WO2004043217A3 - Stimulation for treating eye pathologies - Google Patents

Stimulation for treating eye pathologies Download PDF

Info

Publication number
WO2004043217A3
WO2004043217A3 PCT/IL2003/000965 IL0300965W WO2004043217A3 WO 2004043217 A3 WO2004043217 A3 WO 2004043217A3 IL 0300965 W IL0300965 W IL 0300965W WO 2004043217 A3 WO2004043217 A3 WO 2004043217A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
nerve
spg
branch
ethmoidal
Prior art date
Application number
PCT/IL2003/000965
Other languages
French (fr)
Other versions
WO2004043217A2 (en
Inventor
Yossi Gross
Alon Shalev
Original Assignee
Brainsgate Ltd
Yossi Gross
Alon Shalev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brainsgate Ltd, Yossi Gross, Alon Shalev filed Critical Brainsgate Ltd
Priority to AU2003279514A priority Critical patent/AU2003279514A1/en
Publication of WO2004043217A2 publication Critical patent/WO2004043217A2/en
Publication of WO2004043217A3 publication Critical patent/WO2004043217A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3303—Using a biosensor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0618—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0546—Nasal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0548—Oral electrodes

Abstract

Apparatus is provided for treating a condition of an eye of a subject, comprising a stimulator (4) adapted to stimulate at least one site of the subject, so as to treat the eye condition, the site selected from the list consisting of: a sphenopalatine ganglion (SPG) (6) of the subject, an anterior ethmoidal nerve (404) of the subject, a posterior ethmoidal nerve (406) of the subject, a communicating branch between an anterior ethmoidal nerve (404) and a retro-orbital branch of an SPG (6) of the subject, a communicating branch between a posterior ethmoidal nerve (406) anda retro-orbital branch of an SPG (6) of the subject, a greater palatine nerve of the subject, a lesser palatine nerve of the subject, a sphenopalatine nerve of the subject, a communicating branch between a maxillary nerve and an SPG (6) of the subject, a nasopalatine nerve of the subject, a posterior nasal nerve of the subject, an infraorbital nerve of the subject, an otic ganglion of the subject, an afferent fiber going into the otic ganglion of the subject, an efferent fiber going out of the otic ganglion of the subject, a vidian nerve of the subject, a greater superficial petrosal nerve of the subject, and a lesser deep petrosal nerve of the subject.
PCT/IL2003/000965 2002-11-14 2003-11-13 Stimulation for treating eye pathologies WO2004043217A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003279514A AU2003279514A1 (en) 2002-11-14 2003-11-13 Stimulation for treating eye pathologies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/294,310 US7146209B2 (en) 2000-05-08 2002-11-14 Stimulation for treating eye pathologies
US10/294,310 2002-11-14

Publications (2)

Publication Number Publication Date
WO2004043217A2 WO2004043217A2 (en) 2004-05-27
WO2004043217A3 true WO2004043217A3 (en) 2004-08-19

Family

ID=32312162

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000965 WO2004043217A2 (en) 2002-11-14 2003-11-13 Stimulation for treating eye pathologies

Country Status (3)

