2007-10-08 2009-04-09 Xiao Hu Multi Automated Severity Scoring
CA2702326C (en) 2007-10-10 2018-09-18 Neurotech S.A. Neurostimulator and method for regulating the same
US8906011B2 (en) 2007-11-16 2014-12-09 Kardium Inc. Medical device for use in bodily lumens, for example an atrium
JP2011505964A (en) * 2007-12-12 2011-03-03 カーディアック ペースメイカーズ， インコーポレイテッド Implantable medical device with Hall sensor
US9259591B2 (en) 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US20090171168A1 (en) 2007-12-28 2009-07-02 Leyde Kent W Systems and Method for Recording Clinical Manifestations of a Seizure
US8337404B2 (en) 2010-10-01 2012-12-25 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8382667B2 (en) 2010-10-01 2013-02-26 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8571643B2 (en) 2010-09-16 2013-10-29 Flint Hills Scientific, Llc Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
US9211409B2 (en) 2008-03-31 2015-12-15 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of T-cell activity
US8391986B2 (en) 2008-05-13 2013-03-05 The Board Of Trustees Of The University Of Illinois Apparatus for managing a neurological disorder
AU2009276603B2 (en) 2008-07-30 2015-11-12 Ecole Polytechinique Federale De Lausanne (Epfl) Apparatus and method for optimized stimulation of a neurological target
US8280516B2 (en) 2008-10-09 2012-10-02 Daniel Graupe Method and apparatus for closed-loop deep brain stimulation in treating neurological diseases
US8417344B2 (en) 2008-10-24 2013-04-09 Cyberonics, Inc. Dynamic cranial nerve stimulation based on brain state determination from cardiac data
US8788064B2 (en) 2008-11-12 2014-07-22 Ecole Polytechnique Federale De Lausanne Microfabricated neurostimulation device
US8412338B2 (en) 2008-11-18 2013-04-02 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8239028B2 (en) 2009-04-24 2012-08-07 Cyberonics, Inc. Use of cardiac parameters in methods and systems for treating a chronic medical condition
US8827912B2 (en) 2009-04-24 2014-09-09 Cyberonics, Inc. Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters
US9155885B2 (en) 2009-04-24 2015-10-13 Medtronic, Inc. Incontinence therapy
CN102413872A (en) * 2009-04-30 2012-04-11 麦德托尼克公司 Patient state detection based on support vector machine based algorithm
US8996116B2 (en) 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
WO2010138332A1 (en) 2009-05-27 2010-12-02 Cardiac Pacemakers, Inc. Adaptive event storage in an implantable device
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
AU2010258792B2 (en) 2009-06-09 2015-07-02 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
US8374701B2 (en) * 2009-07-28 2013-02-12 The Invention Science Fund I, Llc Stimulating a nervous system component of a mammal in response to contactlessly acquired information
US9697336B2 (en) 2009-07-28 2017-07-04 Gearbox, Llc Electronically initiating an administration of a neuromodulation treatment regimen chosen in response to contactlessly acquired information
US8942817B2 (en) * 2009-07-28 2015-01-27 The Invention Science Fund I, Llc Broadcasting a signal indicative of a disease, disorder, or symptom determined in response to contactlessly acquired information
US8346354B2 (en) * 2009-07-28 2013-01-01 The Invention Science Fund I, Llc Determining a neuromodulation treatment regimen in response to contactlessly acquired information
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
WO2014169145A1 (en) 2013-04-10 2014-10-16 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US8774937B2 (en) 2009-12-01 2014-07-08 Ecole Polytechnique Federale De Lausanne Microfabricated surface neurostimulation device and methods of making and using the same
EP3636314B1 (en) 2009-12-23 2021-09-08 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts
AU2011234422B2 (en) 2010-04-01 2015-11-05 Ecole Polytechnique Federale De Lausanne (Epfl) Device for interacting with neurological tissue and methods of making and using the same
