WO2004043386A3 - Molecules preferentially associated with effector t cells and methods of their use - Google Patents
Molecules preferentially associated with effector t cells and methods of their use Download PDFInfo
- Publication number
- WO2004043386A3 WO2004043386A3 PCT/US2003/035719 US0335719W WO2004043386A3 WO 2004043386 A3 WO2004043386 A3 WO 2004043386A3 US 0335719 W US0335719 W US 0335719W WO 2004043386 A3 WO2004043386 A3 WO 2004043386A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- effector
- cell function
- cells
- protein kinase
- theta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002505546A CA2505546A1 (en) | 2002-11-08 | 2003-11-10 | Molecules preferentially associated with effector t cells and methods of their use |
JP2005507126A JP2006508191A (en) | 2002-11-08 | 2003-11-10 | Molecules preferentially associated with effector T cells and uses thereof |
EP03783270A EP1565218A2 (en) | 2002-11-08 | 2003-11-10 | Molecules preferentially associated with effector t cells and methods of their use |
AU2003290688A AU2003290688B8 (en) | 2002-11-08 | 2003-11-10 | Molecules preferentially associated with effector T cells and methods of their use |
AU2008202955A AU2008202955A1 (en) | 2002-11-08 | 2008-07-03 | Molecules perferentially associated with effector T cells and methods of their use |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42477702P | 2002-11-08 | 2002-11-08 | |
US60/424,777 | 2002-11-08 | ||
US46747703P | 2003-05-02 | 2003-05-02 | |
US60/467,477 | 2003-05-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004043386A2 WO2004043386A2 (en) | 2004-05-27 |
WO2004043386A3 true WO2004043386A3 (en) | 2004-10-28 |
Family
ID=32314555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/035719 WO2004043386A2 (en) | 2002-11-08 | 2003-11-10 | Molecules preferentially associated with effector t cells and methods of their use |
Country Status (6)
Country | Link |
---|---|
US (1) | US20040166099A1 (en) |
EP (1) | EP1565218A2 (en) |
JP (1) | JP2006508191A (en) |
AU (2) | AU2003290688B8 (en) |
CA (1) | CA2505546A1 (en) |
WO (1) | WO2004043386A2 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004078948A2 (en) * | 2003-03-04 | 2004-09-16 | National Jewish Medical And Research Center | METHOD TO IDENTIFY REGULATORS OF CELLULAR ACTIVATION USING Bcl10 |
WO2005037868A2 (en) * | 2003-10-16 | 2005-04-28 | Case Western Reserve University | Methods of treating nfat-related disorders |
US7884109B2 (en) | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
US7989459B2 (en) | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
WO2008013918A2 (en) * | 2006-07-26 | 2008-01-31 | Myelin Repair Foundation, Inc. | Cell cycle regulation and differentiation |
TW200831104A (en) | 2006-10-04 | 2008-08-01 | Pharmacopeia Inc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
AR063141A1 (en) | 2006-10-04 | 2008-12-30 | Pharmacopeia Inc | DERIVATIVES OF 2- (BENZIMIDAZOLIL) PURINA 8- REPLACED FOR IMMUNOSUPPRESSION |
US7902187B2 (en) | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
WO2008043157A1 (en) | 2006-10-12 | 2008-04-17 | The University Of Queensland | Compositions and methods for modulating immune responses |
WO2010090875A1 (en) | 2009-01-21 | 2010-08-12 | Rigel Pharmaceuticals, Inc. | Derivatives of n2-(3-pyridil or phenyl)-n4-(4-piperidyl)-2,4-pyrimidinediamine useful in the treatment of inflammatory, autoimmune or proliferative diseases |
WO2010126967A1 (en) * | 2009-04-28 | 2010-11-04 | Boehringer Ingelheim International Gmbh | Ex-vivo treatment of immunological disorders with pkc-theta inhibitors |
CA2780759A1 (en) | 2009-12-01 | 2011-06-09 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
US20110142814A1 (en) * | 2009-12-16 | 2011-06-16 | New York University | Methods for Using Protein Kinase C-Theta Inhibitors in Adoptive Immunotherapy |
US8710223B2 (en) | 2010-07-21 | 2014-04-29 | Rigel Pharmaceuticals, Inc. | Protein kinase C inhibitors and uses thereof |
WO2013060328A1 (en) * | 2011-10-26 | 2013-05-02 | Herlev Hospital | Ikb based immunotherapy |
US9645151B2 (en) | 2012-08-17 | 2017-05-09 | California Institute Of Technology | Targeting phosphofructokinase and its glycosylation form for cancer |
JP6357167B2 (en) | 2012-12-04 | 2018-07-11 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Protein kinase C inhibitors and uses thereof |
US9169249B2 (en) | 2013-03-14 | 2015-10-27 | Rigel Pharmaceuticals, Inc. | Protein kinase C inhibitors and uses thereof |
US10227370B2 (en) | 2013-08-02 | 2019-03-12 | California Institute Of Technology | Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity |
US9770461B2 (en) | 2013-08-02 | 2017-09-26 | California Institute Of Technology | Tailored glycopolymers as anticoagulant heparin mimetics |
AU2018363880B2 (en) * | 2017-11-08 | 2022-04-07 | Epiaxis Therapeutics Pty Ltd | Immunogenic compositions and uses therefor |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6040152A (en) * | 1996-12-31 | 2000-03-21 | National Jewish Medical And Research Center | Method and assay for regulation of T cell proliferation |
WO2000036083A2 (en) * | 1998-12-17 | 2000-06-22 | La Jolla Institute For Allergy And Immunology | Pkc-interacting cousin of trx (picot) polypeptides, polynucleotides, and methods of making and using them |
US6190869B1 (en) * | 1999-10-26 | 2001-02-20 | Isis Pharmaceuticals, Inc. | Antisense inhibition of protein kinase C-theta expression |
US20020068271A1 (en) * | 1999-12-27 | 2002-06-06 | Amnon Altman | Methods for identifying agents capable of modulating protein kinase C theta (PKC0) activity |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5776716A (en) * | 1994-02-01 | 1998-07-07 | Terrapin Technologies, Inc. | Methods for identifying agents which block the interaction of fyn with PKC-theta, and uses thereof |
-
2003
- 2003-11-10 US US10/704,921 patent/US20040166099A1/en not_active Abandoned
- 2003-11-10 JP JP2005507126A patent/JP2006508191A/en active Pending
- 2003-11-10 AU AU2003290688A patent/AU2003290688B8/en not_active Ceased
- 2003-11-10 CA CA002505546A patent/CA2505546A1/en not_active Abandoned
- 2003-11-10 EP EP03783270A patent/EP1565218A2/en not_active Withdrawn
- 2003-11-10 WO PCT/US2003/035719 patent/WO2004043386A2/en active Application Filing
-
2008
- 2008-07-03 AU AU2008202955A patent/AU2008202955A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6040152A (en) * | 1996-12-31 | 2000-03-21 | National Jewish Medical And Research Center | Method and assay for regulation of T cell proliferation |
WO2000036083A2 (en) * | 1998-12-17 | 2000-06-22 | La Jolla Institute For Allergy And Immunology | Pkc-interacting cousin of trx (picot) polypeptides, polynucleotides, and methods of making and using them |
US6190869B1 (en) * | 1999-10-26 | 2001-02-20 | Isis Pharmaceuticals, Inc. | Antisense inhibition of protein kinase C-theta expression |
US20020068271A1 (en) * | 1999-12-27 | 2002-06-06 | Amnon Altman | Methods for identifying agents capable of modulating protein kinase C theta (PKC0) activity |
Also Published As
Publication number | Publication date |
---|---|
AU2003290688B2 (en) | 2008-04-03 |
AU2003290688A1 (en) | 2004-06-03 |
US20040166099A1 (en) | 2004-08-26 |
CA2505546A1 (en) | 2004-05-27 |
WO2004043386A2 (en) | 2004-05-27 |
AU2008202955A1 (en) | 2008-07-31 |
AU2003290688B8 (en) | 2008-04-24 |
JP2006508191A (en) | 2006-03-09 |
EP1565218A2 (en) | 2005-08-24 |
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