Country Link
US (2) US7146209B2 (en)
AU (1) AU2003279514A1 (en)
WO (1) WO2004043217A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8406869B2 (en) 2005-08-19 2013-03-26 Brainsgate, Ltd. Post-acute electrical stimulation treatment of adverse cerebrovascular events
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US7117033B2 (en) * 2000-05-08 2006-10-03 Brainsgate, Ltd. Stimulation for acute conditions
US7146209B2 (en) * 2000-05-08 2006-12-05 Brainsgate, Ltd. Stimulation for treating eye pathologies
AU5662001A (en) * 2000-05-08 2001-11-20 Brainsgate Ltd. Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow
US8315711B2 (en) * 2002-01-15 2012-11-20 Campos James M Resonant muscle stimulator
US7684859B2 (en) 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
US7837719B2 (en) 2002-05-09 2010-11-23 Daemen College Electrical stimulation unit and waterbath system
US7561919B2 (en) * 2002-11-14 2009-07-14 Brainsgate Ltd. SPG stimulation via the greater palatine canal
JP2006515999A (en) 2002-11-14 2006-06-15 ブレインズゲート リミティド Surgical tools and techniques for stimulation
CA2580730C (en) * 2003-09-25 2015-01-13 Cenomed, Inc. Tetrahydroindolone derivatives for treatment of neurological conditions
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
WO2006021957A2 (en) * 2004-08-23 2006-03-02 Brainsgate Ltd. Concurrent bilateral spg modulation
US7819812B2 (en) * 2004-12-15 2010-10-26 Neuropace, Inc. Modulation and analysis of cerebral perfusion in epilepsy and other neurological disorders
US7509171B2 (en) * 2005-04-27 2009-03-24 Codman & Shurtleff, Inc. Method of removing deleterious charged molecules from brain tissue
JP2009505947A (en) * 2005-06-23 2009-02-12 エモリー・ユニバーシティ Imaging agent
US20060292073A1 (en) * 2005-06-23 2006-12-28 Emory University Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging
US20090043365A1 (en) 2005-07-18 2009-02-12 Kolis Scientific, Inc. Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma
US8784336B2 (en) 2005-08-24 2014-07-22 C. R. Bard, Inc. Stylet apparatuses and methods of manufacture
US20070173903A1 (en) * 2005-08-30 2007-07-26 Bioq, Inc. Medical device for restoration of neurological function impaired by peripheral neuropathy
US20070073361A1 (en) * 2005-09-23 2007-03-29 Bioq, Inc. Medical device for restoration of autonomic and immune functions impaired by neuropathy
US20070106337A1 (en) * 2005-11-10 2007-05-10 Electrocore, Inc. Methods And Apparatus For Treating Disorders Through Neurological And/Or Muscular Intervention
US20090234417A1 (en) * 2005-11-10 2009-09-17 Electrocore, Inc. Methods And Apparatus For The Treatment Of Metabolic Disorders
US20080004660A1 (en) * 2006-06-28 2008-01-03 Medtrode Inc. Systems and methods for improving a cognitive function
US7965180B2 (en) 2006-09-28 2011-06-21 Semiconductor Energy Laboratory Co., Ltd. Wireless sensor device
US7794407B2 (en) 2006-10-23 2010-09-14 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US8388546B2 (en) 2006-10-23 2013-03-05 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US7831309B1 (en) * 2006-12-06 2010-11-09 University Of Southern California Implants based on bipolar metal oxide semiconductor (MOS) electronics
EP2121124A1 (en) * 2006-12-15 2009-11-25 Nasophlex B.V. Resuscitation device and method for resuscitation
US20080177352A1 (en) * 2007-01-22 2008-07-24 Novavision, Inc. Device for Treating Human Vision Using Combined Optical and Electrical Stimulation
US20090005756A1 (en) * 2007-06-29 2009-01-01 Boston Scientific Neuromodulation Corporation Methods and Systems of Treating Strabismus
US7534991B2 (en) * 2007-07-10 2009-05-19 Cambridge Research & Instrumentation, Inc. Athermalized birefringent filter apparatus and method
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
WO2009062134A1 (en) * 2007-11-09 2009-05-14 Cenomed Biosciences, Llc Treatment of post-traumatic stress disorder with tetrahydroindolone arylpiperazine compounds
US10751509B2 (en) 2007-11-26 2020-08-25 C. R. Bard, Inc. Iconic representations for guidance of an indwelling medical device
US9649048B2 (en) 2007-11-26 2017-05-16 C. R. Bard, Inc. Systems and methods for breaching a sterile field for intravascular placement of a catheter
US10449330B2 (en) 2007-11-26 2019-10-22 C. R. Bard, Inc. Magnetic element-equipped needle assemblies
US8781555B2 (en) 2007-11-26 2014-07-15 C. R. Bard, Inc. System for placement of a catheter including a signal-generating stylet
US8849382B2 (en) 2007-11-26 2014-09-30 C. R. Bard, Inc. Apparatus and display methods relating to intravascular placement of a catheter
US9521961B2 (en) 2007-11-26 2016-12-20 C. R. Bard, Inc. Systems and methods for guiding a medical instrument
US10524691B2 (en) 2007-11-26 2020-01-07 C. R. Bard, Inc. Needle assembly including an aligned magnetic element
US9636031B2 (en) 2007-11-26 2017-05-02 C.R. Bard, Inc. Stylets for use with apparatus for intravascular placement of a catheter
CN101925333B (en) 2007-11-26 2014-02-12 C·R·巴德股份有限公司 Integrated system for intravascular placement of catheter
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
US8478382B2 (en) 2008-02-11 2013-07-02 C. R. Bard, Inc. Systems and methods for positioning a catheter
US20090234236A1 (en) * 2008-03-14 2009-09-17 General Electric Company Nerve blood flow modulation for imaging nerves
US20090264443A1 (en) * 2008-04-18 2009-10-22 David Helton Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
NL2001694C2 (en) * 2008-06-18 2009-12-22 Nasophlex B V Ear stimulator for producing a stimulation signal to an ear.
NL2001697C2 (en) 2008-06-18 2009-12-22 Nasophlex B V Nose stimulator for producing a stimulation signal to a nose.
NL2001695C2 (en) * 2008-06-18 2009-12-22 Kerphos B V Implantable electronic system useful for producing stimulation signal to human, has controller for processing parameter values to generate control signal for stimulation device based on detected parameter values
US9901714B2 (en) 2008-08-22 2018-02-27 C. R. Bard, Inc. Catheter assembly including ECG sensor and magnetic assemblies
US9079031B2 (en) * 2008-09-11 2015-07-14 Trifectas Medical Corp. Method for improving functional recovery after stroke by electrical stimulation of a cranial nerve
US8437833B2 (en) 2008-10-07 2013-05-07 Bard Access Systems, Inc. Percutaneous magnetic gastrostomy
US20100114184A1 (en) * 2008-10-07 2010-05-06 Brainsgate Ltd. Flexible tools for preparing bony canals
WO2010068797A1 (en) * 2008-12-10 2010-06-17 Waverx, Inc. Devices, systems and methods for preventing and treating sensation loss