US8296108B2 (en) * 2010-04-02 2012-10-23 Yugen Kaisha Suwa Torasuto Time series data analyzer, and a computer-readable recording medium recording a time series data analysis program
US8874229B2 (en) * 2010-04-28 2014-10-28 Cyberonics, Inc. Delivering scheduled and unscheduled therapy without detriment to battery life or accuracy of longevity predictions
CA2965141C (en) 2010-04-29 2019-05-21 Cyberonics, Inc. Algorithm for detecting a seizure from cardiac data
US8562536B2 (en) 2010-04-29 2013-10-22 Flint Hills Scientific, Llc Algorithm for detecting a seizure from cardiac data
US8831732B2 (en) 2010-04-29 2014-09-09 Cyberonics, Inc. Method, apparatus and system for validating and quantifying cardiac beat data quality
US8649871B2 (en) 2010-04-29 2014-02-11 Cyberonics, Inc. Validity test adaptive constraint modification for cardiac data used for detection of state changes
US10321841B2 (en) 2010-05-26 2019-06-18 Flint Hills Scientific, Llc Quantitative multivariate analysis of seizures
US8951192B2 (en) * 2010-06-15 2015-02-10 Flint Hills Scientific, Llc Systems approach to disease state and health assessment
US8679009B2 (en) 2010-06-15 2014-03-25 Flint Hills Scientific, Llc Systems approach to comorbidity assessment
EP2582426B1 (en) * 2010-06-16 2019-07-24 Cardiac Pacemakers, Inc. Automatic neural stimulation titration sweep
US8641646B2 (en) 2010-07-30 2014-02-04 Cyberonics, Inc. Seizure detection using coordinate data
US9669226B2 (en) 2010-09-07 2017-06-06 Empi, Inc. Methods and systems for reducing interference in stimulation treatment
JP5710767B2 (en) 2010-09-28 2015-04-30 マシモ コーポレイション Depth of consciousness monitor including oximeter
US8805519B2 (en) 2010-09-30 2014-08-12 Nevro Corporation Systems and methods for detecting intrathecal penetration
US8562524B2 (en) 2011-03-04 2013-10-22 Flint Hills Scientific, Llc Detecting, assessing and managing a risk of death in epilepsy
US8562523B2 (en) 2011-03-04 2013-10-22 Flint Hills Scientific, Llc Detecting, assessing and managing extreme epileptic events
US8684921B2 (en) 2010-10-01 2014-04-01 Flint Hills Scientific Llc Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis
US8565886B2 (en) 2010-11-10 2013-10-22 Medtronic, Inc. Arousal state modulation with electrical stimulation
US9504390B2 (en) 2011-03-04 2016-11-29 Globalfoundries Inc. Detecting, assessing and managing a risk of death in epilepsy
US8844007B2 (en) 2011-04-08 2014-09-23 Dexcom, Inc. Systems and methods for processing and transmitting sensor data
WO2012145265A1 (en) 2011-04-20 2012-10-26 Medtronic, Inc. Electrical therapy parameter determination based on a bioelectrical resonance response
US8892207B2 (en) 2011-04-20 2014-11-18 Medtronic, Inc. Electrical therapy for facilitating inter-area brain synchronization
US8868173B2 (en) 2011-04-20 2014-10-21 Medtronic, Inc. Method and apparatus for assessing neural activation
US9173609B2 (en) 2011-04-20 2015-11-03 Medtronic, Inc. Brain condition monitoring based on co-activation of neural networks
US9498162B2 (en) 2011-04-25 2016-11-22 Cyberonics, Inc. Identifying seizures using heart data from two or more windows
US8812098B2 (en) 2011-04-28 2014-08-19 Medtronic, Inc. Seizure probability metrics
US9878161B2 (en) 2011-04-29 2018-01-30 Medtronic, Inc. Entrainment of bioelectrical brain signals
US9402550B2 (en) 2011-04-29 2016-08-02 Cybertronics, Inc. Dynamic heart rate threshold for neurological event detection
EP2707094B1 (en) 2011-05-09 2016-02-03 Setpoint Medical Corporation Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US20130172774A1 (en) 2011-07-01 2013-07-04 Neuropace, Inc. Systems and Methods for Assessing the Effectiveness of a Therapy Including a Drug Regimen Using an Implantable Medical Device
US9888861B2 (en) 2011-08-25 2018-02-13 Medtronic, Inc. Method and apparatus for detecting a biomarker in the presence of electrical stimulation
