WO2004055491A8 - Novel method for sequence determination using nmr - Google Patents

Novel method for sequence determination using nmr Download PDF

Info

Publication number
WO2004055491A8
WO2004055491A8 PCT/US2003/015850 US0315850W WO2004055491A8 WO 2004055491 A8 WO2004055491 A8 WO 2004055491A8 US 0315850 W US0315850 W US 0315850W WO 2004055491 A8 WO2004055491 A8 WO 2004055491A8
Authority
WO
WIPO (PCT)
Prior art keywords
nmr
novel method
sequence determination
polysaccharides
methods
Prior art date
Application number
PCT/US2003/015850
Other languages
French (fr)
Other versions
WO2004055491A2 (en
WO2004055491A3 (en
Inventor
Ram Sasisekharan
Ganesh Venkataraman
Rahul Raman
Benito Casu
Giangiacomo Torri
Marco Guerrini
Original Assignee
Massachusetts Inst Technology
Istituto G Ronzoni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Istituto G Ronzoni filed Critical Massachusetts Inst Technology
Priority to EP03810037A priority Critical patent/EP1590648A4/en
Priority to AU2003302219A priority patent/AU2003302219B8/en
Priority to CA2486456A priority patent/CA2486456C/en
Priority to JP2004560266A priority patent/JP4657726B2/en
Publication of WO2004055491A2 publication Critical patent/WO2004055491A2/en
Publication of WO2004055491A3 publication Critical patent/WO2004055491A3/en
Publication of WO2004055491A8 publication Critical patent/WO2004055491A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Abstract

The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived (figure 1). Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis (figures 2 & 3).
PCT/US2003/015850 2002-05-20 2003-05-20 Novel method for sequence determination using nmr WO2004055491A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03810037A EP1590648A4 (en) 2002-05-20 2003-05-20 Novel method for sequence determination using nmr
AU2003302219A AU2003302219B8 (en) 2002-05-20 2003-05-20 Novel method for sequence determination using NMR
CA2486456A CA2486456C (en) 2002-05-20 2003-05-20 Method for sequence determination using nmr
JP2004560266A JP4657726B2 (en) 2002-05-20 2003-05-20 A novel method for sequencing using NMR

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38194002P 2002-05-20 2002-05-20
US60/381,940 2002-05-20

Publications (3)

Publication Number Publication Date
WO2004055491A2 WO2004055491A2 (en) 2004-07-01
WO2004055491A3 WO2004055491A3 (en) 2007-04-05
WO2004055491A8 true WO2004055491A8 (en) 2007-05-18

Family

ID=32595013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/015850 WO2004055491A2 (en) 2002-05-20 2003-05-20 Novel method for sequence determination using nmr

Country Status (6)

