WO2004045372A3 - Cohesive demineralized bone compositions - Google Patents

Cohesive demineralized bone compositions Download PDF

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Publication number
WO2004045372A3
WO2004045372A3 PCT/US2003/036393 US0336393W WO2004045372A3 WO 2004045372 A3 WO2004045372 A3 WO 2004045372A3 US 0336393 W US0336393 W US 0336393W WO 2004045372 A3 WO2004045372 A3 WO 2004045372A3
Authority
WO
WIPO (PCT)
Prior art keywords
demineralized bone
bone matrix
matrix fibers
bone compositions
cohesive
Prior art date
Application number
PCT/US2003/036393
Other languages
French (fr)
Other versions
WO2004045372A2 (en
Inventor
Aron D Rosenberg
De Pelichy Laurent Gilles
Original Assignee
Etex Corp
Aron D Rosenberg
De Pelichy Laurent Gilles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Etex Corp, Aron D Rosenberg, De Pelichy Laurent Gilles filed Critical Etex Corp
Priority to KR1020057008746A priority Critical patent/KR101087897B1/en
Priority to JP2004553668A priority patent/JP4628791B2/en
Priority to EP03783469A priority patent/EP1567044A4/en
Priority to AU2003290884A priority patent/AU2003290884B2/en
Priority to CA002505737A priority patent/CA2505737A1/en
Priority to NZ540143A priority patent/NZ540143A/en
Publication of WO2004045372A2 publication Critical patent/WO2004045372A2/en
Publication of WO2004045372A3 publication Critical patent/WO2004045372A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3616—Blood, e.g. platelet-rich plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4645—Devices for grinding or milling bone material

Abstract

Demineralized bone matrix fibers and a demineralized bone matrix composition are provided. The demineralized bone matrix fibers have an average fiber length in the range from about 250 µm to about 2 mm and an aspect ratio of greater than about 4. The demineralized bone matrix composition includes demineralized bone matrix fibers and a biocompatible liquid in an amount to produce a coherent, formable mass. The formable mass retains its cohesiveness when immersed in a liquid. Methods for making the demineralized bone matrix fibers and composition are also provided.
PCT/US2003/036393 2002-11-15 2003-11-14 Cohesive demineralized bone compositions WO2004045372A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1020057008746A KR101087897B1 (en) 2002-11-15 2003-11-14 Cohesive demineralized bone compositions
JP2004553668A JP4628791B2 (en) 2002-11-15 2003-11-14 Agglomerated demineralized bone composition
EP03783469A EP1567044A4 (en) 2002-11-15 2003-11-14 Cohesive demineralized bone compositions
AU2003290884A AU2003290884B2 (en) 2002-11-15 2003-11-14 Cohesive demineralized bone compositions
CA002505737A CA2505737A1 (en) 2002-11-15 2003-11-14 Cohesive demineralized bone compositions
NZ540143A NZ540143A (en) 2002-11-15 2003-11-14 Cohesive demineralized bone compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/298,112 2002-11-15
US10/298,112 US7582309B2 (en) 2002-11-15 2002-11-15 Cohesive demineralized bone compositions

Publications (2)

Publication Number Publication Date
WO2004045372A2 WO2004045372A2 (en) 2004-06-03
WO2004045372A3 true WO2004045372A3 (en) 2004-07-08

Family

ID=32297357

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/036393 WO2004045372A2 (en) 2002-11-15 2003-11-14 Cohesive demineralized bone compositions

Country Status (8)

Country Link
US (1) US7582309B2 (en)
EP (1) EP1567044A4 (en)
JP (1) JP4628791B2 (en)
KR (1) KR101087897B1 (en)
AU (1) AU2003290884B2 (en)
CA (1) CA2505737A1 (en)
NZ (1) NZ540143A (en)
WO (1) WO2004045372A2 (en)

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KR20050075416A (en) 2005-07-20
US7582309B2 (en) 2009-09-01
US20040097612A1 (en) 2004-05-20
NZ540143A (en) 2008-04-30
JP4628791B2 (en) 2011-02-09
EP1567044A2 (en) 2005-08-31
CA2505737A1 (en) 2004-06-03
AU2003290884B2 (en) 2009-06-11
AU2003290884A1 (en) 2004-06-15
KR101087897B1 (en) 2011-11-30
WO2004045372A2 (en) 2004-06-03
JP2006508715A (en) 2006-03-16
EP1567044A4 (en) 2009-12-09

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