US9549677B2 (en) * 2011-10-14 2017-01-24 Flint Hills Scientific, L.L.C. Seizure detection methods, apparatus, and systems using a wavelet transform maximum modulus algorithm
CN104159555B (en) * 2011-12-16 2016-04-20 考地特医疗Ab公司 For the equipment of hypothalamic stimulation
EP2790632B1 (en) 2011-12-16 2017-07-19 Chordate Medical AB Device for treatment of headache disorders
JP6175447B2 (en) * 2011-12-16 2017-08-02 コーデイト・メディカル・アクチエボラーグＣｈｏｒｄａｔｅ Ｍｅｄｉｃａｌ ＡＢ Double stimulation
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
US8918176B2 (en) 2012-04-23 2014-12-23 Medtronic, Inc. Assessing cognitive disorders based on non-motor epileptiform bioelectrical brain activity
US10448839B2 (en) 2012-04-23 2019-10-22 Livanova Usa, Inc. Methods, systems and apparatuses for detecting increased risk of sudden death
US9198592B2 (en) 2012-05-21 2015-12-01 Kardium Inc. Systems and methods for activating transducers
US10827977B2 (en) 2012-05-21 2020-11-10 Kardium Inc. Systems and methods for activating transducers
US9017320B2 (en) 2012-05-21 2015-04-28 Kardium, Inc. Systems and methods for activating transducers
US10220211B2 (en) 2013-01-22 2019-03-05 Livanova Usa, Inc. Methods and systems to diagnose depression
US9056195B2 (en) 2013-03-15 2015-06-16 Cyberonics, Inc. Optimization of cranial nerve stimulation to treat seizure disorderse during sleep
US9370660B2 (en) 2013-03-29 2016-06-21 Rainbow Medical Ltd. Independently-controlled bidirectional nerve stimulation
US9092552B2 (en) 2013-04-26 2015-07-28 Cyberonics, Inc. System monitor for monitoring functional modules of a system
US20140343448A1 (en) * 2013-05-15 2014-11-20 Zephyr Technology Corporation Two-electrode, impedance-based respiration determination
CN104225784A (en) * 2013-06-14 2014-12-24 刘东麒 Long-distance digital electrical-stimulation prescription system
EP4050617A1 (en) 2013-11-07 2022-08-31 Dexcom, Inc. Systems and methods for transmitting and continuous monitoring of analyte values
US9585611B2 (en) 2014-04-25 2017-03-07 Cyberonics, Inc. Detecting seizures based on heartbeat data
US9302109B2 (en) 2014-04-25 2016-04-05 Cyberonics, Inc. Cranial nerve stimulation to treat depression during sleep
US11311718B2 (en) 2014-05-16 2022-04-26 Aleva Neurotherapeutics Sa Device for interacting with neurological tissue and methods of making and using the same
CN110585588A (en) 2014-05-16 2019-12-20 阿莱瓦神经治疗股份有限公司 Implantable microelectrode device
WO2015179915A1 (en) 2014-05-27 2015-12-03 Resmed Limited Remote respiratory therapy device management
US9403011B2 (en) 2014-08-27 2016-08-02 Aleva Neurotherapeutics Leadless neurostimulator
US9474894B2 (en) 2014-08-27 2016-10-25 Aleva Neurotherapeutics Deep brain stimulation lead
WO2016057553A1 (en) 2014-10-07 2016-04-14 Masimo Corporation Modular physiological sensors
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
US10368936B2 (en) 2014-11-17 2019-08-06 Kardium Inc. Systems and methods for selecting, activating, or selecting and activating transducers
US10722184B2 (en) 2014-11-17 2020-07-28 Kardium Inc. Systems and methods for selecting, activating, or selecting and activating transducers
US11406833B2 (en) 2015-02-03 2022-08-09 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US10130813B2 (en) 2015-02-10 2018-11-20 Neuropace, Inc. Seizure onset classification and stimulation parameter selection
US10105540B2 (en) 2015-11-09 2018-10-23 Bluewind Medical Ltd. Optimization of application of current
US10485471B2 (en) 2016-01-07 2019-11-26 The Trustees Of Dartmouth College System and method for identifying ictal states in a patient
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
WO2017127756A1 (en) 2016-01-20 2017-07-27 Setpoint Medical Corporation Control of vagal stimulation
US10314501B2 (en) 2016-01-20 2019-06-11 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
CN109069824B (en) 2016-02-02 2022-09-16 阿莱瓦神经治疗股份有限公司 Treatment of autoimmune diseases using deep brain stimulation
US11045649B2 (en) 2016-02-19 2021-06-29 Medtronic, Inc. Incontinence therapy
EP3532154B1 (en) 2016-10-28 2023-08-23 Medtronic, Inc. Autotitration of therapy using detected electrical activity
CN206576856U (en) 2016-11-26 2017-10-24 张霞玲 A kind of adjustable neurostimulation probe in direction
EP3562380A4 (en) 2016-12-30 2020-08-12 Medtrum Technologies Inc. System and method for algorithm adjustment applying motion sensors in cgm system
AU2018231031B2 (en) 2017-03-09 2023-11-02 Nevro Corp. Paddle leads and delivery tools, and associated systems and methods
EP3629910B1 (en) * 2017-05-25 2022-05-11 Mayo Foundation for Medical Education and Research Seizure onset zone localization
EP3668402A4 (en) 2017-08-14 2021-05-19 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
WO2019060298A1 (en) 2017-09-19 2019-03-28 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
US10729907B2 (en) 2017-10-20 2020-08-04 Neuropace, Inc. Systems and methods for clinical decision making for a patient receiving a neuromodulation therapy based on deep learning
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
WO2019133997A1 (en) 2017-12-31 2019-07-04 Neuroenhancement Lab, LLC System and method for neuroenhancement to enhance emotional response
US10702692B2 (en) 2018-03-02 2020-07-07 Aleva Neurotherapeutics Neurostimulation device
AU2019242906A1 (en) 2018-03-29 2020-10-15 Nevro Corp. Leads having sidewall openings, and associated systems and methods
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
EP3849410A4 (en) 2018-09-14 2022-11-02 Neuroenhancement Lab, LLC System and method of improving sleep
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
US11481578B2 (en) 2019-02-22 2022-10-25 Neuropace, Inc. Systems and methods for labeling large datasets of physiological records based on unsupervised machine learning
US11612750B2 (en) 2019-03-19 2023-03-28 Neuropace, Inc. Methods and systems for optimizing therapy using stimulation mimicking natural seizures
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep
JP2023526080A (en) 2020-05-21 2023-06-20 ザ・フェインステイン・インスティチュート・フォー・メディカル・リサーチ Systems and methods for vagus nerve stimulation
WO2023015046A1 (en) * 2021-08-03 2023-02-09 Icahn School Of Medicine At Mount Sinai System to identify transitions in brain states from electrophysiological markers in dbs for depression
CN116226605B (en) * 2023-04-25 2023-07-25 北京领创医谷科技发展有限责任公司 Fitting method and system for stimulator parameters

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5857978A (en) * 1996-03-20 1999-01-12 Lockheed Martin Energy Systems, Inc. Epileptic seizure prediction by non-linear methods
US5995868A (en) * 1996-01-23 1999-11-30 University Of Kansas System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH480697A (en) 1967-07-18 1969-10-31 Robot Foto Electr Kg Photographic traffic monitoring device
US3522811A (en) * 1969-02-13 1970-08-04 Medtronic Inc Implantable nerve stimulator and method of use
US3967616A (en) * 1972-10-24 1976-07-06 Ross Sidney A Multichannel system for and a multifactorial method of controlling the nervous system of a living organism
US3850161A (en) * 1973-04-09 1974-11-26 S Liss Method and apparatus for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures and the like
US3863625A (en) 1973-11-02 1975-02-04 Us Health Epileptic seizure warning system
US3993046A (en) 1974-11-06 1976-11-23 Heriberto Fernandez Seizure suppression device
US4019518A (en) * 1975-08-11 1977-04-26 Medtronic, Inc. Electrical stimulation system
US4038536A (en) * 1976-03-29 1977-07-26 Rockwell International Corporation Adaptive recursive least mean square error filter
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4295474A (en) * 1979-10-02 1981-10-20 The Johns Hopkins University Recorder with patient alarm and service request systems suitable for use with automatic implantable defibrillator
US4692147A (en) 1980-04-02 1987-09-08 Medtronic, Inc. Drug administration device
US4417592A (en) 1981-05-11 1983-11-29 Roy John E Digital electroencephalographic instrument and method
US4566464A (en) * 1981-07-27 1986-01-28 Piccone Vincent A Implantable epilepsy monitor apparatus
US4610259A (en) 1983-08-31 1986-09-09 Cns, Inc. EEG signal analysis system
US4702254A (en) * 1983-09-14 1987-10-27 Jacob Zabara Neurocybernetic prosthesis
US4581758A (en) * 1983-11-04 1986-04-08 At&T Bell Laboratories Acoustic direction identification system
US4873981A (en) * 1988-10-14 1989-10-17 Somatics, Inc. Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures
US4944299A (en) 1989-08-08 1990-07-31 Siemens-Pacesetter, Inc. High speed digital telemetry system for implantable device
US4974589A (en) * 1989-10-17 1990-12-04 Siemens-Pacesetter, Inc. Automatically adjustable blanking period for implantable pacemaker
DE69123864T2 (en) * 1990-03-24 1997-08-14 Toshiba Kawasaki Kk Device for medical treatment with ultrasound waves
US5113869A (en) 1990-08-21 1992-05-19 Telectronics Pacing Systems, Inc. Implantable ambulatory electrocardiogram monitor
US5269303A (en) * 1991-02-22 1993-12-14 Cyberonics, Inc. Treatment of dementia by nerve stimulation
MY117259A (en) * 1991-05-02 2004-06-30 Thomson Consumer Electronics Autoprogrammed channel mapping for a videocassette recorder.
US5335657A (en) * 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5299569A (en) * 1991-05-03 1994-04-05 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5431691A (en) 1992-03-02 1995-07-11 Siemens Pacesetter, Inc. Method and system for recording and displaying a sequential series of pacing events
US5311876A (en) 1992-11-18 1994-05-17 The Johns Hopkins University Automatic detection of seizures using electroencephalographic signals
US5318591A (en) * 1992-11-23 1994-06-07 Siemens Pacesetter, Inc. Implantable cardioverter-defibrillator having early charging capability
US6117066A (en) 1992-12-04 2000-09-12 Somatics, Inc. Prevention of seizure arising from medical magnetoictal non-convulsive stimulation therapy
US5458619A (en) * 1993-11-29 1995-10-17 Medtronic, Inc. Apparatus and method for treating a tachyarrhythmia
US5752976A (en) 1995-06-23 1998-05-19 Medtronic, Inc. World wide patient location and data telemetry system for implantable medical devices
US6083248A (en) 1995-06-23 2000-07-04 Medtronic, Inc. World wide patient location and data telemetry system for implantable medical devices
US5720770A (en) * 1995-10-06 1998-02-24 Pacesetter, Inc. Cardiac stimulation system with enhanced communication and control capability
US6480743B1 (en) * 2000-04-05 2002-11-12 Neuropace, Inc. System and method for adaptive brain stimulation
US6066163A (en) 1996-02-02 2000-05-23 John; Michael Sasha Adaptive brain stimulation method and system
US5626145A (en) * 1996-03-20 1997-05-06 Lockheed Martin Energy Systems, Inc. Method and apparatus for extraction of low-frequency artifacts from brain waves for alertness detection
US5743860A (en) * 1996-03-20 1998-04-28 Lockheed Martin Energy Systems, Inc. Apparatus and method for epileptic seizure detection using non-linear techniques
US5713922A (en) * 1996-04-25 1998-02-03 Medtronic, Inc. Techniques for adjusting the locus of excitation of neural tissue in the spinal cord or brain
US6094598A (en) 1996-04-25 2000-07-25 Medtronics, Inc. Method of treating movement disorders by brain stimulation and drug infusion
US5716377A (en) * 1996-04-25 1998-02-10 Medtronic, Inc. Method of treating movement disorders by brain stimulation
US5683422A (en) * 1996-04-25 1997-11-04 Medtronic, Inc. Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation
US5713923A (en) * 1996-05-13 1998-02-03 Medtronic, Inc. Techniques for treating epilepsy by brain stimulation and drug infusion
US6128537A (en) * 1997-05-01 2000-10-03 Medtronic, Inc Techniques for treating anxiety by brain stimulation and drug infusion
US6016449A (en) * 1997-10-27 2000-01-18 Neuropace, Inc. System for treatment of neurological disorders
US6459936B2 (en) * 1997-10-27 2002-10-01 Neuropace, Inc. Methods for responsively treating neurological disorders
US6597954B1 (en) 1997-10-27 2003-07-22 Neuropace, Inc. System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes
US6427086B1 (en) * 1997-10-27 2002-07-30 Neuropace, Inc. Means and method for the intracranial placement of a neurostimulator
US6230049B1 (en) 1999-08-13 2001-05-08 Neuro Pace, Inc. Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes
US6647296B2 (en) * 1997-10-27 2003-11-11 Neuropace, Inc. Implantable apparatus for treating neurological disorders
US6227203B1 (en) * 1998-02-12 2001-05-08 Medtronic, Inc. Techniques for controlling abnormal involuntary movements by brain stimulation and drug infusion
JP3365298B2 (en) * 1998-02-27 2003-01-08 松下電器産業株式会社 Video signal recording and playback device
US6374140B1 (en) * 1998-04-30 2002-04-16 Medtronic, Inc. Method and apparatus for treating seizure disorders by stimulating the olfactory senses
US6018682A (en) 1998-04-30 2000-01-25 Medtronic, Inc. Implantable seizure warning system
US6366813B1 (en) 1998-08-05 2002-04-02 Dilorenzo Daniel J. Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease
EP1107693A4 (en) 1998-08-24 2003-03-19 Univ Emory Method and apparatus for predicting the onset of seizures based on features derived from signals indicative of brain activity
US6366814B1 (en) * 1998-10-26 2002-04-02 Birinder R. Boveja External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders
US6385479B1 (en) 1999-03-31 2002-05-07 Science & Technology Corporation @ Unm Method for determining activity in the central nervous system
US6167308A (en) * 1999-04-09 2000-12-26 Medtronic, Inc. Closed loop ATP
US6200265B1 (en) * 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
US6224549B1 (en) 1999-04-20 2001-05-01 Nicolet Biomedical, Inc. Medical signal monitoring and display
US6356784B1 (en) 1999-04-30 2002-03-12 Medtronic, Inc. Method of treating movement disorders by electrical stimulation and/or drug infusion of the pendunulopontine nucleus
US6341236B1 (en) 1999-04-30 2002-01-22 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
US6923784B2 (en) * 1999-04-30 2005-08-02 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
US6560486B1 (en) * 1999-10-12 2003-05-06 Ivan Osorio Bi-directional cerebral interface system
US6609030B1 (en) 2000-02-24 2003-08-19 Electrocore Techniques, Llc Method of treating psychiatric diseases by neuromodulation within the dorsomedial thalamus
US6473639B1 (en) 2000-03-02 2002-10-29 Neuropace, Inc. Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures
US6466822B1 (en) 2000-04-05 2002-10-15 Neuropace, Inc. Multimodal neurostimulator and process of using it
US6353754B1 (en) * 2000-04-24 2002-03-05 Neuropace, Inc. System for the creation of patient specific templates for epileptiform activity detection
JP2001331677A (en) 2000-05-18 2001-11-30 Koto Jimusho:Kk Person searching method using communication means and server (device) that can be applied to the same method
WO2001097907A2 (en) * 2000-06-23 2001-12-27 Medtronic, Inc. Network compatible rf wireless link for medical device data management
US6591138B1 (en) * 2000-08-31 2003-07-08 Neuropace, Inc. Low frequency neurostimulator for the treatment of neurological disorders
US6678548B1 (en) 2000-10-20 2004-01-13 The Trustees Of The University Of Pennsylvania Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device
US6810285B2 (en) * 2001-06-28 2004-10-26 Neuropace, Inc. Seizure sensing and detection using an implantable device
US7149572B2 (en) * 2002-10-15 2006-12-12 Medtronic, Inc. Phase shifting of neurological signals in a medical device system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5995868A (en) * 1996-01-23 1999-11-30 University Of Kansas System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject
US5857978A (en) * 1996-03-20 1999-01-12 Lockheed Martin Energy Systems, Inc. Epileptic seizure prediction by non-linear methods

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8855775B2 (en) 2006-11-14 2014-10-07 Cyberonics, Inc. Systems and methods of reducing artifact in neurological stimulation systems
US9445730B2 (en) 2007-03-21 2016-09-20 Cyberonics, Inc. Implantable systems and methods for identifying a contra-ictal condition in a subject
US9289595B2 (en) 2009-01-09 2016-03-22 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices

Also Published As

Publication number Publication date
EP1558131A4 (en) 2008-05-28
EP1583464B1 (en) 2014-04-09
AU2003301256A1 (en) 2004-05-04
US20040138536A1 (en) 2004-07-15
EP1583464A2 (en) 2005-10-12
EP1558131A2 (en) 2005-08-03
WO2004034880A2 (en) 2004-04-29
US20040152958A1 (en) 2004-08-05
AU2003301256A8 (en) 2004-05-04
AU2003285895A1 (en) 2004-05-04
US7280867B2 (en) 2007-10-09
US7282030B2 (en) 2007-10-16
EP1583464A4 (en) 2008-12-17
WO2004034880A3 (en) 2004-07-22
WO2004034882A2 (en) 2004-04-29
AU2003285895A8 (en) 2004-05-04

Similar Documents

Publication Publication Date Title
WO2004034882A3 (en) Measuring a neurological event using clustering
WO2007047854A3 (en) Methods and systems for establishing parameters for neural stimulation
WO2007124194A3 (en) Method and apparatus for detection of nervous system disorders
WO2007124190A3 (en) Method and apparatus for detection of nervous system disorders
WO2007143234A3 (en) Method and apparatus for detection of nervous system disorders
EP4295898A3 (en) Ecap based control of electrical stimulation therapy
WO2007047852A3 (en) Systems and methods for patient interactive neural stimulation and/or chemical substance delivery
WO2004036765A3 (en) Neural stimulation system and method responsive to collateral neural activity
ATE525954T1 (en) METHOD AND DEVICE FOR DETECTING DISORDERS OF THE NERVOUS SYSTEM
WO2005002664A3 (en) Methods and apparatus for effectuating a lasting change in a neural-function of a patient
IL174573A0 (en) Method and apparatus for controlling extra-systolic stimulation (ess) therapy using ischemia detection
WO2008017055A3 (en) Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems
France et al. Opiate agonist-antagonist interactions: application of a three-key drug discrimination procedure.
WO2008073420A3 (en) Systems and methods for treating patient hypertonicity
WO2004103172A3 (en) Identification of oversensing using sinus r-wave template
WO2007090054A3 (en) Systems and methods for varying electromagnetic and adjunctive neural therapies
EP3257552A3 (en) Systems and methods for identifying and treating patients with high-frequency electrical signals
WO2009044271A3 (en) Systems and methods for treatment of medical conditions related to the central nervous system and for enhancing cognitive functions
WO2006053114A3 (en) Electrode configurations for reducing invasiveness and /or enhancing neural stimulation efficacy, and associated methods
WO2006094072A3 (en) Method of treating cognitive disorders using neuromodulation
WO2005011805A3 (en) Apparatus and methods for applying neural stimulation to a patient
CA2383218A1 (en) Seizure warning and prediction
WO2007011611A3 (en) Deep brain neural prosthetic system
WO2004096018A3 (en) Apparatus and methods of optimal placement of deep brain stimulator
WO2004066112A3 (en) Behavior-based host-based intrusion prevention system

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2003779123

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003779123

Country of ref document: EP

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP