WO2004035762A3 - Microencapsulation and sustained release of biologically active polypeptides - Google Patents

Microencapsulation and sustained release of biologically active polypeptides Download PDF

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Publication number
WO2004035762A3
WO2004035762A3 PCT/US2003/033198 US0333198W WO2004035762A3 WO 2004035762 A3 WO2004035762 A3 WO 2004035762A3 US 0333198 W US0333198 W US 0333198W WO 2004035762 A3 WO2004035762 A3 WO 2004035762A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically active
sustained release
active polypeptides
microencapsulation
compositions
Prior art date
Application number
PCT/US2003/033198
Other languages
French (fr)
Other versions
WO2004035762A2 (en
Inventor
Henry R Costantino
Joyce Hotz
Edward W Bobka
Original Assignee
Alkermes Inc
Amylin Pharmaceuticals Inc
Henry R Costantino
Joyce Hotz
Edward W Bobka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc, Amylin Pharmaceuticals Inc, Henry R Costantino, Joyce Hotz, Edward W Bobka filed Critical Alkermes Inc
Priority to AU2003282955A priority Critical patent/AU2003282955A1/en
Publication of WO2004035762A2 publication Critical patent/WO2004035762A2/en
Publication of WO2004035762A3 publication Critical patent/WO2004035762A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Abstract

This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide, a sugar and a salting-out salt.
PCT/US2003/033198 2002-10-17 2003-10-17 Microencapsulation and sustained release of biologically active polypeptides WO2004035762A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003282955A AU2003282955A1 (en) 2002-10-17 2003-10-17 Microencapsulation and sustained release of biologically active polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41938802P 2002-10-17 2002-10-17
US60/419,388 2002-10-17

Publications (2)

Publication Number Publication Date
WO2004035762A2 WO2004035762A2 (en) 2004-04-29
WO2004035762A3 true WO2004035762A3 (en) 2004-08-05

Family

ID=32108072

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/033168 WO2004036186A2 (en) 2002-10-17 2003-10-17 Microencapsulation and sustained release of biologically active polypeptides
PCT/US2003/033062 WO2004035754A2 (en) 2002-10-17 2003-10-17 Microencapsulation and sustained release of biologically active polypeptides
PCT/US2003/033198 WO2004035762A2 (en) 2002-10-17 2003-10-17 Microencapsulation and sustained release of biologically active polypeptides

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2003/033168 WO2004036186A2 (en) 2002-10-17 2003-10-17 Microencapsulation and sustained release of biologically active polypeptides
PCT/US2003/033062 WO2004035754A2 (en) 2002-10-17 2003-10-17 Microencapsulation and sustained release of biologically active polypeptides

Country Status (3)

Country Link
US (4) US7164005B2 (en)
AU (3) AU2003277446A1 (en)
WO (3) WO2004036186A2 (en)

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Also Published As

Publication number Publication date
AU2003277446A1 (en) 2004-05-04
US20040228833A1 (en) 2004-11-18
AU2003282955A1 (en) 2004-05-04
US20040208929A1 (en) 2004-10-21
AU2003286472A1 (en) 2004-05-04
WO2004035754A2 (en) 2004-04-29
US8129339B2 (en) 2012-03-06
US7462365B2 (en) 2008-12-09
WO2004035762A2 (en) 2004-04-29
AU2003277446A8 (en) 2004-05-04
WO2004036186A2 (en) 2004-04-29
WO2004035754A3 (en) 2004-10-07
WO2004036186A3 (en) 2004-12-23
US7164005B2 (en) 2007-01-16
US20070027085A1 (en) 2007-02-01
AU2003286472A8 (en) 2004-05-04
AU2003282955A8 (en) 2004-05-04
US20090281034A1 (en) 2009-11-12

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