Country Link
US (4) US7508206B2 (en)
EP (1) EP1590648A4 (en)
JP (2) JP4657726B2 (en)
AU (1) AU2003302219B8 (en)
CA (1) CA2486456C (en)
WO (1) WO2004055491A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012726A2 (en) * 1998-08-27 2000-03-09 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase i and ii
EP1190364A2 (en) * 1999-04-23 2002-03-27 Massachusetts Institute Of Technology System and method for polymer notation
WO2001066772A2 (en) * 2000-03-08 2001-09-13 Massachusetts Institute Of Technology Heparinase iii and uses thereof
ATE426805T1 (en) 2000-09-12 2009-04-15 Massachusetts Inst Technology METHODS AND PRODUCTS ASSOCIATED WITH LOW MOLECULAR HEPARIN
EP1328260A2 (en) * 2000-10-18 2003-07-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
CA2484604C (en) * 2002-05-03 2011-08-02 Massachusetts Institute Of Technology .delta. 4,5 glycuronidase and uses thereof
EP1590648A4 (en) 2002-05-20 2007-04-18 Massachusetts Inst Technology Novel method for sequence determination using nmr
AU2003243396A1 (en) * 2002-06-03 2003-12-19 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from chondroitinase b
JP4606712B2 (en) * 2003-01-08 2011-01-05 マサチューセッツ インスティテュート オブ テクノロジー 2-O sulfatase compositions and related methods
EP1737954A2 (en) 2004-03-10 2007-01-03 The Massachusetts Institute Of Technology Recombinant chondroitinase abc i and uses thereof
US20060127950A1 (en) 2004-04-15 2006-06-15 Massachusetts Institute Of Technology Methods and products related to the improved analysis of carbohydrates
WO2005111627A2 (en) * 2004-04-15 2005-11-24 Massachusetts Institute Of Technology Methods and products related to the improved analysis of carbohydrates
EP1768687A2 (en) * 2004-06-29 2007-04-04 Massachusetts Institute Of Technology Methods and compositions related to the modulation of intercellular junctions
WO2006083328A2 (en) * 2004-09-15 2006-08-10 Massachusetts Institute Of Technology Biologically active surfaces and methods of their use
US7767420B2 (en) 2005-11-03 2010-08-03 Momenta Pharmaceuticals, Inc. Heparan sulfate glycosaminoglycan lyase and uses thereof
US20080071148A1 (en) * 2006-04-03 2008-03-20 Massachusetts Institute Of Technology Glycomic patterns for the detection of disease
JP2010515434A (en) 2007-01-05 2010-05-13 マサチューセッツ インスティテュート オブ テクノロジー Compositions and methods using sulfatase from Flavobacterium heparinum
CN102206690A (en) * 2011-03-13 2011-10-05 广元市海鹏生物科技有限公司 Preparation method of heparin oligosaccharides
CN106093379A (en) * 2016-06-08 2016-11-09 中国科学院广州生物医药与健康研究院 A kind of semicarbazides derivatization reagent and rapid detection card thereof
EP3273239A1 (en) 2016-07-19 2018-01-24 Laboratorios Farmacéuticos Rovi, S.A. Procedure of analysis of glycosaminoglycans, heparins and their derivatives by nuclear magnetic resonance
CN110376235B (en) * 2019-07-18 2020-09-15 浙江大学 Space correlation spectrum testing method of cephalomannine based on nuclear magnetic resonance technology
WO2022115339A1 (en) * 2020-11-24 2022-06-02 The Johns Hopkins University Magnetic resonance imaging of glycogen and other polysaccharides by magnetic coupling with water

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962699A (en) * 1974-07-15 1976-06-08 Brunson Raymond D Switch closure responsive logic signal generation means
US5284558A (en) * 1990-07-27 1994-02-08 University Of Iowa Research Foundation Electrophoresis-based sequencing of oligosaccharides
US5667984A (en) * 1991-05-07 1997-09-16 Oxford Glycosystems Ltd. Sequencing of oligosaccharides
US7339604B1 (en) * 1992-02-19 2008-03-04 8X8, Inc. Videoconferencing arrangement having multi-purpose digital still camera
US5607859A (en) 1994-03-28 1997-03-04 Massachusetts Institute Of Technology Methods and products for mass spectrometric molecular weight determination of polyionic analytes employing polyionic reagents
US6217863B1 (en) * 1995-10-30 2001-04-17 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase I
ATE406437T1 (en) * 1996-08-30 2008-09-15 Pasteur Institut METHOD FOR IDENTIFYING ANTIFUNGIC MOLECULES ACTING ON GLUCANOSYL TRANSFERASE ACTIVITY
TW557327B (en) * 1996-11-08 2003-10-11 Hayashibara Biochem Lab Kojibiose phosphorylase, its preparation and uses
US6689604B1 (en) * 1998-03-20 2004-02-10 National Research Council Of Canada Lipopolysaccharide α-2,3 sialyltransferase of Campylobacter jejuni and its uses
US6190522B1 (en) * 1998-04-24 2001-02-20 Board Of Regents, The University Of Texas System Analysis of carbohydrates derivatized with visible dye by high-resolution polyacrylamide gel electrophoresis
WO2000012726A2 (en) 1998-08-27 2000-03-09 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase i and ii
US7056504B1 (en) * 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
US6699705B2 (en) * 1999-02-01 2004-03-02 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
US6429302B1 (en) * 1999-02-02 2002-08-06 Chiron Corporation Polynucleotides related to pancreatic disease
EP1190364A2 (en) * 1999-04-23 2002-03-27 Massachusetts Institute Of Technology System and method for polymer notation
WO2001066772A2 (en) * 2000-03-08 2001-09-13 Massachusetts Institute Of Technology Heparinase iii and uses thereof
ATE426805T1 (en) 2000-09-12 2009-04-15 Massachusetts Inst Technology METHODS AND PRODUCTS ASSOCIATED WITH LOW MOLECULAR HEPARIN
EP1328260A2 (en) * 2000-10-18 2003-07-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
WO2002066952A2 (en) * 2000-10-19 2002-08-29 Target Discovery, Inc Mass defect labeling for the determination of oligomer sequences
US20030008820A1 (en) * 2001-03-27 2003-01-09 Massachusetts Institute Of Technology Methods and products related to FGF dimerization
AU2002312146A1 (en) * 2001-05-30 2002-12-09 Triad Therapeutics, Inc. Nuclear magnetic resonance-docking of compounds
US7157277B2 (en) * 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7317091B2 (en) * 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
EP2284535A1 (en) * 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
CA2484604C (en) * 2002-05-03 2011-08-02 Massachusetts Institute Of Technology .delta. 4,5 glycuronidase and uses thereof
EP1590648A4 (en) * 2002-05-20 2007-04-18 Massachusetts Inst Technology Novel method for sequence determination using nmr
AU2003243396A1 (en) * 2002-06-03 2003-12-19 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from chondroitinase b
JP4606712B2 (en) * 2003-01-08 2011-01-05 マサチューセッツ インスティテュート オブ テクノロジー 2-O sulfatase compositions and related methods
US7407810B2 (en) * 2003-09-04 2008-08-05 Momenta Pharmaceuticals, Inc. Methods and apparatus for characterizing polymeric mixtures
JP4548702B2 (en) * 2003-10-02 2010-09-22 キヤノン株式会社 Imaging apparatus and imaging system
US7851223B2 (en) * 2004-02-27 2010-12-14 Roar Holding Llc Method to detect emphysema
EP1737954A2 (en) 2004-03-10 2007-01-03 The Massachusetts Institute Of Technology Recombinant chondroitinase abc i and uses thereof
WO2005110438A2 (en) 2004-04-15 2005-11-24 Massachusetts Institute Of Technology Methods and products related to the intracellular delivery of polysaccharides
US20060127950A1 (en) 2004-04-15 2006-06-15 Massachusetts Institute Of Technology Methods and products related to the improved analysis of carbohydrates
WO2005111627A2 (en) 2004-04-15 2005-11-24 Massachusetts Institute Of Technology Methods and products related to the improved analysis of carbohydrates
US7358346B2 (en) * 2004-04-23 2008-04-15 L'oreal C-glycosides, uses thereof
EP1768687A2 (en) * 2004-06-29 2007-04-04 Massachusetts Institute Of Technology Methods and compositions related to the modulation of intercellular junctions
WO2006083328A2 (en) 2004-09-15 2006-08-10 Massachusetts Institute Of Technology Biologically active surfaces and methods of their use
EP1835848A4 (en) * 2004-12-30 2009-07-29 Pelikan Technologies Inc Method and apparatus for analyte measurement test time
CA2594013A1 (en) 2005-01-12 2006-07-20 Massachusetts Institute Of Technology Methods and compositions related to modulating the extracellular stem cell environment
WO2006105315A2 (en) 2005-03-29 2006-10-05 Massachusetts Institute Of Technology Compositions and methods for regulating inflammatory responses
WO2006105313A2 (en) 2005-03-29 2006-10-05 Massachusetts Institute Of Technology Compositions of and methods of using oversulfated glycosaminoglycans
US7767420B2 (en) * 2005-11-03 2010-08-03 Momenta Pharmaceuticals, Inc. Heparan sulfate glycosaminoglycan lyase and uses thereof
US7691612B2 (en) * 2005-11-03 2010-04-06 Momenta Pharmaceuticals, Inc. Heparan sulfate glycosaminoglycan lyase and uses thereof
US20080071148A1 (en) * 2006-04-03 2008-03-20 Massachusetts Institute Of Technology Glycomic patterns for the detection of disease
US7541806B2 (en) * 2006-06-24 2009-06-02 Forschungszentrum Julich Gmbh Method for molecule examination by NMR spectroscopy
JP2010515434A (en) * 2007-01-05 2010-05-13 マサチューセッツ インスティテュート オブ テクノロジー Compositions and methods using sulfatase from Flavobacterium heparinum

Also Published As

Publication number Publication date
AU2003302219A1 (en) 2004-07-09
US20080278164A1 (en) 2008-11-13
US7508206B2 (en) 2009-03-24
US7728589B2 (en) 2010-06-01
JP4657726B2 (en) 2011-03-23
CA2486456C (en) 2012-07-17
EP1590648A4 (en) 2007-04-18
JP2006505799A (en) 2006-02-16
US7737692B2 (en) 2010-06-15
US8018231B2 (en) 2011-09-13
AU2003302219B2 (en) 2009-02-19
WO2004055491A2 (en) 2004-07-01
US20090045811A1 (en) 2009-02-19
CA2486456A1 (en) 2004-07-01
JP2009300452A (en) 2009-12-24
EP1590648A2 (en) 2005-11-02
WO2004055491A3 (en) 2007-04-05
AU2003302219B8 (en) 2009-03-26
US20040092037A1 (en) 2004-05-13
US20100216176A1 (en) 2010-08-26

Similar Documents

Publication Publication Date Title
WO2004055491A3 (en) Novel method for sequence determination using nmr
HK1210627A1 (en) Preparing crude biological estracts using protease, suitable for preparing cdna cdna
AU2002316210A1 (en) Method and apparatus for determining and assessing information to be collected based on information-theoretic measures
WO2000001845A3 (en) Method for early diagnosis of carcinomas
WO2007005184A3 (en) Dialog analysis
WO2005014850A3 (en) Systems and methods for analyzing nucleic acid sequences
AU2003248273A1 (en) Analytical chip, analytical chip unit, analyzing apparatus, method of analysis using the apparatus, and method of producing the analytical chip
WO2005065541A3 (en) Methods for using raman spectroscopy to obtain a protein profile of a biological sample
WO2007076128A3 (en) Nanoreporters and methods of manufacturing and use thereof
AU2003235970A1 (en) Analysis instrument, sample analysis method and analysis device using the instrument, and method of forming opening in the instrument
WO2004010249A3 (en) System and method for utilizing profile information
BR0112385A (en) Universal collection medium
WO2004029219A3 (en) Cell-based rna interference and related methods and compositions
WO2004033631A8 (en) Nucleic acid and polypeptide sequences from lawsonia intracellularis and methods of using
AU2002311897A1 (en) Nucleic acid detection in pooled samples
DE60213803D1 (en) Happier mapping
WO2003006951A3 (en) System and method of determining proteomic differences
WO2006087603A3 (en) Isoelectric particles and uses as electrophoretic tags for multiple analyte detection using capillary isoelectric focusing
WO2002080649A3 (en) Methods and systems for searching genomic databases
EP1312673A4 (en) Method of protecting personal information
WO2002066982A3 (en) Analysis of modification and demodification of proteins with ubiquitin-related proteins by means of fret (fluorescence resonance energy transfer)
EP1471444A4 (en) Rna sequence analyzer, and rna sequence analysis method, program and recording medium
WO2003102211A3 (en) Method of detecting dna variation in sequence data
WO2003099222A3 (en) Pseudo-tissues and uses thereof
ITRM20010056A0 (en) EQUIPMENT FOR THE FERMENTATION OF SUBSTANCES, PARTICULARLY FOR WINE MAKING.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2486456

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2004560266

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2003302219

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2003810037

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003810037

Country of ref document: EP