WO2004034977A3 - Orally administered peptides synergize statin activity - Google Patents
Orally administered peptides synergize statin activity Download PDFInfo
- Publication number
- WO2004034977A3 WO2004034977A3 PCT/US2003/032442 US0332442W WO2004034977A3 WO 2004034977 A3 WO2004034977 A3 WO 2004034977A3 US 0332442 W US0332442 W US 0332442W WO 2004034977 A3 WO2004034977 A3 WO 2004034977A3
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- WO
- WIPO (PCT)
- Prior art keywords
- peptides
- orally administered
- activity
- administered peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2003801063671A CN1744909B (en) | 2002-10-16 | 2003-10-14 | Orally administered peptides synergize statin activity |
AU2003284129A AU2003284129B2 (en) | 2002-10-16 | 2003-10-14 | Orally administered peptides synergize statin activity |
JP2005501402A JP2006508179A (en) | 2002-10-16 | 2003-10-14 | Synergistic action of orally administered peptide-statin |
EP03776360A EP1562624A4 (en) | 2002-10-16 | 2003-10-14 | Orally administered peptides synergize statin activity |
CA002501943A CA2501943A1 (en) | 2002-10-16 | 2003-10-14 | Orally administered peptides synergize statin activity |
HK06109556.1A HK1089090A1 (en) | 2002-10-16 | 2006-08-28 | Orally administered peptides synergize statin activity |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/273,386 | 2002-10-16 | ||
US10/273,386 US7166578B2 (en) | 2000-08-24 | 2002-10-16 | Orally administered peptides synergize statin activity |
US10/423,830 | 2003-04-25 | ||
US10/423,830 US7199102B2 (en) | 2000-08-24 | 2003-04-25 | Orally administered peptides synergize statin activity |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004034977A2 WO2004034977A2 (en) | 2004-04-29 |
WO2004034977A3 true WO2004034977A3 (en) | 2004-11-25 |
Family
ID=32109821
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/032442 WO2004034977A2 (en) | 2002-10-16 | 2003-10-14 | Orally administered peptides synergize statin activity |
Country Status (5)
Country | Link |
---|---|
US (7) | US7199102B2 (en) |
EP (1) | EP1562624A4 (en) |
JP (1) | JP2006508179A (en) |
CA (1) | CA2501943A1 (en) |
WO (1) | WO2004034977A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9422363B2 (en) | 2007-08-28 | 2016-08-23 | Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
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TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7199102B2 (en) * | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
US7148197B2 (en) * | 2000-08-24 | 2006-12-12 | The Regents Of The University Of California | Orally administered small peptides synergize statin activity |
US7723303B2 (en) * | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
US8568766B2 (en) * | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
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CA2577026A1 (en) * | 2004-08-11 | 2006-02-23 | The Regents Of The University Of California | Orally administered small peptides synergize statin activity |
JP2008513479A (en) * | 2004-09-16 | 2008-05-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | G-type peptides and other agents for ameliorating atherosclerosis and other pathologies |
WO2006049597A1 (en) * | 2004-10-27 | 2006-05-11 | Avanir Pharmaceuticals | Amino acid-derived compounds as modulators of the reverse cholesterol transport |
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US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
AU2006242651B2 (en) * | 2005-04-29 | 2013-05-16 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
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WO2008021088A2 (en) | 2006-08-08 | 2008-02-21 | The Regents Of The University Of Californina | Salicylanilides enhance oral delivery of therapeutic peptides |
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US8101565B2 (en) * | 2007-09-20 | 2012-01-24 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
US7985728B1 (en) | 2007-09-20 | 2011-07-26 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
US9173890B2 (en) * | 2007-09-20 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
US8044021B2 (en) * | 2007-09-20 | 2011-10-25 | Abbott Cardiovascular Systems Inc. | Sustained release of apo A-I mimetic peptides and methods of treatment |
US7985727B1 (en) | 2007-09-20 | 2011-07-26 | Abbott Cardiovascular Systems Inc. | Apo A-I mimetic peptides and methods of treatment |
US20110166227A1 (en) * | 2008-08-25 | 2011-07-07 | Brandeis University | Balanced myristate- and laurate-containing edible oil |
US8617634B2 (en) * | 2008-08-25 | 2013-12-31 | Brandeis University | Sn-2 myristate-containing edible oil |
US9491955B2 (en) | 2008-08-25 | 2016-11-15 | Brandeis University | Balanced myristate- and laurate-containing edible oil |
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US6037323A (en) * | 1997-09-29 | 2000-03-14 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US20030045460A1 (en) * | 2000-08-24 | 2003-03-06 | Fogelman Alan M. | Orally administered peptides to ameliorate atherosclerosis |
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2003
- 2003-04-25 US US10/423,830 patent/US7199102B2/en not_active Expired - Lifetime
- 2003-10-14 EP EP03776360A patent/EP1562624A4/en not_active Withdrawn
- 2003-10-14 JP JP2005501402A patent/JP2006508179A/en active Pending
- 2003-10-14 CA CA002501943A patent/CA2501943A1/en not_active Abandoned
- 2003-10-14 WO PCT/US2003/032442 patent/WO2004034977A2/en active Application Filing
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- 2007-03-21 US US11/689,037 patent/US7807640B2/en not_active Expired - Fee Related
- 2007-07-30 US US11/830,675 patent/US7820784B2/en not_active Expired - Fee Related
- 2007-07-30 US US11/830,687 patent/US7994132B2/en not_active Expired - Fee Related
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US8404635B2 (en) | 2013-03-26 |
AU2003284129A1 (en) | 2004-05-04 |
US20080096814A1 (en) | 2008-04-24 |
EP1562624A4 (en) | 2009-07-29 |
WO2004034977A2 (en) | 2004-04-29 |
US7820784B2 (en) | 2010-10-26 |
US20080096816A1 (en) | 2008-04-24 |
US20040266671A1 (en) | 2004-12-30 |
US7531514B2 (en) | 2009-05-12 |
CA2501943A1 (en) | 2004-04-29 |
US20070254839A1 (en) | 2007-11-01 |
US7807640B2 (en) | 2010-10-05 |
US20120035095A1 (en) | 2012-02-09 |
JP2006508179A (en) | 2006-03-09 |
US20080096815A1 (en) | 2008-04-24 |
US7199102B2 (en) | 2007-04-03 |
US20080045459A1 (en) | 2008-02-21 |
EP1562624A2 (en) | 2005-08-17 |
US7994132B2 (en) | 2011-08-09 |
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