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US20130110195A1 (en) 2009-01-15 2013-05-02 Autonomic Technologies, Inc. Neurostimulator system, apparatus, and method
US9320908B2 (en) * 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9254383B2 (en) * 2009-03-20 2016-02-09 ElectroCore, LLC Devices and methods for monitoring non-invasive vagus nerve stimulation
US9532724B2 (en) 2009-06-12 2017-01-03 Bard Access Systems, Inc. Apparatus and method for catheter navigation using endovascular energy mapping
JP5795576B2 (en) 2009-06-12 2015-10-14 バード・アクセス・システムズ，インコーポレーテッド Method of operating a computer-based medical device that uses an electrocardiogram (ECG) signal to position an intravascular device in or near the heart
WO2011019760A2 (en) 2009-08-10 2011-02-17 Romedex International Srl Devices and methods for endovascular electrography
EP2470131B1 (en) 2009-08-24 2014-11-12 New Phase Ltd Phase-change materials
US20110105824A1 (en) * 2009-09-22 2011-05-05 Yosef Krespi Parasympathetically induced vasodilatation method and apparatus
US10639008B2 (en) 2009-10-08 2020-05-05 C. R. Bard, Inc. Support and cover structures for an ultrasound probe head
US11103213B2 (en) 2009-10-08 2021-08-31 C. R. Bard, Inc. Spacers for use with an ultrasound probe
EP2531098B1 (en) 2010-02-02 2020-07-15 C.R. Bard, Inc. Apparatus and method for catheter navigation and tip location
DE102010010055A1 (en) * 2010-03-03 2011-09-08 Siemens Aktiengesellschaft Apparatus and method for reducing the heart rate of a patient and apparatus comprising the apparatus
CN103002946B (en) 2010-05-02 2014-11-19 内瓦孚有限公司 Modulating function of the facial nerve system or related neural structures via the ear
US9272157B2 (en) 2010-05-02 2016-03-01 Nervive, Inc. Modulating function of neural structures near the ear
MX2012013858A (en) 2010-05-28 2013-04-08 Bard Inc C R Insertion guidance system for needles and medical components.
WO2011150376A1 (en) 2010-05-28 2011-12-01 C.R. Bard, Inc. Apparatus for use with needle insertion guidance system
US8788045B2 (en) * 2010-06-08 2014-07-22 Bluewind Medical Ltd. Tibial nerve stimulation
MX338127B (en) 2010-08-20 2016-04-04 Bard Inc C R Reconfirmation of ecg-assisted catheter tip placement.
JP6148620B2 (en) * 2010-10-21 2017-06-14 パルティ、ヨーラム Measurement of pulmonary blood pressure using transthoracic Doppler ultrasound
CN103189009B (en) 2010-10-29 2016-09-07 C·R·巴德股份有限公司 The bio-impedance auxiliary of Medical Devices is placed
US9457186B2 (en) 2010-11-15 2016-10-04 Bluewind Medical Ltd. Bilateral feedback
US9186504B2 (en) 2010-11-15 2015-11-17 Rainbow Medical Ltd Sleep apnea treatment
CN103313754B (en) 2010-11-16 2015-09-30 小利兰·斯坦福大学理事会 Be used for the treatment of the system and method for xerophthalmia
US9821159B2 (en) 2010-11-16 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Stimulation devices and methods
US11432760B2 (en) * 2011-01-12 2022-09-06 Electrocore, Inc. Devices and methods for remote therapy and patient monitoring
KR20140051284A (en) 2011-07-06 2014-04-30 씨. 알. 바드, 인크. Needle length determination and calibration for insertion guidance system
USD699359S1 (en) 2011-08-09 2014-02-11 C. R. Bard, Inc. Ultrasound probe head
USD724745S1 (en) 2011-08-09 2015-03-17 C. R. Bard, Inc. Cap for an ultrasound probe
WO2013070775A1 (en) 2011-11-07 2013-05-16 C.R. Bard, Inc Ruggedized ultrasound hydrogel insert
CN104039388B (en) * 2011-12-14 2016-02-10 Med-El电气医疗器械有限公司 For the system and method that eyelid stimulates
US9604057B2 (en) * 2012-01-20 2017-03-28 Autonomic Technologies, Inc. Stimulation method for a sphenopalatine ganglion, sphenopalatine nerve, vidian nerve, or branch thereof for treatment of medical conditions
US20150018728A1 (en) 2012-01-26 2015-01-15 Bluewind Medical Ltd. Wireless neurostimulators
DE102012203880A1 (en) * 2012-03-13 2013-09-19 Robert Bosch Gmbh Functional plaster with sensor and actuator
US9700721B2 (en) * 2012-05-14 2017-07-11 Autonomic Technologies, Inc. Stimulation method for treatment of ocular conditions
US9610441B2 (en) * 2012-05-14 2017-04-04 Autonomic Technologies, Inc. Stimulation method for treatment of dermatological conditions
US20120323214A1 (en) * 2012-05-16 2012-12-20 Totada R Shantha Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis
CN104837413B (en) 2012-06-15 2018-09-11 C·R·巴德股份有限公司 Detect the device and method of removable cap on ultrasonic detector
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
WO2014087337A1 (en) 2012-12-06 2014-06-12 Bluewind Medical Ltd. Delivery of implantable neurostimulators
US9962533B2 (en) * 2013-02-14 2018-05-08 William Harrison Zurn Module for treatment of medical conditions; system for making module and methods of making module
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
US9717627B2 (en) 2013-03-12 2017-08-01 Oculeve, Inc. Implant delivery devices, systems, and methods
US8996137B2 (en) 2013-04-19 2015-03-31 Oculeve, Inc. Nasal stimulation devices and methods
AU2015203275B2 (en) * 2013-04-19 2017-04-13 Oculeve, Inc. Nasal stimulation devices and methods
US9731122B2 (en) 2013-04-29 2017-08-15 Rainbow Medical Ltd. Electroosmotic tissue treatment
US10065047B2 (en) 2013-05-20 2018-09-04 Nervive, Inc. Coordinating emergency treatment of cardiac dysfunction and non-cardiac neural dysfunction
EP2878335B1 (en) 2013-11-10 2018-01-03 Brainsgate Ltd. Implant and delivery system for neural stimulator
US9516995B2 (en) 2013-12-17 2016-12-13 Biovision Technologies, Llc Surgical device for performing a sphenopalatine ganglion block procedure
US9694163B2 (en) 2013-12-17 2017-07-04 Biovision Technologies, Llc Surgical device for performing a sphenopalatine ganglion block procedure
US10016580B2 (en) 2013-12-17 2018-07-10 Biovision Technologies, Llc Methods for treating sinus diseases
US9510743B2 (en) 2013-12-17 2016-12-06 Biovision Technologies, Llc Stabilized surgical device for performing a sphenopalatine ganglion block procedure
ES2811323T3 (en) 2014-02-06 2021-03-11 Bard Inc C R Systems for the guidance and placement of an intravascular device
US9770583B2 (en) 2014-02-25 2017-09-26 Oculeve, Inc. Polymer formulations for nasolacrimal stimulation
WO2016015025A1 (en) * 2014-07-25 2016-01-28 Oculeve, Inc. Stimulation patterns for treating dry eye
ES2809599T3 (en) * 2014-10-22 2021-03-04 Oculeve Inc Stimulation devices to treat dry eyes
US10207108B2 (en) 2014-10-22 2019-02-19 Oculeve, Inc. Implantable nasal stimulator systems and methods
US9764150B2 (en) 2014-10-22 2017-09-19 Oculeve, Inc. Contact lens for increasing tear production
EP3226819B1 (en) 2014-11-25 2018-10-24 New Phase Ltd. Phase-change nanoparticle
US10973584B2 (en) 2015-01-19 2021-04-13 Bard Access Systems, Inc. Device and method for vascular access
US10004896B2 (en) 2015-01-21 2018-06-26 Bluewind Medical Ltd. Anchors and implant devices
US9764146B2 (en) 2015-01-21 2017-09-19 Bluewind Medical Ltd. Extracorporeal implant controllers
US9597521B2 (en) 2015-01-21 2017-03-21 Bluewind Medical Ltd. Transmitting coils for neurostimulation
EP3093043B1 (en) 2015-05-13 2018-11-14 Brainsgate Ltd. Implant and delivery system for neural stimulator
US9782589B2 (en) 2015-06-10 2017-10-10 Bluewind Medical Ltd. Implantable electrostimulator for improving blood flow
EP3310433A1 (en) 2015-06-16 2018-04-25 The Regents of The University of Colorado, A Body Corporate Nasolacrimal implants and related methods for tear stimulation
WO2016210325A1 (en) 2015-06-26 2016-12-29 C.R. Bard, Inc. Connector interface for ecg-based catheter positioning system
US9616221B2 (en) 2015-07-08 2017-04-11 Rainbow Medical Ltd. Electrical treatment of Alzheimer's disease
US10898716B2 (en) 2015-10-29 2021-01-26 Rainbow Medical Ltd. Electrical substance clearance from the brain
US9724515B2 (en) 2015-10-29 2017-08-08 Rainbow Medical Ltd. Electrical substance clearance from the brain for treatment of Alzheimer's disease
US10105540B2 (en) 2015-11-09 2018-10-23 Bluewind Medical Ltd. Optimization of application of current
US9713707B2 (en) 2015-11-12 2017-07-25 Bluewind Medical Ltd. Inhibition of implant migration
US10426958B2 (en) 2015-12-04 2019-10-01 Oculeve, Inc. Intranasal stimulation for enhanced release of ocular mucins and other tear proteins
US9770591B2 (en) 2015-12-29 2017-09-26 Rainbow Medical Ltd. Disc therapy
US9950156B2 (en) 2016-09-13 2018-04-24 Rainbow Medical Ltd. Disc therapy
US10518085B2 (en) 2015-12-29 2019-12-31 Rainbow Medical Ltd. Disc therapy
US11484706B2 (en) 2015-12-29 2022-11-01 Discure Technologies Ltd Disc therapy
US11000207B2 (en) 2016-01-29 2021-05-11 C. R. Bard, Inc. Multiple coil system for tracking a medical device
US10252048B2 (en) 2016-02-19 2019-04-09 Oculeve, Inc. Nasal stimulation for rhinitis, nasal congestion, and ocular allergies
WO2017192572A1 (en) 2016-05-02 2017-11-09 Oculeve, Inc. Intranasal stimulation for treatment of meibomian gland disease and blepharitis
WO2018039602A1 (en) * 2016-08-26 2018-03-01 Wisconsin Alumni Research Foundation Neuromodulation to modulate glymphatic clearance
US20180104514A1 (en) * 2016-10-14 2018-04-19 Olympic Ophthalmics, Inc. Therapeutic ultrasound for eye disorder
US10124178B2 (en) 2016-11-23 2018-11-13 Bluewind Medical Ltd. Implant and delivery tool therefor
RU2019118600A (en) 2016-12-02 2021-01-11 Окулив, Инк. APPARATUS AND METHOD FOR MAKING DRY EYE SYNDROME PREDICTION AND TREATMENT RECOMMENDATIONS
US11123411B2 (en) * 2016-12-08 2021-09-21 Gary E. Borodic Method of treating macular degeneration using botulinum toxin-based pharmaceuticals
US11096993B2 (en) 2016-12-08 2021-08-24 Gary E. Borodic Method of treating macular degeneration using botulinum toxin-based pharmaceuticals
US10569086B2 (en) 2017-01-11 2020-02-25 Rainbow Medical Ltd. Electrical microglial cell activation
US10758722B2 (en) 2017-05-03 2020-09-01 Rainbow Medical Ltd. Electrical treatment of Parkinson's disease
US20180353764A1 (en) 2017-06-13 2018-12-13 Bluewind Medical Ltd. Antenna configuration
WO2019006161A1 (en) * 2017-06-28 2019-01-03 Ovid Therapeutics Inc. Treatment of developmental syndromes
WO2019023652A1 (en) * 2017-07-28 2019-01-31 Galvani Bioelectronics Limited Treatment of eye disorders
US20200368531A1 (en) * 2017-07-28 2020-11-26 Galvani Bioelectronics Limited Treatment of eye disorders
US11147736B2 (en) 2018-02-26 2021-10-19 Olympic Ophthalmics, Inc. Therapeutic handheld devices for disorders
WO2019175879A1 (en) 2018-03-14 2019-09-19 Rainbow Medical Ltd. Electrical substance clearance from the brain
WO2020005910A1 (en) 2018-06-28 2020-01-02 Sandler Scientific, Llc Sino-nasal rinse delivery device with agitation, flow-control and integrated medication management system
AU2019352954B2 (en) 2018-10-01 2022-03-10 Biovisics Medical, Inc. System and methods for controlled electrical modulation for vision therapy
US10992079B2 (en) 2018-10-16 2021-04-27 Bard Access Systems, Inc. Safety-equipped connection systems and methods thereof for establishing electrical connections
US11305118B2 (en) 2018-11-30 2022-04-19 Biovisics Medical, Inc. Head worn apparatuses for vision therapy
US11311454B2 (en) * 2019-03-28 2022-04-26 Softwave Tissue Regeneration Technologies, Llc Handheld acoustic shock wave or pressure pulse application device and methods of use
US11471680B2 (en) 2019-04-10 2022-10-18 Biovisics, Inc. Systems and interfaces for ocular therapy
US11511112B2 (en) 2019-06-14 2022-11-29 Biovisics Medical, Inc. Wearable medical device
US20210022948A1 (en) * 2019-07-22 2021-01-28 Ismail Mohammed Yousif Musallam Neuromodulation for treatment of retinal, choroidal and optic nerve disorders and/or dysregulated reduced ocular blood flow (obf)
US11123197B2 (en) 2019-09-03 2021-09-21 Rainbow Medical Ltd. Hydropneumatic artificial intervertebral disc
US10881858B1 (en) 2019-09-18 2021-01-05 Rainbow Medical Ltd. Electrical substance clearance from the brain
US11298530B1 (en) 2021-05-03 2022-04-12 Discure Technologies Ltd. Synergistic therapies for intervertebral disc degeneration
WO2023012516A2 (en) * 2021-08-05 2023-02-09 Insightec, Ltd. Compositions and methods related to blood-brain barrier penetration
US11344721B1 (en) 2021-08-16 2022-05-31 Rainbow Medical Ltd. Cartilage treatment
US11400299B1 (en) 2021-09-14 2022-08-02 Rainbow Medical Ltd. Flexible antenna for stimulator
WO2023076431A1 (en) * 2021-10-26 2023-05-04 David Pon Treatment of non-ocular diseases/disorders by delivery of electromagnetic energy to ocular tissue
US11413455B1 (en) 2022-02-08 2022-08-16 Rainbow Medical Ltd. Electrical treatment of Alzheimer's disease
CN116270636A (en) * 2023-03-13 2023-06-23 辛晓蓉 Retina function injury protecting medicine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6405079B1 (en) * 2000-09-22 2002-06-11 Mehdi M. Ansarinia Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions
US6526318B1 (en) * 2000-06-16 2003-02-25 Mehdi M. Ansarinia Stimulation method for the sphenopalatine ganglia, sphenopalatine nerve, or vidian nerve for treatment of medical conditions

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4152928A (en) 1977-05-02 1979-05-08 University Patents, Inc. System for detecting fat particles in blood
US4319580A (en) 1979-08-28 1982-03-16 The Board Of Regents Of The University Of Washington Method for detecting air emboli in the blood in an intracorporeal blood vessel
US4666829A (en) * 1985-05-15 1987-05-19 University Of California Polypeptide marker for Alzheimer's disease and its use for diagnosis
US5639853A (en) 1987-09-29 1997-06-17 Praxis Biologics, Inc. Respiratory syncytial virus vaccines
US5223254A (en) 1987-09-29 1993-06-29 Praxis Biologics, Inc. Respiratory syncytial virus: vaccines
US4886493A (en) 1987-10-22 1989-12-12 Jordan Yee Medical applicator process
US5011472A (en) * 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
WO1990006993A1 (en) * 1988-12-21 1990-06-28 The General Hospital Corporation Method of detecting neurological disease or dysfunction
US4979511A (en) 1989-11-03 1990-12-25 Cyberonics, Inc. Strain relief tether for implantable electrode
US5186170A (en) 1989-11-13 1993-02-16 Cyberonics, Inc. Simultaneous radio frequency and magnetic field microprocessor reset circuit
US5179950A (en) 1989-11-13 1993-01-19 Cyberonics, Inc. Implanted apparatus having micro processor controlled current and voltage sources with reduced voltage levels when not providing stimulation
US5235980A (en) 1989-11-13 1993-08-17 Cyberonics, Inc. Implanted apparatus disabling switching regulator operation to allow radio frequency signal reception
US5154172A (en) 1989-11-13 1992-10-13 Cyberonics, Inc. Constant current sources with programmable voltage source
JPH03247151A (en) * 1990-02-26 1991-11-05 Fujitsu Ltd Subscriber state display device
US5031618A (en) 1990-03-07 1991-07-16 Medtronic, Inc. Position-responsive neuro stimulator
US5263480A (en) 1991-02-01 1993-11-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5188104A (en) 1991-02-01 1993-02-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5269303A (en) 1991-02-22 1993-12-14 Cyberonics, Inc. Treatment of dementia by nerve stimulation
US5750542A (en) * 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US5299569A (en) 1991-05-03 1994-04-05 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5335657A (en) 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5215086A (en) 1991-05-03 1993-06-01 Cyberonics, Inc. Therapeutic treatment of migraine symptoms by stimulation
FR2677362B1 (en) 1991-06-04 1995-04-28 Centre Nat Rech Scient NEUROPEPTIDES OF THE TACHYKININ FAMILY.
US5205285A (en) 1991-06-14 1993-04-27 Cyberonics, Inc. Voice suppression of vagal stimulation
US5222494A (en) 1991-07-31 1993-06-29 Cyberonics, Inc. Implantable tissue stimulator output stabilization system
US5231988A (en) 1991-08-09 1993-08-03 Cyberonics, Inc. Treatment of endocrine disorders by nerve stimulation
US5215089A (en) 1991-10-21 1993-06-01 Cyberonics, Inc. Electrode assembly for nerve stimulation
EP0610330B1 (en) * 1991-10-25 1997-06-18 N.V. Innogenetics S.A. Monoclonal antibodies directed against the microtubule-associated protein tau
US5304206A (en) 1991-11-18 1994-04-19 Cyberonics, Inc. Activation techniques for implantable medical device
US5237991A (en) 1991-11-19 1993-08-24 Cyberonics, Inc. Implantable medical device with dummy load for pre-implant testing in sterile package and facilitating electrical lead connection
EP0909814B1 (en) * 1991-12-06 2008-02-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of protein kinases for the diagnosis and treatment of Alzheimer's disease
US5756071A (en) * 1992-06-03 1998-05-26 Arrowdean Limited Method for nasally administering aerosols of therapeutic agents to enhance penetration of the blood brain barrier
US5330515A (en) 1992-06-17 1994-07-19 Cyberonics, Inc. Treatment of pain by vagal afferent stimulation
US5531778A (en) 1994-09-20 1996-07-02 Cyberonics, Inc. Circumneural electrode assembly
US5571150A (en) 1994-12-19 1996-11-05 Cyberonics, Inc. Treatment of patients in coma by nerve stimulation
US5540730A (en) 1995-06-06 1996-07-30 Cyberonics, Inc. Treatment of motility disorders by nerve stimulation
US6061045A (en) * 1995-06-19 2000-05-09 Canon Kabushiki Kaisha Liquid crystal display apparatus and method of driving same
US5707400A (en) 1995-09-19 1998-01-13 Cyberonics, Inc. Treating refractory hypertension by nerve stimulation
US20020169485A1 (en) 1995-10-16 2002-11-14 Neuropace, Inc. Differential neurostimulation therapy driven by physiological context
US6480743B1 (en) 2000-04-05 2002-11-12 Neuropace, Inc. System and method for adaptive brain stimulation
US6678553B2 (en) 1995-11-21 2004-01-13 Intraabrain International Nv Device for enhanced delivery of biologically active substances and compounds in an organism
US5938690A (en) 1996-06-07 1999-08-17 Advanced Neuromodulation Systems, Inc. Pain management system and method
US5752515A (en) * 1996-08-21 1998-05-19 Brigham & Women's Hospital Methods and apparatus for image-guided ultrasound delivery of compounds through the blood-brain barrier
US6325475B1 (en) 1996-09-06 2001-12-04 Microfab Technologies Inc. Devices for presenting airborne materials to the nose
US7033598B2 (en) 1996-11-19 2006-04-25 Intrabrain International N.V. Methods and apparatus for enhanced and controlled delivery of a biologically active agent into the central nervous system of a mammal
US6913763B2 (en) 1996-11-19 2005-07-05 Intrabrain International Nv Method and device for enhanced delivery of a biologically active agent through the spinal spaces into the central nervous system of a mammal
US6410046B1 (en) 1996-11-19 2002-06-25 Intrabrain International Nv Administering pharmaceuticals to the mammalian central nervous system
US6211235B1 (en) * 1996-11-22 2001-04-03 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
US7452538B2 (en) * 1997-01-28 2008-11-18 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
US20040136951A1 (en) * 1997-03-17 2004-07-15 Human Genome Sciences, Inc. Death domain containing receptor 5
US5855907A (en) 1997-03-24 1999-01-05 Peyman; Gholam A. Method of treatment of migraine
US6432986B2 (en) 1997-07-21 2002-08-13 Bruce H. Levin Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches
US20010004644A1 (en) 1997-07-21 2001-06-21 Levin Bruce H. Compositions, kits, apparatus, and methods for inhibiting cephalic inflammation
US7799337B2 (en) * 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US6342350B1 (en) * 1997-09-05 2002-01-29 The General Hospital Corporation Alpha-2-macroglobulin diagnostic test
ATE223058T1 (en) * 1997-09-19 2002-09-15 Evotec Ag METHOD FOR MEASURING THE ASSOCIATION OF PARTIAL STRUCTURES OF PATHOLOGICAL PROTEIN DEPOSITS
US6647296B2 (en) 1997-10-27 2003-11-11 Neuropace, Inc. Implantable apparatus for treating neurological disorders
US6230049B1 (en) 1999-08-13 2001-05-08 Neuro Pace, Inc. Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes
US6597954B1 (en) * 1997-10-27 2003-07-22 Neuropace, Inc. System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes
US6459936B2 (en) 1997-10-27 2002-10-01 Neuropace, Inc. Methods for responsively treating neurological disorders
US6016449A (en) 1997-10-27 2000-01-18 Neuropace, Inc. System for treatment of neurological disorders
US6354299B1 (en) 1997-10-27 2002-03-12 Neuropace, Inc. Implantable device for patient communication
US6427086B1 (en) 1997-10-27 2002-07-30 Neuropace, Inc. Means and method for the intracranial placement of a neurostimulator
US6358681B2 (en) * 1998-10-30 2002-03-19 The Trustees Of The University Of Pennsylvania Diagnostic methods for alzheimer's disease by detection of multiple mRNAs
US20020019412A1 (en) * 1998-03-12 2002-02-14 Henrik Sune Andersen Modulators of protein tyrosine phosphatases (ptpases)
GB2335858A (en) 1998-04-03 1999-10-06 Gyrus Medical Ltd Resectoscope having pivoting electrode assembly
HUP0101627A3 (en) * 1998-04-14 2003-02-28 Gen Hospital Corp Boston Pharmaceutical compositions for treating neuropsychiatric disorders
US5938689A (en) 1998-05-01 1999-08-17 Neuropace, Inc. Electrode configuration for a brain neuropacemaker
US6006124A (en) 1998-05-01 1999-12-21 Neuropace, Inc. Means and method for the placement of brain electrodes
US5928272A (en) 1998-05-02 1999-07-27 Cyberonics, Inc. Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity
CA2269432C (en) * 1998-06-01 2002-04-02 Hyman M. Schipper Ho-1 as a diagnostic and prognostic test for dementing diseases
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
US6251863B1 (en) * 1998-09-08 2001-06-26 Samuel K. Yue Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin
US6277979B1 (en) * 1998-09-10 2001-08-21 Smithkline Beecham Plc KIAA0551 polynucleotides and polypeptides use
AU2862200A (en) 1999-01-27 2000-08-18 Bruce H. Levin Compositions, kits, apparatus, and methods for inhibiting cerebral neurovasculardisorders and muscular headaches
US6087118A (en) * 1999-03-04 2000-07-11 Bristol-Myers Squibb Company Method for diagnosing alzheimer's disease
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
US6338715B1 (en) 1999-03-31 2002-01-15 Microfab Technologies, Inc. Digital olfactometer and method for testing olfactory thresholds
US6161045A (en) 1999-06-01 2000-12-12 Neuropace, Inc. Method for determining stimulation parameters for the treatment of epileptic seizures
US20020002270A1 (en) * 1999-06-16 2002-01-03 Raymond P. Zinkowski Purified antigen for alzheimer's disease, and methods of obtaining and using same
US6587719B1 (en) 1999-07-01 2003-07-01 Cyberonics, Inc. Treatment of obesity by bilateral vagus nerve stimulation
US20020052311A1 (en) * 1999-09-03 2002-05-02 Beka Solomon Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders
US6473644B1 (en) 1999-10-13 2002-10-29 Cyberonics, Inc. Method to enhance cardiac capillary growth in heart failure patients
US6811788B2 (en) 2000-01-19 2004-11-02 Baofa Yu Combinations and methods for treating neoplasms
US7927612B2 (en) * 2000-01-19 2011-04-19 Baofa Yu Combinations and methods for treating neoplasms
AU2001236592A1 (en) * 2000-02-03 2001-08-14 Ortho-Mcneil Pharmaceutical, Inc. Methods for diagnosis of alzheimer's disease
US6525044B2 (en) * 2000-02-17 2003-02-25 Bristol-Myers Squibb Company Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
US6277841B1 (en) 2000-03-02 2001-08-21 Mallinckrodt Inc. Quinoline ligands and metal complexes for diagnosis and therapy
US6473639B1 (en) 2000-03-02 2002-10-29 Neuropace, Inc. Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures
US20020026652A1 (en) 2000-03-22 2002-02-28 Allen Keith D. Transgenic mice containing cGMP phosphodiesterase gene disruptions
US6466822B1 (en) 2000-04-05 2002-10-15 Neuropace, Inc. Multimodal neurostimulator and process of using it
JP2003530115A (en) * 2000-04-07 2003-10-14 アクソニックス，インコーポレイティド Diagnostic test for Alzheimer's disease
EP1289966A1 (en) * 2000-04-11 2003-03-12 Bristol-Myers Squibb Pharma Company SUBSTITUTED LACTAMS AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION
US6353754B1 (en) 2000-04-24 2002-03-05 Neuropace, Inc. System for the creation of patient specific templates for epileptiform activity detection
US7146209B2 (en) * 2000-05-08 2006-12-05 Brainsgate, Ltd. Stimulation for treating eye pathologies
AU5662001A (en) * 2000-05-08 2001-11-20 Brainsgate Ltd. Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow
US6853858B2 (en) 2000-05-08 2005-02-08 Brainsgate, Ltd. Administration of anti-inflammatory drugs into the central nervous system
US20020169307A1 (en) 2000-06-21 2002-11-14 Robert Klein Transgenic mice containing LPR5 gene disruptions
DE60141752D1 (en) * 2000-06-30 2010-05-20 Innogenetics Nv DIFFERENTIAL DIAGNOSIS OF NEUROLOGICAL DISEASES
US6432944B1 (en) * 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
US20020040032A1 (en) * 2000-07-07 2002-04-04 Glasky Michelle S. Methods for stimulation of synthesis of synaptophysin in the central nervous system
US20020009445A1 (en) * 2000-07-12 2002-01-24 Yansheng Du Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease
US6545019B2 (en) * 2000-07-13 2003-04-08 Bristol-Myers Squibb Company Method of modulating microglial activation for the treatment of acute and chronic neurodegenerative disorders
US6514969B2 (en) * 2000-08-16 2003-02-04 Boehringer Ingelheim Pharma Kg β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions
JP4633897B2 (en) * 2000-08-17 2011-02-16 長瀬産業株式会社 Neurite outgrowth agent
US6591138B1 (en) 2000-08-31 2003-07-08 Neuropace, Inc. Low frequency neurostimulator for the treatment of neurological disorders
WO2002042735A2 (en) 2000-10-30 2002-05-30 Vanderbuilt University Human kcr1 regulation of herg potassium channel block
US6591137B1 (en) 2000-11-09 2003-07-08 Neuropace, Inc. Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders
US6529774B1 (en) 2000-11-09 2003-03-04 Neuropace, Inc. Extradural leads, neurostimulator assemblies, and processes of using them for somatosensory and brain stimulation
US6618623B1 (en) 2000-11-28 2003-09-09 Neuropace, Inc. Ferrule for cranial implant
IT1320847B1 (en) 2000-11-28 2003-12-10 Bottero Spa METHOD AND MACHINE FOR THE GRINDING OF COATED GLASS SHEETS.
US6753605B2 (en) * 2000-12-04 2004-06-22 Fairchild Semiconductor Corporation Passivation scheme for bumped wafers
US20030106083A1 (en) * 2000-12-06 2003-06-05 Allen Keith D. Transgenic mice containing RPTPB tyrosine phosphatase gene disruptions
WO2002064791A2 (en) * 2000-12-08 2002-08-22 Curagen Corporation Proteins and nucleic acids encoding same
US20020133841A1 (en) 2000-12-11 2002-09-19 Leviten Michael W. Transgenic mice containing huntingtin interacting protein gene disruptions
US6609025B2 (en) 2001-01-02 2003-08-19 Cyberonics, Inc. Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation
US6788975B1 (en) 2001-01-30 2004-09-07 Advanced Bionics Corporation Fully implantable miniature neurostimulator for stimulation as a therapy for epilepsy
US6735475B1 (en) 2001-01-30 2004-05-11 Advanced Bionics Corporation Fully implantable miniature neurostimulator for stimulation as a therapy for headache and/or facial pain
US6597953B2 (en) 2001-02-20 2003-07-22 Neuropace, Inc. Furcated sensing and stimulation lead
US20030005473A1 (en) 2001-03-29 2003-01-02 Brennan Thomas J. OGR1 gene disruptions, compositions and methods relating thereto
US20030018989A1 (en) * 2001-03-29 2003-01-23 Brennan Thomas J. Transgenic mice containing GPCR5-1 gene disruptions
AU2002255979A1 (en) 2001-03-29 2002-10-15 Deltagen, Inc. Transgenic mice containing beta3galt2 gene disruptions
US20030018988A1 (en) * 2001-03-29 2003-01-23 Allen Keith D. Transgenic mice containing mGluR7 metabotropic glutamate receptor gene disruptions
US20030014772A1 (en) * 2001-03-29 2003-01-16 Allen Keith D. Transgenic mice containing MSK2 serine/threonine kinase gene disruptions
US6535754B2 (en) * 2001-03-30 2003-03-18 The United States Of America As Represented By The Department Of Health And Human Services Lever coil sensor for respiratory and cardiac motion
US20030194798A1 (en) * 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
US20030166099A1 (en) * 2001-06-05 2003-09-04 Sabbadini Roger A. Minicells comprising membrane proteins
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7030291B2 (en) * 2001-06-26 2006-04-18 Deltagen, Inc. CYT28 serpentine receptor disruptions, compositions and methods relating thereto
US20030056238A1 (en) * 2001-06-26 2003-03-20 Wisotzkey Robert G. GABA B1A receptor disruptions, compositions and methods relating thereto
US6810285B2 (en) 2001-06-28 2004-10-26 Neuropace, Inc. Seizure sensing and detection using an implantable device
US6606521B2 (en) 2001-07-09 2003-08-12 Neuropace, Inc. Implantable medical lead
US6622047B2 (en) 2001-07-28 2003-09-16 Cyberonics, Inc. Treatment of neuropsychiatric disorders by near-diaphragmatic nerve stimulation
US6622038B2 (en) 2001-07-28 2003-09-16 Cyberonics, Inc. Treatment of movement disorders by near-diaphragmatic nerve stimulation
EP1420800B1 (en) * 2001-08-02 2011-09-28 Howard Florey Institute Of Experimental Physiology And Medicine Modulation of insulin-regulated aminopeptidase (irap)/angiotensin iv (at 4) receptor activity
US6622041B2 (en) 2001-08-21 2003-09-16 Cyberonics, Inc. Treatment of congestive heart failure and autonomic cardiovascular drive disorders
US6662035B2 (en) 2001-09-13 2003-12-09 Neuropace, Inc. Implantable lead connector assembly for implantable devices and methods of using it
US20030131367A1 (en) * 2001-09-24 2003-07-10 Catherine Guenther Kv3.3b potassium channel disruptions, compositions and methods related thereto
US20030172390A1 (en) * 2001-09-24 2003-09-11 Wisotzkey Robert G. Mo54 gene disruptions, compositions and methods related thereto
US7136695B2 (en) * 2001-10-12 2006-11-14 Pless Benjamin D Patient-specific template development for neurological event detection
US7998080B2 (en) * 2002-01-15 2011-08-16 Orsan Medical Technologies Ltd. Method for monitoring blood flow to brain
US20030144711A1 (en) * 2002-01-29 2003-07-31 Neuropace, Inc. Systems and methods for interacting with an implantable medical device
JP2005515819A (en) * 2002-02-01 2005-06-02 ザ クリーブランド クリニック ファウンデイション A transmission device that stimulates the sympathetic nerve chain
US7110820B2 (en) * 2002-02-05 2006-09-19 Tcheng Thomas K Responsive electrical stimulation for movement disorders
US7277748B2 (en) * 2002-09-13 2007-10-02 Neuropace, Inc. Spatiotemporal pattern recognition for neurological event detection and prediction in an implantable device
US20050074506A1 (en) * 2003-10-02 2005-04-07 Brainsgate Ltd. Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders
US8060207B2 (en) * 2003-12-22 2011-11-15 Boston Scientific Scimed, Inc. Method of intravascularly delivering stimulation leads into direct contact with tissue
US20050137646A1 (en) * 2003-12-22 2005-06-23 Scimed Life Systems, Inc. Method of intravascularly delivering stimulation leads into brain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6526318B1 (en) * 2000-06-16 2003-02-25 Mehdi M. Ansarinia Stimulation method for the sphenopalatine ganglia, sphenopalatine nerve, or vidian nerve for treatment of medical conditions
US6405079B1 (en) * 2000-09-22 2002-06-11 Mehdi M. Ansarinia Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8406869B2 (en) 2005-08-19 2013-03-26 Brainsgate, Ltd. Post-acute electrical stimulation treatment of adverse cerebrovascular events
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation

Also Published As

Publication number Publication date
AU2003279514A1 (en) 2004-06-03
US20030176898A1 (en) 2003-09-18
AU2003279514A8 (en) 2004-06-03
WO2004043217A2 (en) 2004-05-27
US7146209B2 (en) 2006-12-05
US20050159790A1 (en) 2005-07-21

Similar Documents

Publication Publication Date Title
WO2004043217A3 (en) Stimulation for treating eye pathologies
WO2004045242A3 (en) Stimulation for treating ear pathologies
JP2020192343A5 (en)
WO2004028624A3 (en) Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders
US10286213B2 (en) Neurostimulator system, apparatus, and method
US20160001079A1 (en) Neurostimulator system, apparatus and method for conducting a clinical trial
GB2380414A (en) Stimulation method for the sphenopalatine ganglia,sphenopalatine nerve,or vidian nerve for treatment of medical conditions
ATE507872T1 (en) DEVICE FOR TREATING EPILEPSY AND RHYTHM DISORDERS
WO2004103455A3 (en) Selective nerve fiber stimulation for heart treatment
EP1308181A3 (en) Vestibular stimulation system and method
US20140277323A1 (en) Oral neural stimulator
WO2008088469A3 (en) Device for multicentric brain modulation, repair and interface
WO2005002664A3 (en) Methods and apparatus for effectuating a lasting change in a neural-function of a patient
WO2003011392A3 (en) Treatment of neuropsychiatric disorders by near-diaphragmatic nerve stimulation
WO2004069331B1 (en) Neural stimulation
WO2002047757A3 (en) System and method for providing recovery from muscle denervation
ATE408432T1 (en) EXTRAOCULAR DEVICE
WO2006061805A3 (en) Electrode system for transcutaneous nerve and/or muscle stimulation
CN109310858B (en) Electrical stimulation device for the innervation of the external auditory meatus
US9604057B2 (en) Stimulation method for a sphenopalatine ganglion, sphenopalatine nerve, vidian nerve, or branch thereof for treatment of medical conditions
US20020161416A1 (en) Nerves and muscle stimulator
KR101910732B1 (en) Treatment Device for Globus pharyngeus Using Electrostimulation
US20220370786A1 (en) Medical treatment device and method of operation thereof
KR101744673B1 (en) Gibs attached electrical stimulation device and electrical stimulation methods using the same
CA3189795A1 (en) Transcranial alternating current dynamic frequency stimulation (tacs) system and method for alzheimers and dementia

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP